LeishMANIAdb
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Tryparedoxin-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Tryparedoxin-like protein
Gene product:
tryparedoxin 3, putative
Species:
Leishmania mexicana
UniProt:
E9B1Z5_LEIMU
TriTrypDb:
LmxM.30.1960
Length:
191

Annotations

LeishMANIAdb annotations

A large family of kinetoplastid-specific oxidoreductases. Only expanded in the Leptomonas genus. Localization: ER (by feature) / Mitochondial outer membrane (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 7
GO:0005829 cytosol 2 1
GO:0005634 nucleus 5 2
GO:0032473 cytoplasmic side of mitochondrial outer membrane 4 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0098552 side of membrane 2 1
GO:0098562 cytoplasmic side of membrane 3 1

Expansion

Sequence features

E9B1Z5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Z5

PDB structure(s): 3s9f_A

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009987 cellular process 1 1
GO:0042743 hydrogen peroxide metabolic process 4 1
GO:0042744 hydrogen peroxide catabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0072593 reactive oxygen species metabolic process 3 1
GO:0009892 negative regulation of metabolic process 4 2
GO:0009966 regulation of signal transduction 4 2
GO:0009968 negative regulation of signal transduction 5 2
GO:0010605 negative regulation of macromolecule metabolic process 5 2
GO:0010646 regulation of cell communication 4 2
GO:0010648 negative regulation of cell communication 5 2
GO:0019222 regulation of metabolic process 3 2
GO:0023051 regulation of signaling 3 2
GO:0023057 negative regulation of signaling 4 2
GO:0030111 regulation of Wnt signaling pathway 5 2
GO:0030178 negative regulation of Wnt signaling pathway 6 2
GO:0031396 regulation of protein ubiquitination 8 2
GO:0031397 negative regulation of protein ubiquitination 9 2
GO:0031399 regulation of protein modification process 6 2
GO:0031400 negative regulation of protein modification process 7 2
GO:0048519 negative regulation of biological process 3 2
GO:0048523 negative regulation of cellular process 4 2
GO:0048583 regulation of response to stimulus 3 2
GO:0048585 negative regulation of response to stimulus 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051172 negative regulation of nitrogen compound metabolic process 5 2
GO:0051246 regulation of protein metabolic process 5 2
GO:0051248 negative regulation of protein metabolic process 6 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
GO:0080090 regulation of primary metabolic process 4 2
GO:1903320 regulation of protein modification by small protein conjugation or removal 7 2
GO:1903321 negative regulation of protein modification by small protein conjugation or removal 8 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0004791 thioredoxin-disulfide reductase activity 2 13
GO:0015035 protein-disulfide reductase activity 3 13
GO:0015036 disulfide oxidoreductase activity 4 13
GO:0016209 antioxidant activity 1 13
GO:0016491 oxidoreductase activity 2 13
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 13
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4 13
GO:0047134 protein-disulfide reductase (NAD(P)) activity 4 13
GO:0140096 catalytic activity, acting on a protein 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 125 127 PF00675 0.447
CLV_NRD_NRD_1 165 167 PF00675 0.597
CLV_NRD_NRD_1 183 185 PF00675 0.350
CLV_PCSK_KEX2_1 183 185 PF00082 0.392
CLV_PCSK_SKI1_1 46 50 PF00082 0.269
CLV_Separin_Metazoa 78 82 PF03568 0.347
DEG_Nend_UBRbox_2 1 3 PF02207 0.631
DOC_CDC14_PxL_1 111 119 PF14671 0.489
DOC_MAPK_gen_1 166 174 PF00069 0.578
DOC_MAPK_gen_1 62 69 PF00069 0.497
DOC_MAPK_MEF2A_6 112 119 PF00069 0.511
DOC_MAPK_MEF2A_6 166 174 PF00069 0.542
DOC_MAPK_MEF2A_6 28 37 PF00069 0.233
DOC_MAPK_NFAT4_5 167 175 PF00069 0.537
DOC_PP4_FxxP_1 146 149 PF00568 0.588
DOC_WW_Pin1_4 46 51 PF00397 0.471
LIG_14-3-3_CanoR_1 183 188 PF00244 0.359
LIG_AP2alpha_2 140 142 PF02296 0.403
LIG_BIR_III_2 150 154 PF00653 0.410
LIG_Clathr_ClatBox_1 117 121 PF01394 0.494
LIG_FHA_1 106 112 PF00498 0.430
LIG_FHA_1 47 53 PF00498 0.469
LIG_GBD_Chelix_1 170 178 PF00786 0.428
LIG_LIR_Apic_2 38 44 PF02991 0.469
LIG_LIR_Apic_2 89 94 PF02991 0.509
LIG_LIR_Gen_1 29 39 PF02991 0.392
LIG_LIR_Gen_1 66 76 PF02991 0.480
LIG_LIR_Nem_3 140 145 PF02991 0.477
LIG_LIR_Nem_3 185 190 PF02991 0.372
LIG_LIR_Nem_3 29 35 PF02991 0.260
LIG_LIR_Nem_3 66 72 PF02991 0.479
LIG_LIR_Nem_3 89 93 PF02991 0.489
LIG_Pex14_1 105 109 PF04695 0.509
LIG_Pex14_2 142 146 PF04695 0.410
LIG_Pex14_2 37 41 PF04695 0.462
LIG_Pex14_2 65 69 PF04695 0.475
LIG_SH2_CRK 91 95 PF00017 0.499
LIG_SH2_PTP2 32 35 PF00017 0.379
LIG_SH2_SRC 95 98 PF00017 0.415
LIG_SH2_STAP1 164 168 PF00017 0.460
LIG_SH2_STAT5 164 167 PF00017 0.535
LIG_SH2_STAT5 32 35 PF00017 0.471
LIG_SH2_STAT5 82 85 PF00017 0.464
LIG_SH2_STAT5 91 94 PF00017 0.509
LIG_SUMO_SIM_anti_2 9 15 PF11976 0.522
LIG_SUMO_SIM_par_1 174 180 PF11976 0.546
LIG_TRAF2_1 75 78 PF00917 0.397
LIG_UBA3_1 11 16 PF00899 0.448
LIG_WRC_WIRS_1 52 57 PF05994 0.453
MOD_CDK_SPxxK_3 46 53 PF00069 0.526
MOD_CK1_1 182 188 PF00069 0.407
MOD_CK2_1 51 57 PF00069 0.444
MOD_CK2_1 72 78 PF00069 0.512
MOD_DYRK1A_RPxSP_1 46 50 PF00069 0.515
MOD_GlcNHglycan 17 21 PF01048 0.496
MOD_GlcNHglycan 37 40 PF01048 0.259
MOD_GlcNHglycan 8 11 PF01048 0.567
MOD_GSK3_1 179 186 PF00069 0.406
MOD_GSK3_1 68 75 PF00069 0.430
MOD_N-GLC_1 6 11 PF02516 0.560
MOD_NEK2_1 162 167 PF00069 0.605
MOD_NEK2_1 177 182 PF00069 0.452
MOD_NEK2_1 51 56 PF00069 0.445
MOD_NEK2_1 6 11 PF00069 0.571
MOD_NEK2_1 83 88 PF00069 0.415
MOD_PIKK_1 135 141 PF00454 0.611
MOD_PKA_1 183 189 PF00069 0.363
MOD_PKA_2 182 188 PF00069 0.504
MOD_Plk_4 156 162 PF00069 0.607
MOD_Plk_4 51 57 PF00069 0.456
MOD_ProDKin_1 46 52 PF00069 0.471
TRG_DiLeu_BaLyEn_6 47 52 PF01217 0.489
TRG_ENDOCYTIC_2 32 35 PF00928 0.489
TRG_ENDOCYTIC_2 90 93 PF00928 0.496

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HT51 Leptomonas seymouri 55% 100%
A0A0N1HZM3 Leptomonas seymouri 39% 100%
A0A1X0P005 Trypanosomatidae 39% 100%
A0A1X0P190 Trypanosomatidae 36% 96%
A0A3Q8IED6 Leishmania donovani 39% 100%
A0A3Q8IG90 Leishmania donovani 92% 100%
A0A3S7X2H1 Leishmania donovani 36% 100%
A0A422MZX1 Trypanosoma rangeli 38% 99%
A0A6L0XIW2 Leishmania infantum 36% 100%
A0A6L0XKX4 Leishmania infantum 39% 100%
A4HHC6 Leishmania braziliensis 38% 100%
A4HHC7 Leishmania braziliensis 33% 100%
A4HHC8 Leishmania braziliensis 33% 100%
A4HJH8 Leishmania braziliensis 78% 100%
A4I6X1 Leishmania infantum 92% 100%
C9ZKL4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 96%
C9ZL57 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9ADX3 Leishmania major 34% 100%
E9ADX4 Leishmania major 38% 100%
E9ALV7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9ALV8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B1Z6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
O77404 Trypanosoma brucei brucei 41% 100%
Q4Q665 Leishmania major 44% 100%
Q4Q666 Leishmania major 86% 100%
Q5VZ03 Homo sapiens 35% 100%
Q9D531 Mus musculus 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS