Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1Z4_LEIMU

TriTrypDb:

LmxM.30.1950

Length:

575

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B1Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Z4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.470
CLV_NRD_NRD_1	199	201	PF00675	0.454
CLV_NRD_NRD_1	286	288	PF00675	0.516
CLV_NRD_NRD_1	36	38	PF00675	0.509
CLV_NRD_NRD_1	503	505	PF00675	0.561
CLV_PCSK_FUR_1	133	137	PF00082	0.472
CLV_PCSK_KEX2_1	135	137	PF00082	0.471
CLV_PCSK_KEX2_1	199	201	PF00082	0.454
CLV_PCSK_KEX2_1	285	287	PF00082	0.631
CLV_PCSK_KEX2_1	36	38	PF00082	0.514
CLV_PCSK_PC7_1	131	137	PF00082	0.474
CLV_PCSK_SKI1_1	230	234	PF00082	0.518
CLV_PCSK_SKI1_1	347	351	PF00082	0.429
DEG_SPOP_SBC_1	268	272	PF00917	0.627
DEG_SPOP_SBC_1	470	474	PF00917	0.683
DOC_CDC14_PxL_1	334	342	PF14671	0.592
DOC_CYCLIN_yCln2_LP_2	548	554	PF00134	0.765
DOC_MAPK_MEF2A_6	204	211	PF00069	0.664
DOC_PP4_FxxP_1	537	540	PF00568	0.687
DOC_PP4_FxxP_1	552	555	PF00568	0.775
DOC_USP7_MATH_1	237	241	PF00917	0.730
DOC_USP7_MATH_1	252	256	PF00917	0.667
DOC_USP7_MATH_1	392	396	PF00917	0.641
DOC_USP7_MATH_1	486	490	PF00917	0.704
DOC_USP7_MATH_1	562	566	PF00917	0.739
DOC_USP7_MATH_1	75	79	PF00917	0.744
DOC_WW_Pin1_4	114	119	PF00397	0.680
DOC_WW_Pin1_4	184	189	PF00397	0.663
DOC_WW_Pin1_4	203	208	PF00397	0.774
DOC_WW_Pin1_4	223	228	PF00397	0.551
DOC_WW_Pin1_4	248	253	PF00397	0.709
DOC_WW_Pin1_4	264	269	PF00397	0.715
DOC_WW_Pin1_4	287	292	PF00397	0.779
DOC_WW_Pin1_4	298	303	PF00397	0.691
DOC_WW_Pin1_4	359	364	PF00397	0.778
DOC_WW_Pin1_4	379	384	PF00397	0.715
DOC_WW_Pin1_4	397	402	PF00397	0.625
DOC_WW_Pin1_4	413	418	PF00397	0.601
DOC_WW_Pin1_4	453	458	PF00397	0.680
DOC_WW_Pin1_4	461	466	PF00397	0.739
DOC_WW_Pin1_4	471	476	PF00397	0.700
DOC_WW_Pin1_4	499	504	PF00397	0.759
DOC_WW_Pin1_4	536	541	PF00397	0.702
DOC_WW_Pin1_4	547	552	PF00397	0.716
DOC_WW_Pin1_4	70	75	PF00397	0.644
LIG_14-3-3_CanoR_1	199	207	PF00244	0.664
LIG_14-3-3_CanoR_1	210	216	PF00244	0.638
LIG_14-3-3_CanoR_1	296	302	PF00244	0.635
LIG_14-3-3_CanoR_1	393	401	PF00244	0.748
LIG_14-3-3_CanoR_1	511	517	PF00244	0.641
LIG_14-3-3_CanoR_1	543	551	PF00244	0.779
LIG_14-3-3_CterR_2	572	575	PF00244	0.619
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_BRCT_BRCA1_1	186	190	PF00533	0.646
LIG_BRCT_BRCA1_1	243	247	PF00533	0.705
LIG_BRCT_BRCA1_1	325	329	PF00533	0.700
LIG_BRCT_BRCA1_1	381	385	PF00533	0.717
LIG_FHA_1	204	210	PF00498	0.664
LIG_FHA_1	362	368	PF00498	0.733
LIG_FHA_1	379	385	PF00498	0.651
LIG_FHA_1	471	477	PF00498	0.764
LIG_FHA_2	169	175	PF00498	0.641
LIG_FHA_2	290	296	PF00498	0.746
LIG_FHA_2	323	329	PF00498	0.718
LIG_FHA_2	363	369	PF00498	0.612
LIG_FHA_2	44	50	PF00498	0.691
LIG_Integrin_RGD_1	65	67	PF01839	0.541
LIG_LIR_Apic_2	536	540	PF02991	0.747
LIG_LIR_Apic_2	550	555	PF02991	0.773
LIG_LIR_Gen_1	326	337	PF02991	0.697
LIG_LIR_Nem_3	155	159	PF02991	0.637
LIG_LIR_Nem_3	326	332	PF02991	0.698
LIG_LIR_Nem_3	442	446	PF02991	0.711
LIG_LIR_Nem_3	464	470	PF02991	0.769
LIG_LYPXL_yS_3	467	470	PF13949	0.738
LIG_MYND_1	499	503	PF01753	0.672
LIG_MYND_3	340	344	PF01753	0.569
LIG_REV1ctd_RIR_1	281	290	PF16727	0.730
LIG_SH2_NCK_1	39	43	PF00017	0.670
LIG_SH2_NCK_1	72	76	PF00017	0.624
LIG_SH2_SRC	39	42	PF00017	0.723
LIG_SH2_STAP1	418	422	PF00017	0.732
LIG_SH2_STAT5	72	75	PF00017	0.621
LIG_SH3_3	112	118	PF00018	0.681
LIG_SH3_3	246	252	PF00018	0.693
LIG_SH3_3	335	341	PF00018	0.658
LIG_SH3_3	451	457	PF00018	0.739
LIG_SH3_3	462	468	PF00018	0.735
LIG_SH3_3	491	497	PF00018	0.721
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.313
LIG_SUMO_SIM_par_1	13	18	PF11976	0.276
LIG_SUMO_SIM_par_1	168	174	PF11976	0.717
LIG_SUMO_SIM_par_1	2	9	PF11976	0.345
LIG_TRAF2_1	171	174	PF00917	0.634
LIG_TRAF2_1	46	49	PF00917	0.722
LIG_WRC_WIRS_1	534	539	PF05994	0.769
MOD_CDC14_SPxK_1	290	293	PF00782	0.778
MOD_CDC14_SPxK_1	502	505	PF00782	0.760
MOD_CDK_SPK_2	499	504	PF00069	0.753
MOD_CDK_SPxK_1	287	293	PF00069	0.781
MOD_CDK_SPxK_1	499	505	PF00069	0.755
MOD_CDK_SPxxK_3	203	210	PF00069	0.717
MOD_CDK_SPxxK_3	223	230	PF00069	0.599
MOD_CDK_SPxxK_3	536	543	PF00069	0.607
MOD_CK1_1	241	247	PF00069	0.697
MOD_CK1_1	362	368	PF00069	0.814
MOD_CK1_1	395	401	PF00069	0.806
MOD_CK1_1	416	422	PF00069	0.634
MOD_CK1_1	442	448	PF00069	0.675
MOD_CK1_1	453	459	PF00069	0.676
MOD_CK1_1	474	480	PF00069	0.726
MOD_CK1_1	489	495	PF00069	0.736
MOD_CK1_1	538	544	PF00069	0.708
MOD_CK1_1	550	556	PF00069	0.695
MOD_CK1_1	565	571	PF00069	0.783
MOD_CK2_1	168	174	PF00069	0.645
MOD_CK2_1	362	368	PF00069	0.613
MOD_CK2_1	43	49	PF00069	0.721
MOD_DYRK1A_RPxSP_1	114	118	PF00069	0.662
MOD_DYRK1A_RPxSP_1	248	252	PF00069	0.693
MOD_GlcNHglycan	17	20	PF01048	0.307
MOD_GlcNHglycan	254	257	PF01048	0.521
MOD_GlcNHglycan	264	267	PF01048	0.524
MOD_GlcNHglycan	312	315	PF01048	0.559
MOD_GlcNHglycan	390	393	PF01048	0.445
MOD_GlcNHglycan	394	397	PF01048	0.466
MOD_GlcNHglycan	450	453	PF01048	0.478
MOD_GlcNHglycan	476	479	PF01048	0.502
MOD_GlcNHglycan	488	491	PF01048	0.512
MOD_GlcNHglycan	49	53	PF01048	0.525
MOD_GlcNHglycan	516	519	PF01048	0.582
MOD_GlcNHglycan	522	525	PF01048	0.494
MOD_GlcNHglycan	545	548	PF01048	0.565
MOD_GlcNHglycan	564	567	PF01048	0.519
MOD_GlcNHglycan	57	60	PF01048	0.512
MOD_GlcNHglycan	77	80	PF01048	0.543
MOD_GSK3_1	199	206	PF00069	0.673
MOD_GSK3_1	237	244	PF00069	0.762
MOD_GSK3_1	248	255	PF00069	0.669
MOD_GSK3_1	262	269	PF00069	0.717
MOD_GSK3_1	296	303	PF00069	0.775
MOD_GSK3_1	374	381	PF00069	0.762
MOD_GSK3_1	388	395	PF00069	0.635
MOD_GSK3_1	470	477	PF00069	0.736
MOD_GSK3_1	507	514	PF00069	0.723
MOD_GSK3_1	538	545	PF00069	0.685
MOD_GSK3_1	550	557	PF00069	0.694
MOD_GSK3_1	558	565	PF00069	0.737
MOD_N-GLC_1	274	279	PF02516	0.512
MOD_N-GLC_1	309	314	PF02516	0.463
MOD_N-GLC_1	439	444	PF02516	0.509
MOD_N-GLC_2	542	544	PF02516	0.415
MOD_NEK2_1	15	20	PF00069	0.293
MOD_NEK2_1	211	216	PF00069	0.649
MOD_NEK2_1	221	226	PF00069	0.653
MOD_NEK2_1	378	383	PF00069	0.728
MOD_NEK2_1	427	432	PF00069	0.802
MOD_NEK2_1	439	444	PF00069	0.696
MOD_NEK2_1	476	481	PF00069	0.839
MOD_NEK2_1	6	11	PF00069	0.397
MOD_NEK2_2	243	248	PF00069	0.785
MOD_PIKK_1	300	306	PF00454	0.762
MOD_PIKK_1	416	422	PF00454	0.606
MOD_PIKK_1	80	86	PF00454	0.784
MOD_PKA_1	199	205	PF00069	0.658
MOD_PKA_2	199	205	PF00069	0.669
MOD_PKA_2	209	215	PF00069	0.646
MOD_PKA_2	392	398	PF00069	0.737
MOD_PKA_2	542	548	PF00069	0.822
MOD_PKA_2	80	86	PF00069	0.738
MOD_Plk_1	238	244	PF00069	0.774
MOD_Plk_1	330	336	PF00069	0.696
MOD_Plk_1	439	445	PF00069	0.752
MOD_Plk_1	48	54	PF00069	0.717
MOD_Plk_2-3	323	329	PF00069	0.703
MOD_Plk_2-3	43	49	PF00069	0.670
MOD_Plk_4	211	217	PF00069	0.644
MOD_Plk_4	428	434	PF00069	0.605
MOD_ProDKin_1	114	120	PF00069	0.677
MOD_ProDKin_1	184	190	PF00069	0.664
MOD_ProDKin_1	203	209	PF00069	0.773
MOD_ProDKin_1	223	229	PF00069	0.554
MOD_ProDKin_1	248	254	PF00069	0.709
MOD_ProDKin_1	264	270	PF00069	0.715
MOD_ProDKin_1	287	293	PF00069	0.781
MOD_ProDKin_1	298	304	PF00069	0.692
MOD_ProDKin_1	359	365	PF00069	0.778
MOD_ProDKin_1	379	385	PF00069	0.717
MOD_ProDKin_1	397	403	PF00069	0.623
MOD_ProDKin_1	413	419	PF00069	0.600
MOD_ProDKin_1	453	459	PF00069	0.682
MOD_ProDKin_1	461	467	PF00069	0.741
MOD_ProDKin_1	471	477	PF00069	0.702
MOD_ProDKin_1	499	505	PF00069	0.761
MOD_ProDKin_1	536	542	PF00069	0.703
MOD_ProDKin_1	547	553	PF00069	0.715
MOD_ProDKin_1	70	76	PF00069	0.646
MOD_SUMO_for_1	351	354	PF00179	0.730
TRG_DiLeu_BaEn_4	173	179	PF01217	0.707
TRG_ENDOCYTIC_2	106	109	PF00928	0.772
TRG_ENDOCYTIC_2	467	470	PF00928	0.738
TRG_ER_diArg_1	131	134	PF00400	0.677
TRG_ER_diArg_1	139	142	PF00400	0.650
TRG_ER_diArg_1	284	287	PF00400	0.702
TRG_ER_diArg_1	315	318	PF00400	0.800
TRG_ER_diArg_1	36	38	PF00400	0.710
TRG_NLS_MonoExtC_3	286	291	PF00514	0.733
TRG_NLS_MonoExtN_4	285	291	PF00514	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM8	Leptomonas seymouri	45%	78%
A0A3S7X4M7	Leishmania donovani	86%	100%
A4HJH7	Leishmania braziliensis	64%	100%
A4I6X0	Leishmania infantum	86%	100%
Q4Q667	Leishmania major	82%	99%