Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1Z0_LEIMU

TriTrypDb:

LmxM.30.1910

Length:

829

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.535
CLV_C14_Caspase3-7	186	190	PF00656	0.529
CLV_C14_Caspase3-7	200	204	PF00656	0.523
CLV_NRD_NRD_1	131	133	PF00675	0.546
CLV_NRD_NRD_1	292	294	PF00675	0.674
CLV_NRD_NRD_1	54	56	PF00675	0.579
CLV_NRD_NRD_1	606	608	PF00675	0.582
CLV_NRD_NRD_1	626	628	PF00675	0.631
CLV_NRD_NRD_1	632	634	PF00675	0.637
CLV_NRD_NRD_1	678	680	PF00675	0.538
CLV_NRD_NRD_1	68	70	PF00675	0.524
CLV_NRD_NRD_1	730	732	PF00675	0.517
CLV_NRD_NRD_1	734	736	PF00675	0.511
CLV_NRD_NRD_1	778	780	PF00675	0.620
CLV_PCSK_FUR_1	731	735	PF00082	0.410
CLV_PCSK_KEX2_1	102	104	PF00082	0.572
CLV_PCSK_KEX2_1	292	294	PF00082	0.674
CLV_PCSK_KEX2_1	359	361	PF00082	0.597
CLV_PCSK_KEX2_1	54	56	PF00082	0.579
CLV_PCSK_KEX2_1	605	607	PF00082	0.585
CLV_PCSK_KEX2_1	626	628	PF00082	0.663
CLV_PCSK_KEX2_1	632	634	PF00082	0.671
CLV_PCSK_KEX2_1	678	680	PF00082	0.538
CLV_PCSK_KEX2_1	68	70	PF00082	0.524
CLV_PCSK_KEX2_1	732	734	PF00082	0.547
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.572
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.597
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.565
CLV_PCSK_PC1ET2_1	732	734	PF00082	0.547
CLV_PCSK_PC7_1	622	628	PF00082	0.544
CLV_PCSK_SKI1_1	103	107	PF00082	0.509
CLV_PCSK_SKI1_1	388	392	PF00082	0.564
CLV_PCSK_SKI1_1	41	45	PF00082	0.566
CLV_PCSK_SKI1_1	459	463	PF00082	0.642
CLV_PCSK_SKI1_1	54	58	PF00082	0.503
CLV_PCSK_SKI1_1	91	95	PF00082	0.580
DEG_APCC_DBOX_1	458	466	PF00400	0.614
DEG_APCC_DBOX_1	808	816	PF00400	0.466
DEG_Nend_Nbox_1	1	3	PF02207	0.594
DEG_SCF_TRCP1_1	122	127	PF00400	0.515
DEG_SPOP_SBC_1	351	355	PF00917	0.680
DEG_SPOP_SBC_1	372	376	PF00917	0.536
DEG_SPOP_SBC_1	453	457	PF00917	0.534
DOC_CKS1_1	271	276	PF01111	0.517
DOC_CKS1_1	484	489	PF01111	0.503
DOC_CYCLIN_yCln2_LP_2	612	618	PF00134	0.604
DOC_MAPK_gen_1	52	61	PF00069	0.587
DOC_MAPK_gen_1	593	601	PF00069	0.505
DOC_USP7_MATH_1	163	167	PF00917	0.537
DOC_USP7_MATH_1	17	21	PF00917	0.744
DOC_USP7_MATH_1	256	260	PF00917	0.592
DOC_USP7_MATH_1	366	370	PF00917	0.661
DOC_USP7_MATH_1	372	376	PF00917	0.613
DOC_USP7_MATH_1	398	402	PF00917	0.474
DOC_USP7_MATH_1	453	457	PF00917	0.616
DOC_USP7_MATH_1	511	515	PF00917	0.519
DOC_USP7_MATH_1	581	585	PF00917	0.661
DOC_USP7_MATH_1	662	666	PF00917	0.519
DOC_USP7_MATH_1	684	688	PF00917	0.632
DOC_USP7_UBL2_3	257	261	PF12436	0.670
DOC_WW_Pin1_4	187	192	PF00397	0.636
DOC_WW_Pin1_4	203	208	PF00397	0.583
DOC_WW_Pin1_4	270	275	PF00397	0.673
DOC_WW_Pin1_4	334	339	PF00397	0.668
DOC_WW_Pin1_4	353	358	PF00397	0.643
DOC_WW_Pin1_4	449	454	PF00397	0.656
DOC_WW_Pin1_4	463	468	PF00397	0.525
DOC_WW_Pin1_4	483	488	PF00397	0.507
DOC_WW_Pin1_4	491	496	PF00397	0.652
DOC_WW_Pin1_4	506	511	PF00397	0.505
LIG_14-3-3_CanoR_1	292	302	PF00244	0.646
LIG_14-3-3_CanoR_1	322	327	PF00244	0.582
LIG_14-3-3_CanoR_1	620	626	PF00244	0.570
LIG_Actin_WH2_2	298	316	PF00022	0.542
LIG_Actin_WH2_2	41	59	PF00022	0.459
LIG_APCC_ABBA_1	752	757	PF00400	0.359
LIG_BIR_III_4	792	796	PF00653	0.497
LIG_CaM_NSCaTE_8	518	525	PF13499	0.492
LIG_CtBP_PxDLS_1	444	448	PF00389	0.537
LIG_CtBP_PxDLS_1	674	678	PF00389	0.533
LIG_DLG_GKlike_1	74	82	PF00625	0.513
LIG_FHA_1	16	22	PF00498	0.610
LIG_FHA_1	249	255	PF00498	0.584
LIG_FHA_1	271	277	PF00498	0.522
LIG_FHA_1	414	420	PF00498	0.606
LIG_FHA_1	464	470	PF00498	0.582
LIG_FHA_1	484	490	PF00498	0.484
LIG_FHA_1	543	549	PF00498	0.665
LIG_FHA_1	641	647	PF00498	0.640
LIG_FHA_2	151	157	PF00498	0.640
LIG_FHA_2	184	190	PF00498	0.636
LIG_FHA_2	280	286	PF00498	0.591
LIG_FHA_2	466	472	PF00498	0.595
LIG_FHA_2	694	700	PF00498	0.554
LIG_FHA_2	805	811	PF00498	0.558
LIG_FHA_2	92	98	PF00498	0.543
LIG_Integrin_isoDGR_2	781	783	PF01839	0.585
LIG_Integrin_RGD_1	568	570	PF01839	0.502
LIG_Integrin_RGD_1	689	691	PF01839	0.584
LIG_LIR_Apic_2	301	307	PF02991	0.618
LIG_LIR_Apic_2	595	600	PF02991	0.524
LIG_LIR_Gen_1	401	410	PF02991	0.512
LIG_LIR_Gen_1	517	525	PF02991	0.602
LIG_LIR_Gen_1	723	730	PF02991	0.520
LIG_LIR_Nem_3	401	405	PF02991	0.496
LIG_LIR_Nem_3	517	521	PF02991	0.608
LIG_LIR_Nem_3	723	729	PF02991	0.533
LIG_LIR_Nem_3	76	82	PF02991	0.662
LIG_LYPXL_yS_3	709	712	PF13949	0.656
LIG_MYND_3	575	579	PF01753	0.568
LIG_PCNA_yPIPBox_3	739	752	PF02747	0.414
LIG_PDZ_Class_1	824	829	PF00595	0.609
LIG_SH2_CRK	726	730	PF00017	0.502
LIG_SH2_CRK	79	83	PF00017	0.599
LIG_SH2_CRK	802	806	PF00017	0.589
LIG_SH2_NCK_1	546	550	PF00017	0.617
LIG_SH2_NCK_1	726	730	PF00017	0.502
LIG_SH2_SRC	277	280	PF00017	0.536
LIG_SH2_STAP1	546	550	PF00017	0.617
LIG_SH2_STAP1	726	730	PF00017	0.502
LIG_SH2_STAP1	802	806	PF00017	0.589
LIG_SH2_STAT5	499	502	PF00017	0.592
LIG_SH2_STAT5	726	729	PF00017	0.400
LIG_SH2_STAT5	802	805	PF00017	0.458
LIG_SH3_2	345	350	PF14604	0.631
LIG_SH3_2	600	605	PF14604	0.594
LIG_SH3_2	615	620	PF14604	0.519
LIG_SH3_3	177	183	PF00018	0.609
LIG_SH3_3	268	274	PF00018	0.510
LIG_SH3_3	342	348	PF00018	0.763
LIG_SH3_3	402	408	PF00018	0.544
LIG_SH3_3	481	487	PF00018	0.634
LIG_SH3_3	489	495	PF00018	0.613
LIG_SH3_3	507	513	PF00018	0.484
LIG_SH3_3	596	602	PF00018	0.642
LIG_SH3_3	612	618	PF00018	0.508
LIG_SH3_3	628	634	PF00018	0.562
LIG_SH3_3	636	642	PF00018	0.602
LIG_SH3_3	67	73	PF00018	0.611
LIG_SH3_3	709	715	PF00018	0.650
LIG_SH3_4	257	264	PF00018	0.673
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.541
LIG_SUMO_SIM_par_1	169	177	PF11976	0.529
LIG_TRAF2_1	152	155	PF00917	0.590
LIG_WW_3	713	717	PF00397	0.645
MOD_CDK_SPxK_1	353	359	PF00069	0.645
MOD_CDK_SPxxK_3	353	360	PF00069	0.701
MOD_CK1_1	107	113	PF00069	0.624
MOD_CK1_1	11	17	PF00069	0.490
MOD_CK1_1	123	129	PF00069	0.531
MOD_CK1_1	138	144	PF00069	0.526
MOD_CK1_1	240	246	PF00069	0.679
MOD_CK1_1	248	254	PF00069	0.607
MOD_CK1_1	334	340	PF00069	0.619
MOD_CK1_1	353	359	PF00069	0.698
MOD_CK1_1	368	374	PF00069	0.550
MOD_CK1_1	452	458	PF00069	0.645
MOD_CK1_1	463	469	PF00069	0.554
MOD_CK1_1	514	520	PF00069	0.492
MOD_CK1_1	85	91	PF00069	0.608
MOD_CK2_1	454	460	PF00069	0.667
MOD_CK2_1	465	471	PF00069	0.535
MOD_CK2_1	529	535	PF00069	0.517
MOD_CK2_1	647	653	PF00069	0.576
MOD_CK2_1	693	699	PF00069	0.612
MOD_Cter_Amidation	66	69	PF01082	0.502
MOD_GlcNHglycan	110	113	PF01048	0.582
MOD_GlcNHglycan	122	125	PF01048	0.630
MOD_GlcNHglycan	146	149	PF01048	0.547
MOD_GlcNHglycan	165	168	PF01048	0.575
MOD_GlcNHglycan	175	179	PF01048	0.539
MOD_GlcNHglycan	199	202	PF01048	0.530
MOD_GlcNHglycan	263	266	PF01048	0.640
MOD_GlcNHglycan	319	322	PF01048	0.658
MOD_GlcNHglycan	333	336	PF01048	0.670
MOD_GlcNHglycan	370	373	PF01048	0.617
MOD_GlcNHglycan	376	379	PF01048	0.636
MOD_GlcNHglycan	396	399	PF01048	0.478
MOD_GlcNHglycan	4	7	PF01048	0.525
MOD_GlcNHglycan	426	430	PF01048	0.569
MOD_GlcNHglycan	462	465	PF01048	0.580
MOD_GlcNHglycan	495	498	PF01048	0.629
MOD_GlcNHglycan	513	516	PF01048	0.502
MOD_GlcNHglycan	518	521	PF01048	0.557
MOD_GlcNHglycan	531	534	PF01048	0.569
MOD_GlcNHglycan	563	566	PF01048	0.606
MOD_GlcNHglycan	704	707	PF01048	0.565
MOD_GSK3_1	103	110	PF00069	0.600
MOD_GSK3_1	11	18	PF00069	0.613
MOD_GSK3_1	120	127	PF00069	0.516
MOD_GSK3_1	183	190	PF00069	0.581
MOD_GSK3_1	232	239	PF00069	0.673
MOD_GSK3_1	240	247	PF00069	0.622
MOD_GSK3_1	248	255	PF00069	0.528
MOD_GSK3_1	266	273	PF00069	0.520
MOD_GSK3_1	294	301	PF00069	0.762
MOD_GSK3_1	322	329	PF00069	0.721
MOD_GSK3_1	361	368	PF00069	0.661
MOD_GSK3_1	394	401	PF00069	0.676
MOD_GSK3_1	449	456	PF00069	0.644
MOD_GSK3_1	493	500	PF00069	0.606
MOD_GSK3_1	621	628	PF00069	0.622
MOD_GSK3_1	800	807	PF00069	0.458
MOD_GSK3_1	82	89	PF00069	0.613
MOD_LATS_1	358	364	PF00433	0.706
MOD_N-GLC_1	108	113	PF02516	0.641
MOD_N-GLC_1	135	140	PF02516	0.629
MOD_N-GLC_1	203	208	PF02516	0.527
MOD_N-GLC_1	252	257	PF02516	0.516
MOD_N-GLC_1	74	79	PF02516	0.623
MOD_N-GLC_1	800	805	PF02516	0.477
MOD_NEK2_1	104	109	PF00069	0.601
MOD_NEK2_1	173	178	PF00069	0.628
MOD_NEK2_1	2	7	PF00069	0.525
MOD_NEK2_1	227	232	PF00069	0.629
MOD_NEK2_1	236	241	PF00069	0.592
MOD_NEK2_1	326	331	PF00069	0.643
MOD_NEK2_1	516	521	PF00069	0.633
MOD_NEK2_1	592	597	PF00069	0.621
MOD_NEK2_1	625	630	PF00069	0.615
MOD_NEK2_1	692	697	PF00069	0.576
MOD_NEK2_1	800	805	PF00069	0.459
MOD_NEK2_2	621	626	PF00069	0.537
MOD_PIKK_1	241	247	PF00454	0.538
MOD_PIKK_1	446	452	PF00454	0.625
MOD_PIKK_1	454	460	PF00454	0.580
MOD_PIKK_1	625	631	PF00454	0.621
MOD_PIKK_1	664	670	PF00454	0.516
MOD_PK_1	266	272	PF00069	0.509
MOD_PKA_1	292	298	PF00069	0.654
MOD_PKA_2	173	179	PF00069	0.532
MOD_PKA_2	240	246	PF00069	0.643
MOD_PKA_2	249	255	PF00069	0.583
MOD_PKA_2	292	298	PF00069	0.654
MOD_PKA_2	366	372	PF00069	0.687
MOD_PKA_2	621	627	PF00069	0.650
MOD_PKA_2	640	646	PF00069	0.548
MOD_PKA_2	715	721	PF00069	0.524
MOD_PKA_2	86	92	PF00069	0.575
MOD_PKB_1	72	80	PF00069	0.622
MOD_Plk_1	174	180	PF00069	0.637
MOD_Plk_1	298	304	PF00069	0.687
MOD_Plk_1	478	484	PF00069	0.499
MOD_Plk_1	662	668	PF00069	0.517
MOD_Plk_1	690	696	PF00069	0.629
MOD_Plk_1	74	80	PF00069	0.625
MOD_Plk_1	800	806	PF00069	0.459
MOD_Plk_2-3	279	285	PF00069	0.536
MOD_Plk_2-3	653	659	PF00069	0.518
MOD_Plk_4	124	130	PF00069	0.556
MOD_Plk_4	138	144	PF00069	0.629
MOD_Plk_4	298	304	PF00069	0.626
MOD_Plk_4	74	80	PF00069	0.627
MOD_ProDKin_1	187	193	PF00069	0.639
MOD_ProDKin_1	203	209	PF00069	0.584
MOD_ProDKin_1	270	276	PF00069	0.677
MOD_ProDKin_1	334	340	PF00069	0.666
MOD_ProDKin_1	353	359	PF00069	0.645
MOD_ProDKin_1	449	455	PF00069	0.657
MOD_ProDKin_1	463	469	PF00069	0.519
MOD_ProDKin_1	483	489	PF00069	0.510
MOD_ProDKin_1	491	497	PF00069	0.647
MOD_ProDKin_1	506	512	PF00069	0.505
MOD_SUMO_rev_2	26	35	PF00179	0.529
TRG_ENDOCYTIC_2	709	712	PF00928	0.656
TRG_ENDOCYTIC_2	726	729	PF00928	0.405
TRG_ENDOCYTIC_2	749	752	PF00928	0.465
TRG_ENDOCYTIC_2	79	82	PF00928	0.578
TRG_ENDOCYTIC_2	802	805	PF00928	0.608
TRG_ER_diArg_1	287	290	PF00400	0.672
TRG_ER_diArg_1	291	293	PF00400	0.653
TRG_ER_diArg_1	312	315	PF00400	0.498
TRG_ER_diArg_1	54	56	PF00400	0.579
TRG_ER_diArg_1	606	608	PF00400	0.594
TRG_ER_diArg_1	625	627	PF00400	0.574
TRG_ER_diArg_1	631	633	PF00400	0.580
TRG_ER_diArg_1	677	679	PF00400	0.539
TRG_ER_diArg_1	68	70	PF00400	0.524
TRG_ER_diArg_1	731	734	PF00400	0.396
TRG_NLS_MonoCore_2	730	735	PF00514	0.501
TRG_NLS_MonoExtC_3	730	735	PF00514	0.441
TRG_NLS_MonoExtN_4	602	609	PF00514	0.553
TRG_NLS_MonoExtN_4	731	736	PF00514	0.489
TRG_Pf-PMV_PEXEL_1	607	611	PF00026	0.502
TRG_PTS1	826	829	PF00515	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFN0	Leishmania donovani	75%	98%
A4HJH3	Leishmania braziliensis	46%	100%
A4I6W6	Leishmania infantum	75%	98%
Q4Q671	Leishmania major	71%	100%