Peptidase m20/m25/m40 family-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9B1Y8_LEIMU

TriTrypDb:

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Y8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0016787	hydrolase activity	2	21
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0008233	peptidase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	242	246	PF00082	0.360
DEG_APCC_DBOX_1	241	249	PF00400	0.358
DOC_ANK_TNKS_1	106	113	PF00023	0.442
DOC_CYCLIN_RxL_1	239	249	PF00134	0.348
DOC_MAPK_gen_1	180	188	PF00069	0.420
DOC_MAPK_MEF2A_6	182	190	PF00069	0.375
DOC_MAPK_MEF2A_6	329	338	PF00069	0.365
DOC_MAPK_MEF2A_6	76	84	PF00069	0.442
DOC_PP4_FxxP_1	306	309	PF00568	0.420
DOC_USP7_MATH_1	143	147	PF00917	0.468
DOC_USP7_MATH_1	272	276	PF00917	0.349
DOC_WW_Pin1_4	166	171	PF00397	0.431
DOC_WW_Pin1_4	31	36	PF00397	0.440
DOC_WW_Pin1_4	74	79	PF00397	0.431
LIG_14-3-3_CanoR_1	329	335	PF00244	0.375
LIG_14-3-3_CanoR_1	9	13	PF00244	0.482
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_BRCT_BRCA1_1	33	37	PF00533	0.534
LIG_FHA_1	203	209	PF00498	0.363
LIG_FHA_1	235	241	PF00498	0.410
LIG_FHA_1	251	257	PF00498	0.291
LIG_FHA_1	331	337	PF00498	0.369
LIG_FHA_1	41	47	PF00498	0.511
LIG_FHA_1	75	81	PF00498	0.421
LIG_FHA_2	218	224	PF00498	0.375
LIG_LIR_Gen_1	132	143	PF02991	0.403
LIG_LIR_Gen_1	196	204	PF02991	0.355
LIG_LIR_Gen_1	2	12	PF02991	0.497
LIG_LIR_Gen_1	25	35	PF02991	0.411
LIG_LIR_Gen_1	67	73	PF02991	0.498
LIG_LIR_Gen_1	77	85	PF02991	0.282
LIG_LIR_Nem_3	132	138	PF02991	0.375
LIG_LIR_Nem_3	196	202	PF02991	0.355
LIG_LIR_Nem_3	2	8	PF02991	0.494
LIG_LIR_Nem_3	25	30	PF02991	0.409
LIG_LIR_Nem_3	48	54	PF02991	0.476
LIG_LIR_Nem_3	67	71	PF02991	0.456
LIG_LIR_Nem_3	77	82	PF02991	0.301
LIG_LRP6_Inhibitor_1	323	329	PF00058	0.441
LIG_MYND_1	104	108	PF01753	0.363
LIG_Pex14_2	281	285	PF04695	0.388
LIG_Pex14_2	37	41	PF04695	0.558
LIG_SH2_CRK	68	72	PF00017	0.453
LIG_SH2_PTP2	27	30	PF00017	0.437
LIG_SH2_SRC	27	30	PF00017	0.450
LIG_SH2_STAP1	135	139	PF00017	0.390
LIG_SH2_STAP1	199	203	PF00017	0.363
LIG_SH2_STAP1	268	272	PF00017	0.340
LIG_SH2_STAT5	27	30	PF00017	0.437
LIG_SH2_STAT5	70	73	PF00017	0.366
LIG_SH3_1	102	108	PF00018	0.363
LIG_SH3_3	102	108	PF00018	0.355
LIG_SH3_3	253	259	PF00018	0.403
LIG_SH3_5	170	174	PF00018	0.403
LIG_SUMO_SIM_par_1	157	162	PF11976	0.354
LIG_TYR_ITIM	66	71	PF00017	0.476
LIG_UBA3_1	244	252	PF00899	0.431
MOD_CK1_1	224	230	PF00069	0.397
MOD_CK1_1	275	281	PF00069	0.416
MOD_CK2_1	11	17	PF00069	0.524
MOD_CK2_1	217	223	PF00069	0.375
MOD_CK2_1	243	249	PF00069	0.482
MOD_GlcNHglycan	1	4	PF01048	0.593
MOD_GlcNHglycan	165	169	PF01048	0.375
MOD_GlcNHglycan	193	196	PF01048	0.364
MOD_GlcNHglycan	226	229	PF01048	0.354
MOD_GlcNHglycan	24	27	PF01048	0.470
MOD_GlcNHglycan	58	61	PF01048	0.266
MOD_GSK3_1	139	146	PF00069	0.498
MOD_GSK3_1	193	200	PF00069	0.408
MOD_GSK3_1	217	224	PF00069	0.487
MOD_GSK3_1	234	241	PF00069	0.343
MOD_GSK3_1	307	314	PF00069	0.495
MOD_GSK3_1	330	337	PF00069	0.375
MOD_N-GLC_1	197	202	PF02516	0.482
MOD_N-GLC_1	31	36	PF02516	0.457
MOD_NEK2_1	197	202	PF00069	0.389
MOD_NEK2_1	204	209	PF00069	0.329
MOD_NEK2_1	221	226	PF00069	0.340
MOD_NEK2_1	311	316	PF00069	0.441
MOD_NEK2_2	272	277	PF00069	0.215
MOD_PIKK_1	197	203	PF00454	0.482
MOD_PIKK_1	3	9	PF00454	0.451
MOD_PKA_2	238	244	PF00069	0.466
MOD_PKA_2	8	14	PF00069	0.473
MOD_Plk_1	16	22	PF00069	0.458
MOD_Plk_1	197	203	PF00069	0.523
MOD_Plk_1	214	220	PF00069	0.418
MOD_Plk_4	16	22	PF00069	0.447
MOD_Plk_4	90	96	PF00069	0.463
MOD_ProDKin_1	166	172	PF00069	0.431
MOD_ProDKin_1	31	37	PF00069	0.444
MOD_ProDKin_1	74	80	PF00069	0.427
MOD_SUMO_rev_2	246	253	PF00179	0.420
TRG_ENDOCYTIC_2	135	138	PF00928	0.378
TRG_ENDOCYTIC_2	199	202	PF00928	0.375
TRG_ENDOCYTIC_2	27	30	PF00928	0.437
TRG_ENDOCYTIC_2	68	71	PF00928	0.439
TRG_ENDOCYTIC_2	97	100	PF00928	0.363
TRG_NES_CRM1_1	181	193	PF08389	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q9	Leptomonas seymouri	77%	73%
A0A0N1PBD8	Leptomonas seymouri	79%	73%
A0A0S4JJE7	Bodo saltans	60%	73%
A0A1X0P1Q0	Trypanosomatidae	63%	72%
A0A381MQ29	Leishmania infantum	94%	73%
A0A3R7KSZ4	Trypanosoma rangeli	63%	73%
A0A3S7X4P6	Leishmania donovani	94%	73%
A0A3S7X6U2	Leishmania donovani	78%	73%
A4HJG9	Leishmania braziliensis	90%	100%
A4HJH1	Leishmania braziliensis	90%	100%
A4HJI4	Leishmania braziliensis	90%	100%
A4HLM2	Leishmania braziliensis	75%	100%
A4I933	Leishmania infantum	78%	73%
B2KZE7	Corynebacterium striatum	28%	75%
C9ZQ48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	72%
D0A536	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	72%
E9B201	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	73%
E9B3Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	73%
P43616	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	71%
Q3ZC84	Bos taurus	30%	72%
Q4Q426	Leishmania major	77%	100%
Q5AKA5	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	71%
Q5R432	Pongo abelii	30%	72%
Q66HG3	Rattus norvegicus	28%	70%
Q6Q0N1	Rattus norvegicus	30%	72%
Q8BUG2	Mus musculus	28%	70%
Q96KN2	Homo sapiens	29%	68%
Q96KP4	Homo sapiens	30%	72%
Q9D1A2	Mus musculus	30%	72%
V5BHA2	Trypanosoma cruzi	63%	72%