LeishMANIAdb
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Mannosyltransferase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mannosyltransferase-like protein
Gene product:
mannosyltransferase-like protein
Species:
Leishmania mexicana
UniProt:
E9B1Y5_LEIMU
TriTrypDb:
LmxM.30.1870
Length:
963

Annotations

LeishMANIAdb annotations

A complex and fast-evolving family of glycosyltransferases. Their structural innovations and expansion is in accordance with a role in interactions with the environment. Despite the short hydrophobic segment, the N-terminal signal-like stretch is likely to be a signal-anchor as wil all Golgi-resident glycosyltransferases, not a secretory signal. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 13
NetGPI no yes: 0, no: 14
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
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Expansion

Sequence features

E9B1Y5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Y5

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 15
GO:0016740 transferase activity 2 15
GO:0016757 glycosyltransferase activity 3 15
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 386 390 PF00656 0.458
CLV_NRD_NRD_1 370 372 PF00675 0.651
CLV_NRD_NRD_1 39 41 PF00675 0.436
CLV_NRD_NRD_1 4 6 PF00675 0.496
CLV_NRD_NRD_1 400 402 PF00675 0.678
CLV_NRD_NRD_1 479 481 PF00675 0.622
CLV_NRD_NRD_1 503 505 PF00675 0.646
CLV_NRD_NRD_1 511 513 PF00675 0.663
CLV_NRD_NRD_1 610 612 PF00675 0.573
CLV_NRD_NRD_1 630 632 PF00675 0.667
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Homologs

ProteinTaxonomySequence identityCoverage
A0A1X0NJI2 Trypanosomatidae 35% 100%
A0A1X0NR25 Trypanosomatidae 32% 93%
A0A3R7NS98 Trypanosoma rangeli 31% 95%
A0A3R7RH60 Trypanosoma rangeli 39% 100%
A0A3S7X4M2 Leishmania donovani 90% 100%
A0A3S7X4P3 Leishmania donovani 90% 100%
A4HJG8 Leishmania braziliensis 73% 100%
A4I6X8 Leishmania infantum 90% 100%
E9B1Y6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9B1Y7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS