Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1Y4_LEIMU

TriTrypDb:

LmxM.30.1860

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B1Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Y4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.605
CLV_NRD_NRD_1	142	144	PF00675	0.527
CLV_NRD_NRD_1	91	93	PF00675	0.532
CLV_PCSK_KEX2_1	142	144	PF00082	0.532
CLV_PCSK_KEX2_1	222	224	PF00082	0.506
CLV_PCSK_KEX2_1	85	87	PF00082	0.535
CLV_PCSK_KEX2_1	91	93	PF00082	0.537
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.506
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.448
CLV_PCSK_SKI1_1	19	23	PF00082	0.587
CLV_PCSK_SKI1_1	91	95	PF00082	0.606
DEG_APCC_DBOX_1	18	26	PF00400	0.377
DOC_MAPK_RevD_3	70	86	PF00069	0.343
DOC_PP2B_PxIxI_1	111	117	PF00149	0.705
DOC_PP4_FxxP_1	188	191	PF00568	0.718
DOC_USP7_MATH_1	153	157	PF00917	0.729
DOC_USP7_MATH_1	191	195	PF00917	0.759
DOC_USP7_MATH_1	37	41	PF00917	0.489
DOC_USP7_MATH_1	47	51	PF00917	0.577
DOC_WW_Pin1_4	107	112	PF00397	0.626
DOC_WW_Pin1_4	125	130	PF00397	0.614
DOC_WW_Pin1_4	145	150	PF00397	0.694
DOC_WW_Pin1_4	25	30	PF00397	0.461
DOC_WW_Pin1_4	43	48	PF00397	0.460
LIG_14-3-3_CanoR_1	13	22	PF00244	0.446
LIG_14-3-3_CanoR_1	174	179	PF00244	0.628
LIG_14-3-3_CanoR_1	86	94	PF00244	0.756
LIG_BIR_II_1	1	5	PF00653	0.356
LIG_BIR_III_2	179	183	PF00653	0.697
LIG_BRCT_BRCA1_1	64	68	PF00533	0.296
LIG_EH_1	185	189	PF12763	0.709
LIG_FHA_1	133	139	PF00498	0.666
LIG_FHA_1	47	53	PF00498	0.470
LIG_FHA_1	69	75	PF00498	0.260
LIG_FHA_2	128	134	PF00498	0.702
LIG_FHA_2	253	259	PF00498	0.645
LIG_Integrin_RGD_1	101	103	PF01839	0.436
LIG_LIR_Nem_3	65	70	PF02991	0.296
LIG_MLH1_MIPbox_1	64	68	PF16413	0.296
LIG_Pex14_2	4	8	PF04695	0.440
LIG_SH2_CRK	232	236	PF00017	0.735
LIG_SH2_NCK_1	124	128	PF00017	0.754
LIG_SH2_STAT5	11	14	PF00017	0.451
LIG_SH2_STAT5	79	82	PF00017	0.700
LIG_SH3_3	181	187	PF00018	0.707
LIG_SH3_3	233	239	PF00018	0.644
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.236
LIG_SUMO_SIM_par_1	58	63	PF11976	0.223
LIG_TRAF2_1	134	137	PF00917	0.737
LIG_TRAF2_1	235	238	PF00917	0.817
LIG_TRAF2_1	244	247	PF00917	0.733
LIG_WRC_WIRS_1	253	258	PF05994	0.647
MOD_CK1_1	107	113	PF00069	0.669
MOD_CK1_1	125	131	PF00069	0.709
MOD_CK1_1	156	162	PF00069	0.677
MOD_CK1_1	189	195	PF00069	0.748
MOD_CK1_1	31	37	PF00069	0.455
MOD_CK1_1	46	52	PF00069	0.455
MOD_CK1_1	58	64	PF00069	0.236
MOD_CK1_1	84	90	PF00069	0.560
MOD_CK2_1	127	133	PF00069	0.743
MOD_CK2_1	190	196	PF00069	0.756
MOD_CK2_1	241	247	PF00069	0.694
MOD_Cter_Amidation	89	92	PF01082	0.396
MOD_GlcNHglycan	106	109	PF01048	0.483
MOD_GlcNHglycan	124	127	PF01048	0.505
MOD_GlcNHglycan	16	19	PF01048	0.595
MOD_GlcNHglycan	227	230	PF01048	0.617
MOD_GlcNHglycan	264	267	PF01048	0.445
MOD_GlcNHglycan	34	37	PF01048	0.674
MOD_GlcNHglycan	39	42	PF01048	0.708
MOD_GlcNHglycan	62	65	PF01048	0.289
MOD_GSK3_1	103	110	PF00069	0.683
MOD_GSK3_1	127	134	PF00069	0.677
MOD_GSK3_1	186	193	PF00069	0.705
MOD_GSK3_1	24	31	PF00069	0.434
MOD_GSK3_1	37	44	PF00069	0.450
MOD_GSK3_1	46	53	PF00069	0.424
MOD_GSK3_1	58	65	PF00069	0.239
MOD_GSK3_1	81	88	PF00069	0.563
MOD_GSK3_1	9	16	PF00069	0.456
MOD_N-GLC_1	103	108	PF02516	0.433
MOD_N-GLC_1	31	36	PF02516	0.680
MOD_N-GLC_1	37	42	PF02516	0.686
MOD_NEK2_1	122	127	PF00069	0.712
MOD_NEK2_1	230	235	PF00069	0.767
MOD_NEK2_1	55	60	PF00069	0.350
MOD_NEK2_1	62	67	PF00069	0.305
MOD_NEK2_1	68	73	PF00069	0.293
MOD_PIKK_1	127	133	PF00454	0.681
MOD_PKA_1	13	19	PF00069	0.359
MOD_PKA_1	85	91	PF00069	0.659
MOD_PKA_2	12	18	PF00069	0.435
MOD_PKA_2	50	56	PF00069	0.416
MOD_PKA_2	85	91	PF00069	0.745
MOD_Plk_1	47	53	PF00069	0.385
MOD_Plk_2-3	247	253	PF00069	0.640
MOD_Plk_4	55	61	PF00069	0.393
MOD_ProDKin_1	107	113	PF00069	0.624
MOD_ProDKin_1	125	131	PF00069	0.614
MOD_ProDKin_1	145	151	PF00069	0.695
MOD_ProDKin_1	25	31	PF00069	0.461
MOD_ProDKin_1	43	49	PF00069	0.459
TRG_DiLeu_BaEn_4	136	142	PF01217	0.705
TRG_ENDOCYTIC_2	77	80	PF00928	0.636
TRG_ER_diArg_1	141	143	PF00400	0.714
TRG_ER_diArg_1	173	176	PF00400	0.706
TRG_ER_diArg_1	91	93	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFE3	Leishmania donovani	77%	100%
A4I6W0	Leishmania infantum	77%	100%
E9AIU6	Leishmania braziliensis	51%	99%
Q4Q676	Leishmania major	69%	98%