LeishMANIAdb
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Amino acid permease

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amino acid permease
Gene product:
amino acid permease
Species:
Leishmania mexicana
UniProt:
E9B1Y0_LEIMU
TriTrypDb:
LmxM.30.1820
Length:
609

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 8
Forrest at al. (procyclic) no yes: 8
Silverman et al. no yes: 0
Pissara et al. yes yes: 63
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 88
NetGPI no yes: 0, no: 89
Cellular components
Term Name Level Count
GO:0016020 membrane 2 76
GO:0110165 cellular anatomical entity 1 76
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0005886 plasma membrane 3 1
GO:0020016 ciliary pocket 2 1
GO:0020023 kinetoplast 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9B1Y0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Y0

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 16
GO:0006810 transport 3 16
GO:0006865 amino acid transport 5 16
GO:0009987 cellular process 1 16
GO:0015849 organic acid transport 5 16
GO:0051179 localization 1 16
GO:0051234 establishment of localization 2 16
GO:0055085 transmembrane transport 2 16
GO:0071702 organic substance transport 4 16
GO:0071705 nitrogen compound transport 4 16
GO:1903825 organic acid transmembrane transport 3 16
GO:1905039 carboxylic acid transmembrane transport 4 16
GO:0006811 monoatomic ion transport 4 1
GO:0006812 monoatomic cation transport 5 1
GO:0006820 monoatomic anion transport 5 1
GO:0015711 organic anion transport 5 1
GO:0015802 basic amino acid transport 6 1
GO:0015819 lysine transport 6 1
GO:0046942 carboxylic acid transport 6 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 16
GO:0005342 organic acid transmembrane transporter activity 3 16
GO:0015171 amino acid transmembrane transporter activity 5 16
GO:0015179 L-amino acid transmembrane transporter activity 6 16
GO:0022857 transmembrane transporter activity 2 16
GO:0046943 carboxylic acid transmembrane transporter activity 4 16
GO:0008324 monoatomic cation transmembrane transporter activity 4 1
GO:0008509 monoatomic anion transmembrane transporter activity 4 1
GO:0008514 organic anion transmembrane transporter activity 5 1
GO:0015075 monoatomic ion transmembrane transporter activity 3 1
GO:0015174 basic amino acid transmembrane transporter activity 6 1
GO:0015189 L-lysine transmembrane transporter activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 473 477 PF00656 0.444
CLV_C14_Caspase3-7 512 516 PF00656 0.476
CLV_NRD_NRD_1 171 173 PF00675 0.396
CLV_NRD_NRD_1 46 48 PF00675 0.449
CLV_NRD_NRD_1 71 73 PF00675 0.551
CLV_PCSK_KEX2_1 171 173 PF00082 0.396
CLV_PCSK_KEX2_1 71 73 PF00082 0.538
CLV_PCSK_SKI1_1 165 169 PF00082 0.348
CLV_PCSK_SKI1_1 172 176 PF00082 0.346
CLV_PCSK_SKI1_1 229 233 PF00082 0.376
CLV_PCSK_SKI1_1 284 288 PF00082 0.476
CLV_PCSK_SKI1_1 344 348 PF00082 0.366
CLV_PCSK_SKI1_1 375 379 PF00082 0.545
CLV_PCSK_SKI1_1 380 384 PF00082 0.538
CLV_PCSK_SKI1_1 47 51 PF00082 0.444
DEG_APCC_DBOX_1 416 424 PF00400 0.528
DOC_AGCK_PIF_2 367 372 PF00069 0.449
DOC_MAPK_FxFP_2 560 563 PF00069 0.461
DOC_MAPK_gen_1 71 78 PF00069 0.754
DOC_MAPK_MEF2A_6 229 237 PF00069 0.270
DOC_MAPK_MEF2A_6 253 262 PF00069 0.532
DOC_PP1_RVXF_1 215 222 PF00149 0.366
DOC_PP2B_LxvP_1 116 119 PF13499 0.411
DOC_PP2B_LxvP_1 243 246 PF13499 0.348
DOC_PP2B_LxvP_1 538 541 PF13499 0.375
DOC_PP4_FxxP_1 560 563 PF00568 0.392
DOC_USP7_MATH_1 107 111 PF00917 0.419
DOC_USP7_MATH_1 121 125 PF00917 0.385
DOC_USP7_MATH_1 149 153 PF00917 0.574
DOC_USP7_MATH_1 280 284 PF00917 0.400
DOC_USP7_MATH_1 416 420 PF00917 0.584
DOC_USP7_MATH_1 461 465 PF00917 0.530
DOC_USP7_UBL2_3 376 380 PF12436 0.220
DOC_WW_Pin1_4 32 37 PF00397 0.687
DOC_WW_Pin1_4 486 491 PF00397 0.484
LIG_14-3-3_CanoR_1 156 161 PF00244 0.485
LIG_14-3-3_CanoR_1 172 178 PF00244 0.422
LIG_14-3-3_CanoR_1 229 234 PF00244 0.361
LIG_14-3-3_CanoR_1 253 262 PF00244 0.531
LIG_14-3-3_CanoR_1 307 313 PF00244 0.384
LIG_14-3-3_CanoR_1 341 347 PF00244 0.558
LIG_14-3-3_CanoR_1 417 421 PF00244 0.574
LIG_14-3-3_CanoR_1 431 438 PF00244 0.580
LIG_Actin_WH2_2 238 255 PF00022 0.360
LIG_BIR_II_1 1 5 PF00653 0.788
LIG_BRCT_BRCA1_1 100 104 PF00533 0.339
LIG_BRCT_BRCA1_1 342 346 PF00533 0.592
LIG_BRCT_BRCA1_1 553 557 PF00533 0.438
LIG_BRCT_BRCA1_1 569 573 PF00533 0.572
LIG_eIF4E_1 583 589 PF01652 0.445
LIG_FHA_1 230 236 PF00498 0.409
LIG_FHA_1 300 306 PF00498 0.332
LIG_FHA_1 357 363 PF00498 0.444
LIG_FHA_1 482 488 PF00498 0.420
LIG_FHA_1 509 515 PF00498 0.551
LIG_FHA_1 584 590 PF00498 0.390
LIG_FHA_1 602 608 PF00498 0.429
LIG_FHA_1 71 77 PF00498 0.731
LIG_FHA_2 505 511 PF00498 0.543
LIG_KLC1_Yacidic_2 510 515 PF13176 0.564
LIG_LIR_Gen_1 138 148 PF02991 0.455
LIG_LIR_Gen_1 176 186 PF02991 0.469
LIG_LIR_Gen_1 359 369 PF02991 0.417
LIG_LIR_Gen_1 554 565 PF02991 0.415
LIG_LIR_Gen_1 586 595 PF02991 0.377
LIG_LIR_Gen_1 604 609 PF02991 0.475
LIG_LIR_Nem_3 138 143 PF02991 0.400
LIG_LIR_Nem_3 159 163 PF02991 0.547
LIG_LIR_Nem_3 176 181 PF02991 0.396
LIG_LIR_Nem_3 359 364 PF02991 0.395
LIG_LIR_Nem_3 365 370 PF02991 0.409
LIG_LIR_Nem_3 419 424 PF02991 0.546
LIG_LIR_Nem_3 554 560 PF02991 0.382
LIG_LIR_Nem_3 586 590 PF02991 0.389
LIG_LIR_Nem_3 604 609 PF02991 0.529
LIG_LYPXL_SIV_4 397 405 PF13949 0.342
LIG_PALB2_WD40_1 576 584 PF16756 0.557
LIG_PDZ_Class_2 604 609 PF00595 0.549
LIG_Pex14_1 184 188 PF04695 0.424
LIG_Pex14_2 181 185 PF04695 0.375
LIG_Pex14_2 202 206 PF04695 0.271
LIG_Pex14_2 262 266 PF04695 0.396
LIG_Pex14_2 562 566 PF04695 0.433
LIG_PTB_Apo_2 513 520 PF02174 0.566
LIG_SH2_CRK 409 413 PF00017 0.352
LIG_SH2_GRB2like 583 586 PF00017 0.395
LIG_SH2_NCK_1 409 413 PF00017 0.221
LIG_SH2_PTP2 361 364 PF00017 0.392
LIG_SH2_PTP2 398 401 PF00017 0.394
LIG_SH2_PTP2 606 609 PF00017 0.539
LIG_SH2_PTP2 91 94 PF00017 0.531
LIG_SH2_SRC 194 197 PF00017 0.377
LIG_SH2_SRC 21 24 PF00017 0.625
LIG_SH2_SRC 422 425 PF00017 0.567
LIG_SH2_SRC 498 501 PF00017 0.427
LIG_SH2_SRC 91 94 PF00017 0.509
LIG_SH2_STAP1 173 177 PF00017 0.589
LIG_SH2_STAP1 254 258 PF00017 0.359
LIG_SH2_STAT3 323 326 PF00017 0.436
LIG_SH2_STAT5 139 142 PF00017 0.370
LIG_SH2_STAT5 146 149 PF00017 0.358
LIG_SH2_STAT5 194 197 PF00017 0.414
LIG_SH2_STAT5 21 24 PF00017 0.639
LIG_SH2_STAT5 265 268 PF00017 0.402
LIG_SH2_STAT5 323 326 PF00017 0.431
LIG_SH2_STAT5 361 364 PF00017 0.383
LIG_SH2_STAT5 369 372 PF00017 0.376
LIG_SH2_STAT5 398 401 PF00017 0.411
LIG_SH2_STAT5 422 425 PF00017 0.511
LIG_SH2_STAT5 513 516 PF00017 0.572
LIG_SH2_STAT5 583 586 PF00017 0.383
LIG_SH2_STAT5 587 590 PF00017 0.409
LIG_SH2_STAT5 606 609 PF00017 0.437
LIG_SH2_STAT5 91 94 PF00017 0.682
LIG_SH3_3 236 242 PF00018 0.431
LIG_SH3_3 484 490 PF00018 0.420
LIG_SH3_3 89 95 PF00018 0.653
LIG_Sin3_3 408 415 PF02671 0.424
LIG_SUMO_SIM_anti_2 381 386 PF11976 0.295
LIG_SUMO_SIM_anti_2 586 592 PF11976 0.444
LIG_SUMO_SIM_par_1 133 138 PF11976 0.423
LIG_SUMO_SIM_par_1 146 153 PF11976 0.380
LIG_SUMO_SIM_par_1 525 530 PF11976 0.459
LIG_TRAF2_1 388 391 PF00917 0.375
LIG_TRAF2_2 490 495 PF00917 0.434
LIG_TYR_ITIM 137 142 PF00017 0.416
LIG_TYR_ITIM 396 401 PF00017 0.378
LIG_TYR_ITIM 407 412 PF00017 0.383
LIG_TYR_ITSM 357 364 PF00017 0.383
LIG_TYR_ITSM 602 609 PF00017 0.438
LIG_UBA3_1 240 247 PF00899 0.422
LIG_WRC_WIRS_1 157 162 PF05994 0.575
MOD_CDC14_SPxK_1 35 38 PF00782 0.625
MOD_CDK_SPxK_1 32 38 PF00069 0.628
MOD_CK1_1 141 147 PF00069 0.438
MOD_CK1_1 152 158 PF00069 0.574
MOD_CK1_1 2 8 PF00069 0.799
MOD_CK1_1 530 536 PF00069 0.389
MOD_GlcNHglycan 100 103 PF01048 0.405
MOD_GlcNHglycan 123 126 PF01048 0.562
MOD_GlcNHglycan 188 191 PF01048 0.469
MOD_GlcNHglycan 255 258 PF01048 0.384
MOD_GlcNHglycan 288 291 PF01048 0.660
MOD_GlcNHglycan 348 351 PF01048 0.391
MOD_GlcNHglycan 4 7 PF01048 0.483
MOD_GlcNHglycan 468 471 PF01048 0.361
MOD_GlcNHglycan 553 556 PF01048 0.436
MOD_GlcNHglycan 56 59 PF01048 0.630
MOD_GlcNHglycan 569 572 PF01048 0.372
MOD_GSK3_1 152 159 PF00069 0.536
MOD_GSK3_1 308 315 PF00069 0.355
MOD_GSK3_1 32 39 PF00069 0.702
MOD_GSK3_1 340 347 PF00069 0.529
MOD_GSK3_1 482 489 PF00069 0.484
MOD_GSK3_1 5 12 PF00069 0.712
MOD_GSK3_1 504 511 PF00069 0.569
MOD_GSK3_1 567 574 PF00069 0.579
MOD_GSK3_1 579 586 PF00069 0.559
MOD_GSK3_1 59 66 PF00069 0.775
MOD_GSK3_1 601 608 PF00069 0.381
MOD_N-GLC_1 2 7 PF02516 0.445
MOD_N-GLC_1 431 436 PF02516 0.245
MOD_N-GLC_1 571 576 PF02516 0.301
MOD_NEK2_1 106 111 PF00069 0.411
MOD_NEK2_1 221 226 PF00069 0.319
MOD_NEK2_1 279 284 PF00069 0.256
MOD_NEK2_1 305 310 PF00069 0.350
MOD_NEK2_1 346 351 PF00069 0.571
MOD_NEK2_1 356 361 PF00069 0.449
MOD_NEK2_1 378 383 PF00069 0.340
MOD_NEK2_1 527 532 PF00069 0.311
MOD_NEK2_2 416 421 PF00069 0.574
MOD_PIKK_1 222 228 PF00454 0.254
MOD_PIKK_1 488 494 PF00454 0.443
MOD_PIKK_1 59 65 PF00454 0.777
MOD_PKA_2 340 346 PF00069 0.516
MOD_PKA_2 416 422 PF00069 0.602
MOD_PKA_2 70 76 PF00069 0.791
MOD_PKB_1 429 437 PF00069 0.557
MOD_Plk_1 152 158 PF00069 0.458
MOD_Plk_1 508 514 PF00069 0.525
MOD_Plk_1 571 577 PF00069 0.507
MOD_Plk_2-3 509 515 PF00069 0.580
MOD_Plk_4 229 235 PF00069 0.376
MOD_Plk_4 299 305 PF00069 0.366
MOD_Plk_4 308 314 PF00069 0.344
MOD_Plk_4 356 362 PF00069 0.342
MOD_Plk_4 378 384 PF00069 0.320
MOD_Plk_4 416 422 PF00069 0.596
MOD_Plk_4 509 515 PF00069 0.507
MOD_Plk_4 530 536 PF00069 0.421
MOD_Plk_4 542 548 PF00069 0.339
MOD_Plk_4 583 589 PF00069 0.405
MOD_Plk_4 601 607 PF00069 0.302
MOD_ProDKin_1 32 38 PF00069 0.688
MOD_ProDKin_1 486 492 PF00069 0.484
MOD_SUMO_rev_2 211 219 PF00179 0.220
MOD_SUMO_rev_2 289 298 PF00179 0.362
TRG_DiLeu_BaEn_2 439 445 PF01217 0.444
TRG_DiLeu_BaEn_3 390 396 PF01217 0.369
TRG_ENDOCYTIC_2 139 142 PF00928 0.387
TRG_ENDOCYTIC_2 265 268 PF00928 0.438
TRG_ENDOCYTIC_2 361 364 PF00928 0.375
TRG_ENDOCYTIC_2 369 372 PF00928 0.387
TRG_ENDOCYTIC_2 398 401 PF00928 0.383
TRG_ENDOCYTIC_2 409 412 PF00928 0.353
TRG_ENDOCYTIC_2 421 424 PF00928 0.517
TRG_ENDOCYTIC_2 587 590 PF00928 0.366
TRG_ENDOCYTIC_2 606 609 PF00928 0.497
TRG_ENDOCYTIC_2 91 94 PF00928 0.639
TRG_ER_diArg_1 171 173 PF00400 0.599
TRG_ER_diArg_1 430 433 PF00400 0.567
TRG_ER_diArg_1 70 72 PF00400 0.772
TRG_NLS_MonoExtC_3 46 51 PF00514 0.628

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P285 Leptomonas seymouri 29% 100%
A0A0N0P8T9 Leptomonas seymouri 34% 100%
A0A0N1I2L5 Leptomonas seymouri 32% 100%
A0A0N1IJ81 Leptomonas seymouri 21% 100%
A0A0N1PA98 Leptomonas seymouri 63% 99%
A0A0S4IV32 Bodo saltans 23% 100%
A0A3Q8ICL1 Leishmania donovani 86% 100%
A0A3Q8ID74 Leishmania donovani 34% 100%
A0A3Q8IDG8 Leishmania donovani 34% 100%
A0A3Q8IG00 Leishmania donovani 38% 100%
A0A3Q8IGE6 Leishmania donovani 85% 100%
A0A3Q8IHG8 Leishmania donovani 33% 100%
A0A3Q8IHH7 Leishmania donovani 22% 100%
A0A3Q8IJH2 Leishmania donovani 32% 100%
A0A3Q8IJX8 Leishmania donovani 33% 100%
A0A3Q8ILE0 Leishmania donovani 33% 100%
A0A3Q8IQG8 Leishmania donovani 23% 100%
A0A3R7MQD8 Trypanosoma rangeli 22% 100%
A0A3R7MWF1 Trypanosoma rangeli 22% 100%
A0A3S5H6T4 Leishmania donovani 35% 100%
A0A3S5H7P4 Leishmania donovani 32% 100%
A0A3S7WQ39 Leishmania donovani 35% 100%
A0A3S7X443 Leishmania donovani 32% 100%
A0A3S7X458 Leishmania donovani 32% 100%
A0A3S7X4A1 Leishmania donovani 33% 100%
A0A3S7X4L2 Leishmania donovani 87% 100%
A0A3S7X4N4 Leishmania donovani 86% 100%
A0A3S7X4P0 Leishmania donovani 86% 100%
A0A3S7XA86 Leishmania donovani 23% 100%
A0A422NZS1 Trypanosoma rangeli 33% 100%
A4H565 Leishmania braziliensis 35% 100%
A4HC75 Leishmania braziliensis 36% 100%
A4HFT5 Leishmania braziliensis 36% 100%
A4HJ07 Leishmania braziliensis 37% 100%
A4HJ09 Leishmania braziliensis 37% 100%
A4HJ35 Leishmania braziliensis 37% 100%
A4HJ36 Leishmania braziliensis 31% 100%
A4HJ63 Leishmania braziliensis 36% 100%
A4HJF8 Leishmania braziliensis 74% 100%
A4HJF9 Leishmania braziliensis 77% 100%
A4HJG1 Leishmania braziliensis 75% 100%
A4HJG3 Leishmania braziliensis 74% 100%
A4HJG5 Leishmania braziliensis 74% 100%
A4HKQ7 Leishmania braziliensis 31% 100%
A4HNJ6 Leishmania braziliensis 21% 100%
A4HNQ0 Leishmania braziliensis 25% 100%
A4HTE2 Leishmania infantum 36% 100%
A4HZQ0 Leishmania infantum 33% 100%
A4I6F1 Leishmania infantum 32% 100%
A4I6I1 Leishmania infantum 33% 100%
A4I6J8 Leishmania infantum 34% 100%
A4I6J9 Leishmania infantum 33% 100%
A4I6L3 Leishmania infantum 38% 100%
A4I6L4 Leishmania infantum 33% 100%
A4I6W4 Leishmania infantum 86% 100%
A4I887 Leishmania infantum 31% 100%
A4I914 Leishmania infantum 22% 100%
A4IC53 Leishmania infantum 23% 100%
A4ICU5 Leishmania infantum 23% 100%
C9ZMD1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
C9ZMD3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
D0AAF6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
D0AAF8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E8NHF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E8NHS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9AD44 Leishmania major 32% 100%
E9AD45 Leishmania major 34% 100%
E9ADD7 Leishmania major 33% 100%
E9AG08 Leishmania major 21% 100%
E9AG09 Leishmania major 23% 100%
E9AHD7 Leishmania infantum 33% 100%
E9AHD9 Leishmania infantum 34% 100%
E9AHL1 Leishmania infantum 86% 100%
E9AHL2 Leishmania infantum 85% 100%
E9AHL3 Leishmania infantum 87% 100%
E9ALD5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9ASF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9AVK6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9AYW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AYW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AZ62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B1I4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9B1I6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B1K7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B1N8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B1N9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B1X9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B345 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B3X9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B761 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B762 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
P40074 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
Q4Q236 Leishmania major 24% 100%
Q4Q445 Leishmania major 21% 96%
Q4Q509 Leishmania major 31% 100%
Q4Q680 Leishmania major 86% 98%
Q4Q682 Leishmania major 82% 97%
Q4Q683 Leishmania major 86% 98%
Q4Q6H5 Leishmania major 34% 100%
Q4Q6K5 Leishmania major 31% 100%
Q4Q6K6 Leishmania major 39% 100%
Q4Q6M9 Leishmania major 32% 100%
Q4Q6N0 Leishmania major 32% 100%
Q4Q6N1 Leishmania major 34% 100%
Q4QBX3 Leishmania major 37% 100%
Q4QIH0 Leishmania major 35% 100%
V5AXD0 Trypanosoma cruzi 23% 100%
V5BIJ1 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS