LeishMANIAdb
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Amino acid permease

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amino acid permease
Gene product:
amino acid permease
Species:
Leishmania mexicana
UniProt:
E9B1X9_LEIMU
TriTrypDb:
LmxM.30.1800 *
Length:
776

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0016020 membrane 2 23
GO:0110165 cellular anatomical entity 1 23

Expansion

Sequence features

E9B1X9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1X9

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 5
GO:0006810 transport 3 5
GO:0006865 amino acid transport 5 5
GO:0009987 cellular process 1 5
GO:0015849 organic acid transport 5 5
GO:0051179 localization 1 5
GO:0051234 establishment of localization 2 5
GO:0055085 transmembrane transport 2 5
GO:0071702 organic substance transport 4 5
GO:0071705 nitrogen compound transport 4 5
GO:1903825 organic acid transmembrane transport 3 5
GO:1905039 carboxylic acid transmembrane transport 4 5
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 5
GO:0005342 organic acid transmembrane transporter activity 3 5
GO:0015171 amino acid transmembrane transporter activity 5 5
GO:0015179 L-amino acid transmembrane transporter activity 6 5
GO:0022857 transmembrane transporter activity 2 5
GO:0046943 carboxylic acid transmembrane transporter activity 4 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 218 222 PF00656 0.697
CLV_C14_Caspase3-7 640 644 PF00656 0.531
CLV_C14_Caspase3-7 679 683 PF00656 0.524
CLV_MEL_PAP_1 44 50 PF00089 0.450
CLV_NRD_NRD_1 106 108 PF00675 0.452
CLV_NRD_NRD_1 109 111 PF00675 0.471
CLV_NRD_NRD_1 238 240 PF00675 0.538
CLV_NRD_NRD_1 338 340 PF00675 0.363
CLV_PCSK_FUR_1 104 108 PF00082 0.448
CLV_PCSK_KEX2_1 106 108 PF00082 0.452
CLV_PCSK_KEX2_1 109 111 PF00082 0.471
CLV_PCSK_KEX2_1 238 240 PF00082 0.539
CLV_PCSK_KEX2_1 338 340 PF00082 0.363
CLV_PCSK_SKI1_1 332 336 PF00082 0.343
CLV_PCSK_SKI1_1 339 343 PF00082 0.342
CLV_PCSK_SKI1_1 396 400 PF00082 0.406
CLV_PCSK_SKI1_1 451 455 PF00082 0.502
CLV_PCSK_SKI1_1 511 515 PF00082 0.427
CLV_PCSK_SKI1_1 542 546 PF00082 0.544
CLV_PCSK_SKI1_1 547 551 PF00082 0.506
CLV_PCSK_SKI1_1 58 62 PF00082 0.401
DEG_APCC_DBOX_1 442 450 PF00400 0.259
DEG_APCC_DBOX_1 583 591 PF00400 0.568
DEG_SPOP_SBC_1 215 219 PF00917 0.742
DOC_AGCK_PIF_2 534 539 PF00069 0.365
DOC_ANK_TNKS_1 2 9 PF00023 0.655
DOC_CYCLIN_yCln2_LP_2 170 176 PF00134 0.660
DOC_MAPK_DCC_7 116 125 PF00069 0.656
DOC_MAPK_FxFP_2 727 730 PF00069 0.380
DOC_MAPK_gen_1 104 113 PF00069 0.660
DOC_MAPK_gen_1 238 245 PF00069 0.751
DOC_MAPK_HePTP_8 113 125 PF00069 0.659
DOC_MAPK_MEF2A_6 116 125 PF00069 0.656
DOC_MAPK_MEF2A_6 396 404 PF00069 0.404
DOC_MAPK_MEF2A_6 420 429 PF00069 0.542
DOC_PP1_RVXF_1 382 389 PF00149 0.302
DOC_PP2B_LxvP_1 161 164 PF13499 0.651
DOC_PP2B_LxvP_1 170 173 PF13499 0.664
DOC_PP2B_LxvP_1 190 193 PF13499 0.673
DOC_PP2B_LxvP_1 283 286 PF13499 0.355
DOC_PP2B_LxvP_1 410 413 PF13499 0.360
DOC_PP2B_LxvP_1 66 69 PF13499 0.607
DOC_PP2B_LxvP_1 705 708 PF13499 0.397
DOC_PP4_FxxP_1 727 730 PF00568 0.384
DOC_USP7_MATH_1 176 180 PF00917 0.668
DOC_USP7_MATH_1 195 199 PF00917 0.689
DOC_USP7_MATH_1 214 218 PF00917 0.739
DOC_USP7_MATH_1 274 278 PF00917 0.351
DOC_USP7_MATH_1 288 292 PF00917 0.363
DOC_USP7_MATH_1 316 320 PF00917 0.573
DOC_USP7_MATH_1 447 451 PF00917 0.380
DOC_USP7_MATH_1 583 587 PF00917 0.524
DOC_USP7_MATH_1 628 632 PF00917 0.495
DOC_USP7_MATH_1 69 73 PF00917 0.619
DOC_USP7_MATH_2 176 182 PF00917 0.662
DOC_USP7_UBL2_3 543 547 PF12436 0.262
DOC_WW_Pin1_4 138 143 PF00397 0.682
DOC_WW_Pin1_4 147 152 PF00397 0.659
DOC_WW_Pin1_4 18 23 PF00397 0.659
DOC_WW_Pin1_4 210 215 PF00397 0.747
DOC_WW_Pin1_4 31 36 PF00397 0.671
DOC_WW_Pin1_4 37 42 PF00397 0.674
DOC_WW_Pin1_4 46 51 PF00397 0.664
DOC_WW_Pin1_4 653 658 PF00397 0.477
LIG_14-3-3_CanoR_1 109 114 PF00244 0.673
LIG_14-3-3_CanoR_1 323 328 PF00244 0.575
LIG_14-3-3_CanoR_1 339 345 PF00244 0.487
LIG_14-3-3_CanoR_1 396 401 PF00244 0.401
LIG_14-3-3_CanoR_1 420 429 PF00244 0.555
LIG_14-3-3_CanoR_1 474 480 PF00244 0.323
LIG_14-3-3_CanoR_1 508 514 PF00244 0.547
LIG_14-3-3_CanoR_1 58 68 PF00244 0.599
LIG_14-3-3_CanoR_1 584 588 PF00244 0.536
LIG_14-3-3_CanoR_1 598 605 PF00244 0.536
LIG_14-3-3_CanoR_1 73 77 PF00244 0.611
LIG_Actin_WH2_2 405 422 PF00022 0.380
LIG_BRCT_BRCA1_1 121 125 PF00533 0.654
LIG_BRCT_BRCA1_1 165 169 PF00533 0.643
LIG_BRCT_BRCA1_1 267 271 PF00533 0.375
LIG_BRCT_BRCA1_1 41 45 PF00533 0.664
LIG_BRCT_BRCA1_1 509 513 PF00533 0.467
LIG_BRCT_BRCA1_1 720 724 PF00533 0.352
LIG_BRCT_BRCA1_1 736 740 PF00533 0.591
LIG_eIF4E_1 750 756 PF01652 0.538
LIG_FHA_1 106 112 PF00498 0.662
LIG_FHA_1 238 244 PF00498 0.700
LIG_FHA_1 397 403 PF00498 0.397
LIG_FHA_1 426 432 PF00498 0.477
LIG_FHA_1 467 473 PF00498 0.332
LIG_FHA_1 510 516 PF00498 0.559
LIG_FHA_1 60 66 PF00498 0.592
LIG_FHA_1 649 655 PF00498 0.462
LIG_FHA_1 676 682 PF00498 0.524
LIG_FHA_1 751 757 PF00498 0.398
LIG_FHA_2 216 222 PF00498 0.696
LIG_FHA_2 672 678 PF00498 0.531
LIG_FHA_2 769 775 PF00498 0.307
LIG_Integrin_RGD_1 204 206 PF01839 0.519
LIG_KLC1_Yacidic_2 677 682 PF13176 0.522
LIG_LIR_Gen_1 166 176 PF02991 0.655
LIG_LIR_Gen_1 305 315 PF02991 0.396
LIG_LIR_Gen_1 343 352 PF02991 0.391
LIG_LIR_Gen_1 42 52 PF02991 0.648
LIG_LIR_Gen_1 575 583 PF02991 0.277
LIG_LIR_Gen_1 721 732 PF02991 0.355
LIG_LIR_Gen_1 753 762 PF02991 0.395
LIG_LIR_Gen_1 771 776 PF02991 0.497
LIG_LIR_Nem_3 166 172 PF02991 0.655
LIG_LIR_Nem_3 305 310 PF02991 0.396
LIG_LIR_Nem_3 326 330 PF02991 0.568
LIG_LIR_Nem_3 343 348 PF02991 0.391
LIG_LIR_Nem_3 42 48 PF02991 0.658
LIG_LIR_Nem_3 428 432 PF02991 0.399
LIG_LIR_Nem_3 532 537 PF02991 0.537
LIG_LIR_Nem_3 575 579 PF02991 0.403
LIG_LIR_Nem_3 586 591 PF02991 0.551
LIG_LIR_Nem_3 721 727 PF02991 0.373
LIG_LIR_Nem_3 753 757 PF02991 0.398
LIG_LIR_Nem_3 771 776 PF02991 0.524
LIG_PALB2_WD40_1 743 751 PF16756 0.524
LIG_PCNA_yPIPBox_3 78 88 PF02747 0.624
LIG_PDZ_Class_3 771 776 PF00595 0.409
LIG_Pex14_2 348 352 PF04695 0.354
LIG_Pex14_2 429 433 PF04695 0.394
LIG_Pex14_2 729 733 PF04695 0.369
LIG_PTB_Apo_2 680 687 PF02174 0.524
LIG_SH2_CRK 576 580 PF00017 0.355
LIG_SH2_GRB2like 750 753 PF00017 0.524
LIG_SH2_PTP2 258 261 PF00017 0.583
LIG_SH2_PTP2 565 568 PF00017 0.375
LIG_SH2_SRC 258 261 PF00017 0.571
LIG_SH2_SRC 361 364 PF00017 0.397
LIG_SH2_SRC 589 592 PF00017 0.524
LIG_SH2_SRC 665 668 PF00017 0.482
LIG_SH2_STAP1 340 344 PF00017 0.571
LIG_SH2_STAP1 421 425 PF00017 0.360
LIG_SH2_STAT3 490 493 PF00017 0.360
LIG_SH2_STAT5 18 21 PF00017 0.661
LIG_SH2_STAT5 258 261 PF00017 0.615
LIG_SH2_STAT5 306 309 PF00017 0.378
LIG_SH2_STAT5 313 316 PF00017 0.369
LIG_SH2_STAT5 361 364 PF00017 0.397
LIG_SH2_STAT5 432 435 PF00017 0.369
LIG_SH2_STAT5 490 493 PF00017 0.343
LIG_SH2_STAT5 536 539 PF00017 0.388
LIG_SH2_STAT5 565 568 PF00017 0.393
LIG_SH2_STAT5 589 592 PF00017 0.524
LIG_SH2_STAT5 680 683 PF00017 0.534
LIG_SH2_STAT5 750 753 PF00017 0.538
LIG_SH2_STAT5 754 757 PF00017 0.388
LIG_SH3_3 114 120 PF00018 0.660
LIG_SH3_3 139 145 PF00018 0.717
LIG_SH3_3 170 176 PF00018 0.678
LIG_SH3_3 189 195 PF00018 0.707
LIG_SH3_3 208 214 PF00018 0.710
LIG_SH3_3 256 262 PF00018 0.611
LIG_SH3_3 29 35 PF00018 0.669
LIG_SH3_3 403 409 PF00018 0.380
LIG_SH3_3 651 657 PF00018 0.477
LIG_Sin3_3 64 71 PF02671 0.610
LIG_SUMO_SIM_anti_2 548 553 PF11976 0.335
LIG_SUMO_SIM_anti_2 753 759 PF11976 0.387
LIG_SUMO_SIM_par_1 300 305 PF11976 0.355
LIG_SUMO_SIM_par_1 313 320 PF11976 0.436
LIG_SUMO_SIM_par_1 692 697 PF11976 0.355
LIG_TRAF2_1 555 558 PF00917 0.315
LIG_TRAF2_2 657 662 PF00917 0.502
LIG_TRFH_1 159 163 PF08558 0.639
LIG_TYR_ITIM 304 309 PF00017 0.361
LIG_TYR_ITIM 563 568 PF00017 0.454
LIG_TYR_ITIM 574 579 PF00017 0.355
LIG_TYR_ITSM 769 776 PF00017 0.446
LIG_UBA3_1 407 414 PF00899 0.400
LIG_WRC_WIRS_1 324 329 PF05994 0.528
MOD_CDK_SPK_2 31 36 PF00069 0.667
MOD_CK1_1 134 140 PF00069 0.678
MOD_CK1_1 179 185 PF00069 0.706
MOD_CK1_1 308 314 PF00069 0.370
MOD_CK1_1 319 325 PF00069 0.578
MOD_CK1_1 46 52 PF00069 0.660
MOD_CK1_1 697 703 PF00069 0.339
MOD_CK1_1 72 78 PF00069 0.617
MOD_CK2_1 129 135 PF00069 0.681
MOD_CK2_1 768 774 PF00069 0.307
MOD_DYRK1A_RPxSP_1 210 214 PF00069 0.701
MOD_DYRK1A_RPxSP_1 39 43 PF00069 0.664
MOD_GlcNHglycan 267 270 PF01048 0.392
MOD_GlcNHglycan 290 293 PF01048 0.568
MOD_GlcNHglycan 355 358 PF01048 0.359
MOD_GlcNHglycan 422 425 PF01048 0.363
MOD_GlcNHglycan 455 458 PF01048 0.559
MOD_GlcNHglycan 515 518 PF01048 0.433
MOD_GlcNHglycan 635 638 PF01048 0.336
MOD_GlcNHglycan 696 699 PF01048 0.253
MOD_GlcNHglycan 720 723 PF01048 0.379
MOD_GlcNHglycan 736 739 PF01048 0.391
MOD_GSK3_1 105 112 PF00069 0.664
MOD_GSK3_1 12 19 PF00069 0.666
MOD_GSK3_1 125 132 PF00069 0.673
MOD_GSK3_1 134 141 PF00069 0.683
MOD_GSK3_1 143 150 PF00069 0.678
MOD_GSK3_1 195 202 PF00069 0.770
MOD_GSK3_1 210 217 PF00069 0.878
MOD_GSK3_1 319 326 PF00069 0.542
MOD_GSK3_1 39 46 PF00069 0.682
MOD_GSK3_1 475 482 PF00069 0.323
MOD_GSK3_1 507 514 PF00069 0.542
MOD_GSK3_1 649 656 PF00069 0.471
MOD_GSK3_1 671 678 PF00069 0.528
MOD_GSK3_1 72 79 PF00069 0.618
MOD_GSK3_1 734 741 PF00069 0.380
MOD_GSK3_1 746 753 PF00069 0.542
MOD_GSK3_1 768 775 PF00069 0.374
MOD_GSK3_1 89 96 PF00069 0.626
MOD_N-GLC_1 598 603 PF02516 0.339
MOD_N-GLC_1 738 743 PF02516 0.321
MOD_NEK2_1 100 105 PF00069 0.639
MOD_NEK2_1 125 130 PF00069 0.674
MOD_NEK2_1 23 28 PF00069 0.665
MOD_NEK2_1 273 278 PF00069 0.405
MOD_NEK2_1 388 393 PF00069 0.422
MOD_NEK2_1 472 477 PF00069 0.338
MOD_NEK2_1 513 518 PF00069 0.574
MOD_NEK2_1 522 527 PF00069 0.489
MOD_NEK2_1 529 534 PF00069 0.344
MOD_NEK2_1 545 550 PF00069 0.324
MOD_NEK2_1 59 64 PF00069 0.601
MOD_NEK2_1 694 699 PF00069 0.339
MOD_NEK2_1 76 81 PF00069 0.612
MOD_NEK2_1 87 92 PF00069 0.628
MOD_NEK2_2 583 588 PF00069 0.524
MOD_PIKK_1 389 395 PF00454 0.359
MOD_PIKK_1 655 661 PF00454 0.531
MOD_PIKK_1 76 82 PF00454 0.615
MOD_PKA_1 109 115 PF00069 0.669
MOD_PKA_2 100 106 PF00069 0.645
MOD_PKA_2 109 115 PF00069 0.675
MOD_PKA_2 176 182 PF00069 0.695
MOD_PKA_2 199 205 PF00069 0.715
MOD_PKA_2 237 243 PF00069 0.723
MOD_PKA_2 507 513 PF00069 0.519
MOD_PKA_2 583 589 PF00069 0.527
MOD_PKA_2 69 75 PF00069 0.622
MOD_PKB_1 107 115 PF00069 0.666
MOD_PKB_1 596 604 PF00069 0.514
MOD_Plk_1 319 325 PF00069 0.531
MOD_Plk_1 675 681 PF00069 0.540
MOD_Plk_1 738 744 PF00069 0.521
MOD_Plk_2-3 676 682 PF00069 0.537
MOD_Plk_4 164 170 PF00069 0.643
MOD_Plk_4 185 191 PF00069 0.681
MOD_Plk_4 396 402 PF00069 0.384
MOD_Plk_4 425 431 PF00069 0.401
MOD_Plk_4 466 472 PF00069 0.364
MOD_Plk_4 475 481 PF00069 0.314
MOD_Plk_4 523 529 PF00069 0.361
MOD_Plk_4 545 551 PF00069 0.355
MOD_Plk_4 583 589 PF00069 0.525
MOD_Plk_4 676 682 PF00069 0.530
MOD_Plk_4 697 703 PF00069 0.360
MOD_Plk_4 709 715 PF00069 0.385
MOD_Plk_4 750 756 PF00069 0.539
MOD_Plk_4 768 774 PF00069 0.407
MOD_ProDKin_1 138 144 PF00069 0.682
MOD_ProDKin_1 147 153 PF00069 0.658
MOD_ProDKin_1 18 24 PF00069 0.658
MOD_ProDKin_1 210 216 PF00069 0.749
MOD_ProDKin_1 31 37 PF00069 0.670
MOD_ProDKin_1 39 45 PF00069 0.679
MOD_ProDKin_1 46 52 PF00069 0.659
MOD_ProDKin_1 653 659 PF00069 0.477
MOD_SUMO_rev_2 378 386 PF00179 0.262
MOD_SUMO_rev_2 456 465 PF00179 0.353
TRG_DiLeu_BaEn_2 606 612 PF01217 0.531
TRG_DiLeu_BaEn_3 557 563 PF01217 0.315
TRG_DiLeu_BaLyEn_6 51 56 PF01217 0.615
TRG_DiLeu_BaLyEn_6 83 88 PF01217 0.628
TRG_ENDOCYTIC_2 258 261 PF00928 0.649
TRG_ENDOCYTIC_2 306 309 PF00928 0.398
TRG_ENDOCYTIC_2 432 435 PF00928 0.358
TRG_ENDOCYTIC_2 536 539 PF00928 0.402
TRG_ENDOCYTIC_2 565 568 PF00928 0.452
TRG_ENDOCYTIC_2 576 579 PF00928 0.372
TRG_ENDOCYTIC_2 588 591 PF00928 0.578
TRG_ENDOCYTIC_2 754 757 PF00928 0.395
TRG_ENDOCYTIC_2 773 776 PF00928 0.439
TRG_ER_diArg_1 104 107 PF00400 0.647
TRG_ER_diArg_1 109 111 PF00400 0.672
TRG_ER_diArg_1 237 239 PF00400 0.774
TRG_ER_diArg_1 338 340 PF00400 0.580
TRG_ER_diArg_1 597 600 PF00400 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA98 Leptomonas seymouri 62% 100%
A0A3Q8ICL1 Leishmania donovani 84% 100%
A0A3Q8IGE6 Leishmania donovani 88% 100%
A0A3S7X4L2 Leishmania donovani 86% 100%
A0A3S7X4N4 Leishmania donovani 86% 100%
A0A3S7X4P0 Leishmania donovani 89% 100%
A4HJ06 Leishmania braziliensis 32% 100%
A4HJ36 Leishmania braziliensis 30% 100%
A4HJ37 Leishmania braziliensis 30% 100%
A4HJF8 Leishmania braziliensis 72% 100%
A4HJF9 Leishmania braziliensis 75% 100%
A4HJG1 Leishmania braziliensis 75% 100%
A4HJG3 Leishmania braziliensis 72% 100%
A4HJG5 Leishmania braziliensis 72% 100%
A4I6W4 Leishmania infantum 86% 100%
E8NHS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
E9AHL1 Leishmania infantum 85% 100%
E9AHL3 Leishmania infantum 84% 100%
E9B1Y0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q680 Leishmania major 83% 100%
Q4Q682 Leishmania major 87% 100%
Q4Q683 Leishmania major 83% 100%
Q4Q6K5 Leishmania major 31% 100%
Q4Q6N1 Leishmania major 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS