TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sphingosine N-acyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B1X8_LEIMU

TriTrypDb:

LmxM.30.1780

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B1X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1X8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	14
GO:0006643	membrane lipid metabolic process	4	14
GO:0006665	sphingolipid metabolic process	4	14
GO:0006672	ceramide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0008610	lipid biosynthetic process	4	14
GO:0009058	biosynthetic process	2	14
GO:0009987	cellular process	1	14
GO:0030148	sphingolipid biosynthetic process	5	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044255	cellular lipid metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0046467	membrane lipid biosynthetic process	4	14
GO:0046513	ceramide biosynthetic process	5	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016410	N-acyltransferase activity	5	14
GO:0016740	transferase activity	2	14
GO:0016746	acyltransferase activity	3	14
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	14
GO:0050291	sphingosine N-acyltransferase activity	6	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	246	252	PF00089	0.533
CLV_NRD_NRD_1	127	129	PF00675	0.384
CLV_NRD_NRD_1	137	139	PF00675	0.322
CLV_NRD_NRD_1	297	299	PF00675	0.337
CLV_NRD_NRD_1	35	37	PF00675	0.720
CLV_NRD_NRD_1	452	454	PF00675	0.565
CLV_NRD_NRD_1	457	459	PF00675	0.560
CLV_PCSK_KEX2_1	127	129	PF00082	0.388
CLV_PCSK_KEX2_1	221	223	PF00082	0.238
CLV_PCSK_KEX2_1	35	37	PF00082	0.720
CLV_PCSK_KEX2_1	452	454	PF00082	0.566
CLV_PCSK_KEX2_1	457	459	PF00082	0.562
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.256
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.517
CLV_PCSK_PC7_1	453	459	PF00082	0.517
CLV_PCSK_SKI1_1	140	144	PF00082	0.350
CLV_PCSK_SKI1_1	218	222	PF00082	0.312
CLV_PCSK_SKI1_1	299	303	PF00082	0.269
CLV_PCSK_SKI1_1	407	411	PF00082	0.489
CLV_PCSK_SKI1_1	427	431	PF00082	0.366
CLV_Separin_Metazoa	8	12	PF03568	0.242
DOC_ANK_TNKS_1	10	17	PF00023	0.403
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.333
DOC_MAPK_gen_1	136	144	PF00069	0.509
DOC_MAPK_MEF2A_6	143	152	PF00069	0.480
DOC_PP2B_LxvP_1	183	186	PF13499	0.326
DOC_PP2B_LxvP_1	25	28	PF13499	0.486
DOC_PP4_FxxP_1	171	174	PF00568	0.247
DOC_SPAK_OSR1_1	104	108	PF12202	0.602
DOC_USP7_MATH_1	18	22	PF00917	0.450
DOC_USP7_MATH_1	297	301	PF00917	0.393
DOC_USP7_MATH_1	435	439	PF00917	0.755
DOC_USP7_UBL2_3	139	143	PF12436	0.577
DOC_USP7_UBL2_3	288	292	PF12436	0.473
DOC_USP7_UBL2_3	295	299	PF12436	0.523
DOC_WW_Pin1_4	131	136	PF00397	0.644
DOC_WW_Pin1_4	14	19	PF00397	0.438
DOC_WW_Pin1_4	339	344	PF00397	0.326
LIG_14-3-3_CanoR_1	298	302	PF00244	0.539
LIG_14-3-3_CanoR_1	304	314	PF00244	0.526
LIG_14-3-3_CanoR_1	35	39	PF00244	0.486
LIG_14-3-3_CanoR_1	4	12	PF00244	0.396
LIG_14-3-3_CanoR_1	407	415	PF00244	0.578
LIG_14-3-3_CanoR_1	42	46	PF00244	0.419
LIG_Actin_WH2_2	372	390	PF00022	0.561
LIG_BIR_II_1	1	5	PF00653	0.415
LIG_BRCT_BRCA1_1	156	160	PF00533	0.302
LIG_Clathr_ClatBox_1	213	217	PF01394	0.423
LIG_FHA_1	231	237	PF00498	0.294
LIG_GBD_Chelix_1	355	363	PF00786	0.348
LIG_LIR_Gen_1	100	109	PF02991	0.572
LIG_LIR_Gen_1	17	27	PF02991	0.419
LIG_LIR_Gen_1	44	55	PF02991	0.390
LIG_LIR_Nem_3	100	105	PF02991	0.594
LIG_LIR_Nem_3	157	163	PF02991	0.324
LIG_LIR_Nem_3	167	173	PF02991	0.226
LIG_LIR_Nem_3	17	22	PF02991	0.393
LIG_LIR_Nem_3	223	228	PF02991	0.450
LIG_LIR_Nem_3	247	253	PF02991	0.246
LIG_LIR_Nem_3	44	50	PF02991	0.362
LIG_LIR_Nem_3	52	57	PF02991	0.336
LIG_LIR_Nem_3	79	85	PF02991	0.244
LIG_LYPXL_S_1	81	85	PF13949	0.362
LIG_LYPXL_yS_3	82	85	PF13949	0.362
LIG_NRBOX	354	360	PF00104	0.290
LIG_Pex14_1	149	153	PF04695	0.315
LIG_Pex14_1	353	357	PF04695	0.393
LIG_Pex14_2	319	323	PF04695	0.290
LIG_REV1ctd_RIR_1	323	331	PF16727	0.311
LIG_SH2_CRK	108	112	PF00017	0.556
LIG_SH2_CRK	19	23	PF00017	0.422
LIG_SH2_CRK	329	333	PF00017	0.440
LIG_SH2_NCK_1	189	193	PF00017	0.333
LIG_SH2_STAP1	5	9	PF00017	0.267
LIG_SH2_STAT3	162	165	PF00017	0.302
LIG_SH2_STAT3	273	276	PF00017	0.533
LIG_SH2_STAT5	154	157	PF00017	0.300
LIG_SH2_STAT5	163	166	PF00017	0.274
LIG_SH2_STAT5	206	209	PF00017	0.292
LIG_SH2_STAT5	228	231	PF00017	0.205
LIG_SH2_STAT5	253	256	PF00017	0.296
LIG_SH2_STAT5	26	29	PF00017	0.487
LIG_SH2_STAT5	305	308	PF00017	0.497
LIG_SH2_STAT5	329	332	PF00017	0.391
LIG_SH2_STAT5	96	99	PF00017	0.550
LIG_SH3_3	185	191	PF00018	0.239
LIG_SH3_3	77	83	PF00018	0.362
LIG_Sin3_3	375	382	PF02671	0.234
LIG_SUMO_SIM_anti_2	233	242	PF11976	0.318
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.295
LIG_SUMO_SIM_par_1	233	242	PF11976	0.320
LIG_SUMO_SIM_par_1	261	268	PF11976	0.326
LIG_SUMO_SIM_par_1	375	380	PF11976	0.467
LIG_TRAF2_1	191	194	PF00917	0.324
LIG_TRAF2_1	417	420	PF00917	0.760
LIG_TYR_ITIM	80	85	PF00017	0.415
LIG_UBA3_1	213	221	PF00899	0.440
MOD_CDK_SPK_2	131	136	PF00069	0.644
MOD_CDK_SPK_2	339	344	PF00069	0.290
MOD_CDK_SPxxK_3	131	138	PF00069	0.582
MOD_CDK_SPxxK_3	339	346	PF00069	0.326
MOD_CK1_1	17	23	PF00069	0.413
MOD_CK1_1	34	40	PF00069	0.451
MOD_CK1_1	438	444	PF00069	0.762
MOD_CK1_1	76	82	PF00069	0.137
MOD_CK2_1	18	24	PF00069	0.427
MOD_CK2_1	389	395	PF00069	0.654
MOD_Cter_Amidation	125	128	PF01082	0.451
MOD_GlcNHglycan	124	127	PF01048	0.461
MOD_GlcNHglycan	51	54	PF01048	0.614
MOD_GlcNHglycan	68	71	PF01048	0.503
MOD_GSK3_1	110	117	PF00069	0.598
MOD_GSK3_1	14	21	PF00069	0.440
MOD_GSK3_1	263	270	PF00069	0.396
MOD_GSK3_1	335	342	PF00069	0.329
MOD_GSK3_1	37	44	PF00069	0.447
MOD_GSK3_1	395	402	PF00069	0.684
MOD_GSK3_1	409	416	PF00069	0.677
MOD_GSK3_1	427	434	PF00069	0.745
MOD_GSK3_1	435	442	PF00069	0.757
MOD_GSK3_1	443	450	PF00069	0.769
MOD_GSK3_1	45	52	PF00069	0.410
MOD_LATS_1	405	411	PF00433	0.662
MOD_N-GLC_1	31	36	PF02516	0.648
MOD_N-GLC_1	427	432	PF02516	0.365
MOD_N-GLC_1	447	452	PF02516	0.542
MOD_N-GLC_2	313	315	PF02516	0.393
MOD_NEK2_1	148	153	PF00069	0.389
MOD_NEK2_1	265	270	PF00069	0.315
MOD_NEK2_1	377	382	PF00069	0.480
MOD_NEK2_1	409	414	PF00069	0.690
MOD_NEK2_1	439	444	PF00069	0.756
MOD_NEK2_1	73	78	PF00069	0.305
MOD_NEK2_2	335	340	PF00069	0.301
MOD_PIKK_1	447	453	PF00454	0.755
MOD_PKA_1	452	458	PF00069	0.774
MOD_PKA_2	297	303	PF00069	0.535
MOD_PKA_2	3	9	PF00069	0.394
MOD_PKA_2	34	40	PF00069	0.504
MOD_PKA_2	41	47	PF00069	0.449
MOD_PKA_2	452	458	PF00069	0.774
MOD_Plk_1	177	183	PF00069	0.333
MOD_Plk_1	73	79	PF00069	0.332
MOD_Plk_2-3	389	395	PF00069	0.601
MOD_Plk_4	148	154	PF00069	0.346
MOD_Plk_4	209	215	PF00069	0.331
MOD_Plk_4	232	238	PF00069	0.373
MOD_Plk_4	297	303	PF00069	0.496
MOD_Plk_4	73	79	PF00069	0.347
MOD_ProDKin_1	131	137	PF00069	0.639
MOD_ProDKin_1	14	20	PF00069	0.442
MOD_ProDKin_1	339	345	PF00069	0.326
MOD_SUMO_for_1	382	385	PF00179	0.440
MOD_SUMO_rev_2	131	141	PF00179	0.417
MOD_SUMO_rev_2	291	297	PF00179	0.445
MOD_SUMO_rev_2	380	390	PF00179	0.580
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.506
TRG_ENDOCYTIC_2	108	111	PF00928	0.504
TRG_ENDOCYTIC_2	19	22	PF00928	0.396
TRG_ENDOCYTIC_2	253	256	PF00928	0.290
TRG_ENDOCYTIC_2	369	372	PF00928	0.368
TRG_ENDOCYTIC_2	82	85	PF00928	0.417
TRG_ENDOCYTIC_2	86	89	PF00928	0.402
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N8	Leptomonas seymouri	63%	100%
A0A0S4JEY3	Bodo saltans	32%	100%
A0A0S4JIF9	Bodo saltans	35%	100%
A0A1X0NPU5	Trypanosomatidae	45%	100%
A0A1X0NPY1	Trypanosomatidae	45%	100%
A0A3S7X4J5	Leishmania donovani	88%	100%
A0A422MNN3	Trypanosoma rangeli	45%	100%
A4HJG0	Leishmania braziliensis	69%	100%
A4I6V5	Leishmania infantum	89%	100%
C9ZMC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZWR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4Q684	Leishmania major	88%	100%
Q5E9R6	Bos taurus	29%	100%
Q9HA82	Homo sapiens	28%	100%