Histidine kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Histidine kinase

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1X7_LEIMU

TriTrypDb:

LmxM.30.1770

Length:

1020

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9B1X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1X7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.358
CLV_C14_Caspase3-7	247	251	PF00656	0.344
CLV_C14_Caspase3-7	327	331	PF00656	0.441
CLV_C14_Caspase3-7	427	431	PF00656	0.460
CLV_C14_Caspase3-7	656	660	PF00656	0.652
CLV_NRD_NRD_1	1015	1017	PF00675	0.454
CLV_NRD_NRD_1	300	302	PF00675	0.643
CLV_NRD_NRD_1	596	598	PF00675	0.445
CLV_NRD_NRD_1	852	854	PF00675	0.410
CLV_NRD_NRD_1	923	925	PF00675	0.508
CLV_PCSK_FUR_1	850	854	PF00082	0.412
CLV_PCSK_KEX2_1	156	158	PF00082	0.370
CLV_PCSK_KEX2_1	205	207	PF00082	0.699
CLV_PCSK_KEX2_1	300	302	PF00082	0.643
CLV_PCSK_KEX2_1	596	598	PF00082	0.408
CLV_PCSK_KEX2_1	852	854	PF00082	0.415
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.370
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.699
CLV_PCSK_PC7_1	592	598	PF00082	0.342
CLV_PCSK_SKI1_1	193	197	PF00082	0.691
CLV_PCSK_SKI1_1	246	250	PF00082	0.665
CLV_PCSK_SKI1_1	394	398	PF00082	0.718
CLV_PCSK_SKI1_1	449	453	PF00082	0.667
CLV_PCSK_SKI1_1	599	603	PF00082	0.454
CLV_PCSK_SKI1_1	936	940	PF00082	0.478
CLV_PCSK_SKI1_1	986	990	PF00082	0.565
DEG_APCC_DBOX_1	591	599	PF00400	0.654
DEG_MDM2_SWIB_1	569	576	PF02201	0.226
DEG_ODPH_VHL_1	86	97	PF01847	0.726
DEG_SCF_FBW7_2	4	11	PF00400	0.650
DEG_SIAH_1	366	374	PF03145	0.454
DEG_SPOP_SBC_1	662	666	PF00917	0.653
DEG_SPOP_SBC_1	693	697	PF00917	0.640
DEG_SPOP_SBC_1	755	759	PF00917	0.657
DOC_CKS1_1	180	185	PF01111	0.609
DOC_CKS1_1	635	640	PF01111	0.712
DOC_CKS1_1	677	682	PF01111	0.671
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	703	706	PF00134	0.734
DOC_MAPK_gen_1	156	166	PF00069	0.534
DOC_MAPK_gen_1	933	943	PF00069	0.596
DOC_MAPK_MEF2A_6	159	168	PF00069	0.534
DOC_MAPK_MEF2A_6	307	316	PF00069	0.444
DOC_MAPK_MEF2A_6	946	955	PF00069	0.267
DOC_MAPK_RevD_3	1002	1017	PF00069	0.380
DOC_PP1_RVXF_1	938	944	PF00149	0.476
DOC_PP2B_LxvP_1	146	149	PF13499	0.734
DOC_PP2B_LxvP_1	349	352	PF13499	0.583
DOC_PP2B_LxvP_1	702	705	PF13499	0.735
DOC_PP4_FxxP_1	180	183	PF00568	0.614
DOC_USP7_MATH_1	268	272	PF00917	0.497
DOC_USP7_MATH_1	352	356	PF00917	0.490
DOC_USP7_MATH_1	419	423	PF00917	0.486
DOC_USP7_MATH_1	431	435	PF00917	0.435
DOC_USP7_MATH_1	604	608	PF00917	0.530
DOC_USP7_MATH_1	662	666	PF00917	0.653
DOC_USP7_MATH_1	716	720	PF00917	0.764
DOC_USP7_MATH_1	78	82	PF00917	0.830
DOC_USP7_MATH_1	876	880	PF00917	0.690
DOC_USP7_MATH_1	923	927	PF00917	0.640
DOC_USP7_MATH_1	995	999	PF00917	0.388
DOC_WW_Pin1_4	11	16	PF00397	0.707
DOC_WW_Pin1_4	127	132	PF00397	0.661
DOC_WW_Pin1_4	150	155	PF00397	0.708
DOC_WW_Pin1_4	179	184	PF00397	0.595
DOC_WW_Pin1_4	220	225	PF00397	0.452
DOC_WW_Pin1_4	308	313	PF00397	0.632
DOC_WW_Pin1_4	4	9	PF00397	0.757
DOC_WW_Pin1_4	492	497	PF00397	0.487
DOC_WW_Pin1_4	553	558	PF00397	0.483
DOC_WW_Pin1_4	634	639	PF00397	0.708
DOC_WW_Pin1_4	664	669	PF00397	0.735
DOC_WW_Pin1_4	676	681	PF00397	0.659
DOC_WW_Pin1_4	68	73	PF00397	0.711
DOC_WW_Pin1_4	686	691	PF00397	0.738
DOC_WW_Pin1_4	733	738	PF00397	0.750
DOC_WW_Pin1_4	794	799	PF00397	0.704
DOC_WW_Pin1_4	81	86	PF00397	0.762
DOC_WW_Pin1_4	907	912	PF00397	0.699
LIG_14-3-3_CanoR_1	157	162	PF00244	0.557
LIG_14-3-3_CanoR_1	246	255	PF00244	0.346
LIG_14-3-3_CanoR_1	269	278	PF00244	0.506
LIG_14-3-3_CanoR_1	300	304	PF00244	0.558
LIG_14-3-3_CanoR_1	502	512	PF00244	0.473
LIG_14-3-3_CanoR_1	529	536	PF00244	0.492
LIG_14-3-3_CanoR_1	548	557	PF00244	0.400
LIG_14-3-3_CanoR_1	674	678	PF00244	0.654
LIG_14-3-3_CanoR_1	793	798	PF00244	0.663
LIG_14-3-3_CanoR_1	852	860	PF00244	0.719
LIG_14-3-3_CanoR_1	922	928	PF00244	0.672
LIG_14-3-3_CanoR_1	986	996	PF00244	0.355
LIG_AP2alpha_1	256	260	PF02296	0.488
LIG_APCC_ABBA_1	566	571	PF00400	0.388
LIG_APCC_ABBAyCdc20_2	599	605	PF00400	0.538
LIG_BIR_II_1	1	5	PF00653	0.753
LIG_BIR_III_4	356	360	PF00653	0.582
LIG_CSL_BTD_1	818	821	PF09270	0.684
LIG_deltaCOP1_diTrp_1	1015	1020	PF00928	0.553
LIG_deltaCOP1_diTrp_1	845	848	PF00928	0.621
LIG_eIF4E_1	161	167	PF01652	0.388
LIG_eIF4E_1	89	95	PF01652	0.619
LIG_EVH1_1	148	152	PF00568	0.673
LIG_FHA_1	131	137	PF00498	0.706
LIG_FHA_1	184	190	PF00498	0.484
LIG_FHA_1	281	287	PF00498	0.482
LIG_FHA_1	403	409	PF00498	0.519
LIG_FHA_1	761	767	PF00498	0.774
LIG_FHA_1	913	919	PF00498	0.661
LIG_FHA_1	937	943	PF00498	0.587
LIG_FHA_2	442	448	PF00498	0.491
LIG_FHA_2	459	465	PF00498	0.365
LIG_FHA_2	514	520	PF00498	0.556
LIG_FHA_2	635	641	PF00498	0.714
LIG_FHA_2	646	652	PF00498	0.699
LIG_FHA_2	654	660	PF00498	0.693
LIG_FHA_2	867	873	PF00498	0.776
LIG_LIR_Apic_2	179	183	PF02991	0.384
LIG_LIR_Apic_2	740	746	PF02991	0.765
LIG_LIR_Apic_2	903	907	PF02991	0.805
LIG_LIR_Gen_1	160	170	PF02991	0.388
LIG_LIR_Gen_1	186	195	PF02991	0.371
LIG_LIR_Gen_1	217	227	PF02991	0.449
LIG_LIR_Gen_1	272	281	PF02991	0.530
LIG_LIR_Gen_1	474	485	PF02991	0.429
LIG_LIR_Gen_1	571	581	PF02991	0.388
LIG_LIR_Gen_1	926	935	PF02991	0.657
LIG_LIR_Nem_3	160	165	PF02991	0.388
LIG_LIR_Nem_3	179	184	PF02991	0.416
LIG_LIR_Nem_3	186	191	PF02991	0.436
LIG_LIR_Nem_3	217	222	PF02991	0.449
LIG_LIR_Nem_3	261	265	PF02991	0.497
LIG_LIR_Nem_3	272	278	PF02991	0.454
LIG_LIR_Nem_3	454	458	PF02991	0.512
LIG_LIR_Nem_3	474	480	PF02991	0.356
LIG_LIR_Nem_3	571	576	PF02991	0.388
LIG_LIR_Nem_3	926	930	PF02991	0.662
LIG_NRBOX	937	943	PF00104	0.622
LIG_Pex14_2	256	260	PF04695	0.488
LIG_Pex14_2	569	573	PF04695	0.388
LIG_SH2_CRK	162	166	PF00017	0.384
LIG_SH2_CRK	455	459	PF00017	0.503
LIG_SH2_CRK	927	931	PF00017	0.651
LIG_SH2_GRB2like	188	191	PF00017	0.374
LIG_SH2_NCK_1	603	607	PF00017	0.534
LIG_SH2_NCK_1	944	948	PF00017	0.307
LIG_SH2_PTP2	275	278	PF00017	0.538
LIG_SH2_PTP2	477	480	PF00017	0.490
LIG_SH2_PTP2	904	907	PF00017	0.716
LIG_SH2_SRC	523	526	PF00017	0.397
LIG_SH2_SRC	603	606	PF00017	0.533
LIG_SH2_STAP1	162	166	PF00017	0.307
LIG_SH2_STAP1	43	47	PF00017	0.608
LIG_SH2_STAP1	927	931	PF00017	0.533
LIG_SH2_STAP1	944	948	PF00017	0.283
LIG_SH2_STAT3	39	42	PF00017	0.725
LIG_SH2_STAT3	614	617	PF00017	0.660
LIG_SH2_STAT3	742	745	PF00017	0.716
LIG_SH2_STAT3	89	92	PF00017	0.622
LIG_SH2_STAT3	931	934	PF00017	0.520
LIG_SH2_STAT5	188	191	PF00017	0.374
LIG_SH2_STAT5	275	278	PF00017	0.538
LIG_SH2_STAT5	424	427	PF00017	0.508
LIG_SH2_STAT5	465	468	PF00017	0.471
LIG_SH2_STAT5	477	480	PF00017	0.409
LIG_SH2_STAT5	63	66	PF00017	0.653
LIG_SH2_STAT5	743	746	PF00017	0.762
LIG_SH2_STAT5	904	907	PF00017	0.716
LIG_SH2_STAT5	927	930	PF00017	0.642
LIG_SH2_STAT5	931	934	PF00017	0.601
LIG_SH2_STAT5	987	990	PF00017	0.477
LIG_SH3_1	795	801	PF00018	0.715
LIG_SH3_2	151	156	PF14604	0.703
LIG_SH3_2	497	502	PF14604	0.483
LIG_SH3_2	88	93	PF14604	0.728
LIG_SH3_3	122	128	PF00018	0.751
LIG_SH3_3	146	152	PF00018	0.725
LIG_SH3_3	306	312	PF00018	0.557
LIG_SH3_3	476	482	PF00018	0.486
LIG_SH3_3	490	496	PF00018	0.451
LIG_SH3_3	514	520	PF00018	0.550
LIG_SH3_3	538	544	PF00018	0.496
LIG_SH3_3	629	635	PF00018	0.752
LIG_SH3_3	721	727	PF00018	0.688
LIG_SH3_3	79	85	PF00018	0.807
LIG_SH3_3	795	801	PF00018	0.806
LIG_SH3_3	818	824	PF00018	0.747
LIG_SH3_3	833	839	PF00018	0.642
LIG_SH3_3	875	881	PF00018	0.640
LIG_SH3_3	94	100	PF00018	0.640
LIG_SH3_5	900	904	PF00018	0.607
LIG_SUMO_SIM_anti_2	379	385	PF11976	0.420
LIG_SUMO_SIM_anti_2	563	569	PF11976	0.334
LIG_SUMO_SIM_par_1	1006	1011	PF11976	0.303
LIG_SUMO_SIM_par_1	381	388	PF11976	0.419
LIG_SUMO_SIM_par_1	579	584	PF11976	0.295
LIG_TRAF2_1	869	872	PF00917	0.721
LIG_TRFH_1	742	746	PF08558	0.764
LIG_TYR_ITSM	158	165	PF00017	0.476
LIG_TYR_ITSM	472	479	PF00017	0.424
LIG_UBA3_1	918	925	PF00899	0.654
LIG_WRC_WIRS_1	177	182	PF05994	0.388
LIG_WW_1	15	18	PF00397	0.644
LIG_WW_1	705	708	PF00397	0.682
LIG_WW_3	671	675	PF00397	0.700
MOD_CDC14_SPxK_1	153	156	PF00782	0.693
MOD_CDC14_SPxK_1	499	502	PF00782	0.479
MOD_CDK_SPK_2	68	73	PF00069	0.645
MOD_CDK_SPxK_1	150	156	PF00069	0.708
MOD_CDK_SPxK_1	496	502	PF00069	0.483
MOD_CDK_SPxxK_3	150	157	PF00069	0.590
MOD_CDK_SPxxK_3	907	914	PF00069	0.671
MOD_CK1_1	130	136	PF00069	0.670
MOD_CK1_1	179	185	PF00069	0.600
MOD_CK1_1	2	8	PF00069	0.754
MOD_CK1_1	223	229	PF00069	0.456
MOD_CK1_1	26	32	PF00069	0.690
MOD_CK1_1	271	277	PF00069	0.524
MOD_CK1_1	324	330	PF00069	0.588
MOD_CK1_1	495	501	PF00069	0.555
MOD_CK1_1	551	557	PF00069	0.397
MOD_CK1_1	661	667	PF00069	0.770
MOD_CK1_1	68	74	PF00069	0.708
MOD_CK1_1	692	698	PF00069	0.754
MOD_CK1_1	736	742	PF00069	0.755
MOD_CK1_1	757	763	PF00069	0.662
MOD_CK1_1	81	87	PF00069	0.777
MOD_CK1_1	841	847	PF00069	0.740
MOD_CK1_1	863	869	PF00069	0.747
MOD_CK1_1	965	971	PF00069	0.481
MOD_CK2_1	458	464	PF00069	0.485
MOD_CK2_1	513	519	PF00069	0.558
MOD_CK2_1	634	640	PF00069	0.711
MOD_CK2_1	645	651	PF00069	0.671
MOD_CK2_1	68	74	PF00069	0.645
MOD_CK2_1	855	861	PF00069	0.798
MOD_CK2_1	866	872	PF00069	0.705
MOD_CK2_1	884	890	PF00069	0.632
MOD_CK2_1	907	913	PF00069	0.673
MOD_Cter_Amidation	298	301	PF01082	0.646
MOD_GlcNHglycan	200	203	PF01048	0.590
MOD_GlcNHglycan	216	219	PF01048	0.633
MOD_GlcNHglycan	241	244	PF01048	0.663
MOD_GlcNHglycan	262	265	PF01048	0.692
MOD_GlcNHglycan	323	326	PF01048	0.831
MOD_GlcNHglycan	420	424	PF01048	0.690
MOD_GlcNHglycan	437	440	PF01048	0.589
MOD_GlcNHglycan	444	447	PF01048	0.644
MOD_GlcNHglycan	503	506	PF01048	0.814
MOD_GlcNHglycan	551	554	PF01048	0.714
MOD_GlcNHglycan	562	565	PF01048	0.566
MOD_GlcNHglycan	659	663	PF01048	0.480
MOD_GlcNHglycan	684	687	PF01048	0.517
MOD_GlcNHglycan	718	721	PF01048	0.569
MOD_GlcNHglycan	782	785	PF01048	0.483
MOD_GlcNHglycan	803	806	PF01048	0.530
MOD_GlcNHglycan	808	811	PF01048	0.508
MOD_GlcNHglycan	840	843	PF01048	0.435
MOD_GlcNHglycan	865	868	PF01048	0.570
MOD_GlcNHglycan	964	967	PF01048	0.666
MOD_GlcNHglycan	969	972	PF01048	0.667
MOD_GlcNHglycan	989	992	PF01048	0.539
MOD_GSK3_1	179	186	PF00069	0.583
MOD_GSK3_1	18	25	PF00069	0.680
MOD_GSK3_1	189	196	PF00069	0.412
MOD_GSK3_1	223	230	PF00069	0.351
MOD_GSK3_1	308	315	PF00069	0.478
MOD_GSK3_1	426	433	PF00069	0.496
MOD_GSK3_1	492	499	PF00069	0.549
MOD_GSK3_1	549	556	PF00069	0.393
MOD_GSK3_1	658	665	PF00069	0.740
MOD_GSK3_1	672	679	PF00069	0.697
MOD_GSK3_1	682	689	PF00069	0.681
MOD_GSK3_1	711	718	PF00069	0.750
MOD_GSK3_1	756	763	PF00069	0.659
MOD_GSK3_1	862	869	PF00069	0.817
MOD_N-GLC_1	18	23	PF02516	0.567
MOD_N-GLC_1	189	194	PF02516	0.689
MOD_N-GLC_1	330	335	PF02516	0.706
MOD_N-GLC_1	376	381	PF02516	0.737
MOD_N-GLC_1	411	416	PF02516	0.691
MOD_NEK2_1	176	181	PF00069	0.384
MOD_NEK2_1	189	194	PF00069	0.399
MOD_NEK2_1	214	219	PF00069	0.454
MOD_NEK2_1	22	27	PF00069	0.640
MOD_NEK2_1	260	265	PF00069	0.496
MOD_NEK2_1	3	8	PF00069	0.756
MOD_NEK2_1	385	390	PF00069	0.569
MOD_NEK2_1	411	416	PF00069	0.517
MOD_NEK2_1	458	463	PF00069	0.372
MOD_NEK2_1	528	533	PF00069	0.531
MOD_NEK2_1	663	668	PF00069	0.772
MOD_NEK2_1	694	699	PF00069	0.701
MOD_NEK2_1	860	865	PF00069	0.720
MOD_NEK2_1	957	962	PF00069	0.372
MOD_NEK2_1	997	1002	PF00069	0.323
MOD_NEK2_2	312	317	PF00069	0.448
MOD_NEK2_2	513	518	PF00069	0.490
MOD_NEK2_2	65	70	PF00069	0.650
MOD_PIKK_1	853	859	PF00454	0.720
MOD_PKA_2	268	274	PF00069	0.504
MOD_PKA_2	299	305	PF00069	0.442
MOD_PKA_2	501	507	PF00069	0.511
MOD_PKA_2	528	534	PF00069	0.491
MOD_PKA_2	673	679	PF00069	0.655
MOD_PKA_2	760	766	PF00069	0.774
MOD_PKA_2	923	929	PF00069	0.680
MOD_Plk_1	18	24	PF00069	0.766
MOD_Plk_1	376	382	PF00069	0.537
MOD_Plk_1	411	417	PF00069	0.486
MOD_Plk_1	419	425	PF00069	0.433
MOD_Plk_1	513	519	PF00069	0.534
MOD_Plk_1	604	610	PF00069	0.645
MOD_Plk_1	65	71	PF00069	0.707
MOD_Plk_1	658	664	PF00069	0.652
MOD_Plk_1	860	866	PF00069	0.605
MOD_Plk_1	912	918	PF00069	0.656
MOD_Plk_4	176	182	PF00069	0.388
MOD_Plk_4	18	24	PF00069	0.766
MOD_Plk_4	223	229	PF00069	0.456
MOD_Plk_4	271	277	PF00069	0.524
MOD_Plk_4	411	417	PF00069	0.528
MOD_Plk_4	481	487	PF00069	0.385
MOD_Plk_4	689	695	PF00069	0.648
MOD_Plk_4	855	861	PF00069	0.740
MOD_ProDKin_1	11	17	PF00069	0.705
MOD_ProDKin_1	127	133	PF00069	0.658
MOD_ProDKin_1	150	156	PF00069	0.708
MOD_ProDKin_1	179	185	PF00069	0.600
MOD_ProDKin_1	220	226	PF00069	0.450
MOD_ProDKin_1	308	314	PF00069	0.633
MOD_ProDKin_1	4	10	PF00069	0.755
MOD_ProDKin_1	492	498	PF00069	0.489
MOD_ProDKin_1	553	559	PF00069	0.479
MOD_ProDKin_1	634	640	PF00069	0.711
MOD_ProDKin_1	664	670	PF00069	0.737
MOD_ProDKin_1	676	682	PF00069	0.661
MOD_ProDKin_1	68	74	PF00069	0.711
MOD_ProDKin_1	686	692	PF00069	0.736
MOD_ProDKin_1	733	739	PF00069	0.749
MOD_ProDKin_1	794	800	PF00069	0.702
MOD_ProDKin_1	81	87	PF00069	0.761
MOD_ProDKin_1	907	913	PF00069	0.697
MOD_SUMO_rev_2	1011	1019	PF00179	0.545
MOD_SUMO_rev_2	441	451	PF00179	0.496
TRG_DiLeu_BaEn_1	571	576	PF01217	0.388
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.675
TRG_ENDOCYTIC_2	161	164	PF00928	0.388
TRG_ENDOCYTIC_2	188	191	PF00928	0.374
TRG_ENDOCYTIC_2	219	222	PF00928	0.453
TRG_ENDOCYTIC_2	262	265	PF00928	0.492
TRG_ENDOCYTIC_2	275	278	PF00928	0.450
TRG_ENDOCYTIC_2	455	458	PF00928	0.511
TRG_ENDOCYTIC_2	476	479	PF00928	0.486
TRG_ENDOCYTIC_2	927	930	PF00928	0.661
TRG_ER_diArg_1	595	597	PF00400	0.600
TRG_ER_diArg_1	850	853	PF00400	0.615
TRG_ER_diArg_1	921	924	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	891	896	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4J6	Leishmania donovani	75%	93%
A4I6V4	Leishmania infantum	75%	93%
Q4Q685	Leishmania major	74%	100%