Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1X6_LEIMU

TriTrypDb:

LmxM.30.1760

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1X6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.737
CLV_NRD_NRD_1	123	125	PF00675	0.718
CLV_NRD_NRD_1	189	191	PF00675	0.711
CLV_NRD_NRD_1	353	355	PF00675	0.593
CLV_NRD_NRD_1	360	362	PF00675	0.618
CLV_NRD_NRD_1	84	86	PF00675	0.603
CLV_PCSK_KEX2_1	123	125	PF00082	0.718
CLV_PCSK_KEX2_1	189	191	PF00082	0.591
CLV_PCSK_KEX2_1	269	271	PF00082	0.638
CLV_PCSK_KEX2_1	353	355	PF00082	0.593
CLV_PCSK_KEX2_1	360	362	PF00082	0.618
CLV_PCSK_KEX2_1	84	86	PF00082	0.603
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.732
CLV_PCSK_PC7_1	185	191	PF00082	0.629
CLV_PCSK_SKI1_1	18	22	PF00082	0.534
CLV_PCSK_SKI1_1	313	317	PF00082	0.811
CLV_PCSK_SKI1_1	354	358	PF00082	0.602
CLV_PCSK_SKI1_1	84	88	PF00082	0.733
DEG_SPOP_SBC_1	31	35	PF00917	0.651
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.774
DOC_MAPK_gen_1	100	108	PF00069	0.610
DOC_MAPK_MEF2A_6	89	96	PF00069	0.638
DOC_PP2B_LxvP_1	108	111	PF13499	0.682
DOC_PP4_FxxP_1	14	17	PF00568	0.517
DOC_PP4_FxxP_1	326	329	PF00568	0.687
DOC_USP7_MATH_1	146	150	PF00917	0.730
DOC_USP7_MATH_1	322	326	PF00917	0.558
DOC_USP7_MATH_1	4	8	PF00917	0.727
DOC_USP7_MATH_1	55	59	PF00917	0.669
DOC_USP7_UBL2_3	300	304	PF12436	0.667
DOC_USP7_UBL2_3	309	313	PF12436	0.784
DOC_WW_Pin1_4	122	127	PF00397	0.535
DOC_WW_Pin1_4	19	24	PF00397	0.731
DOC_WW_Pin1_4	191	196	PF00397	0.659
DOC_WW_Pin1_4	220	225	PF00397	0.769
DOC_WW_Pin1_4	228	233	PF00397	0.567
DOC_WW_Pin1_4	314	319	PF00397	0.813
DOC_WW_Pin1_4	38	43	PF00397	0.794
DOC_WW_Pin1_4	68	73	PF00397	0.738
LIG_14-3-3_CanoR_1	18	23	PF00244	0.611
LIG_14-3-3_CanoR_1	263	267	PF00244	0.573
LIG_14-3-3_CanoR_1	360	368	PF00244	0.632
LIG_BIR_II_1	1	5	PF00653	0.779
LIG_BIR_III_3	1	5	PF00653	0.779
LIG_BRCT_BRCA1_1	10	14	PF00533	0.511
LIG_BRCT_BRCA1_1	256	260	PF00533	0.422
LIG_FHA_1	100	106	PF00498	0.487
LIG_FHA_1	172	178	PF00498	0.734
LIG_FHA_1	19	25	PF00498	0.752
LIG_FHA_1	245	251	PF00498	0.622
LIG_FHA_1	274	280	PF00498	0.758
LIG_FHA_1	285	291	PF00498	0.581
LIG_FHA_1	8	14	PF00498	0.711
LIG_FHA_2	150	156	PF00498	0.649
LIG_FHA_2	171	177	PF00498	0.632
LIG_FHA_2	287	293	PF00498	0.757
LIG_FHA_2	332	338	PF00498	0.707
LIG_FHA_2	360	366	PF00498	0.624
LIG_Integrin_RGD_1	164	166	PF01839	0.772
LIG_LIR_Apic_2	11	17	PF02991	0.514
LIG_LIR_Apic_2	323	329	PF02991	0.693
LIG_LIR_Gen_1	334	343	PF02991	0.613
LIG_LIR_Nem_3	334	338	PF02991	0.613
LIG_PCNA_yPIPBox_3	202	211	PF02747	0.457
LIG_Pex14_2	168	172	PF04695	0.765
LIG_SH2_STAT5	187	190	PF00017	0.655
LIG_SH2_STAT5	255	258	PF00017	0.661
LIG_SH3_1	192	198	PF00018	0.755
LIG_SH3_3	103	109	PF00018	0.679
LIG_SH3_3	157	163	PF00018	0.676
LIG_SH3_3	192	198	PF00018	0.658
LIG_SH3_3	226	232	PF00018	0.748
LIG_SH3_3	275	281	PF00018	0.665
LIG_SH3_3	321	327	PF00018	0.649
LIG_SH3_3	41	47	PF00018	0.785
LIG_SH3_3	57	63	PF00018	0.533
LIG_SUMO_SIM_par_1	341	346	PF11976	0.701
LIG_TRAF2_2	126	131	PF00917	0.537
MOD_CDC14_SPxK_1	22	25	PF00782	0.773
MOD_CDK_SPK_2	40	45	PF00069	0.522
MOD_CDK_SPxK_1	19	25	PF00069	0.776
MOD_CDK_SPxxK_3	122	129	PF00069	0.538
MOD_CDK_SPxxK_3	38	45	PF00069	0.525
MOD_CK1_1	132	138	PF00069	0.593
MOD_CK1_1	149	155	PF00069	0.495
MOD_CK1_1	298	304	PF00069	0.739
MOD_CK1_1	317	323	PF00069	0.529
MOD_CK1_1	35	41	PF00069	0.759
MOD_CK1_1	7	13	PF00069	0.706
MOD_CK1_1	75	81	PF00069	0.606
MOD_CK2_1	149	155	PF00069	0.556
MOD_CK2_1	170	176	PF00069	0.602
MOD_CK2_1	286	292	PF00069	0.756
MOD_CK2_1	359	365	PF00069	0.622
MOD_GlcNHglycan	176	180	PF01048	0.435
MOD_GlcNHglycan	297	300	PF01048	0.700
MOD_GlcNHglycan	35	38	PF01048	0.684
MOD_GlcNHglycan	57	60	PF01048	0.729
MOD_GlcNHglycan	7	10	PF01048	0.495
MOD_GlcNHglycan	80	83	PF01048	0.705
MOD_GSK3_1	12	19	PF00069	0.694
MOD_GSK3_1	171	178	PF00069	0.552
MOD_GSK3_1	291	298	PF00069	0.670
MOD_GSK3_1	31	38	PF00069	0.741
MOD_GSK3_1	316	323	PF00069	0.709
MOD_GSK3_1	4	11	PF00069	0.778
MOD_GSK3_1	68	75	PF00069	0.604
MOD_LATS_1	359	365	PF00433	0.622
MOD_NEK2_1	168	173	PF00069	0.758
MOD_NEK2_1	87	92	PF00069	0.643
MOD_NEK2_2	255	260	PF00069	0.699
MOD_PIKK_1	8	14	PF00454	0.655
MOD_PKA_2	262	268	PF00069	0.620
MOD_PKA_2	359	365	PF00069	0.653
MOD_PKA_2	88	94	PF00069	0.636
MOD_PKA_2	99	105	PF00069	0.666
MOD_Plk_1	168	174	PF00069	0.703
MOD_Plk_1	175	181	PF00069	0.593
MOD_Plk_4	255	261	PF00069	0.604
MOD_Plk_4	262	268	PF00069	0.678
MOD_Plk_4	88	94	PF00069	0.591
MOD_ProDKin_1	122	128	PF00069	0.535
MOD_ProDKin_1	19	25	PF00069	0.731
MOD_ProDKin_1	191	197	PF00069	0.653
MOD_ProDKin_1	220	226	PF00069	0.768
MOD_ProDKin_1	228	234	PF00069	0.563
MOD_ProDKin_1	314	320	PF00069	0.812
MOD_ProDKin_1	38	44	PF00069	0.790
MOD_ProDKin_1	68	74	PF00069	0.733
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.715
TRG_ENDOCYTIC_2	335	338	PF00928	0.712
TRG_ER_diArg_1	188	190	PF00400	0.728
TRG_ER_diArg_1	83	85	PF00400	0.598
TRG_NES_CRM1_1	254	268	PF08389	0.699
TRG_NLS_MonoExtN_4	303	310	PF00514	0.651
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V3	Leptomonas seymouri	39%	92%
A0A3Q8ISN5	Leishmania donovani	86%	100%
A4I6V3	Leishmania infantum	86%	100%
Q4Q686	Leishmania major	83%	100%