Nucleosome assembly protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein-like protein

Species:

Leishmania mexicana

UniProt:

E9B1X5_LEIMU

TriTrypDb:

LmxM.30.1750

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0000785	chromatin	2	1

Expansion

Sequence features

E9B1X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1X5

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	12
GO:0006334	nucleosome assembly	7	12
GO:0006338	chromatin remodeling	5	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0034728	nucleosome organization	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0065004	protein-DNA complex assembly	6	12
GO:0071824	protein-DNA complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.757
CLV_NRD_NRD_1	40	42	PF00675	0.288
CLV_NRD_NRD_1	80	82	PF00675	0.347
CLV_PCSK_KEX2_1	39	41	PF00082	0.325
CLV_PCSK_SKI1_1	119	123	PF00082	0.318
CLV_PCSK_SKI1_1	12	16	PF00082	0.612
CLV_PCSK_SKI1_1	169	173	PF00082	0.281
CLV_PCSK_SKI1_1	192	196	PF00082	0.379
CLV_PCSK_SKI1_1	240	244	PF00082	0.286
CLV_PCSK_SKI1_1	316	320	PF00082	0.322
CLV_PCSK_SKI1_1	89	93	PF00082	0.299
DEG_APCC_DBOX_1	168	176	PF00400	0.491
DOC_ANK_TNKS_1	179	186	PF00023	0.527
DOC_MAPK_gen_1	167	175	PF00069	0.501
DOC_MAPK_gen_1	236	246	PF00069	0.517
DOC_MAPK_gen_1	252	261	PF00069	0.408
DOC_MAPK_MEF2A_6	239	246	PF00069	0.545
DOC_PP1_RVXF_1	117	124	PF00149	0.527
DOC_PP1_RVXF_1	190	196	PF00149	0.522
DOC_PP4_FxxP_1	123	126	PF00568	0.527
DOC_PP4_FxxP_1	274	277	PF00568	0.482
DOC_USP7_MATH_1	140	144	PF00917	0.550
DOC_USP7_MATH_1	159	163	PF00917	0.564
DOC_USP7_MATH_1	20	24	PF00917	0.749
DOC_USP7_MATH_1	267	271	PF00917	0.575
DOC_USP7_MATH_1	367	371	PF00917	0.758
DOC_USP7_UBL2_3	118	122	PF12436	0.540
DOC_USP7_UBL2_3	236	240	PF12436	0.497
DOC_USP7_UBL2_3	250	254	PF12436	0.439
DOC_WW_Pin1_4	138	143	PF00397	0.556
DOC_WW_Pin1_4	195	200	PF00397	0.547
DOC_WW_Pin1_4	273	278	PF00397	0.574
DOC_WW_Pin1_4	381	386	PF00397	0.718
LIG_BIR_III_2	113	117	PF00653	0.577
LIG_CaM_IQ_9	42	58	PF13499	0.574
LIG_eIF4E_1	43	49	PF01652	0.491
LIG_FHA_1	224	230	PF00498	0.565
LIG_FHA_1	241	247	PF00498	0.395
LIG_FHA_1	308	314	PF00498	0.565
LIG_FHA_1	86	92	PF00498	0.477
LIG_FHA_2	104	110	PF00498	0.574
LIG_FHA_2	11	17	PF00498	0.716
LIG_FHA_2	163	169	PF00498	0.480
LIG_FHA_2	174	180	PF00498	0.482
LIG_FHA_2	212	218	PF00498	0.528
LIG_FHA_2	327	333	PF00498	0.607
LIG_FHA_2	33	39	PF00498	0.509
LIG_FHA_2	90	96	PF00498	0.490
LIG_LIR_Gen_1	269	280	PF02991	0.482
LIG_LIR_Nem_3	269	275	PF02991	0.482
LIG_LIR_Nem_3	370	375	PF02991	0.738
LIG_LIR_Nem_3	51	55	PF02991	0.505
LIG_NRBOX	44	50	PF00104	0.491
LIG_PCNA_PIPBox_1	46	55	PF02747	0.577
LIG_PCNA_yPIPBox_3	39	53	PF02747	0.462
LIG_Pex14_2	271	275	PF04695	0.479
LIG_SH2_STAT3	43	46	PF00017	0.574
LIG_SH2_STAT5	202	205	PF00017	0.483
LIG_SH2_STAT5	321	324	PF00017	0.491
LIG_SH3_2	105	110	PF14604	0.577
LIG_SH3_2	277	282	PF14604	0.390
LIG_SH3_3	102	108	PF00018	0.593
LIG_SH3_3	274	280	PF00018	0.575
LIG_SUMO_SIM_anti_2	26	33	PF11976	0.584
LIG_SUMO_SIM_par_1	26	33	PF11976	0.545
LIG_TRAF2_1	400	403	PF00917	0.781
LIG_TRAF2_1	92	95	PF00917	0.505
MOD_CDK_SPxxK_3	381	388	PF00069	0.723
MOD_CK1_1	162	168	PF00069	0.474
MOD_CK1_1	18	24	PF00069	0.723
MOD_CK2_1	103	109	PF00069	0.399
MOD_CK2_1	152	158	PF00069	0.555
MOD_CK2_1	173	179	PF00069	0.594
MOD_CK2_1	18	24	PF00069	0.698
MOD_CK2_1	32	38	PF00069	0.386
MOD_CK2_1	326	332	PF00069	0.572
MOD_CK2_1	339	345	PF00069	0.700
MOD_CK2_1	346	352	PF00069	0.487
MOD_CK2_1	89	95	PF00069	0.490
MOD_GlcNHglycan	132	135	PF01048	0.383
MOD_GlcNHglycan	142	145	PF01048	0.369
MOD_GSK3_1	10	17	PF00069	0.762
MOD_GSK3_1	85	92	PF00069	0.476
MOD_GSK3_1	99	106	PF00069	0.493
MOD_N-GLC_1	204	209	PF02516	0.344
MOD_N-GLC_1	240	245	PF02516	0.291
MOD_N-GLC_2	68	70	PF02516	0.377
MOD_NEK2_1	10	15	PF00069	0.579
MOD_NEK2_1	149	154	PF00069	0.479
MOD_NEK2_1	242	247	PF00069	0.577
MOD_NEK2_2	267	272	PF00069	0.574
MOD_PIKK_1	307	313	PF00454	0.577
MOD_PKA_2	223	229	PF00069	0.588
MOD_Plk_1	204	210	PF00069	0.544
MOD_Plk_1	240	246	PF00069	0.490
MOD_Plk_1	32	38	PF00069	0.485
MOD_Plk_2-3	211	217	PF00069	0.533
MOD_Plk_2-3	344	350	PF00069	0.758
MOD_Plk_4	159	165	PF00069	0.488
MOD_Plk_4	267	273	PF00069	0.479
MOD_ProDKin_1	138	144	PF00069	0.556
MOD_ProDKin_1	195	201	PF00069	0.547
MOD_ProDKin_1	273	279	PF00069	0.574
MOD_ProDKin_1	381	387	PF00069	0.720
TRG_ENDOCYTIC_2	52	55	PF00928	0.491
TRG_ER_diArg_1	376	379	PF00400	0.768
TRG_ER_diArg_1	39	41	PF00400	0.416
TRG_ER_diArg_1	55	58	PF00400	0.574
TRG_NES_CRM1_1	26	38	PF08389	0.478
TRG_NLS_Bipartite_1	239	253	PF00514	0.574
TRG_NLS_MonoExtN_4	247	253	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J2	Leptomonas seymouri	32%	100%
A0A0N1IJI7	Leptomonas seymouri	70%	100%
A0A0S4J1L1	Bodo saltans	39%	99%
A0A1X0NTY9	Trypanosomatidae	41%	94%
A0A3Q8IA70	Leishmania donovani	32%	100%
A0A3R7KHX6	Trypanosoma rangeli	40%	94%
A0A3R7KRI5	Trypanosoma rangeli	28%	100%
A0A3S7X4M4	Leishmania donovani	92%	100%
A4HA02	Leishmania braziliensis	34%	100%
A4HJF7	Leishmania braziliensis	83%	99%
A4HY66	Leishmania infantum	32%	100%
A4I6V2	Leishmania infantum	92%	100%
A6H767	Bos taurus	33%	100%
B8AW64	Oryza sativa subsp. indica	32%	100%
B8B2R4	Oryza sativa subsp. indica	32%	100%
C9ZXT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	97%
D0A0I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O59797	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P25293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	98%
P28656	Mus musculus	33%	100%
P55209	Homo sapiens	32%	100%
P78920	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q28EB4	Xenopus tropicalis	33%	100%
Q2TA40	Bos taurus	34%	100%
Q4Q687	Leishmania major	92%	100%
Q4QDH7	Leishmania major	31%	100%
Q4U0Y4	Xenopus laevis	30%	100%
Q53WK4	Oryza sativa subsp. japonica	32%	100%
Q55ED1	Dictyostelium discoideum	30%	100%
Q5AAI8	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	94%
Q5R4D4	Pongo abelii	32%	100%
Q5U2Z3	Rattus norvegicus	34%	100%
Q5VND6	Oryza sativa subsp. japonica	33%	100%
Q70Z16	Nicotiana tabacum	32%	100%
Q70Z17	Nicotiana tabacum	34%	100%
Q70Z18	Nicotiana tabacum	33%	100%
Q70Z19	Nicotiana tabacum	32%	100%
Q78ZA7	Mus musculus	35%	100%
Q7ZY81	Xenopus laevis	32%	100%
Q94K07	Arabidopsis thaliana	34%	100%
Q99733	Homo sapiens	35%	100%
Q9SZI2	Arabidopsis thaliana	35%	100%
Q9Z2G8	Rattus norvegicus	32%	100%
Q9ZUP3	Arabidopsis thaliana	35%	100%
V5BUC1	Trypanosoma cruzi	42%	90%
V5BX23	Trypanosoma cruzi	28%	100%