Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1X4_LEIMU

TriTrypDb:

LmxM.30.1740

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.542
CLV_NRD_NRD_1	249	251	PF00675	0.607
CLV_NRD_NRD_1	405	407	PF00675	0.656
CLV_PCSK_FUR_1	401	405	PF00082	0.573
CLV_PCSK_KEX2_1	249	251	PF00082	0.607
CLV_PCSK_KEX2_1	403	405	PF00082	0.654
CLV_PCSK_PC7_1	399	405	PF00082	0.696
CLV_PCSK_SKI1_1	109	113	PF00082	0.494
CLV_PCSK_SKI1_1	130	134	PF00082	0.529
CLV_PCSK_SKI1_1	210	214	PF00082	0.614
CLV_PCSK_SKI1_1	274	278	PF00082	0.438
CLV_PCSK_SKI1_1	374	378	PF00082	0.580
DEG_MDM2_SWIB_1	295	302	PF02201	0.530
DEG_Nend_UBRbox_1	1	4	PF02207	0.787
DEG_SCF_FBW7_1	192	199	PF00400	0.484
DEG_SCF_FBW7_1	278	283	PF00400	0.455
DEG_SPOP_SBC_1	197	201	PF00917	0.637
DOC_CKS1_1	101	106	PF01111	0.632
DOC_CKS1_1	72	77	PF01111	0.575
DOC_CYCLIN_yCln2_LP_2	69	72	PF00134	0.571
DOC_MAPK_gen_1	109	119	PF00069	0.589
DOC_MAPK_gen_1	205	215	PF00069	0.571
DOC_MAPK_MEF2A_6	110	119	PF00069	0.604
DOC_MAPK_NFAT4_5	112	120	PF00069	0.466
DOC_PP2B_LxvP_1	121	124	PF13499	0.601
DOC_PP2B_LxvP_1	69	72	PF13499	0.571
DOC_USP7_MATH_1	197	201	PF00917	0.697
DOC_USP7_MATH_1	291	295	PF00917	0.561
DOC_USP7_MATH_1	344	348	PF00917	0.697
DOC_USP7_MATH_1	358	362	PF00917	0.538
DOC_USP7_MATH_1	391	395	PF00917	0.732
DOC_USP7_MATH_1	8	12	PF00917	0.600
DOC_WW_Pin1_4	100	105	PF00397	0.550
DOC_WW_Pin1_4	192	197	PF00397	0.574
DOC_WW_Pin1_4	198	203	PF00397	0.569
DOC_WW_Pin1_4	238	243	PF00397	0.690
DOC_WW_Pin1_4	254	259	PF00397	0.427
DOC_WW_Pin1_4	276	281	PF00397	0.627
DOC_WW_Pin1_4	284	289	PF00397	0.656
DOC_WW_Pin1_4	348	353	PF00397	0.610
DOC_WW_Pin1_4	71	76	PF00397	0.610
LIG_14-3-3_CanoR_1	109	119	PF00244	0.557
LIG_14-3-3_CanoR_1	2	7	PF00244	0.602
LIG_14-3-3_CanoR_1	249	255	PF00244	0.643
LIG_14-3-3_CanoR_1	274	279	PF00244	0.635
LIG_14-3-3_CanoR_1	60	70	PF00244	0.596
LIG_Actin_RPEL_3	102	121	PF02755	0.538
LIG_BRCT_BRCA1_1	250	254	PF00533	0.711
LIG_CaM_NSCaTE_8	129	136	PF13499	0.457
LIG_deltaCOP1_diTrp_1	297	304	PF00928	0.470
LIG_FHA_1	180	186	PF00498	0.575
LIG_FHA_1	22	28	PF00498	0.575
LIG_FHA_1	277	283	PF00498	0.657
LIG_FHA_1	287	293	PF00498	0.664
LIG_FHA_1	335	341	PF00498	0.512
LIG_FHA_1	393	399	PF00498	0.644
LIG_FHA_1	409	415	PF00498	0.510
LIG_FHA_2	101	107	PF00498	0.692
LIG_GSK3_LRP6_1	71	76	PF00069	0.520
LIG_LIR_Gen_1	113	124	PF02991	0.522
LIG_LIR_Gen_1	294	303	PF02991	0.475
LIG_LIR_Nem_3	113	119	PF02991	0.582
LIG_LIR_Nem_3	294	298	PF02991	0.540
LIG_LIR_Nem_3	33	39	PF02991	0.753
LIG_LYPXL_yS_3	36	39	PF13949	0.565
LIG_MYND_1	100	104	PF01753	0.553
LIG_MYND_1	18	22	PF01753	0.576
LIG_NRBOX	264	270	PF00104	0.467
LIG_Pex14_2	295	299	PF04695	0.537
LIG_PTAP_UEV_1	31	36	PF05743	0.559
LIG_SH2_CRK	223	227	PF00017	0.553
LIG_SH2_CRK	310	314	PF00017	0.560
LIG_SH2_CRK	357	361	PF00017	0.642
LIG_SH2_NCK_1	159	163	PF00017	0.629
LIG_SH2_NCK_1	223	227	PF00017	0.553
LIG_SH2_NCK_1	357	361	PF00017	0.642
LIG_SH2_SRC	223	226	PF00017	0.556
LIG_SH2_STAT3	98	101	PF00017	0.642
LIG_SH2_STAT5	369	372	PF00017	0.449
LIG_SH3_1	26	32	PF00018	0.449
LIG_SH3_3	219	225	PF00018	0.582
LIG_SH3_3	236	242	PF00018	0.602
LIG_SH3_3	26	32	PF00018	0.670
LIG_SH3_3	69	75	PF00018	0.627
LIG_SUMO_SIM_par_1	229	237	PF11976	0.543
LIG_TRAF2_1	243	246	PF00917	0.638
LIG_TYR_ITIM	355	360	PF00017	0.591
LIG_UBA3_1	264	270	PF00899	0.600
LIG_WRC_WIRS_1	292	297	PF05994	0.509
MOD_CDK_SPxxK_3	198	205	PF00069	0.510
MOD_CK1_1	176	182	PF00069	0.623
MOD_CK1_1	200	206	PF00069	0.602
MOD_CK1_1	248	254	PF00069	0.741
MOD_CK1_1	347	353	PF00069	0.704
MOD_CK1_1	392	398	PF00069	0.731
MOD_CK1_1	45	51	PF00069	0.694
MOD_CK2_1	185	191	PF00069	0.404
MOD_GlcNHglycan	11	14	PF01048	0.687
MOD_GlcNHglycan	147	150	PF01048	0.599
MOD_GlcNHglycan	226	229	PF01048	0.764
MOD_GlcNHglycan	32	35	PF01048	0.706
MOD_GlcNHglycan	347	350	PF01048	0.685
MOD_GlcNHglycan	82	85	PF01048	0.533
MOD_GSK3_1	172	179	PF00069	0.601
MOD_GSK3_1	192	199	PF00069	0.670
MOD_GSK3_1	233	240	PF00069	0.718
MOD_GSK3_1	244	251	PF00069	0.728
MOD_GSK3_1	274	281	PF00069	0.570
MOD_GSK3_1	282	289	PF00069	0.602
MOD_GSK3_1	334	341	PF00069	0.607
MOD_GSK3_1	344	351	PF00069	0.653
MOD_GSK3_1	385	392	PF00069	0.714
MOD_GSK3_1	9	16	PF00069	0.626
MOD_NEK2_1	1	6	PF00069	0.578
MOD_NEK2_1	119	124	PF00069	0.514
MOD_NEK2_1	185	190	PF00069	0.602
MOD_NEK2_1	282	287	PF00069	0.464
MOD_NEK2_2	54	59	PF00069	0.668
MOD_PIKK_1	286	292	PF00454	0.631
MOD_PIKK_1	327	333	PF00454	0.630
MOD_PIKK_1	358	364	PF00454	0.598
MOD_PIKK_1	45	51	PF00454	0.587
MOD_PK_1	43	49	PF00069	0.624
MOD_PKA_2	1	7	PF00069	0.643
MOD_PKA_2	185	191	PF00069	0.456
MOD_PKA_2	248	254	PF00069	0.781
MOD_PKA_2	30	36	PF00069	0.716
MOD_PKA_2	42	48	PF00069	0.554
MOD_PKA_2	8	14	PF00069	0.591
MOD_PKB_1	7	15	PF00069	0.598
MOD_Plk_4	185	191	PF00069	0.474
MOD_ProDKin_1	100	106	PF00069	0.544
MOD_ProDKin_1	192	198	PF00069	0.576
MOD_ProDKin_1	238	244	PF00069	0.690
MOD_ProDKin_1	254	260	PF00069	0.422
MOD_ProDKin_1	276	282	PF00069	0.633
MOD_ProDKin_1	284	290	PF00069	0.653
MOD_ProDKin_1	348	354	PF00069	0.608
MOD_ProDKin_1	71	77	PF00069	0.612
MOD_SUMO_rev_2	105	111	PF00179	0.438
MOD_SUMO_rev_2	126	132	PF00179	0.486
MOD_SUMO_rev_2	87	95	PF00179	0.730
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.463
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.527
TRG_ENDOCYTIC_2	310	313	PF00928	0.427
TRG_ENDOCYTIC_2	357	360	PF00928	0.648
TRG_ENDOCYTIC_2	36	39	PF00928	0.565
TRG_ER_diArg_1	401	404	PF00400	0.726
TRG_ER_diArg_1	6	9	PF00400	0.686
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T2	Leptomonas seymouri	48%	100%
A0A1X0NVH2	Trypanosomatidae	27%	100%
A0A3R7MTX4	Trypanosoma rangeli	28%	100%
A0A3S7X4N0	Leishmania donovani	89%	100%
A4HJF6	Leishmania braziliensis	70%	98%
A4I6V1	Leishmania infantum	89%	100%
D0A7B7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q688	Leishmania major	88%	100%
V5C1D3	Trypanosoma cruzi	30%	100%