Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1X0_LEIMU

TriTrypDb:

LmxM.30.1700

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1X0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	654	658	PF00656	0.521
CLV_NRD_NRD_1	138	140	PF00675	0.684
CLV_NRD_NRD_1	168	170	PF00675	0.652
CLV_NRD_NRD_1	196	198	PF00675	0.598
CLV_NRD_NRD_1	227	229	PF00675	0.496
CLV_NRD_NRD_1	304	306	PF00675	0.533
CLV_PCSK_KEX2_1	138	140	PF00082	0.715
CLV_PCSK_KEX2_1	170	172	PF00082	0.568
CLV_PCSK_KEX2_1	196	198	PF00082	0.648
CLV_PCSK_KEX2_1	226	228	PF00082	0.514
CLV_PCSK_KEX2_1	304	306	PF00082	0.634
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.568
CLV_PCSK_SKI1_1	495	499	PF00082	0.340
CLV_PCSK_SKI1_1	547	551	PF00082	0.490
CLV_PCSK_SKI1_1	634	638	PF00082	0.473
CLV_PCSK_SKI1_1	69	73	PF00082	0.567
DEG_SCF_TRCP1_1	379	385	PF00400	0.371
DEG_SPOP_SBC_1	356	360	PF00917	0.530
DOC_ANK_TNKS_1	557	564	PF00023	0.604
DOC_ANK_TNKS_1	566	573	PF00023	0.564
DOC_CKS1_1	351	356	PF01111	0.548
DOC_CYCLIN_RxL_1	276	290	PF00134	0.452
DOC_CYCLIN_RxL_1	544	554	PF00134	0.518
DOC_MAPK_gen_1	226	232	PF00069	0.505
DOC_MAPK_gen_1	425	434	PF00069	0.559
DOC_MAPK_gen_1	66	75	PF00069	0.783
DOC_MAPK_MEF2A_6	212	221	PF00069	0.532
DOC_PP1_RVXF_1	235	242	PF00149	0.444
DOC_PP1_RVXF_1	545	552	PF00149	0.441
DOC_PP4_FxxP_1	550	553	PF00568	0.528
DOC_SPAK_OSR1_1	614	618	PF12202	0.327
DOC_USP7_MATH_1	126	130	PF00917	0.734
DOC_USP7_MATH_1	163	167	PF00917	0.669
DOC_USP7_MATH_1	189	193	PF00917	0.732
DOC_USP7_MATH_1	352	356	PF00917	0.500
DOC_USP7_MATH_1	39	43	PF00917	0.734
DOC_USP7_MATH_1	399	403	PF00917	0.530
DOC_USP7_MATH_1	426	430	PF00917	0.655
DOC_USP7_MATH_1	533	537	PF00917	0.399
DOC_USP7_MATH_1	651	655	PF00917	0.581
DOC_USP7_UBL2_3	242	246	PF12436	0.446
DOC_WW_Pin1_4	124	129	PF00397	0.700
DOC_WW_Pin1_4	138	143	PF00397	0.638
DOC_WW_Pin1_4	146	151	PF00397	0.632
DOC_WW_Pin1_4	159	164	PF00397	0.581
DOC_WW_Pin1_4	261	266	PF00397	0.446
DOC_WW_Pin1_4	350	355	PF00397	0.565
DOC_WW_Pin1_4	360	365	PF00397	0.481
DOC_WW_Pin1_4	382	387	PF00397	0.501
DOC_WW_Pin1_4	414	419	PF00397	0.753
DOC_WW_Pin1_4	448	453	PF00397	0.402
DOC_WW_Pin1_4	486	491	PF00397	0.498
DOC_WW_Pin1_4	88	93	PF00397	0.720
LIG_14-3-3_CanoR_1	10	17	PF00244	0.671
LIG_14-3-3_CanoR_1	119	128	PF00244	0.714
LIG_14-3-3_CanoR_1	38	46	PF00244	0.721
LIG_14-3-3_CanoR_1	486	490	PF00244	0.381
LIG_14-3-3_CanoR_1	579	587	PF00244	0.419
LIG_14-3-3_CanoR_1	644	652	PF00244	0.544
LIG_APCC_ABBA_1	219	224	PF00400	0.568
LIG_APCC_ABBA_1	661	666	PF00400	0.452
LIG_BRCT_BRCA1_1	547	551	PF00533	0.537
LIG_Clathr_ClatBox_1	431	435	PF01394	0.494
LIG_deltaCOP1_diTrp_1	331	335	PF00928	0.493
LIG_FHA_1	132	138	PF00498	0.768
LIG_FHA_1	205	211	PF00498	0.641
LIG_FHA_1	383	389	PF00498	0.457
LIG_FHA_1	496	502	PF00498	0.475
LIG_FHA_1	520	526	PF00498	0.369
LIG_FHA_1	586	592	PF00498	0.500
LIG_FHA_1	594	600	PF00498	0.309
LIG_FHA_2	288	294	PF00498	0.348
LIG_FHA_2	449	455	PF00498	0.397
LIG_FHA_2	480	486	PF00498	0.443
LIG_Integrin_RGD_1	560	562	PF01839	0.469
LIG_LIR_Apic_2	548	553	PF02991	0.520
LIG_LIR_Gen_1	289	299	PF02991	0.381
LIG_LIR_Gen_1	459	466	PF02991	0.398
LIG_LIR_Gen_1	596	605	PF02991	0.420
LIG_LIR_Gen_1	607	618	PF02991	0.424
LIG_LIR_LC3C_4	216	221	PF02991	0.624
LIG_LIR_Nem_3	289	294	PF02991	0.384
LIG_LIR_Nem_3	368	374	PF02991	0.349
LIG_LIR_Nem_3	459	463	PF02991	0.365
LIG_LIR_Nem_3	541	546	PF02991	0.349
LIG_LIR_Nem_3	607	613	PF02991	0.425
LIG_MLH1_MIPbox_1	547	551	PF16413	0.439
LIG_NRBOX	631	637	PF00104	0.398
LIG_Pex14_1	330	334	PF04695	0.444
LIG_SH2_CRK	374	378	PF00017	0.424
LIG_SH2_CRK	493	497	PF00017	0.361
LIG_SH2_CRK	546	550	PF00017	0.375
LIG_SH2_GRB2like	96	99	PF00017	0.480
LIG_SH2_NCK_1	291	295	PF00017	0.363
LIG_SH2_PTP2	460	463	PF00017	0.312
LIG_SH2_SRC	215	218	PF00017	0.626
LIG_SH2_SRC	291	294	PF00017	0.358
LIG_SH2_STAP1	291	295	PF00017	0.335
LIG_SH2_STAP1	493	497	PF00017	0.361
LIG_SH2_STAP1	506	510	PF00017	0.387
LIG_SH2_STAT5	164	167	PF00017	0.555
LIG_SH2_STAT5	33	36	PF00017	0.739
LIG_SH2_STAT5	376	379	PF00017	0.558
LIG_SH2_STAT5	391	394	PF00017	0.250
LIG_SH2_STAT5	455	458	PF00017	0.339
LIG_SH2_STAT5	460	463	PF00017	0.312
LIG_SH2_STAT5	506	509	PF00017	0.452
LIG_SH2_STAT5	524	527	PF00017	0.425
LIG_SH2_STAT5	610	613	PF00017	0.528
LIG_SH2_STAT5	76	79	PF00017	0.587
LIG_SH3_2	553	558	PF14604	0.651
LIG_SH3_3	144	150	PF00018	0.713
LIG_SH3_3	358	364	PF00018	0.435
LIG_SH3_3	550	556	PF00018	0.589
LIG_SH3_3	86	92	PF00018	0.710
LIG_Sin3_3	509	516	PF02671	0.481
LIG_SUMO_SIM_anti_2	429	435	PF11976	0.543
LIG_SUMO_SIM_par_1	429	435	PF11976	0.543
LIG_TRAF2_1	113	116	PF00917	0.547
LIG_TRAF2_1	156	159	PF00917	0.383
LIG_TRAF2_1	482	485	PF00917	0.546
LIG_TRFH_1	448	452	PF08558	0.386
LIG_UBA3_1	631	637	PF00899	0.471
LIG_WRC_WIRS_1	594	599	PF05994	0.486
MOD_CDC14_SPxK_1	141	144	PF00782	0.713
MOD_CDK_SPK_2	128	133	PF00069	0.717
MOD_CDK_SPK_2	382	387	PF00069	0.501
MOD_CDK_SPxK_1	138	144	PF00069	0.757
MOD_CDK_SPxxK_3	128	135	PF00069	0.689
MOD_CDK_SPxxK_3	261	268	PF00069	0.442
MOD_CK1_1	100	106	PF00069	0.601
MOD_CK1_1	110	116	PF00069	0.564
MOD_CK1_1	127	133	PF00069	0.785
MOD_CK1_1	149	155	PF00069	0.581
MOD_CK1_1	261	267	PF00069	0.446
MOD_CK1_1	316	322	PF00069	0.735
MOD_CK1_1	343	349	PF00069	0.520
MOD_CK1_1	355	361	PF00069	0.472
MOD_CK1_1	408	414	PF00069	0.677
MOD_CK1_1	581	587	PF00069	0.678
MOD_CK1_1	593	599	PF00069	0.357
MOD_CK1_1	65	71	PF00069	0.776
MOD_CK1_1	91	97	PF00069	0.581
MOD_CK2_1	110	116	PF00069	0.646
MOD_CK2_1	153	159	PF00069	0.472
MOD_CK2_1	261	267	PF00069	0.433
MOD_CK2_1	448	454	PF00069	0.402
MOD_CK2_1	479	485	PF00069	0.435
MOD_CMANNOS	330	333	PF00535	0.506
MOD_DYRK1A_RPxSP_1	146	150	PF00069	0.451
MOD_GlcNHglycan	109	112	PF01048	0.819
MOD_GlcNHglycan	11	14	PF01048	0.629
MOD_GlcNHglycan	187	190	PF01048	0.686
MOD_GlcNHglycan	319	322	PF01048	0.651
MOD_GlcNHglycan	324	327	PF01048	0.717
MOD_GlcNHglycan	343	346	PF01048	0.684
MOD_GlcNHglycan	354	357	PF01048	0.571
MOD_GlcNHglycan	379	382	PF01048	0.430
MOD_GlcNHglycan	428	431	PF01048	0.617
MOD_GlcNHglycan	568	571	PF01048	0.637
MOD_GlcNHglycan	580	583	PF01048	0.725
MOD_GlcNHglycan	653	656	PF01048	0.578
MOD_GlcNHglycan	69	72	PF01048	0.633
MOD_GSK3_1	110	117	PF00069	0.801
MOD_GSK3_1	120	127	PF00069	0.739
MOD_GSK3_1	149	156	PF00069	0.559
MOD_GSK3_1	159	166	PF00069	0.633
MOD_GSK3_1	185	192	PF00069	0.655
MOD_GSK3_1	313	320	PF00069	0.627
MOD_GSK3_1	336	343	PF00069	0.628
MOD_GSK3_1	352	359	PF00069	0.501
MOD_GSK3_1	475	482	PF00069	0.393
MOD_GSK3_1	581	588	PF00069	0.670
MOD_GSK3_1	604	611	PF00069	0.523
MOD_N-GLC_1	107	112	PF02516	0.501
MOD_N-GLC_1	97	102	PF02516	0.472
MOD_NEK2_1	1	6	PF00069	0.706
MOD_NEK2_1	317	322	PF00069	0.657
MOD_NEK2_1	340	345	PF00069	0.636
MOD_NEK2_1	377	382	PF00069	0.483
MOD_NEK2_1	545	550	PF00069	0.371
MOD_NEK2_1	664	669	PF00069	0.483
MOD_NEK2_1	67	72	PF00069	0.671
MOD_NEK2_2	164	169	PF00069	0.578
MOD_PIKK_1	120	126	PF00454	0.711
MOD_PKA_2	174	180	PF00069	0.722
MOD_PKA_2	34	40	PF00069	0.782
MOD_PKA_2	426	432	PF00069	0.573
MOD_PKA_2	475	481	PF00069	0.383
MOD_PKA_2	485	491	PF00069	0.430
MOD_PKA_2	533	539	PF00069	0.399
MOD_PKA_2	566	572	PF00069	0.815
MOD_PKA_2	578	584	PF00069	0.655
MOD_PKA_2	9	15	PF00069	0.597
MOD_PKB_1	285	293	PF00069	0.366
MOD_Plk_1	336	342	PF00069	0.491
MOD_Plk_1	453	459	PF00069	0.340
MOD_Plk_1	664	670	PF00069	0.366
MOD_Plk_1	97	103	PF00069	0.642
MOD_Plk_2-3	206	212	PF00069	0.561
MOD_Plk_4	100	106	PF00069	0.734
MOD_Plk_4	149	155	PF00069	0.628
MOD_Plk_4	18	24	PF00069	0.623
MOD_Plk_4	268	274	PF00069	0.526
MOD_Plk_4	294	300	PF00069	0.497
MOD_Plk_4	336	342	PF00069	0.529
MOD_Plk_4	357	363	PF00069	0.494
MOD_Plk_4	437	443	PF00069	0.340
MOD_Plk_4	456	462	PF00069	0.317
MOD_Plk_4	520	526	PF00069	0.457
MOD_Plk_4	538	544	PF00069	0.464
MOD_Plk_4	590	596	PF00069	0.454
MOD_Plk_4	91	97	PF00069	0.647
MOD_ProDKin_1	124	130	PF00069	0.701
MOD_ProDKin_1	138	144	PF00069	0.635
MOD_ProDKin_1	146	152	PF00069	0.625
MOD_ProDKin_1	159	165	PF00069	0.573
MOD_ProDKin_1	261	267	PF00069	0.446
MOD_ProDKin_1	350	356	PF00069	0.556
MOD_ProDKin_1	360	366	PF00069	0.473
MOD_ProDKin_1	382	388	PF00069	0.496
MOD_ProDKin_1	414	420	PF00069	0.751
MOD_ProDKin_1	448	454	PF00069	0.402
MOD_ProDKin_1	486	492	PF00069	0.489
MOD_ProDKin_1	88	94	PF00069	0.720
MOD_SUMO_rev_2	429	438	PF00179	0.525
MOD_SUMO_rev_2	654	661	PF00179	0.517
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.344
TRG_ENDOCYTIC_2	248	251	PF00928	0.368
TRG_ENDOCYTIC_2	291	294	PF00928	0.372
TRG_ENDOCYTIC_2	374	377	PF00928	0.375
TRG_ENDOCYTIC_2	460	463	PF00928	0.312
TRG_ENDOCYTIC_2	493	496	PF00928	0.364
TRG_ENDOCYTIC_2	546	549	PF00928	0.380
TRG_ENDOCYTIC_2	610	613	PF00928	0.384
TRG_ER_diArg_1	132	135	PF00400	0.635
TRG_ER_diArg_1	137	139	PF00400	0.611
TRG_ER_diArg_1	168	171	PF00400	0.580
TRG_ER_diArg_1	226	228	PF00400	0.537
TRG_ER_diArg_1	284	287	PF00400	0.377
TRG_ER_diArg_1	303	305	PF00400	0.593
TRG_ER_diArg_1	557	560	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ1	Leptomonas seymouri	65%	100%
A0A1X0NQ51	Trypanosomatidae	43%	100%
A0A3R7LJ81	Trypanosoma rangeli	44%	100%
A0A3S7X4H9	Leishmania donovani	91%	100%
A4HJF2	Leishmania braziliensis	78%	99%
A4I6U7	Leishmania infantum	91%	100%
C9ZMB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q692	Leishmania major	89%	100%
V5B8N6	Trypanosoma cruzi	41%	100%