Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1W8_LEIMU

TriTrypDb:

LmxM.30.1680

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B1W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.540
CLV_NRD_NRD_1	149	151	PF00675	0.393
CLV_NRD_NRD_1	272	274	PF00675	0.539
CLV_PCSK_KEX2_1	142	144	PF00082	0.510
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.599
CLV_PCSK_SKI1_1	104	108	PF00082	0.545
CLV_PCSK_SKI1_1	151	155	PF00082	0.472
DOC_ANK_TNKS_1	164	171	PF00023	0.560
DOC_PP1_RVXF_1	72	78	PF00149	0.712
DOC_USP7_MATH_1	196	200	PF00917	0.532
DOC_USP7_MATH_1	235	239	PF00917	0.457
DOC_USP7_MATH_1	67	71	PF00917	0.582
DOC_USP7_MATH_1	99	103	PF00917	0.702
LIG_14-3-3_CanoR_1	120	126	PF00244	0.689
LIG_BIR_III_4	167	171	PF00653	0.563
LIG_FHA_1	87	93	PF00498	0.525
LIG_FHA_2	205	211	PF00498	0.598
LIG_FHA_2	214	220	PF00498	0.424
LIG_FHA_2	86	92	PF00498	0.738
LIG_Integrin_isoDGR_2	95	97	PF01839	0.531
LIG_LIR_Gen_1	238	248	PF02991	0.566
LIG_LIR_Nem_3	219	224	PF02991	0.438
LIG_LIR_Nem_3	238	243	PF02991	0.469
LIG_PTAP_UEV_1	1	6	PF05743	0.494
LIG_SH2_CRK	240	244	PF00017	0.574
LIG_SH2_STAT5	230	233	PF00017	0.539
LIG_SH2_STAT5	247	250	PF00017	0.337
LIG_SH2_STAT5	61	64	PF00017	0.557
LIG_SUMO_SIM_par_1	212	219	PF11976	0.498
LIG_UBA3_1	162	171	PF00899	0.490
MOD_CK1_1	102	108	PF00069	0.546
MOD_CK1_1	3	9	PF00069	0.579
MOD_CK2_1	213	219	PF00069	0.502
MOD_GlcNHglycan	2	5	PF01048	0.514
MOD_GlcNHglycan	62	65	PF01048	0.677
MOD_GlcNHglycan	68	72	PF01048	0.681
MOD_GSK3_1	29	36	PF00069	0.643
MOD_GSK3_1	82	89	PF00069	0.621
MOD_GSK3_1	98	105	PF00069	0.711
MOD_NEK2_1	131	136	PF00069	0.619
MOD_NEK2_1	181	186	PF00069	0.494
MOD_NEK2_1	204	209	PF00069	0.612
MOD_NEK2_1	60	65	PF00069	0.622
MOD_NEK2_2	196	201	PF00069	0.537
MOD_NEK2_2	73	78	PF00069	0.624
MOD_NEK2_2	99	104	PF00069	0.544
MOD_OFUCOSY	47	53	PF10250	0.508
MOD_PIKK_1	19	25	PF00454	0.521
MOD_PIKK_1	190	196	PF00454	0.557
MOD_PKA_2	253	259	PF00069	0.400
MOD_Plk_1	67	73	PF00069	0.663
MOD_Plk_4	210	216	PF00069	0.519
MOD_SUMO_for_1	141	144	PF00179	0.598
MOD_SUMO_rev_2	144	153	PF00179	0.452
MOD_SUMO_rev_2	167	173	PF00179	0.574
TRG_DiLeu_BaEn_4	250	256	PF01217	0.430
TRG_ENDOCYTIC_2	221	224	PF00928	0.441
TRG_ENDOCYTIC_2	240	243	PF00928	0.450
TRG_ER_diArg_1	257	260	PF00400	0.557
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I0	Leptomonas seymouri	60%	100%
A0A1X0NRC6	Trypanosomatidae	45%	99%
A0A3Q8IFD5	Leishmania donovani	96%	100%
A0A422MYM9	Trypanosoma rangeli	45%	99%
A4HJF0	Leishmania braziliensis	83%	100%
A4I6U5	Leishmania infantum	97%	100%
C9ZMB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q694	Leishmania major	93%	100%
V5AZM2	Trypanosoma cruzi	45%	100%