Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1W7_LEIMU

TriTrypDb:

LmxM.30.1670

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1W7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.682
CLV_NRD_NRD_1	225	227	PF00675	0.424
CLV_NRD_NRD_1	260	262	PF00675	0.454
CLV_PCSK_KEX2_1	128	130	PF00082	0.597
CLV_PCSK_KEX2_1	224	226	PF00082	0.473
CLV_PCSK_KEX2_1	260	262	PF00082	0.481
CLV_PCSK_SKI1_1	225	229	PF00082	0.580
CLV_PCSK_SKI1_1	241	245	PF00082	0.364
CLV_PCSK_SKI1_1	260	264	PF00082	0.345
CLV_PCSK_SKI1_1	58	62	PF00082	0.659
DEG_APCC_DBOX_1	224	232	PF00400	0.477
DOC_CYCLIN_RxL_1	219	232	PF00134	0.561
DOC_MAPK_gen_1	108	115	PF00069	0.517
DOC_PP2B_LxvP_1	60	63	PF13499	0.593
DOC_USP7_MATH_1	152	156	PF00917	0.572
DOC_USP7_MATH_1	25	29	PF00917	0.638
DOC_USP7_UBL2_3	18	22	PF12436	0.715
DOC_WW_Pin1_4	172	177	PF00397	0.528
LIG_14-3-3_CanoR_1	129	135	PF00244	0.551
LIG_14-3-3_CanoR_1	96	101	PF00244	0.510
LIG_Actin_WH2_2	227	243	PF00022	0.462
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_FHA_1	102	108	PF00498	0.600
LIG_FHA_2	131	137	PF00498	0.636
LIG_FHA_2	252	258	PF00498	0.433
LIG_LIR_Nem_3	146	151	PF02991	0.621
LIG_LIR_Nem_3	157	163	PF02991	0.654
LIG_LIR_Nem_3	213	218	PF02991	0.446
LIG_NRBOX	235	241	PF00104	0.407
LIG_PTB_Apo_2	147	154	PF02174	0.486
LIG_SH2_CRK	215	219	PF00017	0.443
LIG_SH2_CRK	57	61	PF00017	0.513
LIG_SH2_STAT3	276	279	PF00017	0.603
LIG_SH2_STAT5	160	163	PF00017	0.660
LIG_SH3_3	244	250	PF00018	0.446
LIG_SH3_3	73	79	PF00018	0.496
MOD_CDC14_SPxK_1	175	178	PF00782	0.500
MOD_CDK_SPxK_1	172	178	PF00069	0.523
MOD_CK1_1	169	175	PF00069	0.493
MOD_CK2_1	229	235	PF00069	0.532
MOD_GlcNHglycan	109	112	PF01048	0.577
MOD_GlcNHglycan	120	123	PF01048	0.618
MOD_GlcNHglycan	172	175	PF01048	0.603
MOD_GSK3_1	107	114	PF00069	0.677
MOD_GSK3_1	166	173	PF00069	0.518
MOD_GSK3_1	58	65	PF00069	0.633
MOD_GSK3_1	7	14	PF00069	0.604
MOD_N-GLC_1	208	213	PF02516	0.473
MOD_N-GLC_1	251	256	PF02516	0.425
MOD_N-GLC_1	30	35	PF02516	0.621
MOD_NEK2_1	1	6	PF00069	0.607
MOD_NEK2_1	153	158	PF00069	0.568
MOD_NEK2_1	251	256	PF00069	0.425
MOD_NEK2_1	95	100	PF00069	0.567
MOD_PIKK_1	17	23	PF00454	0.570
MOD_PK_1	12	18	PF00069	0.597
MOD_PKA_1	17	23	PF00069	0.484
MOD_PKA_2	95	101	PF00069	0.588
MOD_Plk_1	50	56	PF00069	0.616
MOD_Plk_4	130	136	PF00069	0.581
MOD_ProDKin_1	172	178	PF00069	0.523
MOD_SUMO_rev_2	238	246	PF00179	0.527
TRG_DiLeu_BaEn_1	235	240	PF01217	0.482
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.356
TRG_ENDOCYTIC_2	160	163	PF00928	0.660
TRG_ENDOCYTIC_2	215	218	PF00928	0.586
TRG_ENDOCYTIC_2	57	60	PF00928	0.523
TRG_ER_diArg_1	127	129	PF00400	0.600
TRG_ER_diArg_1	193	196	PF00400	0.492
TRG_ER_diArg_1	224	226	PF00400	0.563
TRG_ER_diArg_1	259	261	PF00400	0.466
TRG_NES_CRM1_1	177	189	PF08389	0.419
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBJ9	Leptomonas seymouri	75%	99%
A0A1X0NQE4	Trypanosomatidae	54%	100%
A0A3Q8IK28	Leishmania donovani	95%	100%
A0A3R7JXC5	Trypanosoma rangeli	59%	100%
A4HJE9	Leishmania braziliensis	90%	100%
A4I6U4	Leishmania infantum	95%	100%
C9ZMB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
Q4Q695	Leishmania major	95%	100%
V5AJB0	Trypanosoma cruzi	53%	100%