MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9B1W5_LEIMU

TriTrypDb:

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1W5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.516
CLV_C14_Caspase3-7	39	43	PF00656	0.550
CLV_C14_Caspase3-7	4	8	PF00656	0.731
CLV_NRD_NRD_1	163	165	PF00675	0.520
CLV_NRD_NRD_1	174	176	PF00675	0.521
CLV_NRD_NRD_1	453	455	PF00675	0.544
CLV_PCSK_KEX2_1	174	176	PF00082	0.521
CLV_PCSK_KEX2_1	453	455	PF00082	0.613
CLV_PCSK_KEX2_1	48	50	PF00082	0.539
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.539
CLV_PCSK_SKI1_1	120	124	PF00082	0.496
CLV_PCSK_SKI1_1	181	185	PF00082	0.351
CLV_PCSK_SKI1_1	201	205	PF00082	0.591
CLV_PCSK_SKI1_1	288	292	PF00082	0.360
CLV_PCSK_SKI1_1	315	319	PF00082	0.507
CLV_PCSK_SKI1_1	321	325	PF00082	0.417
CLV_PCSK_SKI1_1	395	399	PF00082	0.652
CLV_PCSK_SKI1_1	417	421	PF00082	0.333
CLV_PCSK_SKI1_1	74	78	PF00082	0.481
CLV_PCSK_SKI1_1	82	86	PF00082	0.460
CLV_PCSK_SKI1_1	90	94	PF00082	0.445
DEG_APCC_DBOX_1	320	328	PF00400	0.506
DOC_MAPK_gen_1	174	182	PF00069	0.530
DOC_MAPK_gen_1	218	227	PF00069	0.480
DOC_MAPK_gen_1	232	241	PF00069	0.361
DOC_MAPK_MEF2A_6	218	227	PF00069	0.600
DOC_MAPK_MEF2A_6	373	381	PF00069	0.517
DOC_PP1_RVXF_1	179	186	PF00149	0.383
DOC_PP1_RVXF_1	199	205	PF00149	0.632
DOC_PP1_RVXF_1	72	79	PF00149	0.537
DOC_PP2B_LxvP_1	383	386	PF13499	0.457
DOC_USP7_MATH_1	195	199	PF00917	0.605
DOC_USP7_MATH_1	349	353	PF00917	0.476
DOC_USP7_MATH_1	391	395	PF00917	0.490
DOC_USP7_MATH_1	408	412	PF00917	0.589
DOC_USP7_UBL2_3	330	334	PF12436	0.510
DOC_USP7_UBL2_3	417	421	PF12436	0.363
DOC_WW_Pin1_4	191	196	PF00397	0.543
DOC_WW_Pin1_4	300	305	PF00397	0.506
DOC_WW_Pin1_4	42	47	PF00397	0.590
DOC_WW_Pin1_4	429	434	PF00397	0.398
DOC_WW_Pin1_4	456	461	PF00397	0.652
DOC_WW_Pin1_4	6	11	PF00397	0.777
LIG_14-3-3_CanoR_1	164	168	PF00244	0.455
LIG_14-3-3_CanoR_1	453	457	PF00244	0.661
LIG_14-3-3_CanoR_1	82	89	PF00244	0.576
LIG_AP2alpha_2	69	71	PF02296	0.437
LIG_BRCT_BRCA1_1	178	182	PF00533	0.480
LIG_deltaCOP1_diTrp_1	439	446	PF00928	0.417
LIG_eIF4E_1	286	292	PF01652	0.475
LIG_FHA_1	155	161	PF00498	0.474
LIG_FHA_1	222	228	PF00498	0.499
LIG_FHA_1	314	320	PF00498	0.516
LIG_FHA_1	376	382	PF00498	0.451
LIG_FHA_1	414	420	PF00498	0.421
LIG_FHA_2	10	16	PF00498	0.798
LIG_FHA_2	139	145	PF00498	0.569
LIG_FHA_2	343	349	PF00498	0.417
LIG_FHA_2	369	375	PF00498	0.409
LIG_FHA_2	413	419	PF00498	0.449
LIG_GBD_Chelix_1	52	60	PF00786	0.477
LIG_Integrin_isoDGR_2	281	283	PF01839	0.525
LIG_LIR_Apic_2	428	433	PF02991	0.398
LIG_LIR_Gen_1	179	187	PF02991	0.433
LIG_LIR_Gen_1	289	298	PF02991	0.481
LIG_LIR_Gen_1	354	365	PF02991	0.423
LIG_LIR_Gen_1	378	388	PF02991	0.436
LIG_LIR_Gen_1	77	84	PF02991	0.496
LIG_LIR_Nem_3	101	106	PF02991	0.411
LIG_LIR_Nem_3	171	176	PF02991	0.396
LIG_LIR_Nem_3	179	185	PF02991	0.341
LIG_LIR_Nem_3	289	295	PF02991	0.402
LIG_LIR_Nem_3	35	40	PF02991	0.537
LIG_LIR_Nem_3	354	360	PF02991	0.409
LIG_LIR_Nem_3	378	383	PF02991	0.381
LIG_LIR_Nem_3	77	83	PF02991	0.503
LIG_NRBOX	122	128	PF00104	0.521
LIG_Pex14_1	36	40	PF04695	0.407
LIG_Pex14_2	258	262	PF04695	0.539
LIG_SH2_CRK	216	220	PF00017	0.564
LIG_SH2_CRK	80	84	PF00017	0.510
LIG_SH2_NCK_1	80	84	PF00017	0.510
LIG_SH2_STAT5	286	289	PF00017	0.454
LIG_SH2_STAT5	370	373	PF00017	0.456
LIG_SH2_STAT5	430	433	PF00017	0.328
LIG_SH3_1	454	460	PF00018	0.710
LIG_SH3_3	111	117	PF00018	0.298
LIG_SH3_3	407	413	PF00018	0.458
LIG_SH3_3	454	460	PF00018	0.698
LIG_UBA3_1	176	181	PF00899	0.383
LIG_WRC_WIRS_1	204	209	PF05994	0.551
MOD_CDC14_SPxK_1	45	48	PF00782	0.598
MOD_CDK_SPxK_1	42	48	PF00069	0.591
MOD_CDK_SPxxK_3	42	49	PF00069	0.588
MOD_CK1_1	115	121	PF00069	0.532
MOD_CK1_1	143	149	PF00069	0.563
MOD_CK1_1	166	172	PF00069	0.355
MOD_CK1_1	194	200	PF00069	0.598
MOD_CK1_1	300	306	PF00069	0.527
MOD_CK1_1	313	319	PF00069	0.371
MOD_CK1_1	352	358	PF00069	0.314
MOD_CK1_1	452	458	PF00069	0.663
MOD_CK1_1	5	11	PF00069	0.750
MOD_CK2_1	138	144	PF00069	0.615
MOD_CK2_1	342	348	PF00069	0.476
MOD_CK2_1	368	374	PF00069	0.430
MOD_CK2_1	381	387	PF00069	0.405
MOD_CK2_1	5	11	PF00069	0.772
MOD_GlcNHglycan	168	171	PF01048	0.505
MOD_GlcNHglycan	312	315	PF01048	0.542
MOD_GlcNHglycan	351	354	PF01048	0.484
MOD_GlcNHglycan	383	386	PF01048	0.457
MOD_GlcNHglycan	422	425	PF01048	0.328
MOD_GSK3_1	106	113	PF00069	0.509
MOD_GSK3_1	159	166	PF00069	0.340
MOD_GSK3_1	191	198	PF00069	0.566
MOD_GSK3_1	2	9	PF00069	0.714
MOD_GSK3_1	299	306	PF00069	0.513
MOD_GSK3_1	348	355	PF00069	0.371
MOD_GSK3_1	408	415	PF00069	0.490
MOD_GSK3_1	425	432	PF00069	0.368
MOD_GSK3_1	452	459	PF00069	0.641
MOD_N-GLC_1	42	47	PF02516	0.570
MOD_N-GLC_1	90	95	PF02516	0.623
MOD_N-GLC_2	261	263	PF02516	0.552
MOD_N-GLC_2	445	447	PF02516	0.475
MOD_NEK2_1	112	117	PF00069	0.561
MOD_NEK2_1	163	168	PF00069	0.475
MOD_NEK2_1	176	181	PF00069	0.368
MOD_NEK2_1	183	188	PF00069	0.346
MOD_NEK2_1	203	208	PF00069	0.552
MOD_NEK2_1	251	256	PF00069	0.532
MOD_NEK2_1	381	386	PF00069	0.478
MOD_NEK2_1	420	425	PF00069	0.340
MOD_NEK2_1	61	66	PF00069	0.448
MOD_NEK2_2	159	164	PF00069	0.447
MOD_NEK2_2	425	430	PF00069	0.363
MOD_OFUCOSY	407	412	PF10250	0.582
MOD_PIKK_1	452	458	PF00454	0.690
MOD_PKA_2	163	169	PF00069	0.348
MOD_PKA_2	452	458	PF00069	0.663
MOD_PKA_2	5	11	PF00069	0.784
MOD_Plk_1	425	431	PF00069	0.449
MOD_Plk_4	145	151	PF00069	0.547
MOD_Plk_4	20	26	PF00069	0.545
MOD_Plk_4	203	209	PF00069	0.460
MOD_Plk_4	221	227	PF00069	0.371
MOD_Plk_4	375	381	PF00069	0.465
MOD_Plk_4	425	431	PF00069	0.344
MOD_Plk_4	458	464	PF00069	0.673
MOD_Plk_4	61	67	PF00069	0.479
MOD_Plk_4	74	80	PF00069	0.369
MOD_ProDKin_1	191	197	PF00069	0.546
MOD_ProDKin_1	300	306	PF00069	0.509
MOD_ProDKin_1	42	48	PF00069	0.591
MOD_ProDKin_1	429	435	PF00069	0.398
MOD_ProDKin_1	456	462	PF00069	0.657
MOD_ProDKin_1	6	12	PF00069	0.777
MOD_SUMO_for_1	329	332	PF00179	0.498
MOD_SUMO_rev_2	331	336	PF00179	0.528
TRG_DiLeu_BaEn_1	119	124	PF01217	0.512
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.568
TRG_ENDOCYTIC_2	216	219	PF00928	0.491
TRG_ENDOCYTIC_2	357	360	PF00928	0.414
TRG_ENDOCYTIC_2	80	83	PF00928	0.482
TRG_ER_diArg_1	173	175	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJJ2	Leptomonas seymouri	80%	100%
A0A0S4JQ55	Bodo saltans	30%	69%
A0A1X0NPU0	Trypanosomatidae	35%	96%
A0A3R7M2S8	Trypanosoma rangeli	36%	95%
A0A3S7X4J0	Leishmania donovani	98%	97%
A4HJE7	Leishmania braziliensis	94%	100%
A4I6U2	Leishmania infantum	98%	97%
C9ZMB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	91%
Q4Q697	Leishmania major	98%	100%
V5B432	Trypanosoma cruzi	37%	95%