Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1W0_LEIMU

TriTrypDb:

LmxM.30.1600

Length:

811

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B1W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1W0

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006457	protein folding	2	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007021	tubulin complex assembly	6	1
GO:0007023	post-chaperonin tubulin folding pathway	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.536
CLV_C14_Caspase3-7	454	458	PF00656	0.484
CLV_C14_Caspase3-7	67	71	PF00656	0.421
CLV_NRD_NRD_1	286	288	PF00675	0.486
CLV_NRD_NRD_1	31	33	PF00675	0.803
CLV_NRD_NRD_1	60	62	PF00675	0.645
CLV_NRD_NRD_1	654	656	PF00675	0.498
CLV_NRD_NRD_1	765	767	PF00675	0.559
CLV_PCSK_FUR_1	58	62	PF00082	0.647
CLV_PCSK_FUR_1	652	656	PF00082	0.270
CLV_PCSK_KEX2_1	286	288	PF00082	0.439
CLV_PCSK_KEX2_1	31	33	PF00082	0.803
CLV_PCSK_KEX2_1	60	62	PF00082	0.645
CLV_PCSK_KEX2_1	654	656	PF00082	0.465
CLV_PCSK_KEX2_1	787	789	PF00082	0.486
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.486
CLV_PCSK_SKI1_1	138	142	PF00082	0.469
CLV_PCSK_SKI1_1	196	200	PF00082	0.513
CLV_PCSK_SKI1_1	420	424	PF00082	0.492
CLV_PCSK_SKI1_1	517	521	PF00082	0.484
CLV_PCSK_SKI1_1	551	555	PF00082	0.591
CLV_PCSK_SKI1_1	766	770	PF00082	0.503
CLV_PCSK_SKI1_1	802	806	PF00082	0.648
DEG_APCC_DBOX_1	272	280	PF00400	0.446
DEG_SCF_FBW7_1	658	665	PF00400	0.395
DEG_SPOP_SBC_1	52	56	PF00917	0.666
DOC_CDC14_PxL_1	372	380	PF14671	0.442
DOC_CDC14_PxL_1	510	518	PF14671	0.490
DOC_CYCLIN_RxL_1	417	425	PF00134	0.488
DOC_CYCLIN_RxL_1	512	525	PF00134	0.535
DOC_MAPK_gen_1	34	43	PF00069	0.716
DOC_MAPK_gen_1	512	521	PF00069	0.464
DOC_MAPK_gen_1	766	775	PF00069	0.440
DOC_MAPK_MEF2A_6	36	45	PF00069	0.493
DOC_MAPK_MEF2A_6	512	520	PF00069	0.487
DOC_MAPK_MEF2A_6	766	775	PF00069	0.496
DOC_MAPK_NFAT4_5	766	774	PF00069	0.439
DOC_PP1_RVXF_1	433	440	PF00149	0.442
DOC_PP2B_LxvP_1	109	112	PF13499	0.655
DOC_USP7_MATH_1	22	26	PF00917	0.674
DOC_USP7_MATH_1	233	237	PF00917	0.473
DOC_USP7_MATH_1	30	34	PF00917	0.782
DOC_USP7_MATH_1	51	55	PF00917	0.772
DOC_USP7_MATH_1	662	666	PF00917	0.480
DOC_USP7_MATH_1	671	675	PF00917	0.288
DOC_USP7_MATH_1	730	734	PF00917	0.548
DOC_USP7_MATH_1	90	94	PF00917	0.695
DOC_USP7_MATH_2	177	183	PF00917	0.558
DOC_USP7_UBL2_3	192	196	PF12436	0.519
DOC_USP7_UBL2_3	770	774	PF12436	0.421
DOC_WW_Pin1_4	171	176	PF00397	0.560
DOC_WW_Pin1_4	24	29	PF00397	0.685
DOC_WW_Pin1_4	658	663	PF00397	0.387
LIG_14-3-3_CanoR_1	131	140	PF00244	0.453
LIG_14-3-3_CanoR_1	149	155	PF00244	0.596
LIG_14-3-3_CanoR_1	273	282	PF00244	0.502
LIG_14-3-3_CanoR_1	36	43	PF00244	0.704
LIG_14-3-3_CanoR_1	420	425	PF00244	0.517
LIG_14-3-3_CanoR_1	466	471	PF00244	0.459
LIG_14-3-3_CanoR_1	667	675	PF00244	0.469
LIG_Actin_WH2_2	202	219	PF00022	0.467
LIG_Actin_WH2_2	686	702	PF00022	0.444
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BIR_III_2	50	54	PF00653	0.546
LIG_BIR_III_4	70	74	PF00653	0.390
LIG_BRCT_BRCA1_1	551	555	PF00533	0.480
LIG_BRCT_BRCA1_1	702	706	PF00533	0.491
LIG_Clathr_ClatBox_1	421	425	PF01394	0.439
LIG_Clathr_ClatBox_1	736	740	PF01394	0.477
LIG_FHA_1	104	110	PF00498	0.666
LIG_FHA_1	142	148	PF00498	0.634
LIG_FHA_1	197	203	PF00498	0.509
LIG_FHA_1	211	217	PF00498	0.390
LIG_FHA_1	446	452	PF00498	0.468
LIG_FHA_1	92	98	PF00498	0.674
LIG_FHA_2	174	180	PF00498	0.570
LIG_FHA_2	377	383	PF00498	0.513
LIG_FHA_2	452	458	PF00498	0.493
LIG_FHA_2	467	473	PF00498	0.445
LIG_FHA_2	567	573	PF00498	0.509
LIG_FHA_2	681	687	PF00498	0.511
LIG_LIR_Gen_1	2	11	PF02991	0.527
LIG_LIR_Gen_1	399	410	PF02991	0.529
LIG_LIR_Gen_1	44	53	PF02991	0.737
LIG_LIR_Gen_1	542	553	PF02991	0.525
LIG_LIR_Gen_1	564	573	PF02991	0.316
LIG_LIR_Gen_1	703	712	PF02991	0.477
LIG_LIR_Gen_1	751	759	PF02991	0.457
LIG_LIR_Gen_1	777	786	PF02991	0.498
LIG_LIR_Nem_3	2	6	PF02991	0.528
LIG_LIR_Nem_3	296	302	PF02991	0.317
LIG_LIR_Nem_3	399	405	PF02991	0.520
LIG_LIR_Nem_3	44	48	PF02991	0.704
LIG_LIR_Nem_3	462	467	PF02991	0.547
LIG_LIR_Nem_3	542	548	PF02991	0.540
LIG_LIR_Nem_3	552	557	PF02991	0.392
LIG_LIR_Nem_3	564	568	PF02991	0.347
LIG_LIR_Nem_3	687	693	PF02991	0.506
LIG_LIR_Nem_3	703	709	PF02991	0.250
LIG_LIR_Nem_3	751	755	PF02991	0.454
LIG_LIR_Nem_3	777	783	PF02991	0.499
LIG_LRP6_Inhibitor_1	429	435	PF00058	0.432
LIG_MLH1_MIPbox_1	551	555	PF16413	0.480
LIG_NRBOX	153	159	PF00104	0.526
LIG_NRBOX	417	423	PF00104	0.465
LIG_NRBOX	515	521	PF00104	0.434
LIG_PCNA_yPIPBox_3	149	158	PF02747	0.548
LIG_Rb_LxCxE_1	159	179	PF01857	0.430
LIG_SH2_CRK	752	756	PF00017	0.506
LIG_SH2_GRB2like	402	405	PF00017	0.464
LIG_SH2_NCK_1	752	756	PF00017	0.331
LIG_SH2_NCK_1	780	784	PF00017	0.511
LIG_SH2_PTP2	565	568	PF00017	0.241
LIG_SH2_SRC	780	783	PF00017	0.510
LIG_SH2_STAP1	210	214	PF00017	0.485
LIG_SH2_STAP1	780	784	PF00017	0.511
LIG_SH2_STAT5	15	18	PF00017	0.444
LIG_SH2_STAT5	377	380	PF00017	0.497
LIG_SH2_STAT5	402	405	PF00017	0.464
LIG_SH2_STAT5	565	568	PF00017	0.332
LIG_SH2_STAT5	752	755	PF00017	0.549
LIG_SH2_STAT5	785	788	PF00017	0.514
LIG_SH3_3	172	178	PF00018	0.562
LIG_SH3_3	97	103	PF00018	0.604
LIG_SUMO_SIM_anti_2	528	533	PF11976	0.431
LIG_SUMO_SIM_anti_2	674	679	PF11976	0.322
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.665
LIG_SUMO_SIM_anti_2	806	811	PF11976	0.607
LIG_SUMO_SIM_par_1	419	425	PF11976	0.445
LIG_SUMO_SIM_par_1	447	454	PF11976	0.473
LIG_SUMO_SIM_par_1	517	522	PF11976	0.427
LIG_SUMO_SIM_par_1	7	14	PF11976	0.609
LIG_TRAF2_1	608	611	PF00917	0.487
LIG_TYR_ITIM	400	405	PF00017	0.468
LIG_TYR_ITIM	563	568	PF00017	0.235
LIG_TYR_ITIM	750	755	PF00017	0.535
LIG_TYR_ITIM	778	783	PF00017	0.445
LIG_UBA3_1	400	407	PF00899	0.477
LIG_UBA3_1	768	774	PF00899	0.483
LIG_WRC_WIRS_1	205	210	PF05994	0.464
MOD_CDK_SPxxK_3	24	31	PF00069	0.687
MOD_CK1_1	134	140	PF00069	0.550
MOD_CK1_1	171	177	PF00069	0.558
MOD_CK1_1	2	8	PF00069	0.688
MOD_CK1_1	212	218	PF00069	0.528
MOD_CK1_1	445	451	PF00069	0.472
MOD_CK1_1	561	567	PF00069	0.524
MOD_CK1_1	593	599	PF00069	0.507
MOD_CK1_1	640	646	PF00069	0.549
MOD_CK1_1	665	671	PF00069	0.426
MOD_CK1_1	85	91	PF00069	0.616
MOD_CK2_1	150	156	PF00069	0.593
MOD_CK2_1	173	179	PF00069	0.571
MOD_CK2_1	233	239	PF00069	0.526
MOD_CK2_1	605	611	PF00069	0.511
MOD_CK2_1	716	722	PF00069	0.498
MOD_Cter_Amidation	58	61	PF01082	0.650
MOD_GlcNHglycan	103	106	PF01048	0.661
MOD_GlcNHglycan	133	136	PF01048	0.674
MOD_GlcNHglycan	170	173	PF01048	0.539
MOD_GlcNHglycan	313	316	PF01048	0.438
MOD_GlcNHglycan	457	460	PF01048	0.478
MOD_GlcNHglycan	534	537	PF01048	0.334
MOD_GlcNHglycan	550	554	PF01048	0.447
MOD_GlcNHglycan	560	563	PF01048	0.380
MOD_GlcNHglycan	669	672	PF01048	0.457
MOD_GlcNHglycan	84	87	PF01048	0.685
MOD_GSK3_1	134	141	PF00069	0.631
MOD_GSK3_1	204	211	PF00069	0.426
MOD_GSK3_1	30	37	PF00069	0.770
MOD_GSK3_1	307	314	PF00069	0.511
MOD_GSK3_1	382	389	PF00069	0.478
MOD_GSK3_1	405	412	PF00069	0.501
MOD_GSK3_1	416	423	PF00069	0.504
MOD_GSK3_1	447	454	PF00069	0.422
MOD_GSK3_1	471	478	PF00069	0.484
MOD_GSK3_1	521	528	PF00069	0.497
MOD_GSK3_1	589	596	PF00069	0.486
MOD_GSK3_1	636	643	PF00069	0.407
MOD_GSK3_1	658	665	PF00069	0.530
MOD_GSK3_1	667	674	PF00069	0.476
MOD_GSK3_1	700	707	PF00069	0.424
MOD_GSK3_1	725	732	PF00069	0.466
MOD_N-GLC_1	138	143	PF02516	0.605
MOD_N-GLC_1	150	155	PF02516	0.550
MOD_N-GLC_1	168	173	PF02516	0.330
MOD_N-GLC_1	244	249	PF02516	0.494
MOD_N-GLC_1	481	486	PF02516	0.490
MOD_N-GLC_1	678	683	PF02516	0.380
MOD_N-GLC_1	748	753	PF02516	0.429
MOD_NEK2_1	150	155	PF00069	0.550
MOD_NEK2_1	184	189	PF00069	0.520
MOD_NEK2_1	208	213	PF00069	0.553
MOD_NEK2_1	288	293	PF00069	0.490
MOD_NEK2_1	307	312	PF00069	0.441
MOD_NEK2_1	335	340	PF00069	0.508
MOD_NEK2_1	381	386	PF00069	0.403
MOD_NEK2_1	394	399	PF00069	0.425
MOD_NEK2_1	405	410	PF00069	0.430
MOD_NEK2_1	41	46	PF00069	0.636
MOD_NEK2_1	440	445	PF00069	0.481
MOD_NEK2_1	451	456	PF00069	0.388
MOD_NEK2_1	475	480	PF00069	0.484
MOD_NEK2_1	497	502	PF00069	0.437
MOD_NEK2_1	519	524	PF00069	0.522
MOD_NEK2_1	555	560	PF00069	0.523
MOD_NEK2_1	614	619	PF00069	0.482
MOD_NEK2_1	626	631	PF00069	0.448
MOD_NEK2_1	636	641	PF00069	0.423
MOD_NEK2_1	678	683	PF00069	0.336
MOD_NEK2_1	704	709	PF00069	0.467
MOD_NEK2_1	748	753	PF00069	0.498
MOD_NEK2_1	82	87	PF00069	0.658
MOD_NEK2_2	103	108	PF00069	0.487
MOD_NEK2_2	637	642	PF00069	0.494
MOD_NEK2_2	662	667	PF00069	0.344
MOD_PIKK_1	113	119	PF00454	0.619
MOD_PIKK_1	15	21	PF00454	0.603
MOD_PIKK_1	35	41	PF00454	0.697
MOD_PIKK_1	394	400	PF00454	0.484
MOD_PIKK_1	53	59	PF00454	0.680
MOD_PIKK_1	707	713	PF00454	0.432
MOD_PKA_2	30	36	PF00069	0.685
MOD_PKA_2	340	346	PF00069	0.502
MOD_PKA_2	478	484	PF00069	0.500
MOD_PKA_2	760	766	PF00069	0.486
MOD_PKA_2	82	88	PF00069	0.719
MOD_PKB_1	32	40	PF00069	0.653
MOD_Plk_1	138	144	PF00069	0.468
MOD_Plk_1	150	156	PF00069	0.551
MOD_Plk_1	244	250	PF00069	0.506
MOD_Plk_1	416	422	PF00069	0.271
MOD_Plk_1	435	441	PF00069	0.458
MOD_Plk_1	471	477	PF00069	0.469
MOD_Plk_1	549	555	PF00069	0.534
MOD_Plk_1	748	754	PF00069	0.440
MOD_Plk_1	805	811	PF00069	0.648
MOD_Plk_2-3	525	531	PF00069	0.475
MOD_Plk_2-3	605	611	PF00069	0.498
MOD_Plk_4	204	210	PF00069	0.533
MOD_Plk_4	249	255	PF00069	0.615
MOD_Plk_4	383	389	PF00069	0.524
MOD_Plk_4	396	402	PF00069	0.390
MOD_Plk_4	435	441	PF00069	0.497
MOD_Plk_4	451	457	PF00069	0.268
MOD_Plk_4	497	503	PF00069	0.481
MOD_Plk_4	561	567	PF00069	0.458
MOD_Plk_4	805	811	PF00069	0.660
MOD_ProDKin_1	171	177	PF00069	0.558
MOD_ProDKin_1	24	30	PF00069	0.685
MOD_ProDKin_1	658	664	PF00069	0.393
MOD_SUMO_rev_2	537	546	PF00179	0.474
TRG_DiLeu_BaEn_2	203	209	PF01217	0.470
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.465
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.493
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.482
TRG_ENDOCYTIC_2	402	405	PF00928	0.464
TRG_ENDOCYTIC_2	565	568	PF00928	0.332
TRG_ENDOCYTIC_2	752	755	PF00928	0.549
TRG_ENDOCYTIC_2	780	783	PF00928	0.510
TRG_ER_diArg_1	285	287	PF00400	0.441
TRG_ER_diArg_1	31	34	PF00400	0.802
TRG_ER_diArg_1	339	342	PF00400	0.509
TRG_ER_diArg_1	58	61	PF00400	0.650
TRG_ER_diArg_1	652	655	PF00400	0.506
TRG_LysEnd_GGAAcLL_1	806	811	PF00790	0.607
TRG_NES_CRM1_1	413	425	PF08389	0.440
TRG_NES_CRM1_1	511	525	PF08389	0.487
TRG_Pf-PMV_PEXEL_1	420	425	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	607	611	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGD6	Leishmania donovani	93%	100%
A4H3R1	Leishmania braziliensis	23%	100%
A4I6T8	Leishmania infantum	93%	100%
D0A4F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	96%
E9AIU4	Leishmania braziliensis	78%	100%
Q4Q6A2	Leishmania major	92%	100%
V5BI55	Trypanosoma cruzi	26%	72%
V5BKI3	Trypanosoma cruzi	25%	97%