LeishMANIAdb
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E3 ubiquitin-protein ligase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
E3 ubiquitin-protein ligase
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B1V6_LEIMU
TriTrypDb:
LmxM.30.1560
Length:
322

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1V6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1V6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 130 134 PF00656 0.481
CLV_NRD_NRD_1 226 228 PF00675 0.520
CLV_NRD_NRD_1 319 321 PF00675 0.584
CLV_PCSK_KEX2_1 226 228 PF00082 0.467
CLV_PCSK_SKI1_1 260 264 PF00082 0.365
CLV_PCSK_SKI1_1 77 81 PF00082 0.496
DEG_Nend_Nbox_1 1 3 PF02207 0.353
DEG_SPOP_SBC_1 239 243 PF00917 0.472
DOC_CKS1_1 101 106 PF01111 0.430
DOC_CKS1_1 58 63 PF01111 0.470
DOC_CYCLIN_yCln2_LP_2 67 73 PF00134 0.459
DOC_MAPK_gen_1 41 48 PF00069 0.543
DOC_MAPK_MEF2A_6 41 48 PF00069 0.558
DOC_PP2B_LxvP_1 44 47 PF13499 0.541
DOC_USP7_MATH_1 106 110 PF00917 0.631
DOC_USP7_MATH_1 291 295 PF00917 0.512
DOC_USP7_MATH_1 71 75 PF00917 0.651
DOC_WW_Pin1_4 100 105 PF00397 0.642
DOC_WW_Pin1_4 57 62 PF00397 0.563
DOC_WW_Pin1_4 66 71 PF00397 0.744
LIG_14-3-3_CanoR_1 148 155 PF00244 0.380
LIG_14-3-3_CanoR_1 214 222 PF00244 0.517
LIG_14-3-3_CanoR_1 268 274 PF00244 0.487
LIG_14-3-3_CanoR_1 309 315 PF00244 0.451
LIG_14-3-3_CanoR_1 41 47 PF00244 0.633
LIG_14-3-3_CanoR_1 5 11 PF00244 0.463
LIG_14-3-3_CanoR_1 72 81 PF00244 0.498
LIG_Actin_WH2_2 307 322 PF00022 0.554
LIG_BRCT_BRCA1_1 108 112 PF00533 0.502
LIG_CSL_BTD_1 11 14 PF09270 0.334
LIG_eIF4E_1 82 88 PF01652 0.489
LIG_FHA_1 130 136 PF00498 0.479
LIG_FHA_1 182 188 PF00498 0.314
LIG_FHA_1 280 286 PF00498 0.572
LIG_FHA_1 29 35 PF00498 0.379
LIG_FHA_1 58 64 PF00498 0.614
LIG_LIR_Nem_3 109 115 PF02991 0.476
LIG_LIR_Nem_3 183 188 PF02991 0.337
LIG_PCNA_yPIPBox_3 226 237 PF02747 0.479
LIG_SH2_CRK 212 216 PF00017 0.393
LIG_SH2_SRC 118 121 PF00017 0.379
LIG_SH2_STAT5 118 121 PF00017 0.377
LIG_SH2_STAT5 212 215 PF00017 0.490
LIG_SH3_3 1 7 PF00018 0.301
LIG_SH3_3 252 258 PF00018 0.444
LIG_SH3_3 8 14 PF00018 0.281
LIG_SH3_3 88 94 PF00018 0.471
LIG_SUMO_SIM_anti_2 19 24 PF11976 0.331
LIG_SUMO_SIM_par_1 135 141 PF11976 0.395
LIG_SUMO_SIM_par_1 153 159 PF11976 0.494
LIG_SUMO_SIM_par_1 234 246 PF11976 0.517
LIG_SUMO_SIM_par_1 30 35 PF11976 0.394
LIG_TRAF2_1 276 279 PF00917 0.590
MOD_CDC14_SPxK_1 69 72 PF00782 0.460
MOD_CDK_SPxK_1 66 72 PF00069 0.462
MOD_CK1_1 122 128 PF00069 0.498
MOD_CK1_1 138 144 PF00069 0.549
MOD_CK1_1 242 248 PF00069 0.616
MOD_CK1_1 294 300 PF00069 0.574
MOD_CK2_1 111 117 PF00069 0.550
MOD_CK2_1 166 172 PF00069 0.607
MOD_CK2_1 273 279 PF00069 0.577
MOD_GlcNHglycan 108 111 PF01048 0.570
MOD_GlcNHglycan 129 132 PF01048 0.510
MOD_GlcNHglycan 202 205 PF01048 0.523
MOD_GlcNHglycan 285 288 PF01048 0.515
MOD_GlcNHglycan 296 299 PF01048 0.448
MOD_GSK3_1 119 126 PF00069 0.515
MOD_GSK3_1 12 19 PF00069 0.396
MOD_GSK3_1 143 150 PF00069 0.470
MOD_GSK3_1 238 245 PF00069 0.536
MOD_GSK3_1 269 276 PF00069 0.561
MOD_GSK3_1 279 286 PF00069 0.572
MOD_GSK3_1 71 78 PF00069 0.678
MOD_N-GLC_1 273 278 PF02516 0.529
MOD_NEK2_1 119 124 PF00069 0.546
MOD_NEK2_1 135 140 PF00069 0.370
MOD_NEK2_1 147 152 PF00069 0.339
MOD_NEK2_1 161 166 PF00069 0.352
MOD_NEK2_1 187 192 PF00069 0.353
MOD_NEK2_1 200 205 PF00069 0.364
MOD_NEK2_1 215 220 PF00069 0.315
MOD_NEK2_2 36 41 PF00069 0.419
MOD_PIKK_1 245 251 PF00454 0.701
MOD_PKA_2 147 153 PF00069 0.381
MOD_PKA_2 279 285 PF00069 0.531
MOD_PKA_2 294 300 PF00069 0.407
MOD_PKA_2 42 48 PF00069 0.621
MOD_PKA_2 71 77 PF00069 0.434
MOD_Plk_1 119 125 PF00069 0.491
MOD_Plk_1 161 167 PF00069 0.421
MOD_Plk_1 273 279 PF00069 0.526
MOD_Plk_1 75 81 PF00069 0.657
MOD_Plk_4 111 117 PF00069 0.472
MOD_Plk_4 16 22 PF00069 0.272
MOD_Plk_4 28 34 PF00069 0.437
MOD_Plk_4 6 12 PF00069 0.368
MOD_ProDKin_1 100 106 PF00069 0.641
MOD_ProDKin_1 57 63 PF00069 0.575
MOD_ProDKin_1 66 72 PF00069 0.745
TRG_DiLeu_BaEn_1 76 81 PF01217 0.507
TRG_DiLeu_BaEn_4 196 202 PF01217 0.480
TRG_DiLeu_BaLyEn_6 44 49 PF01217 0.534
TRG_ENDOCYTIC_2 212 215 PF00928 0.378
TRG_ER_diArg_1 226 228 PF00400 0.520
TRG_ER_diArg_1 40 43 PF00400 0.607
TRG_Pf-PMV_PEXEL_1 226 230 PF00026 0.448
TRG_Pf-PMV_PEXEL_1 24 28 PF00026 0.375

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A2 Leptomonas seymouri 63% 99%
A0A1X0NQ31 Trypanosomatidae 39% 97%
A0A3R7KN88 Trypanosoma rangeli 42% 100%
A0A3S7X4K4 Leishmania donovani 93% 100%
A4HJD7 Leishmania braziliensis 86% 100%
A4I6T4 Leishmania infantum 93% 100%
C9ZMA6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
Q4Q6A6 Leishmania major 92% 100%
V5BFH9 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS