LeishMANIAdb
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Proteophosphoglycan ppg4

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Proteophosphoglycan ppg4
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9B1U5_LEIMU
TriTrypDb:
LmxM.30.1445
Length:
420

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 125
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 50, no: 5
NetGPI no yes: 0, no: 55
Cellular components
TermNameLevelCount
GO:0005929 cilium 4 56
GO:0016020 membrane 2 18
GO:0042995 cell projection 2 56
GO:0043226 organelle 2 56
GO:0043227 membrane-bounded organelle 3 56
GO:0110165 cellular anatomical entity 1 56
GO:0120025 plasma membrane bounded cell projection 3 56
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Expansion

Sequence features

E9B1U5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1U5

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 246 248 PF00675 0.475
CLV_NRD_NRD_1 3 5 PF00675 0.645
CLV_PCSK_KEX2_1 246 248 PF00082 0.475
CLV_PCSK_KEX2_1 264 266 PF00082 0.498
CLV_PCSK_KEX2_1 3 5 PF00082 0.645
CLV_PCSK_KEX2_1 389 391 PF00082 0.541
CLV_PCSK_PC1ET2_1 264 266 PF00082 0.497
CLV_PCSK_PC1ET2_1 389 391 PF00082 0.541
CLV_PCSK_SKI1_1 42 46 PF00082 0.574
DEG_Nend_Nbox_1 1 3 PF02207 0.468
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I121 Leptomonas seymouri 27% 84%
A0A3Q8I9A6 Leishmania donovani 37% 100%
A0A3Q8I9B4 Leishmania donovani 37% 68%
A0A3Q8I9D0 Leishmania donovani 45% 100%
A0A3Q8I9D9 Leishmania donovani 37% 67%
A0A3Q8IFC2 Leishmania donovani 79% 96%
A0A3Q8IIJ9 Leishmania donovani 34% 100%
A0A3S5H6D6 Leishmania donovani 30% 100%
A0A3S5H6L9 Leishmania donovani 37% 73%
A0A3S7WP69 Leishmania donovani 26% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS