Proteophosphoglycan ppg4

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1U5_LEIMU

TriTrypDb:

LmxM.30.1445

Length:

420

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 50, no: 5
NetGPI	no	yes: 0, no: 55

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	56
GO:0042995	cell projection	2	56
GO:0043226	organelle	2	56
GO:0043227	membrane-bounded organelle	3	56
GO:0110165	cellular anatomical entity	1	56
GO:0120025	plasma membrane bounded cell projection	3	56
GO:0016020	membrane	2	18

Expansion

Sequence features

E9B1U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1U5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	246	248	PF00675	0.475
CLV_NRD_NRD_1	3	5	PF00675	0.645
CLV_PCSK_KEX2_1	246	248	PF00082	0.475
CLV_PCSK_KEX2_1	264	266	PF00082	0.498
CLV_PCSK_KEX2_1	3	5	PF00082	0.645
CLV_PCSK_KEX2_1	389	391	PF00082	0.541
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.497
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.541
CLV_PCSK_SKI1_1	42	46	PF00082	0.574
DEG_Nend_Nbox_1	1	3	PF02207	0.468
DEG_SPOP_SBC_1	154	158	PF00917	0.232
DEG_SPOP_SBC_1	288	292	PF00917	0.484
DEG_SPOP_SBC_1	296	300	PF00917	0.455
DEG_SPOP_SBC_1	304	308	PF00917	0.420
DEG_SPOP_SBC_1	312	316	PF00917	0.444
DEG_SPOP_SBC_1	320	324	PF00917	0.444
DEG_SPOP_SBC_1	328	332	PF00917	0.454
DEG_SPOP_SBC_1	336	340	PF00917	0.458
DEG_SPOP_SBC_1	344	348	PF00917	0.438
DOC_MAPK_gen_1	264	272	PF00069	0.324
DOC_MAPK_MEF2A_6	145	154	PF00069	0.250
DOC_USP7_MATH_1	274	278	PF00917	0.387
DOC_USP7_MATH_1	406	410	PF00917	0.259
DOC_USP7_MATH_1	72	76	PF00917	0.267
DOC_USP7_MATH_2	212	218	PF00917	0.274
DOC_WW_Pin1_4	395	400	PF00397	0.412
LIG_14-3-3_CanoR_1	246	255	PF00244	0.320
LIG_14-3-3_CanoR_1	265	269	PF00244	0.310
LIG_14-3-3_CanoR_1	51	60	PF00244	0.320
LIG_BIR_III_2	71	75	PF00653	0.292
LIG_BRCT_BRCA1_1	400	404	PF00533	0.210
LIG_deltaCOP1_diTrp_1	261	268	PF00928	0.290
LIG_FHA_1	149	155	PF00498	0.249
LIG_FHA_1	197	203	PF00498	0.290
LIG_FHA_1	60	66	PF00498	0.323
LIG_FHA_1	9	15	PF00498	0.525
LIG_FHA_1	93	99	PF00498	0.296
LIG_FHA_2	106	112	PF00498	0.454
LIG_FHA_2	346	352	PF00498	0.432
LIG_FHA_2	368	374	PF00498	0.287
LIG_FHA_2	77	83	PF00498	0.319
LIG_FXI_DFP_1	109	113	PF00024	0.448
LIG_LIR_Gen_1	115	126	PF02991	0.273
LIG_LIR_Gen_1	174	183	PF02991	0.297
LIG_LIR_Gen_1	214	223	PF02991	0.284
LIG_LIR_Gen_1	237	245	PF02991	0.317
LIG_LIR_Nem_3	115	121	PF02991	0.306
LIG_LIR_Nem_3	141	146	PF02991	0.321
LIG_LIR_Nem_3	166	170	PF02991	0.270
LIG_LIR_Nem_3	174	178	PF02991	0.309
LIG_NRBOX	16	22	PF00104	0.491
LIG_Pex14_2	231	235	PF04695	0.279
LIG_SH2_CRK	118	122	PF00017	0.257
LIG_SH2_GRB2like	118	121	PF00017	0.241
LIG_SH2_STAP1	118	122	PF00017	0.256
LIG_SH2_STAP1	203	207	PF00017	0.256
LIG_SH2_STAT3	203	206	PF00017	0.265
LIG_SH2_STAT5	127	130	PF00017	0.317
LIG_SH2_STAT5	148	151	PF00017	0.311
LIG_SH3_3	107	113	PF00018	0.332
LIG_SH3_3	283	289	PF00018	0.336
LIG_SH3_3	29	35	PF00018	0.470
LIG_SUMO_SIM_par_1	17	24	PF11976	0.462
LIG_SUMO_SIM_par_1	198	205	PF11976	0.276
LIG_SUMO_SIM_par_1	94	101	PF11976	0.262
LIG_TYR_ITIM	116	121	PF00017	0.328
MOD_CK1_1	101	107	PF00069	0.324
MOD_CK1_1	133	139	PF00069	0.297
MOD_CK1_1	166	172	PF00069	0.337
MOD_CK1_1	177	183	PF00069	0.271
MOD_CK1_1	192	198	PF00069	0.358
MOD_CK1_1	217	223	PF00069	0.348
MOD_CK1_1	397	403	PF00069	0.220
MOD_CK1_1	53	59	PF00069	0.345
MOD_CK1_1	87	93	PF00069	0.320
MOD_CK2_1	231	237	PF00069	0.279
MOD_CK2_1	345	351	PF00069	0.447
MOD_GlcNHglycan	100	103	PF01048	0.591
MOD_GlcNHglycan	135	138	PF01048	0.530
MOD_GlcNHglycan	159	162	PF01048	0.513
MOD_GlcNHglycan	183	186	PF01048	0.518
MOD_GlcNHglycan	207	210	PF01048	0.521
MOD_GlcNHglycan	248	251	PF01048	0.493
MOD_GlcNHglycan	276	279	PF01048	0.592
MOD_GlcNHglycan	376	379	PF01048	0.530
MOD_GlcNHglycan	391	394	PF01048	0.599
MOD_GlcNHglycan	55	58	PF01048	0.571
MOD_GSK3_1	101	108	PF00069	0.340
MOD_GSK3_1	131	138	PF00069	0.359
MOD_GSK3_1	153	160	PF00069	0.343
MOD_GSK3_1	174	181	PF00069	0.357
MOD_GSK3_1	189	196	PF00069	0.362
MOD_GSK3_1	213	220	PF00069	0.348
MOD_GSK3_1	231	238	PF00069	0.345
MOD_GSK3_1	264	271	PF00069	0.351
MOD_GSK3_1	287	294	PF00069	0.437
MOD_GSK3_1	295	302	PF00069	0.463
MOD_GSK3_1	303	310	PF00069	0.520
MOD_GSK3_1	311	318	PF00069	0.528
MOD_GSK3_1	319	326	PF00069	0.453
MOD_GSK3_1	327	334	PF00069	0.447
MOD_GSK3_1	335	342	PF00069	0.471
MOD_GSK3_1	343	350	PF00069	0.455
MOD_GSK3_1	394	401	PF00069	0.514
MOD_GSK3_1	72	79	PF00069	0.294
MOD_GSK3_1	87	94	PF00069	0.442
MOD_N-GLC_2	254	256	PF02516	0.510
MOD_NEK2_1	178	183	PF00069	0.282
MOD_NEK2_1	190	195	PF00069	0.345
MOD_NEK2_1	202	207	PF00069	0.288
MOD_NEK2_1	231	236	PF00069	0.328
MOD_NEK2_1	76	81	PF00069	0.321
MOD_NEK2_1	98	103	PF00069	0.298
MOD_OFUCOSY	84	91	PF10250	0.518
MOD_PIKK_1	202	208	PF00454	0.259
MOD_PK_1	85	91	PF00069	0.276
MOD_PKA_1	246	252	PF00069	0.266
MOD_PKA_1	264	270	PF00069	0.286
MOD_PKA_1	389	395	PF00069	0.368
MOD_PKA_2	246	252	PF00069	0.327
MOD_PKA_2	264	270	PF00069	0.287
MOD_PKA_2	389	395	PF00069	0.368
MOD_PKA_2	50	56	PF00069	0.286
MOD_Plk_1	213	219	PF00069	0.334
MOD_Plk_2-3	351	357	PF00069	0.368
MOD_Plk_4	171	177	PF00069	0.274
MOD_Plk_4	196	202	PF00069	0.319
MOD_Plk_4	92	98	PF00069	0.296
MOD_ProDKin_1	395	401	PF00069	0.412
MOD_SUMO_rev_2	267	277	PF00179	0.325
TRG_ENDOCYTIC_2	118	121	PF00928	0.351
TRG_ER_diArg_1	2	4	PF00400	0.533
TRG_ER_diArg_1	245	247	PF00400	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I121	Leptomonas seymouri	27%	84%
A0A3Q8I9A6	Leishmania donovani	37%	100%
A0A3Q8I9B4	Leishmania donovani	37%	68%
A0A3Q8I9D0	Leishmania donovani	45%	100%
A0A3Q8I9D9	Leishmania donovani	37%	67%
A0A3Q8IFC2	Leishmania donovani	79%	96%
A0A3Q8IIJ9	Leishmania donovani	34%	100%
A0A3S5H6D6	Leishmania donovani	30%	100%
A0A3S5H6L9	Leishmania donovani	37%	73%
A0A3S7WP69	Leishmania donovani	26%	100%
A0A3S7WPB2	Leishmania donovani	26%	100%
A0A3S7X4J4	Leishmania donovani	34%	100%
A4H4D2	Leishmania braziliensis	26%	100%
A4H4G6	Leishmania braziliensis	26%	100%
A4H5P0	Leishmania braziliensis	30%	100%
A4HJC8	Leishmania braziliensis	35%	100%
A4HJX1	Leishmania braziliensis	65%	100%
A4HSL2	Leishmania infantum	26%	100%
A4HTX9	Leishmania infantum	32%	100%
A4HVB0	Leishmania infantum	37%	100%
A4I6S3	Leishmania infantum	85%	84%
A4I6S4	Leishmania infantum	34%	100%
D1GJ51	Leishmania infantum	35%	91%
E8NHG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ACQ0	Leishmania major	26%	100%
E9AEF4	Leishmania major	60%	100%
E9AG65	Leishmania infantum	26%	100%
E9AGG5	Leishmania infantum	40%	100%
E9AGH0	Leishmania infantum	39%	100%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	97%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q25331	Leishmania major	39%	91%
Q4Q6B6	Leishmania major	33%	100%
Q4Q6B7	Leishmania major	33%	100%
Q4Q6B8	Leishmania major	48%	79%
Q4QGI6	Leishmania major	36%	77%
Q4QGJ4	Leishmania major	39%	91%
Q4QGJ6	Leishmania major	36%	73%
Q4QGJ7	Leishmania major	40%	100%
Q4QGJ9	Leishmania major	37%	72%
Q4QGK6	Leishmania major	39%	91%
Q4QGL4	Leishmania major	37%	100%
Q4QGL5	Leishmania major	34%	77%
Q4QGL8	Leishmania major	29%	69%
Q4QHW6	Leishmania major	32%	100%
Q4QJB2	Leishmania major	26%	100%