LRRNT_2 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1U4_LEIMU

TriTrypDb:

LmxM.30.1442

Length:

342

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 105

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 45, no: 8
NetGPI	no	yes: 0, no: 53

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	54
GO:0016020	membrane	2	13
GO:0042995	cell projection	2	54
GO:0043226	organelle	2	54
GO:0043227	membrane-bounded organelle	3	54
GO:0110165	cellular anatomical entity	1	54
GO:0120025	plasma membrane bounded cell projection	3	54

Expansion

Sequence features

E9B1U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1U4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.450
CLV_PCSK_KEX2_1	157	159	PF00082	0.450
CLV_PCSK_KEX2_1	312	314	PF00082	0.604
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.545
CLV_PCSK_SKI1_1	109	113	PF00082	0.455
DEG_Nend_UBRbox_3	1	3	PF02207	0.242
DEG_SPOP_SBC_1	224	228	PF00917	0.478
DEG_SPOP_SBC_1	232	236	PF00917	0.499
DEG_SPOP_SBC_1	257	261	PF00917	0.553
DOC_MAPK_gen_1	80	89	PF00069	0.274
DOC_PP2B_PxIxI_1	129	135	PF00149	0.228
DOC_USP7_MATH_1	125	129	PF00917	0.314
DOC_USP7_MATH_1	231	235	PF00917	0.488
DOC_USP7_MATH_1	256	260	PF00917	0.602
DOC_USP7_MATH_1	289	293	PF00917	0.324
DOC_USP7_MATH_1	328	332	PF00917	0.264
DOC_USP7_MATH_1	7	11	PF00917	0.266
DOC_WW_Pin1_4	198	203	PF00397	0.293
DOC_WW_Pin1_4	225	230	PF00397	0.520
DOC_WW_Pin1_4	270	275	PF00397	0.439
LIG_AP2alpha_1	115	119	PF02296	0.227
LIG_BRCT_BRCA1_1	106	110	PF00533	0.301
LIG_Clathr_ClatBox_1	55	59	PF01394	0.293
LIG_deltaCOP1_diTrp_1	196	205	PF00928	0.283
LIG_FHA_1	137	143	PF00498	0.376
LIG_FHA_1	201	207	PF00498	0.326
LIG_FHA_1	39	45	PF00498	0.400
LIG_FHA_1	69	75	PF00498	0.344
LIG_FHA_1	84	90	PF00498	0.255
LIG_FHA_2	143	149	PF00498	0.384
LIG_FHA_2	225	231	PF00498	0.504
LIG_FHA_2	250	256	PF00498	0.425
LIG_FHA_2	41	47	PF00498	0.415
LIG_LIR_Gen_1	101	110	PF02991	0.294
LIG_LIR_Gen_1	112	123	PF02991	0.323
LIG_LIR_Gen_1	148	156	PF02991	0.330
LIG_LIR_Gen_1	173	180	PF02991	0.369
LIG_LIR_Gen_1	32	40	PF02991	0.283
LIG_LIR_Gen_1	50	61	PF02991	0.299
LIG_LIR_Gen_1	76	84	PF02991	0.321
LIG_LIR_Nem_3	107	113	PF02991	0.259
LIG_LIR_Nem_3	114	118	PF02991	0.280
LIG_LIR_Nem_3	20	24	PF02991	0.360
LIG_LIR_Nem_3	203	208	PF02991	0.313
LIG_LIR_Nem_3	296	302	PF02991	0.340
LIG_LIR_Nem_3	32	36	PF02991	0.377
LIG_LIR_Nem_3	50	56	PF02991	0.444
LIG_LIR_Nem_3	76	81	PF02991	0.349
LIG_MYND_1	278	282	PF01753	0.292
LIG_MYND_3	177	181	PF01753	0.313
LIG_PDZ_Class_2	337	342	PF00595	0.268
LIG_Pex14_2	115	119	PF04695	0.264
LIG_Pex14_2	170	174	PF04695	0.358
LIG_SH2_CRK	53	57	PF00017	0.290
LIG_SH2_CRK	91	95	PF00017	0.236
LIG_SH2_NCK_1	91	95	PF00017	0.236
LIG_SH2_STAT5	302	305	PF00017	0.313
LIG_SH2_STAT5	91	94	PF00017	0.256
LIG_SH3_1	271	277	PF00018	0.377
LIG_SH3_3	271	277	PF00018	0.380
LIG_SH3_3	319	325	PF00018	0.223
LIG_SH3_3	42	48	PF00018	0.363
LIG_Sin3_3	326	333	PF02671	0.220
LIG_SUMO_SIM_anti_2	131	136	PF11976	0.271
LIG_TYR_ITIM	51	56	PF00017	0.343
LIG_TYR_ITIM	89	94	PF00017	0.228
MOD_CK1_1	101	107	PF00069	0.375
MOD_CK1_1	128	134	PF00069	0.286
MOD_CK1_1	235	241	PF00069	0.513
MOD_CK1_1	243	249	PF00069	0.540
MOD_CK1_1	259	265	PF00069	0.426
MOD_CK1_1	38	44	PF00069	0.378
MOD_CK1_1	73	79	PF00069	0.313
MOD_CK2_1	142	148	PF00069	0.360
MOD_CK2_1	170	176	PF00069	0.330
MOD_CK2_1	224	230	PF00069	0.487
MOD_CK2_1	249	255	PF00069	0.424
MOD_CK2_1	40	46	PF00069	0.398
MOD_GlcNHglycan	13	16	PF01048	0.527
MOD_GlcNHglycan	142	145	PF01048	0.505
MOD_GlcNHglycan	235	238	PF01048	0.691
MOD_GlcNHglycan	242	245	PF01048	0.675
MOD_GlcNHglycan	299	302	PF01048	0.527
MOD_GlcNHglycan	330	333	PF01048	0.257
MOD_GlcNHglycan	94	97	PF01048	0.505
MOD_GSK3_1	100	107	PF00069	0.344
MOD_GSK3_1	109	116	PF00069	0.263
MOD_GSK3_1	136	143	PF00069	0.268
MOD_GSK3_1	148	155	PF00069	0.312
MOD_GSK3_1	166	173	PF00069	0.390
MOD_GSK3_1	194	201	PF00069	0.331
MOD_GSK3_1	231	238	PF00069	0.512
MOD_GSK3_1	240	247	PF00069	0.577
MOD_GSK3_1	256	263	PF00069	0.446
MOD_GSK3_1	266	273	PF00069	0.442
MOD_GSK3_1	289	296	PF00069	0.366
MOD_GSK3_1	7	14	PF00069	0.401
MOD_GSK3_1	70	77	PF00069	0.350
MOD_GSK3_1	90	97	PF00069	0.332
MOD_N-GLC_1	29	34	PF02516	0.502
MOD_NEK2_1	111	116	PF00069	0.352
MOD_NEK2_1	136	141	PF00069	0.337
MOD_NEK2_1	142	147	PF00069	0.357
MOD_NEK2_1	166	171	PF00069	0.365
MOD_NEK2_1	89	94	PF00069	0.363
MOD_PIKK_1	137	143	PF00454	0.291
MOD_Plk_1	148	154	PF00069	0.340
MOD_Plk_1	289	295	PF00069	0.271
MOD_Plk_1	29	35	PF00069	0.370
MOD_Plk_1	51	57	PF00069	0.405
MOD_Plk_2-3	176	182	PF00069	0.267
MOD_Plk_4	194	200	PF00069	0.357
MOD_Plk_4	29	35	PF00069	0.306
MOD_Plk_4	51	57	PF00069	0.304
MOD_ProDKin_1	198	204	PF00069	0.289
MOD_ProDKin_1	225	231	PF00069	0.522
MOD_ProDKin_1	270	276	PF00069	0.426
TRG_ENDOCYTIC_2	53	56	PF00928	0.372
TRG_ENDOCYTIC_2	91	94	PF00928	0.338
TRG_ER_diArg_1	156	158	PF00400	0.263
TRG_NES_CRM1_1	176	189	PF08389	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L4	Leptomonas seymouri	50%	100%
A0A0N0P4M2	Leptomonas seymouri	28%	100%
A0A0N1HZ17	Leptomonas seymouri	33%	100%
A0A0N1I121	Leptomonas seymouri	26%	68%
A0A0S4J7Q5	Bodo saltans	25%	98%
A0A3Q8I9A6	Leishmania donovani	32%	89%
A0A3Q8I9D0	Leishmania donovani	41%	100%
A0A3Q8IFC2	Leishmania donovani	44%	100%
A0A3Q8IIJ9	Leishmania donovani	32%	100%
A0A3S5H6D6	Leishmania donovani	31%	100%
A0A3S7WP69	Leishmania donovani	27%	100%
A0A3S7WPB2	Leishmania donovani	25%	100%
A0A3S7X4J4	Leishmania donovani	32%	100%
A0A422NUB2	Trypanosoma rangeli	28%	100%
A4H4D2	Leishmania braziliensis	27%	100%
A4H4G6	Leishmania braziliensis	25%	100%
A4H5P0	Leishmania braziliensis	31%	100%
A4HBX3	Leishmania braziliensis	30%	75%
A4HJC8	Leishmania braziliensis	32%	100%
A4HJX1	Leishmania braziliensis	43%	100%
A4HSL2	Leishmania infantum	27%	100%
A4HTX9	Leishmania infantum	31%	100%
A4HVB0	Leishmania infantum	34%	85%
A4I6S2	Leishmania infantum	86%	78%
A4I6S4	Leishmania infantum	31%	100%
D1GJ51	Leishmania infantum	36%	74%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ACQ0	Leishmania major	27%	100%
E9AEF4	Leishmania major	41%	100%
E9AG65	Leishmania infantum	25%	100%
E9AGG5	Leishmania infantum	35%	82%
E9AGH0	Leishmania infantum	33%	91%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AP01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	99%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B1U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	75%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	81%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
P21978	Leishmania amazonensis	30%	72%
Q25331	Leishmania major	34%	100%
Q4Q6B6	Leishmania major	32%	100%
Q4Q6B7	Leishmania major	32%	100%
Q4QGJ4	Leishmania major	34%	100%
Q4QGJ7	Leishmania major	35%	100%
Q4QGK6	Leishmania major	34%	100%
Q4QGL4	Leishmania major	30%	100%
Q4QHW6	Leishmania major	33%	100%
Q4QJB2	Leishmania major	27%	100%