Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1T7_LEIMU

TriTrypDb:

LmxM.30.1390

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1T7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.451
CLV_NRD_NRD_1	231	233	PF00675	0.790
CLV_NRD_NRD_1	494	496	PF00675	0.738
CLV_NRD_NRD_1	504	506	PF00675	0.591
CLV_NRD_NRD_1	638	640	PF00675	0.747
CLV_PCSK_KEX2_1	231	233	PF00082	0.790
CLV_PCSK_KEX2_1	297	299	PF00082	0.722
CLV_PCSK_KEX2_1	494	496	PF00082	0.734
CLV_PCSK_KEX2_1	504	506	PF00082	0.588
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.651
CLV_PCSK_SKI1_1	19	23	PF00082	0.775
CLV_PCSK_SKI1_1	231	235	PF00082	0.750
CLV_PCSK_SKI1_1	39	43	PF00082	0.648
CLV_PCSK_SKI1_1	668	672	PF00082	0.744
CLV_Separin_Metazoa	554	558	PF03568	0.526
DEG_APCC_DBOX_1	667	675	PF00400	0.540
DEG_APCC_DBOX_1	693	701	PF00400	0.466
DEG_ODPH_VHL_1	543	555	PF01847	0.447
DEG_SPOP_SBC_1	213	217	PF00917	0.553
DEG_SPOP_SBC_1	437	441	PF00917	0.441
DOC_CDC14_PxL_1	700	708	PF14671	0.365
DOC_CYCLIN_RxL_1	16	24	PF00134	0.568
DOC_CYCLIN_RxL_1	548	558	PF00134	0.451
DOC_CYCLIN_yClb1_LxF_4	79	84	PF00134	0.439
DOC_MAPK_gen_1	297	305	PF00069	0.442
DOC_MAPK_MEF2A_6	326	333	PF00069	0.570
DOC_MAPK_MEF2A_6	593	601	PF00069	0.546
DOC_MAPK_MEF2A_6	717	724	PF00069	0.332
DOC_PP2B_LxvP_1	454	457	PF13499	0.609
DOC_PP2B_LxvP_1	479	482	PF13499	0.488
DOC_PP2B_LxvP_1	653	656	PF13499	0.499
DOC_PP4_FxxP_1	424	427	PF00568	0.500
DOC_USP7_MATH_1	154	158	PF00917	0.561
DOC_USP7_MATH_1	213	217	PF00917	0.576
DOC_USP7_MATH_1	225	229	PF00917	0.487
DOC_USP7_MATH_1	253	257	PF00917	0.525
DOC_USP7_MATH_1	267	271	PF00917	0.575
DOC_USP7_MATH_1	306	310	PF00917	0.589
DOC_USP7_MATH_1	319	323	PF00917	0.505
DOC_USP7_MATH_1	329	333	PF00917	0.537
DOC_USP7_MATH_1	337	341	PF00917	0.465
DOC_USP7_MATH_1	353	357	PF00917	0.478
DOC_USP7_MATH_1	358	362	PF00917	0.473
DOC_USP7_MATH_1	373	377	PF00917	0.514
DOC_USP7_MATH_1	437	441	PF00917	0.501
DOC_USP7_MATH_1	469	473	PF00917	0.443
DOC_USP7_MATH_1	487	491	PF00917	0.422
DOC_USP7_MATH_1	584	588	PF00917	0.566
DOC_USP7_MATH_1	626	630	PF00917	0.588
DOC_USP7_MATH_1	656	660	PF00917	0.486
DOC_USP7_MATH_1	675	679	PF00917	0.409
DOC_USP7_MATH_1	97	101	PF00917	0.448
DOC_WW_Pin1_4	231	236	PF00397	0.585
DOC_WW_Pin1_4	249	254	PF00397	0.424
DOC_WW_Pin1_4	257	262	PF00397	0.492
DOC_WW_Pin1_4	281	286	PF00397	0.621
DOC_WW_Pin1_4	369	374	PF00397	0.590
DOC_WW_Pin1_4	388	393	PF00397	0.615
DOC_WW_Pin1_4	423	428	PF00397	0.522
DOC_WW_Pin1_4	74	79	PF00397	0.625
LIG_14-3-3_CanoR_1	238	244	PF00244	0.594
LIG_14-3-3_CanoR_1	346	354	PF00244	0.464
LIG_14-3-3_CanoR_1	383	393	PF00244	0.529
LIG_14-3-3_CanoR_1	438	444	PF00244	0.516
LIG_14-3-3_CanoR_1	494	500	PF00244	0.497
LIG_14-3-3_CanoR_1	504	513	PF00244	0.509
LIG_14-3-3_CanoR_1	614	620	PF00244	0.466
LIG_14-3-3_CanoR_1	632	637	PF00244	0.434
LIG_14-3-3_CanoR_1	694	698	PF00244	0.533
LIG_14-3-3_CanoR_1	705	715	PF00244	0.589
LIG_14-3-3_CanoR_1	81	87	PF00244	0.548
LIG_BIR_III_2	316	320	PF00653	0.566
LIG_BIR_III_2	588	592	PF00653	0.601
LIG_BIR_III_4	61	65	PF00653	0.584
LIG_BRCT_BRCA1_1	156	160	PF00533	0.496
LIG_BRCT_BRCA1_1	416	420	PF00533	0.423
LIG_BRCT_BRCA1_2	156	162	PF00533	0.495
LIG_Clathr_ClatBox_1	729	733	PF01394	0.466
LIG_CtBP_PxDLS_1	552	556	PF00389	0.452
LIG_deltaCOP1_diTrp_1	613	619	PF00928	0.390
LIG_deltaCOP1_diTrp_1	733	739	PF00928	0.483
LIG_eIF4E_1	666	672	PF01652	0.545
LIG_eIF4E_1	701	707	PF01652	0.642
LIG_FHA_1	287	293	PF00498	0.575
LIG_FHA_1	462	468	PF00498	0.495
LIG_FHA_1	594	600	PF00498	0.545
LIG_FHA_1	610	616	PF00498	0.366
LIG_FHA_1	632	638	PF00498	0.505
LIG_FHA_1	694	700	PF00498	0.416
LIG_FHA_1	707	713	PF00498	0.611
LIG_FHA_1	724	730	PF00498	0.292
LIG_FHA_1	752	758	PF00498	0.475
LIG_FHA_1	83	89	PF00498	0.514
LIG_FHA_2	133	139	PF00498	0.459
LIG_FHA_2	246	252	PF00498	0.463
LIG_FHA_2	40	46	PF00498	0.593
LIG_FHA_2	507	513	PF00498	0.556
LIG_FHA_2	532	538	PF00498	0.514
LIG_FHA_2	559	565	PF00498	0.525
LIG_GBD_Chelix_1	707	715	PF00786	0.438
LIG_IRF3_LxIS_1	595	602	PF10401	0.575
LIG_LIR_Apic_2	423	427	PF02991	0.490
LIG_LIR_Apic_2	664	669	PF02991	0.544
LIG_LIR_Gen_1	352	360	PF02991	0.554
LIG_LIR_Nem_3	352	357	PF02991	0.551
LIG_LIR_Nem_3	737	742	PF02991	0.391
LIG_MYND_1	541	545	PF01753	0.444
LIG_Pex14_2	420	424	PF04695	0.493
LIG_RPA_C_Fungi	499	511	PF08784	0.491
LIG_SH2_CRK	666	670	PF00017	0.685
LIG_SH2_NCK_1	147	151	PF00017	0.646
LIG_SH2_NCK_1	211	215	PF00017	0.497
LIG_SH2_SRC	106	109	PF00017	0.787
LIG_SH2_SRC	414	417	PF00017	0.550
LIG_SH2_STAP1	101	105	PF00017	0.774
LIG_SH2_STAP1	245	249	PF00017	0.700
LIG_SH2_STAP1	745	749	PF00017	0.621
LIG_SH2_STAT5	12	15	PF00017	0.784
LIG_SH2_STAT5	134	137	PF00017	0.652
LIG_SH2_STAT5	666	669	PF00017	0.685
LIG_SH3_2	392	397	PF14604	0.801
LIG_SH3_3	389	395	PF00018	0.755
LIG_SH3_3	454	460	PF00018	0.715
LIG_SH3_3	649	655	PF00018	0.532
LIG_SH3_3	669	675	PF00018	0.674
LIG_SH3_3	73	79	PF00018	0.778
LIG_SUMO_SIM_anti_2	696	701	PF11976	0.416
LIG_SUMO_SIM_anti_2	754	759	PF11976	0.384
LIG_SUMO_SIM_par_1	426	432	PF11976	0.773
LIG_SUMO_SIM_par_1	753	759	PF11976	0.488
LIG_TRAF2_1	129	132	PF00917	0.548
LIG_TRAF2_1	561	564	PF00917	0.722
LIG_WW_3	78	82	PF00397	0.768
MOD_CDC14_SPxK_1	260	263	PF00782	0.706
MOD_CDC14_SPxK_1	394	397	PF00782	0.800
MOD_CDK_SPK_2	281	286	PF00069	0.776
MOD_CDK_SPK_2	369	374	PF00069	0.715
MOD_CDK_SPxK_1	257	263	PF00069	0.716
MOD_CDK_SPxK_1	391	397	PF00069	0.803
MOD_CDK_SPxxK_3	231	238	PF00069	0.740
MOD_CDK_SPxxK_3	74	81	PF00069	0.778
MOD_CK1_1	10	16	PF00069	0.768
MOD_CK1_1	196	202	PF00069	0.571
MOD_CK1_1	217	223	PF00069	0.734
MOD_CK1_1	352	358	PF00069	0.610
MOD_CK1_1	386	392	PF00069	0.804
MOD_CK1_1	558	564	PF00069	0.550
MOD_CK1_1	618	624	PF00069	0.509
MOD_CK2_1	126	132	PF00069	0.563
MOD_CK2_1	145	151	PF00069	0.617
MOD_CK2_1	245	251	PF00069	0.565
MOD_CK2_1	369	375	PF00069	0.827
MOD_CK2_1	39	45	PF00069	0.752
MOD_CK2_1	513	519	PF00069	0.673
MOD_CK2_1	531	537	PF00069	0.642
MOD_CK2_1	558	564	PF00069	0.728
MOD_CK2_1	607	613	PF00069	0.685
MOD_CK2_1	756	762	PF00069	0.671
MOD_CMANNOS	616	619	PF00535	0.481
MOD_CMANNOS	736	739	PF00535	0.604
MOD_Cter_Amidation	637	640	PF01082	0.687
MOD_GlcNHglycan	128	131	PF01048	0.547
MOD_GlcNHglycan	148	151	PF01048	0.691
MOD_GlcNHglycan	156	159	PF01048	0.698
MOD_GlcNHglycan	217	220	PF01048	0.741
MOD_GlcNHglycan	227	230	PF01048	0.647
MOD_GlcNHglycan	269	272	PF01048	0.723
MOD_GlcNHglycan	321	324	PF01048	0.713
MOD_GlcNHglycan	335	338	PF01048	0.637
MOD_GlcNHglycan	351	354	PF01048	0.585
MOD_GlcNHglycan	471	474	PF01048	0.695
MOD_GlcNHglycan	476	479	PF01048	0.751
MOD_GlcNHglycan	48	53	PF01048	0.722
MOD_GlcNHglycan	490	493	PF01048	0.740
MOD_GlcNHglycan	495	498	PF01048	0.648
MOD_GlcNHglycan	506	509	PF01048	0.448
MOD_GlcNHglycan	515	518	PF01048	0.678
MOD_GlcNHglycan	571	574	PF01048	0.730
MOD_GlcNHglycan	656	659	PF01048	0.727
MOD_GlcNHglycan	717	720	PF01048	0.332
MOD_GlcNHglycan	758	761	PF01048	0.391
MOD_GSK3_1	154	161	PF00069	0.582
MOD_GSK3_1	172	179	PF00069	0.541
MOD_GSK3_1	189	196	PF00069	0.584
MOD_GSK3_1	213	220	PF00069	0.753
MOD_GSK3_1	245	252	PF00069	0.667
MOD_GSK3_1	253	260	PF00069	0.670
MOD_GSK3_1	267	274	PF00069	0.736
MOD_GSK3_1	27	34	PF00069	0.780
MOD_GSK3_1	277	284	PF00069	0.743
MOD_GSK3_1	306	313	PF00069	0.774
MOD_GSK3_1	329	336	PF00069	0.753
MOD_GSK3_1	345	352	PF00069	0.528
MOD_GSK3_1	35	42	PF00069	0.716
MOD_GSK3_1	369	376	PF00069	0.569
MOD_GSK3_1	383	390	PF00069	0.615
MOD_GSK3_1	531	538	PF00069	0.601
MOD_GSK3_1	580	587	PF00069	0.731
MOD_GSK3_1	593	600	PF00069	0.604
MOD_GSK3_1	615	622	PF00069	0.641
MOD_GSK3_1	626	633	PF00069	0.668
MOD_GSK3_1	675	682	PF00069	0.594
MOD_LATS_1	523	529	PF00433	0.638
MOD_N-GLC_1	35	40	PF02516	0.681
MOD_N-GLC_1	607	612	PF02516	0.653
MOD_N-GLC_1	751	756	PF02516	0.504
MOD_N-GLC_2	349	351	PF02516	0.524
MOD_NEK2_1	21	26	PF00069	0.780
MOD_NEK2_1	287	292	PF00069	0.579
MOD_NEK2_1	420	425	PF00069	0.696
MOD_NEK2_1	488	493	PF00069	0.562
MOD_NEK2_1	530	535	PF00069	0.691
MOD_NEK2_1	597	602	PF00069	0.714
MOD_NEK2_1	679	684	PF00069	0.537
MOD_NEK2_1	706	711	PF00069	0.636
MOD_NEK2_1	715	720	PF00069	0.331
MOD_NEK2_1	723	728	PF00069	0.211
MOD_NEK2_1	756	761	PF00069	0.616
MOD_NEK2_2	253	258	PF00069	0.720
MOD_PIKK_1	304	310	PF00454	0.750
MOD_PIKK_1	31	37	PF00454	0.794
MOD_PIKK_1	627	633	PF00454	0.564
MOD_PIKK_1	734	740	PF00454	0.449
MOD_PK_1	632	638	PF00069	0.557
MOD_PKA_1	504	510	PF00069	0.488
MOD_PKA_2	10	16	PF00069	0.664
MOD_PKA_2	126	132	PF00069	0.595
MOD_PKA_2	274	280	PF00069	0.544
MOD_PKA_2	345	351	PF00069	0.519
MOD_PKA_2	396	402	PF00069	0.729
MOD_PKA_2	437	443	PF00069	0.705
MOD_PKA_2	493	499	PF00069	0.684
MOD_PKA_2	504	510	PF00069	0.578
MOD_PKA_2	558	564	PF00069	0.627
MOD_PKA_2	579	585	PF00069	0.730
MOD_PKA_2	631	637	PF00069	0.688
MOD_PKA_2	693	699	PF00069	0.483
MOD_Plk_1	196	202	PF00069	0.571
MOD_Plk_1	245	251	PF00069	0.519
MOD_Plk_1	301	307	PF00069	0.597
MOD_Plk_1	751	757	PF00069	0.504
MOD_Plk_2-3	115	121	PF00069	0.672
MOD_Plk_2-3	132	138	PF00069	0.544
MOD_Plk_4	531	537	PF00069	0.552
MOD_Plk_4	632	638	PF00069	0.646
MOD_Plk_4	661	667	PF00069	0.682
MOD_Plk_4	679	685	PF00069	0.226
MOD_Plk_4	693	699	PF00069	0.243
MOD_Plk_4	707	713	PF00069	0.574
MOD_Plk_4	751	757	PF00069	0.486
MOD_ProDKin_1	231	237	PF00069	0.739
MOD_ProDKin_1	249	255	PF00069	0.517
MOD_ProDKin_1	257	263	PF00069	0.608
MOD_ProDKin_1	281	287	PF00069	0.789
MOD_ProDKin_1	369	375	PF00069	0.747
MOD_ProDKin_1	388	394	PF00069	0.778
MOD_ProDKin_1	423	429	PF00069	0.654
MOD_ProDKin_1	74	80	PF00069	0.794
TRG_DiLeu_BaLyEn_6	666	671	PF01217	0.684
TRG_DiLeu_BaLyEn_6	702	707	PF01217	0.368
TRG_ER_diArg_1	230	232	PF00400	0.748
TRG_ER_diArg_1	549	552	PF00400	0.724
TRG_ER_diArg_1	556	559	PF00400	0.633
TRG_ER_diArg_1	9	12	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.740
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	668	673	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IG54	Leishmania donovani	75%	100%
A4HJC2	Leishmania braziliensis	49%	99%
A4I6R5	Leishmania infantum	75%	100%
Q4Q6C4	Leishmania major	74%	99%