DUF4201 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1T4_LEIMU

TriTrypDb:

LmxM.30.1360

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1T4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.420
CLV_C14_Caspase3-7	184	188	PF00656	0.479
CLV_C14_Caspase3-7	294	298	PF00656	0.422
CLV_NRD_NRD_1	118	120	PF00675	0.557
CLV_NRD_NRD_1	155	157	PF00675	0.428
CLV_NRD_NRD_1	253	255	PF00675	0.530
CLV_NRD_NRD_1	260	262	PF00675	0.497
CLV_NRD_NRD_1	64	66	PF00675	0.546
CLV_PCSK_FUR_1	62	66	PF00082	0.447
CLV_PCSK_KEX2_1	118	120	PF00082	0.581
CLV_PCSK_KEX2_1	155	157	PF00082	0.461
CLV_PCSK_KEX2_1	167	169	PF00082	0.449
CLV_PCSK_KEX2_1	252	254	PF00082	0.536
CLV_PCSK_KEX2_1	283	285	PF00082	0.485
CLV_PCSK_KEX2_1	64	66	PF00082	0.546
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.418
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.427
CLV_PCSK_PC7_1	279	285	PF00082	0.429
CLV_PCSK_SKI1_1	284	288	PF00082	0.410
CLV_PCSK_SKI1_1	65	69	PF00082	0.550
DEG_APCC_DBOX_1	145	153	PF00400	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.519
DOC_MAPK_gen_1	232	240	PF00069	0.455
DOC_MAPK_gen_1	283	289	PF00069	0.437
DOC_MAPK_MEF2A_6	274	282	PF00069	0.528
DOC_PP2B_LxvP_1	186	189	PF13499	0.457
DOC_PP4_FxxP_1	135	138	PF00568	0.516
DOC_USP7_MATH_1	12	16	PF00917	0.589
DOC_USP7_MATH_1	138	142	PF00917	0.431
DOC_USP7_MATH_1	213	217	PF00917	0.733
DOC_USP7_MATH_1	23	27	PF00917	0.432
DOC_USP7_UBL2_3	111	115	PF12436	0.567
LIG_14-3-3_CanoR_1	100	110	PF00244	0.495
LIG_14-3-3_CanoR_1	155	163	PF00244	0.481
LIG_14-3-3_CanoR_1	328	334	PF00244	0.437
LIG_14-3-3_CanoR_1	33	41	PF00244	0.457
LIG_Actin_WH2_2	110	126	PF00022	0.506
LIG_FHA_1	328	334	PF00498	0.419
LIG_FHA_1	35	41	PF00498	0.481
LIG_FHA_1	43	49	PF00498	0.436
LIG_LIR_Nem_3	332	337	PF02991	0.583
LIG_Pex14_2	131	135	PF04695	0.510
LIG_SH2_GRB2like	307	310	PF00017	0.366
LIG_SH3_3	186	192	PF00018	0.484
LIG_SUMO_SIM_par_1	43	49	PF11976	0.470
LIG_WRC_WIRS_1	13	18	PF05994	0.644
MOD_CK1_1	248	254	PF00069	0.428
MOD_CK1_1	76	82	PF00069	0.432
MOD_CK2_1	155	161	PF00069	0.531
MOD_GlcNHglycan	215	218	PF01048	0.808
MOD_GlcNHglycan	315	318	PF01048	0.564
MOD_GlcNHglycan	54	57	PF01048	0.545
MOD_GlcNHglycan	58	61	PF01048	0.600
MOD_GSK3_1	213	220	PF00069	0.699
MOD_GSK3_1	248	255	PF00069	0.476
MOD_GSK3_1	52	59	PF00069	0.705
MOD_N-GLC_1	194	199	PF02516	0.569
MOD_NEK2_1	163	168	PF00069	0.551
MOD_NEK2_1	34	39	PF00069	0.480
MOD_NEK2_1	73	78	PF00069	0.637
MOD_NEK2_2	12	17	PF00069	0.536
MOD_OFUCOSY	326	331	PF10250	0.395
MOD_PIKK_1	155	161	PF00454	0.531
MOD_PIKK_1	263	269	PF00454	0.480
MOD_PKA_1	155	161	PF00069	0.353
MOD_PKA_1	252	258	PF00069	0.553
MOD_PKA_2	101	107	PF00069	0.368
MOD_PKA_2	155	161	PF00069	0.483
MOD_PKA_2	245	251	PF00069	0.518
MOD_PKA_2	252	258	PF00069	0.459
MOD_PKA_2	260	266	PF00069	0.446
MOD_PKA_2	327	333	PF00069	0.395
MOD_PKA_2	34	40	PF00069	0.599
MOD_Plk_1	42	48	PF00069	0.414
MOD_SUMO_rev_2	108	117	PF00179	0.504
MOD_SUMO_rev_2	166	175	PF00179	0.516
MOD_SUMO_rev_2	297	306	PF00179	0.522
TRG_DiLeu_BaEn_1	176	181	PF01217	0.352
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.511
TRG_ER_diArg_1	117	119	PF00400	0.607
TRG_ER_diArg_1	252	254	PF00400	0.659
TRG_ER_diArg_1	62	65	PF00400	0.447
TRG_ER_diArg_1	99	102	PF00400	0.389
TRG_NES_CRM1_1	276	292	PF08389	0.432
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXL4	Leptomonas seymouri	39%	100%
A0A3S7X4F2	Leishmania donovani	86%	100%
A4HJB9	Leishmania braziliensis	74%	100%
A4I6R2	Leishmania infantum	86%	100%
C9ZWT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4Q6C7	Leishmania major	83%	100%