SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1T3_LEIMU

TriTrypDb:

LmxM.30.1350

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1T3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	274	276	PF00675	0.648
CLV_NRD_NRD_1	317	319	PF00675	0.343
CLV_PCSK_FUR_1	292	296	PF00082	0.418
CLV_PCSK_KEX2_1	294	296	PF00082	0.458
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.458
CLV_PCSK_SKI1_1	263	267	PF00082	0.684
CLV_PCSK_SKI1_1	318	322	PF00082	0.488
DEG_SPOP_SBC_1	199	203	PF00917	0.562
DEG_SPOP_SBC_1	328	332	PF00917	0.521
DOC_CDC14_PxL_1	179	187	PF14671	0.494
DOC_CDC14_PxL_1	309	317	PF14671	0.413
DOC_CKS1_1	69	74	PF01111	0.556
DOC_MAPK_HePTP_8	478	493	PF00069	0.499
DOC_PP1_RVXF_1	261	267	PF00149	0.484
DOC_PP1_RVXF_1	431	437	PF00149	0.424
DOC_PP2B_LxvP_1	242	245	PF13499	0.665
DOC_PP2B_LxvP_1	463	466	PF13499	0.599
DOC_PP2B_LxvP_1	492	495	PF13499	0.433
DOC_USP7_MATH_1	197	201	PF00917	0.560
DOC_USP7_MATH_1	213	217	PF00917	0.600
DOC_USP7_MATH_1	233	237	PF00917	0.622
DOC_USP7_MATH_1	343	347	PF00917	0.697
DOC_USP7_MATH_1	4	8	PF00917	0.594
DOC_USP7_MATH_1	429	433	PF00917	0.438
DOC_USP7_MATH_1	506	510	PF00917	0.693
DOC_USP7_MATH_1	517	521	PF00917	0.533
DOC_USP7_UBL2_3	353	357	PF12436	0.506
DOC_WW_Pin1_4	221	226	PF00397	0.544
DOC_WW_Pin1_4	253	258	PF00397	0.562
DOC_WW_Pin1_4	268	273	PF00397	0.666
DOC_WW_Pin1_4	31	36	PF00397	0.681
DOC_WW_Pin1_4	335	340	PF00397	0.690
DOC_WW_Pin1_4	68	73	PF00397	0.564
LIG_14-3-3_CanoR_1	318	326	PF00244	0.405
LIG_14-3-3_CanoR_1	507	516	PF00244	0.564
LIG_APCC_ABBAyCdc20_2	284	290	PF00400	0.322
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BIR_III_1	1	5	PF00653	0.564
LIG_BIR_III_3	1	5	PF00653	0.564
LIG_BRCT_BRCA1_1	194	198	PF00533	0.683
LIG_eIF4E_1	309	315	PF01652	0.401
LIG_EVH1_1	242	246	PF00568	0.598
LIG_FHA_1	224	230	PF00498	0.605
LIG_FHA_1	269	275	PF00498	0.657
LIG_FHA_1	306	312	PF00498	0.403
LIG_FHA_1	511	517	PF00498	0.577
LIG_FHA_1	63	69	PF00498	0.637
LIG_FHA_2	185	191	PF00498	0.687
LIG_FHA_2	397	403	PF00498	0.482
LIG_FHA_2	509	515	PF00498	0.620
LIG_LIR_Gen_1	147	154	PF02991	0.628
LIG_LIR_Nem_3	147	153	PF02991	0.635
LIG_LIR_Nem_3	306	312	PF02991	0.386
LIG_LIR_Nem_3	402	407	PF02991	0.400
LIG_SH2_CRK	150	154	PF00017	0.653
LIG_SH2_CRK	250	254	PF00017	0.752
LIG_SH2_CRK	302	306	PF00017	0.378
LIG_SH2_CRK	309	313	PF00017	0.372
LIG_SH2_CRK	407	411	PF00017	0.440
LIG_SH2_STAP1	250	254	PF00017	0.707
LIG_SH2_STAT3	115	118	PF00017	0.680
LIG_SH2_STAT5	115	118	PF00017	0.600
LIG_SH2_STAT5	138	141	PF00017	0.572
LIG_SH2_STAT5	387	390	PF00017	0.493
LIG_SH3_3	106	112	PF00018	0.660
LIG_SH3_3	16	22	PF00018	0.520
LIG_SH3_3	205	211	PF00018	0.528
LIG_SH3_3	237	243	PF00018	0.692
LIG_SH3_3	251	257	PF00018	0.564
LIG_SH3_3	391	397	PF00018	0.380
LIG_SH3_3	423	429	PF00018	0.457
LIG_SH3_3	490	496	PF00018	0.421
LIG_SH3_CIN85_PxpxPR_1	339	344	PF14604	0.657
LIG_SUMO_SIM_anti_2	490	495	PF11976	0.423
LIG_SUMO_SIM_par_1	362	369	PF11976	0.600
LIG_TRAF2_1	466	469	PF00917	0.539
LIG_TRFH_1	309	313	PF08558	0.386
LIG_TYR_ITIM	405	410	PF00017	0.417
LIG_UBA3_1	311	319	PF00899	0.391
LIG_WW_1	247	250	PF00397	0.699
MOD_CDK_SPxxK_3	268	275	PF00069	0.654
MOD_CDK_SPxxK_3	335	342	PF00069	0.663
MOD_CK1_1	114	120	PF00069	0.534
MOD_CK1_1	12	18	PF00069	0.606
MOD_CK1_1	132	138	PF00069	0.691
MOD_CK1_1	141	147	PF00069	0.581
MOD_CK1_1	148	154	PF00069	0.606
MOD_CK1_1	177	183	PF00069	0.707
MOD_CK1_1	184	190	PF00069	0.651
MOD_CK1_1	200	206	PF00069	0.606
MOD_CK1_1	218	224	PF00069	0.584
MOD_CK1_1	236	242	PF00069	0.521
MOD_CK1_1	24	30	PF00069	0.544
MOD_CK1_1	268	274	PF00069	0.700
MOD_CK1_1	346	352	PF00069	0.808
MOD_CK1_1	520	526	PF00069	0.596
MOD_CK1_1	54	60	PF00069	0.623
MOD_CK2_1	184	190	PF00069	0.666
MOD_CK2_1	327	333	PF00069	0.669
MOD_CK2_1	508	514	PF00069	0.624
MOD_GlcNHglycan	123	126	PF01048	0.715
MOD_GlcNHglycan	131	134	PF01048	0.728
MOD_GlcNHglycan	14	17	PF01048	0.649
MOD_GlcNHglycan	140	143	PF01048	0.521
MOD_GlcNHglycan	174	177	PF01048	0.540
MOD_GlcNHglycan	217	220	PF01048	0.598
MOD_GlcNHglycan	233	236	PF01048	0.675
MOD_GlcNHglycan	27	30	PF01048	0.657
MOD_GlcNHglycan	305	308	PF01048	0.370
MOD_GlcNHglycan	345	348	PF01048	0.631
MOD_GlcNHglycan	43	46	PF01048	0.682
MOD_GlcNHglycan	474	477	PF01048	0.486
MOD_GlcNHglycan	508	511	PF01048	0.700
MOD_GlcNHglycan	517	520	PF01048	0.571
MOD_GlcNHglycan	57	60	PF01048	0.523
MOD_GSK3_1	116	123	PF00069	0.577
MOD_GSK3_1	132	139	PF00069	0.663
MOD_GSK3_1	141	148	PF00069	0.561
MOD_GSK3_1	177	184	PF00069	0.767
MOD_GSK3_1	21	28	PF00069	0.626
MOD_GSK3_1	213	220	PF00069	0.560
MOD_GSK3_1	249	256	PF00069	0.592
MOD_GSK3_1	506	513	PF00069	0.599
MOD_GSK3_1	51	58	PF00069	0.607
MOD_GSK3_1	515	522	PF00069	0.539
MOD_GSK3_1	524	531	PF00069	0.472
MOD_GSK3_1	64	71	PF00069	0.752
MOD_GSK3_1	87	94	PF00069	0.545
MOD_NEK2_1	129	134	PF00069	0.619
MOD_NEK2_1	136	141	PF00069	0.578
MOD_NEK2_1	145	150	PF00069	0.598
MOD_NEK2_1	198	203	PF00069	0.676
MOD_NEK2_1	217	222	PF00069	0.508
MOD_NEK2_1	51	56	PF00069	0.674
MOD_NEK2_1	96	101	PF00069	0.549
MOD_PIKK_1	114	120	PF00454	0.519
MOD_PIKK_1	177	183	PF00454	0.613
MOD_PIKK_1	57	63	PF00454	0.611
MOD_PIKK_1	96	102	PF00454	0.450
MOD_PKA_1	318	324	PF00069	0.388
MOD_PKA_2	343	349	PF00069	0.752
MOD_PKA_2	506	512	PF00069	0.563
MOD_Plk_1	189	195	PF00069	0.706
MOD_Plk_1	96	102	PF00069	0.445
MOD_Plk_2-3	396	402	PF00069	0.306
MOD_Plk_2-3	448	454	PF00069	0.519
MOD_Plk_4	111	117	PF00069	0.533
MOD_Plk_4	148	154	PF00069	0.553
MOD_Plk_4	249	255	PF00069	0.774
MOD_Plk_4	51	57	PF00069	0.603
MOD_Plk_4	64	70	PF00069	0.666
MOD_Plk_4	87	93	PF00069	0.601
MOD_ProDKin_1	221	227	PF00069	0.544
MOD_ProDKin_1	253	259	PF00069	0.559
MOD_ProDKin_1	268	274	PF00069	0.659
MOD_ProDKin_1	31	37	PF00069	0.682
MOD_ProDKin_1	335	341	PF00069	0.691
MOD_ProDKin_1	68	74	PF00069	0.564
MOD_SUMO_for_1	436	439	PF00179	0.383
MOD_SUMO_rev_2	448	456	PF00179	0.491
TRG_DiLeu_BaEn_1	469	474	PF01217	0.479
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.480
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.402
TRG_DiLeu_LyEn_5	360	365	PF01217	0.560
TRG_ENDOCYTIC_2	150	153	PF00928	0.666
TRG_ENDOCYTIC_2	250	253	PF00928	0.711
TRG_ENDOCYTIC_2	302	305	PF00928	0.396
TRG_ENDOCYTIC_2	309	312	PF00928	0.364
TRG_ENDOCYTIC_2	317	320	PF00928	0.460
TRG_ENDOCYTIC_2	407	410	PF00928	0.428
TRG_ENDOCYTIC_2	486	489	PF00928	0.368
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J5	Leptomonas seymouri	40%	91%
A0A3Q8ICJ1	Leishmania donovani	81%	100%
A4HJB8	Leishmania braziliensis	59%	100%
A4HJX4	Leishmania braziliensis	56%	100%
A4I6R1	Leishmania infantum	81%	100%
Q4Q6C8	Leishmania major	81%	100%