CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

'Cold-shock' DNA-binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1T2_LEIMU

TriTrypDb:

LmxM.30.1340

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1T2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003677	DNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.597
CLV_C14_Caspase3-7	474	478	PF00656	0.498
CLV_NRD_NRD_1	237	239	PF00675	0.520
CLV_PCSK_KEX2_1	340	342	PF00082	0.433
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.433
CLV_PCSK_SKI1_1	319	323	PF00082	0.464
CLV_PCSK_SKI1_1	395	399	PF00082	0.357
DEG_COP1_1	269	280	PF00400	0.618
DEG_COP1_1	302	312	PF00400	0.453
DEG_Nend_Nbox_1	1	3	PF02207	0.574
DEG_SPOP_SBC_1	162	166	PF00917	0.693
DEG_SPOP_SBC_1	167	171	PF00917	0.638
DEG_SPOP_SBC_1	250	254	PF00917	0.611
DOC_MAPK_DCC_7	394	402	PF00069	0.350
DOC_MAPK_gen_1	238	245	PF00069	0.563
DOC_MAPK_gen_1	394	402	PF00069	0.465
DOC_PP1_RVXF_1	423	429	PF00149	0.477
DOC_PP2B_LxvP_1	281	284	PF13499	0.647
DOC_PP2B_LxvP_1	312	315	PF13499	0.590
DOC_PP2B_LxvP_1	78	81	PF13499	0.468
DOC_PP4_FxxP_1	307	310	PF00568	0.736
DOC_PP4_MxPP_1	259	262	PF00568	0.555
DOC_PP4_MxPP_1	450	453	PF00568	0.416
DOC_SPAK_OSR1_1	427	431	PF12202	0.503
DOC_USP7_MATH_1	250	254	PF00917	0.585
DOC_USP7_MATH_1	264	268	PF00917	0.677
DOC_USP7_MATH_1	284	288	PF00917	0.589
DOC_USP7_MATH_1	373	377	PF00917	0.579
DOC_USP7_MATH_1	57	61	PF00917	0.508
DOC_USP7_UBL2_3	391	395	PF12436	0.401
DOC_WW_Pin1_4	109	114	PF00397	0.770
DOC_WW_Pin1_4	137	142	PF00397	0.762
DOC_WW_Pin1_4	191	196	PF00397	0.654
DOC_WW_Pin1_4	214	219	PF00397	0.542
DOC_WW_Pin1_4	232	237	PF00397	0.495
DOC_WW_Pin1_4	302	307	PF00397	0.560
DOC_WW_Pin1_4	369	374	PF00397	0.692
DOC_WW_Pin1_4	395	400	PF00397	0.494
LIG_14-3-3_CanoR_1	319	325	PF00244	0.622
LIG_14-3-3_CanoR_1	76	81	PF00244	0.573
LIG_BRCT_BRCA1_1	303	307	PF00533	0.620
LIG_EVH1_1	314	318	PF00568	0.583
LIG_FHA_1	162	168	PF00498	0.511
LIG_FHA_1	229	235	PF00498	0.539
LIG_FHA_1	309	315	PF00498	0.488
LIG_FHA_1	352	358	PF00498	0.430
LIG_FHA_1	417	423	PF00498	0.499
LIG_FHA_2	242	248	PF00498	0.587
LIG_FHA_2	384	390	PF00498	0.606
LIG_LIR_Apic_2	254	260	PF02991	0.646
LIG_LIR_Apic_2	304	310	PF02991	0.673
LIG_LIR_Apic_2	51	57	PF02991	0.536
LIG_LIR_Nem_3	333	338	PF02991	0.393
LIG_LIR_Nem_3	415	420	PF02991	0.579
LIG_PCNA_PIPBox_1	328	337	PF02747	0.366
LIG_PCNA_yPIPBox_3	322	335	PF02747	0.515
LIG_SH2_CRK	257	261	PF00017	0.631
LIG_SH2_CRK	54	58	PF00017	0.585
LIG_SH2_CRK	6	10	PF00017	0.572
LIG_SH2_GRB2like	6	9	PF00017	0.600
LIG_SH2_NCK_1	257	261	PF00017	0.631
LIG_SH2_STAP1	505	509	PF00017	0.481
LIG_SH2_STAP1	522	526	PF00017	0.530
LIG_SH2_STAT5	280	283	PF00017	0.652
LIG_SH2_STAT5	54	57	PF00017	0.446
LIG_SH2_STAT5	69	72	PF00017	0.614
LIG_SH3_1	257	263	PF00018	0.621
LIG_SH3_2	317	322	PF14604	0.637
LIG_SH3_3	192	198	PF00018	0.728
LIG_SH3_3	201	207	PF00018	0.591
LIG_SH3_3	215	221	PF00018	0.578
LIG_SH3_3	22	28	PF00018	0.673
LIG_SH3_3	257	263	PF00018	0.666
LIG_SH3_3	307	313	PF00018	0.748
LIG_SH3_3	314	320	PF00018	0.615
LIG_SH3_3	477	483	PF00018	0.573
LIG_TRAF2_1	387	390	PF00917	0.463
LIG_WRC_WIRS_1	286	291	PF05994	0.592
LIG_WW_3	316	320	PF00397	0.574
MOD_CDK_SPxK_1	232	238	PF00069	0.501
MOD_CDK_SPxxK_3	232	239	PF00069	0.508
MOD_CK1_1	100	106	PF00069	0.691
MOD_CK1_1	154	160	PF00069	0.595
MOD_CK1_1	163	169	PF00069	0.669
MOD_CK1_1	228	234	PF00069	0.472
MOD_CK1_1	246	252	PF00069	0.618
MOD_CK1_1	253	259	PF00069	0.649
MOD_CK1_1	267	273	PF00069	0.591
MOD_CK1_1	276	282	PF00069	0.590
MOD_CK1_1	302	308	PF00069	0.663
MOD_CK1_1	33	39	PF00069	0.602
MOD_CK1_1	459	465	PF00069	0.611
MOD_CK1_1	60	66	PF00069	0.558
MOD_CK2_1	149	155	PF00069	0.683
MOD_CK2_1	383	389	PF00069	0.562
MOD_CK2_1	493	499	PF00069	0.481
MOD_GlcNHglycan	102	105	PF01048	0.617
MOD_GlcNHglycan	173	176	PF01048	0.805
MOD_GlcNHglycan	247	251	PF01048	0.652
MOD_GlcNHglycan	270	273	PF01048	0.752
MOD_GlcNHglycan	301	304	PF01048	0.698
MOD_GlcNHglycan	367	370	PF01048	0.615
MOD_GlcNHglycan	459	462	PF01048	0.570
MOD_GlcNHglycan	93	96	PF01048	0.619
MOD_GSK3_1	137	144	PF00069	0.689
MOD_GSK3_1	150	157	PF00069	0.546
MOD_GSK3_1	161	168	PF00069	0.580
MOD_GSK3_1	171	178	PF00069	0.715
MOD_GSK3_1	180	187	PF00069	0.574
MOD_GSK3_1	205	212	PF00069	0.794
MOD_GSK3_1	228	235	PF00069	0.601
MOD_GSK3_1	241	248	PF00069	0.628
MOD_GSK3_1	249	256	PF00069	0.607
MOD_GSK3_1	264	271	PF00069	0.690
MOD_GSK3_1	272	279	PF00069	0.623
MOD_GSK3_1	295	302	PF00069	0.634
MOD_GSK3_1	351	358	PF00069	0.506
MOD_GSK3_1	361	368	PF00069	0.514
MOD_GSK3_1	369	376	PF00069	0.672
MOD_GSK3_1	4	11	PF00069	0.710
MOD_GSK3_1	455	462	PF00069	0.534
MOD_GSK3_1	65	72	PF00069	0.774
MOD_N-GLC_1	184	189	PF02516	0.651
MOD_N-GLC_1	377	382	PF02516	0.614
MOD_NEK2_1	160	165	PF00069	0.737
MOD_NEK2_1	20	25	PF00069	0.678
MOD_NEK2_1	200	205	PF00069	0.543
MOD_NEK2_1	225	230	PF00069	0.504
MOD_NEK2_1	297	302	PF00069	0.645
MOD_NEK2_1	30	35	PF00069	0.565
MOD_NEK2_1	351	356	PF00069	0.423
MOD_NEK2_1	457	462	PF00069	0.606
MOD_NEK2_2	493	498	PF00069	0.477
MOD_PIKK_1	20	26	PF00454	0.511
MOD_PIKK_1	264	270	PF00454	0.693
MOD_PIKK_1	33	39	PF00454	0.602
MOD_PK_1	76	82	PF00069	0.475
MOD_Plk_1	60	66	PF00069	0.620
MOD_Plk_2-3	241	247	PF00069	0.608
MOD_Plk_2-3	486	492	PF00069	0.493
MOD_Plk_4	276	282	PF00069	0.654
MOD_Plk_4	355	361	PF00069	0.405
MOD_Plk_4	65	71	PF00069	0.608
MOD_ProDKin_1	109	115	PF00069	0.771
MOD_ProDKin_1	137	143	PF00069	0.761
MOD_ProDKin_1	191	197	PF00069	0.653
MOD_ProDKin_1	214	220	PF00069	0.537
MOD_ProDKin_1	232	238	PF00069	0.501
MOD_ProDKin_1	302	308	PF00069	0.564
MOD_ProDKin_1	369	375	PF00069	0.690
MOD_ProDKin_1	395	401	PF00069	0.498
MOD_SUMO_for_1	58	61	PF00179	0.576
MOD_SUMO_rev_2	511	517	PF00179	0.450
TRG_DiLeu_BaLyEn_6	513	518	PF01217	0.534
TRG_ENDOCYTIC_2	335	338	PF00928	0.427
TRG_ER_diArg_1	425	428	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	515	519	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P654	Leptomonas seymouri	40%	96%
A0A3S7X4H1	Leishmania donovani	84%	99%
A4HJB7	Leishmania braziliensis	62%	99%
A4I6R0	Leishmania infantum	84%	99%
Q4Q6C9	Leishmania major	83%	100%