MT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microtubule-binding stalk of dynein motor, putative

Species:

Leishmania mexicana

UniProt:

E9B1S4_LEIMU

TriTrypDb:

LmxM.30.1260

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005875	microtubule associated complex	2	12
GO:0030286	dynein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B1S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1S4

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035721	intraciliary retrograde transport	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008569	minus-end-directed microtubule motor activity	3	12
GO:0045505	dynein intermediate chain binding	3	12
GO:0051959	dynein light intermediate chain binding	3	12
GO:0140657	ATP-dependent activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.517
CLV_C14_Caspase3-7	462	466	PF00656	0.586
CLV_NRD_NRD_1	10	12	PF00675	0.783
CLV_NRD_NRD_1	113	115	PF00675	0.376
CLV_NRD_NRD_1	229	231	PF00675	0.336
CLV_NRD_NRD_1	297	299	PF00675	0.600
CLV_NRD_NRD_1	596	598	PF00675	0.611
CLV_NRD_NRD_1	620	622	PF00675	0.619
CLV_PCSK_FUR_1	295	299	PF00082	0.600
CLV_PCSK_FUR_1	310	314	PF00082	0.568
CLV_PCSK_KEX2_1	105	107	PF00082	0.522
CLV_PCSK_KEX2_1	213	215	PF00082	0.323
CLV_PCSK_KEX2_1	228	230	PF00082	0.341
CLV_PCSK_KEX2_1	297	299	PF00082	0.592
CLV_PCSK_KEX2_1	312	314	PF00082	0.689
CLV_PCSK_KEX2_1	596	598	PF00082	0.340
CLV_PCSK_KEX2_1	620	622	PF00082	0.512
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.592
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.338
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.689
CLV_PCSK_PC7_1	209	215	PF00082	0.362
CLV_PCSK_PC7_1	616	622	PF00082	0.514
CLV_PCSK_SKI1_1	105	109	PF00082	0.587
CLV_PCSK_SKI1_1	126	130	PF00082	0.587
CLV_PCSK_SKI1_1	182	186	PF00082	0.358
CLV_PCSK_SKI1_1	209	213	PF00082	0.363
CLV_PCSK_SKI1_1	392	396	PF00082	0.576
CLV_PCSK_SKI1_1	422	426	PF00082	0.558
CLV_PCSK_SKI1_1	453	457	PF00082	0.601
CLV_PCSK_SKI1_1	467	471	PF00082	0.535
DEG_APCC_DBOX_1	208	216	PF00400	0.581
DOC_PP1_RVXF_1	193	200	PF00149	0.524
DOC_USP7_MATH_1	340	344	PF00917	0.634
DOC_USP7_UBL2_3	285	289	PF12436	0.617
DOC_USP7_UBL2_3	422	426	PF12436	0.464
DOC_USP7_UBL2_3	437	441	PF12436	0.582
DOC_USP7_UBL2_3	537	541	PF12436	0.785
DOC_WW_Pin1_4	12	17	PF00397	0.682
DOC_WW_Pin1_4	221	226	PF00397	0.425
DOC_WW_Pin1_4	315	320	PF00397	0.708
DOC_WW_Pin1_4	332	337	PF00397	0.750
DOC_WW_Pin1_4	347	352	PF00397	0.825
DOC_WW_Pin1_4	361	366	PF00397	0.829
DOC_WW_Pin1_4	411	416	PF00397	0.599
DOC_WW_Pin1_4	6	11	PF00397	0.717
LIG_14-3-3_CanoR_1	207	212	PF00244	0.521
LIG_14-3-3_CanoR_1	240	247	PF00244	0.504
LIG_14-3-3_CanoR_1	41	45	PF00244	0.536
LIG_Actin_WH2_2	189	206	PF00022	0.454
LIG_Actin_WH2_2	406	424	PF00022	0.629
LIG_APCC_ABBAyCdc20_2	428	434	PF00400	0.581
LIG_BIR_III_2	7	11	PF00653	0.516
LIG_Clathr_ClatBox_1	47	51	PF01394	0.521
LIG_CSL_BTD_1	348	351	PF09270	0.635
LIG_FHA_1	15	21	PF00498	0.747
LIG_FHA_1	498	504	PF00498	0.691
LIG_FHA_2	125	131	PF00498	0.315
LIG_FHA_2	189	195	PF00498	0.562
LIG_FHA_2	240	246	PF00498	0.501
LIG_LIR_Apic_2	173	177	PF02991	0.519
LIG_LIR_Gen_1	198	206	PF02991	0.488
LIG_LIR_Nem_3	165	171	PF02991	0.490
LIG_LIR_Nem_3	198	202	PF02991	0.479
LIG_PTB_Apo_2	235	242	PF02174	0.501
LIG_SH2_NCK_1	379	383	PF00017	0.624
LIG_SH2_NCK_1	403	407	PF00017	0.559
LIG_SH2_PTP2	174	177	PF00017	0.562
LIG_SH2_SRC	403	406	PF00017	0.551
LIG_SH2_STAP1	142	146	PF00017	0.544
LIG_SH2_STAT5	174	177	PF00017	0.562
LIG_SH2_STAT5	201	204	PF00017	0.541
LIG_SH2_STAT5	235	238	PF00017	0.490
LIG_SH2_STAT5	52	55	PF00017	0.516
LIG_SH2_STAT5	622	625	PF00017	0.639
LIG_SH3_1	366	372	PF00018	0.794
LIG_SH3_2	13	18	PF14604	0.767
LIG_SH3_3	172	178	PF00018	0.537
LIG_SH3_3	366	372	PF00018	0.794
LIG_SH3_3	500	506	PF00018	0.708
LIG_SH3_3	7	13	PF00018	0.729
LIG_SH3_4	537	544	PF00018	0.733
LIG_SUMO_SIM_par_1	188	194	PF11976	0.507
LIG_SUMO_SIM_par_1	408	414	PF11976	0.666
LIG_TRAF2_1	117	120	PF00917	0.598
LIG_TRAF2_1	156	159	PF00917	0.581
LIG_TRFH_1	235	239	PF08558	0.525
LIG_UBA3_1	584	590	PF00899	0.620
MOD_CDC14_SPxK_1	15	18	PF00782	0.771
MOD_CDC14_SPxK_1	318	321	PF00782	0.564
MOD_CDC14_SPxK_1	9	12	PF00782	0.787
MOD_CDK_SPK_2	347	352	PF00069	0.825
MOD_CDK_SPK_2	361	366	PF00069	0.829
MOD_CDK_SPK_2	6	11	PF00069	0.777
MOD_CDK_SPxK_1	315	321	PF00069	0.537
MOD_CDK_SPxK_1	6	12	PF00069	0.793
MOD_CDK_SPxxK_3	221	228	PF00069	0.454
MOD_CDK_SPxxK_3	361	368	PF00069	0.822
MOD_CK1_1	14	20	PF00069	0.765
MOD_CK1_1	224	230	PF00069	0.465
MOD_CK1_1	267	273	PF00069	0.427
MOD_CK2_1	124	130	PF00069	0.466
MOD_CK2_1	188	194	PF00069	0.539
MOD_CK2_1	81	87	PF00069	0.585
MOD_Cter_Amidation	542	545	PF01082	0.735
MOD_GlcNHglycan	343	346	PF01048	0.767
MOD_GlcNHglycan	83	86	PF01048	0.639
MOD_GSK3_1	19	26	PF00069	0.694
MOD_GSK3_1	217	224	PF00069	0.580
MOD_GSK3_1	239	246	PF00069	0.555
MOD_GSK3_1	263	270	PF00069	0.420
MOD_GSK3_1	332	339	PF00069	0.762
MOD_GSK3_1	377	384	PF00069	0.626
MOD_GSK3_1	405	412	PF00069	0.610
MOD_GSK3_1	561	568	PF00069	0.680
MOD_N-GLC_1	124	129	PF02516	0.540
MOD_N-GLC_1	560	565	PF02516	0.773
MOD_NEK2_1	124	129	PF00069	0.547
MOD_NEK2_1	188	193	PF00069	0.549
MOD_NEK2_1	247	252	PF00069	0.487
MOD_NEK2_1	290	295	PF00069	0.591
MOD_NEK2_1	395	400	PF00069	0.487
MOD_NEK2_1	497	502	PF00069	0.646
MOD_NEK2_1	565	570	PF00069	0.673
MOD_NEK2_1	79	84	PF00069	0.479
MOD_PIKK_1	217	223	PF00454	0.568
MOD_PK_1	33	39	PF00069	0.583
MOD_PKA_1	11	17	PF00069	0.734
MOD_PKA_1	596	602	PF00069	0.324
MOD_PKA_2	239	245	PF00069	0.504
MOD_PKA_2	40	46	PF00069	0.527
MOD_PKA_2	596	602	PF00069	0.474
MOD_Plk_1	124	130	PF00069	0.544
MOD_Plk_1	267	273	PF00069	0.454
MOD_Plk_1	290	296	PF00069	0.586
MOD_Plk_1	306	312	PF00069	0.640
MOD_Plk_4	26	32	PF00069	0.683
MOD_Plk_4	381	387	PF00069	0.660
MOD_Plk_4	395	401	PF00069	0.480
MOD_Plk_4	406	412	PF00069	0.596
MOD_ProDKin_1	221	227	PF00069	0.425
MOD_ProDKin_1	315	321	PF00069	0.716
MOD_ProDKin_1	332	338	PF00069	0.749
MOD_ProDKin_1	347	353	PF00069	0.825
MOD_ProDKin_1	361	367	PF00069	0.827
MOD_ProDKin_1	411	417	PF00069	0.594
MOD_ProDKin_1	6	12	PF00069	0.718
MOD_SUMO_for_1	156	159	PF00179	0.373
MOD_SUMO_rev_2	277	287	PF00179	0.525
MOD_SUMO_rev_2	389	394	PF00179	0.618
MOD_SUMO_rev_2	434	442	PF00179	0.613
MOD_SUMO_rev_2	462	469	PF00179	0.600
MOD_SUMO_rev_2	481	490	PF00179	0.610
MOD_SUMO_rev_2	530	538	PF00179	0.690
TRG_DiLeu_BaEn_1	521	526	PF01217	0.625
TRG_DiLeu_BaEn_1	600	605	PF01217	0.331
TRG_DiLeu_BaEn_4	119	125	PF01217	0.613
TRG_ER_diArg_1	206	209	PF00400	0.523
TRG_ER_diArg_1	228	230	PF00400	0.586
TRG_ER_diArg_1	294	297	PF00400	0.626
TRG_ER_diArg_1	365	368	PF00400	0.817
TRG_ER_diArg_1	595	597	PF00400	0.326
TRG_ER_diArg_1	619	621	PF00400	0.564
TRG_NES_CRM1_1	179	194	PF08389	0.581
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.707
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ8	Leptomonas seymouri	24%	67%
A0A0N1PDQ0	Leptomonas seymouri	55%	100%
A0A1X0NQ11	Trypanosomatidae	37%	74%
A0A3S7X4D8	Leishmania donovani	90%	100%
A0A422NZ91	Trypanosoma rangeli	36%	77%
A4HJA9	Leishmania braziliensis	72%	99%
A4I6Q2	Leishmania infantum	90%	100%
C9ZWT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	74%
Q4Q6D7	Leishmania major	89%	100%
V5DGE3	Trypanosoma cruzi	34%	78%