Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1R8_LEIMU

TriTrypDb:

LmxM.30.1200

Length:

135

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9B1R8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1R8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0020037	heme binding	4	2
GO:0046906	tetrapyrrole binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.352
CLV_NRD_NRD_1	129	131	PF00675	0.677
CLV_NRD_NRD_1	83	85	PF00675	0.375
CLV_NRD_NRD_1	96	98	PF00675	0.354
CLV_PCSK_KEX2_1	103	105	PF00082	0.396
CLV_PCSK_KEX2_1	129	131	PF00082	0.575
CLV_PCSK_KEX2_1	96	98	PF00082	0.441
CLV_PCSK_SKI1_1	84	88	PF00082	0.362
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.519
DOC_MAPK_MEF2A_6	14	22	PF00069	0.588
DOC_PP2B_LxvP_1	18	21	PF13499	0.510
LIG_14-3-3_CanoR_1	106	112	PF00244	0.474
LIG_14-3-3_CanoR_1	14	19	PF00244	0.470
LIG_14-3-3_CanoR_1	96	105	PF00244	0.650
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_eIF4E_1	13	19	PF01652	0.522
LIG_FHA_1	107	113	PF00498	0.465
LIG_FHA_2	61	67	PF00498	0.454
LIG_LIR_Gen_1	5	16	PF02991	0.519
LIG_LIR_LC3C_4	17	20	PF02991	0.482
LIG_LIR_Nem_3	5	11	PF02991	0.535
LIG_LIR_Nem_3	71	76	PF02991	0.584
LIG_SH2_GRB2like	39	42	PF00017	0.466
LIG_SH2_NCK_1	77	81	PF00017	0.533
LIG_SH2_PTP2	8	11	PF00017	0.503
LIG_SH2_STAT3	35	38	PF00017	0.454
LIG_SH2_STAT3	39	42	PF00017	0.454
LIG_SH2_STAT5	35	38	PF00017	0.454
LIG_SH2_STAT5	8	11	PF00017	0.518
LIG_WRC_WIRS_1	61	66	PF05994	0.278
MOD_CK2_1	43	49	PF00069	0.272
MOD_CK2_1	60	66	PF00069	0.423
MOD_CK2_1	88	94	PF00069	0.457
MOD_GlcNHglycan	45	48	PF01048	0.305
MOD_GSK3_1	106	113	PF00069	0.293
MOD_N-GLC_1	51	56	PF02516	0.388
MOD_NEK2_1	60	65	PF00069	0.277
MOD_PKA_1	96	102	PF00069	0.496
MOD_PKA_2	107	113	PF00069	0.353
MOD_PKA_2	96	102	PF00069	0.505
MOD_PKB_1	104	112	PF00069	0.425
MOD_Plk_1	4	10	PF00069	0.337
MOD_Plk_4	107	113	PF00069	0.396
MOD_Plk_4	14	20	PF00069	0.387
MOD_Plk_4	4	10	PF00069	0.556
TRG_ENDOCYTIC_2	8	11	PF00928	0.347
TRG_ER_diArg_1	102	104	PF00400	0.468
TRG_ER_diArg_1	105	108	PF00400	0.463
TRG_ER_diArg_1	128	130	PF00400	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3U0	Leptomonas seymouri	54%	100%
A0A3Q8ICI2	Leishmania donovani	32%	89%
A0A3Q8IG43	Leishmania donovani	93%	100%
A0A3S7WPP2	Leishmania donovani	29%	100%
A4HJ98	Leishmania braziliensis	32%	92%
A4HJA1	Leishmania braziliensis	82%	98%
A4HT20	Leishmania infantum	28%	100%
A4I6P3	Leishmania infantum	32%	89%
A4I6P6	Leishmania infantum	93%	100%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	97%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	97%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	93%
Q4Q6E3	Leishmania major	93%	99%
Q4Q6E6	Leishmania major	32%	90%