Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1R6_LEIMU

TriTrypDb:

LmxM.30.1180

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B1R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1R6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.514
CLV_C14_Caspase3-7	61	65	PF00656	0.475
CLV_PCSK_KEX2_1	155	157	PF00082	0.629
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.629
CLV_PCSK_SKI1_1	40	44	PF00082	0.462
CLV_PCSK_SKI1_1	8	12	PF00082	0.339
DEG_SIAH_1	97	105	PF03145	0.584
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.313
DOC_MAPK_MEF2A_6	126	135	PF00069	0.613
DOC_PP2B_LxvP_1	133	136	PF13499	0.313
DOC_PP4_FxxP_1	69	72	PF00568	0.554
DOC_USP7_MATH_1	111	115	PF00917	0.685
DOC_USP7_MATH_1	28	32	PF00917	0.587
DOC_USP7_MATH_1	49	53	PF00917	0.680
DOC_USP7_MATH_1	73	77	PF00917	0.627
DOC_USP7_MATH_1	93	97	PF00917	0.610
DOC_WW_Pin1_4	100	105	PF00397	0.628
LIG_14-3-3_CanoR_1	12	17	PF00244	0.467
LIG_Actin_WH2_2	139	154	PF00022	0.217
LIG_APCC_ABBA_1	34	39	PF00400	0.574
LIG_BRCT_BRCA1_1	144	148	PF00533	0.219
LIG_deltaCOP1_diTrp_1	60	69	PF00928	0.526
LIG_FHA_1	101	107	PF00498	0.666
LIG_FHA_2	122	128	PF00498	0.668
LIG_LIR_Apic_2	15	19	PF02991	0.559
LIG_LIR_Apic_2	66	72	PF02991	0.539
LIG_LIR_Gen_1	145	153	PF02991	0.264
LIG_LIR_Nem_3	145	151	PF02991	0.219
LIG_NRP_CendR_1	155	157	PF00754	0.654
LIG_REV1ctd_RIR_1	7	16	PF16727	0.537
LIG_SH2_SRC	16	19	PF00017	0.539
LIG_SH2_SRC	22	25	PF00017	0.550
LIG_SH2_STAT5	150	153	PF00017	0.510
LIG_SH2_STAT5	16	19	PF00017	0.569
LIG_SH2_STAT5	22	25	PF00017	0.568
LIG_SH2_STAT5	37	40	PF00017	0.547
LIG_SH3_3	101	107	PF00018	0.610
LIG_SH3_3	125	131	PF00018	0.619
LIG_SH3_3	69	75	PF00018	0.623
LIG_TRAF2_1	81	84	PF00917	0.704
MOD_CK2_1	121	127	PF00069	0.697
MOD_CK2_1	88	94	PF00069	0.620
MOD_GlcNHglycan	113	116	PF01048	0.408
MOD_GlcNHglycan	74	78	PF01048	0.456
MOD_GSK3_1	117	124	PF00069	0.676
MOD_NEK2_1	142	147	PF00069	0.348
MOD_NEK2_1	151	156	PF00069	0.398
MOD_PKA_2	151	157	PF00069	0.355
MOD_Plk_1	49	55	PF00069	0.598
MOD_Plk_1	93	99	PF00069	0.590
MOD_Plk_4	12	18	PF00069	0.578
MOD_ProDKin_1	100	106	PF00069	0.626
MOD_SUMO_rev_2	84	89	PF00179	0.625
TRG_ENDOCYTIC_2	150	153	PF00928	0.545
TRG_ENDOCYTIC_2	7	10	PF00928	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X4E5	Leishmania donovani	76%	97%
A4HJ97	Leishmania braziliensis	38%	100%
A4HJ98	Leishmania braziliensis	41%	100%
A4HJ99	Leishmania braziliensis	64%	100%
A4I6P4	Leishmania infantum	76%	97%
Q4Q6E5	Leishmania major	79%	100%