LeishMANIAdb
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Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cytochrome b5 heme-binding domain-containing protein
Gene product:
cytochrome b5-like Heme/Steroid binding domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9B1R5_LEIMU
TriTrypDb:
LmxM.30.1170
Length:
112

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 3
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 3
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Expansion

Sequence features

E9B1R5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1R5

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0005488 binding 1 3
GO:0020037 heme binding 4 3
GO:0046906 tetrapyrrole binding 3 3
GO:0097159 organic cyclic compound binding 2 3
GO:1901363 heterocyclic compound binding 2 3
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 108 110 PF00675 0.560
CLV_PCSK_KEX2_1 76 78 PF00082 0.357
CLV_PCSK_PC1ET2_1 76 78 PF00082 0.374
CLV_PCSK_SKI1_1 31 35 PF00082 0.255
CLV_PCSK_SKI1_1 40 44 PF00082 0.258
DOC_MAPK_gen_1 89 97 PF00069 0.447
DOC_USP7_MATH_1 3 7 PF00917 0.607
DOC_USP7_MATH_1 49 53 PF00917 0.508
DOC_USP7_MATH_1 64 68 PF00917 0.509
LIG_14-3-3_CanoR_1 89 99 PF00244 0.422
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HX76 Leptomonas seymouri 35% 79%
A0A0N1I3U0 Leptomonas seymouri 31% 84%
A0A0N1IH82 Leptomonas seymouri 75% 100%
A0A3Q8ICI2 Leishmania donovani 96% 100%
A0A3Q8IG43 Leishmania donovani 35% 84%
A0A3Q8IGB7 Leishmania donovani 36% 86%
A0A3Q8ILC3 Leishmania donovani 35% 91%
A0A3S7WPP2 Leishmania donovani 37% 91%
A0A3S7X4C9 Leishmania donovani 29% 93%
A4H4U1 Leishmania braziliensis 42% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS