Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1R5_LEIMU

TriTrypDb:

LmxM.30.1170

Length:

112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9B1R5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1R5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0020037	heme binding	4	3
GO:0046906	tetrapyrrole binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.560
CLV_PCSK_KEX2_1	76	78	PF00082	0.357
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.374
CLV_PCSK_SKI1_1	31	35	PF00082	0.255
CLV_PCSK_SKI1_1	40	44	PF00082	0.258
DOC_MAPK_gen_1	89	97	PF00069	0.447
DOC_USP7_MATH_1	3	7	PF00917	0.607
DOC_USP7_MATH_1	49	53	PF00917	0.508
DOC_USP7_MATH_1	64	68	PF00917	0.509
LIG_14-3-3_CanoR_1	89	99	PF00244	0.422
LIG_14-3-3_CterR_2	109	112	PF00244	0.350
LIG_Actin_WH2_2	95	111	PF00022	0.272
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BRCT_BRCA1_1	5	9	PF00533	0.496
LIG_deltaCOP1_diTrp_1	84	90	PF00928	0.540
LIG_TRAF2_1	45	48	PF00917	0.418
LIG_UBA3_1	34	40	PF00899	0.437
MOD_CK1_1	21	27	PF00069	0.391
MOD_CK2_1	64	70	PF00069	0.543
MOD_GlcNHglycan	1	4	PF01048	0.368
MOD_GlcNHglycan	65	69	PF01048	0.348
MOD_NEK2_2	3	8	PF00069	0.507
MOD_PKA_2	90	96	PF00069	0.419
MOD_Plk_4	18	24	PF00069	0.439
TRG_DiLeu_BaEn_1	70	75	PF01217	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX76	Leptomonas seymouri	35%	79%
A0A0N1I3U0	Leptomonas seymouri	31%	84%
A0A0N1IH82	Leptomonas seymouri	75%	100%
A0A3Q8ICI2	Leishmania donovani	96%	100%
A0A3Q8IG43	Leishmania donovani	35%	84%
A0A3Q8IGB7	Leishmania donovani	36%	86%
A0A3Q8ILC3	Leishmania donovani	35%	91%
A0A3S7WPP2	Leishmania donovani	37%	91%
A0A3S7X4C9	Leishmania donovani	29%	93%
A4H4U1	Leishmania braziliensis	42%	100%
A4HJ97	Leishmania braziliensis	31%	93%
A4HJ98	Leishmania braziliensis	86%	100%
A4HJA0	Leishmania braziliensis	36%	86%
A4HT20	Leishmania infantum	39%	91%
A4I6P2	Leishmania infantum	29%	93%
A4I6P3	Leishmania infantum	96%	100%
A4I6P5	Leishmania infantum	37%	86%
A4I6P6	Leishmania infantum	34%	84%
E9ACS1	Leishmania major	37%	100%
E9AGY1	Leishmania infantum	35%	91%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	93%
E9B1R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	86%
E9B1R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	83%
P49096	Musca domestica	36%	84%
Q4Q6E3	Leishmania major	33%	100%
Q4Q6E4	Leishmania major	38%	86%
Q4Q6E6	Leishmania major	95%	100%
Q4QIU6	Leishmania major	38%	100%
Q9HFV1	Rhizopus stolonifer	38%	85%