Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9B1R4_LEIMU

TriTrypDb:

LmxM.30.1165

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

E9B1R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1R4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0020037	heme binding	4	3
GO:0046906	tetrapyrrole binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	73	75	PF00675	0.407
CLV_PCSK_KEX2_1	73	75	PF00082	0.422
CLV_PCSK_SKI1_1	73	77	PF00082	0.405
DOC_MAPK_MEF2A_6	52	60	PF00069	0.418
DOC_USP7_MATH_1	108	112	PF00917	0.264
DOC_USP7_MATH_1	51	55	PF00917	0.547
DOC_WW_Pin1_4	65	70	PF00397	0.522
DOC_WW_Pin1_4	73	78	PF00397	0.588
LIG_14-3-3_CanoR_1	52	60	PF00244	0.435
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BRCT_BRCA1_1	15	19	PF00533	0.491
LIG_FHA_1	111	117	PF00498	0.278
LIG_LIR_Apic_2	16	21	PF02991	0.532
LIG_LIR_Nem_3	16	22	PF02991	0.466
LIG_MLH1_MIPbox_1	15	19	PF16413	0.459
LIG_NRP_CendR_1	119	120	PF00754	0.588
LIG_PTB_Apo_2	12	19	PF02174	0.483
LIG_PTB_Phospho_1	12	18	PF10480	0.483
LIG_SH2_GRB2like	39	42	PF00017	0.486
LIG_SH2_STAT3	39	42	PF00017	0.437
LIG_SH2_STAT5	18	21	PF00017	0.478
LIG_SH2_STAT5	39	42	PF00017	0.437
LIG_SH3_2	69	74	PF14604	0.590
LIG_SH3_3	66	72	PF00018	0.571
MOD_GlcNHglycan	77	80	PF01048	0.510
MOD_GSK3_1	75	82	PF00069	0.675
MOD_GSK3_1	9	16	PF00069	0.500
MOD_PIKK_1	42	48	PF00454	0.495
MOD_PKA_2	51	57	PF00069	0.433
MOD_ProDKin_1	65	71	PF00069	0.525
MOD_ProDKin_1	73	79	PF00069	0.588
TRG_ER_diArg_1	72	74	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.236

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICI2	Leishmania donovani	31%	100%
A0A3Q8IGB7	Leishmania donovani	32%	92%
A0A3S7WPP2	Leishmania donovani	32%	98%
A0A3S7X4C9	Leishmania donovani	87%	99%
A4H4U1	Leishmania braziliensis	32%	100%
A4HJ97	Leishmania braziliensis	74%	100%
A4HJ98	Leishmania braziliensis	32%	100%
A4HJA2	Leishmania braziliensis	39%	100%
A4HT20	Leishmania infantum	32%	98%
A4I6P2	Leishmania infantum	87%	99%
A4I6P3	Leishmania infantum	31%	100%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4Q6E4	Leishmania major	35%	100%
Q4Q6E6	Leishmania major	31%	100%
Q4QIU6	Leishmania major	30%	100%