Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1R3_LEIMU

TriTrypDb:

LmxM.30.1160

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005856	cytoskeleton	5	1
GO:0015630	microtubule cytoskeleton	6	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9B1R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1R3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.396
CLV_C14_Caspase3-7	480	484	PF00656	0.364
CLV_NRD_NRD_1	186	188	PF00675	0.479
CLV_NRD_NRD_1	22	24	PF00675	0.575
CLV_NRD_NRD_1	291	293	PF00675	0.471
CLV_NRD_NRD_1	339	341	PF00675	0.468
CLV_NRD_NRD_1	559	561	PF00675	0.675
CLV_PCSK_FUR_1	557	561	PF00082	0.508
CLV_PCSK_KEX2_1	129	131	PF00082	0.518
CLV_PCSK_KEX2_1	22	24	PF00082	0.610
CLV_PCSK_KEX2_1	291	293	PF00082	0.405
CLV_PCSK_KEX2_1	339	341	PF00082	0.364
CLV_PCSK_KEX2_1	557	559	PF00082	0.640
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.518
CLV_PCSK_SKI1_1	113	117	PF00082	0.517
CLV_PCSK_SKI1_1	120	124	PF00082	0.440
CLV_PCSK_SKI1_1	233	237	PF00082	0.449
CLV_PCSK_SKI1_1	291	295	PF00082	0.376
CLV_PCSK_SKI1_1	412	416	PF00082	0.469
CLV_PCSK_SKI1_1	457	461	PF00082	0.460
CLV_Separin_Metazoa	608	612	PF03568	0.326
DEG_APCC_DBOX_1	411	419	PF00400	0.394
DEG_APCC_DBOX_1	610	618	PF00400	0.428
DOC_CDC14_PxL_1	215	223	PF14671	0.377
DOC_CDC14_PxL_1	413	421	PF14671	0.559
DOC_CKS1_1	182	187	PF01111	0.410
DOC_CKS1_1	38	43	PF01111	0.573
DOC_MAPK_gen_1	520	529	PF00069	0.395
DOC_MAPK_gen_1	557	566	PF00069	0.442
DOC_MAPK_gen_1	73	80	PF00069	0.647
DOC_MAPK_MEF2A_6	120	128	PF00069	0.593
DOC_MAPK_MEF2A_6	299	307	PF00069	0.296
DOC_PP1_RVXF_1	103	110	PF00149	0.448
DOC_PP2B_LxvP_1	214	217	PF13499	0.390
DOC_USP7_MATH_1	17	21	PF00917	0.494
DOC_USP7_MATH_1	2	6	PF00917	0.573
DOC_USP7_MATH_1	217	221	PF00917	0.388
DOC_USP7_MATH_1	234	238	PF00917	0.349
DOC_USP7_MATH_1	426	430	PF00917	0.450
DOC_USP7_MATH_1	532	536	PF00917	0.377
DOC_USP7_MATH_1	68	72	PF00917	0.592
DOC_USP7_UBL2_3	188	192	PF12436	0.435
DOC_WW_Pin1_4	181	186	PF00397	0.384
DOC_WW_Pin1_4	37	42	PF00397	0.680
DOC_WW_Pin1_4	422	427	PF00397	0.443
DOC_WW_Pin1_4	468	473	PF00397	0.354
LIG_14-3-3_CanoR_1	113	122	PF00244	0.554
LIG_14-3-3_CanoR_1	130	138	PF00244	0.462
LIG_14-3-3_CanoR_1	22	26	PF00244	0.743
LIG_14-3-3_CanoR_1	254	259	PF00244	0.463
LIG_14-3-3_CanoR_1	274	281	PF00244	0.473
LIG_14-3-3_CanoR_1	284	293	PF00244	0.426
LIG_14-3-3_CanoR_1	30	39	PF00244	0.579
LIG_14-3-3_CanoR_1	339	344	PF00244	0.354
LIG_14-3-3_CanoR_1	457	462	PF00244	0.561
LIG_14-3-3_CanoR_1	511	518	PF00244	0.398
LIG_14-3-3_CanoR_1	520	525	PF00244	0.382
LIG_14-3-3_CanoR_1	558	566	PF00244	0.564
LIG_14-3-3_CanoR_1	591	597	PF00244	0.589
LIG_14-3-3_CanoR_1	73	82	PF00244	0.422
LIG_Actin_WH2_2	234	250	PF00022	0.286
LIG_Actin_WH2_2	260	276	PF00022	0.339
LIG_Actin_WH2_2	463	480	PF00022	0.492
LIG_Actin_WH2_2	497	515	PF00022	0.408
LIG_APCC_ABBA_1	78	83	PF00400	0.364
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BIR_III_4	282	286	PF00653	0.360
LIG_BRCT_BRCA1_1	374	378	PF00533	0.503
LIG_CtBP_PxDLS_1	137	141	PF00389	0.465
LIG_DLG_GKlike_1	254	261	PF00625	0.413
LIG_EVH1_2	152	156	PF00568	0.452
LIG_FHA_1	11	17	PF00498	0.570
LIG_FHA_1	121	127	PF00498	0.441
LIG_FHA_1	209	215	PF00498	0.353
LIG_FHA_1	32	38	PF00498	0.598
LIG_FHA_2	145	151	PF00498	0.471
LIG_FHA_2	191	197	PF00498	0.588
LIG_FHA_2	200	206	PF00498	0.448
LIG_FHA_2	234	240	PF00498	0.385
LIG_FHA_2	458	464	PF00498	0.467
LIG_FHA_2	478	484	PF00498	0.220
LIG_FHA_2	545	551	PF00498	0.513
LIG_LIR_Gen_1	205	215	PF02991	0.442
LIG_LIR_Gen_1	351	361	PF02991	0.355
LIG_LIR_Gen_1	428	438	PF02991	0.453
LIG_LIR_Gen_1	87	96	PF02991	0.444
LIG_LIR_Nem_3	205	210	PF02991	0.435
LIG_LIR_Nem_3	211	216	PF02991	0.368
LIG_LIR_Nem_3	297	303	PF02991	0.344
LIG_LIR_Nem_3	312	316	PF02991	0.426
LIG_LIR_Nem_3	320	326	PF02991	0.511
LIG_LIR_Nem_3	428	433	PF02991	0.431
LIG_LIR_Nem_3	483	489	PF02991	0.370
LIG_LIR_Nem_3	500	506	PF02991	0.294
LIG_LIR_Nem_3	87	93	PF02991	0.611
LIG_LYPXL_S_1	415	419	PF13949	0.478
LIG_LYPXL_yS_3	416	419	PF13949	0.476
LIG_NRBOX	565	571	PF00104	0.404
LIG_SH2_CRK	323	327	PF00017	0.389
LIG_SH2_CRK	90	94	PF00017	0.453
LIG_SH2_GRB2like	503	506	PF00017	0.356
LIG_SH2_PTP2	503	506	PF00017	0.356
LIG_SH2_STAP1	57	61	PF00017	0.625
LIG_SH2_STAT5	39	42	PF00017	0.575
LIG_SH2_STAT5	503	506	PF00017	0.356
LIG_SH2_STAT5	539	542	PF00017	0.298
LIG_SH2_STAT5	79	82	PF00017	0.523
LIG_SH3_3	379	385	PF00018	0.479
LIG_SH3_3	38	44	PF00018	0.573
LIG_SUMO_SIM_anti_2	222	228	PF11976	0.379
LIG_SUMO_SIM_par_1	136	143	PF11976	0.518
LIG_SUMO_SIM_par_1	440	447	PF11976	0.493
LIG_SUMO_SIM_par_1	568	573	PF11976	0.514
LIG_TRAF2_1	547	550	PF00917	0.445
LIG_TRAF2_1	96	99	PF00917	0.472
LIG_TRAF2_2	167	172	PF00917	0.446
LIG_TYR_ITIM	414	419	PF00017	0.494
LIG_TYR_ITIM	501	506	PF00017	0.364
LIG_UBA3_1	197	206	PF00899	0.397
LIG_UBA3_1	241	248	PF00899	0.458
LIG_WRC_WIRS_1	207	212	PF05994	0.374
MOD_CDK_SPxK_1	181	187	PF00069	0.400
MOD_CDK_SPxxK_3	181	188	PF00069	0.410
MOD_CK1_1	139	145	PF00069	0.592
MOD_CK1_1	21	27	PF00069	0.548
MOD_CK1_1	220	226	PF00069	0.460
MOD_CK1_1	237	243	PF00069	0.451
MOD_CK1_1	257	263	PF00069	0.458
MOD_CK1_1	425	431	PF00069	0.560
MOD_CK1_1	442	448	PF00069	0.445
MOD_CK1_1	568	574	PF00069	0.721
MOD_CK2_1	144	150	PF00069	0.529
MOD_CK2_1	190	196	PF00069	0.434
MOD_CK2_1	199	205	PF00069	0.334
MOD_CK2_1	233	239	PF00069	0.561
MOD_CK2_1	428	434	PF00069	0.417
MOD_CK2_1	457	463	PF00069	0.475
MOD_CK2_1	520	526	PF00069	0.546
MOD_CK2_1	544	550	PF00069	0.556
MOD_CK2_1	91	97	PF00069	0.430
MOD_GlcNHglycan	13	16	PF01048	0.602
MOD_GlcNHglycan	142	145	PF01048	0.605
MOD_GlcNHglycan	244	247	PF01048	0.449
MOD_GlcNHglycan	287	290	PF01048	0.540
MOD_GlcNHglycan	323	326	PF01048	0.483
MOD_GlcNHglycan	357	361	PF01048	0.583
MOD_GlcNHglycan	394	397	PF01048	0.611
MOD_GlcNHglycan	4	7	PF01048	0.631
MOD_GlcNHglycan	405	409	PF01048	0.503
MOD_GlcNHglycan	446	449	PF01048	0.489
MOD_GlcNHglycan	486	489	PF01048	0.462
MOD_GlcNHglycan	528	532	PF01048	0.367
MOD_GlcNHglycan	549	553	PF01048	0.492
MOD_GlcNHglycan	572	575	PF01048	0.625
MOD_GlcNHglycan	93	96	PF01048	0.526
MOD_GSK3_1	109	116	PF00069	0.667
MOD_GSK3_1	136	143	PF00069	0.568
MOD_GSK3_1	17	24	PF00069	0.617
MOD_GSK3_1	173	180	PF00069	0.475
MOD_GSK3_1	233	240	PF00069	0.455
MOD_GSK3_1	250	257	PF00069	0.321
MOD_GSK3_1	369	376	PF00069	0.499
MOD_GSK3_1	390	397	PF00069	0.523
MOD_GSK3_1	400	407	PF00069	0.554
MOD_GSK3_1	418	425	PF00069	0.627
MOD_GSK3_1	438	445	PF00069	0.424
MOD_GSK3_1	478	485	PF00069	0.371
MOD_GSK3_1	493	500	PF00069	0.398
MOD_GSK3_1	507	514	PF00069	0.505
MOD_GSK3_1	544	551	PF00069	0.637
MOD_GSK3_1	586	593	PF00069	0.609
MOD_GSK3_1	69	76	PF00069	0.430
MOD_N-GLC_1	285	290	PF02516	0.356
MOD_N-GLC_1	507	512	PF02516	0.261
MOD_N-GLC_1	532	537	PF02516	0.281
MOD_N-GLC_1	8	13	PF02516	0.493
MOD_NEK2_1	138	143	PF00069	0.572
MOD_NEK2_1	190	195	PF00069	0.312
MOD_NEK2_1	319	324	PF00069	0.382
MOD_NEK2_1	356	361	PF00069	0.523
MOD_NEK2_1	394	399	PF00069	0.440
MOD_NEK2_1	438	443	PF00069	0.315
MOD_NEK2_1	477	482	PF00069	0.393
MOD_NEK2_1	495	500	PF00069	0.527
MOD_NEK2_1	570	575	PF00069	0.638
MOD_NEK2_1	8	13	PF00069	0.759
MOD_PIKK_1	161	167	PF00454	0.510
MOD_PIKK_1	208	214	PF00454	0.398
MOD_PIKK_1	262	268	PF00454	0.383
MOD_PIKK_1	330	336	PF00454	0.344
MOD_PIKK_1	428	434	PF00454	0.382
MOD_PIKK_1	586	592	PF00454	0.588
MOD_PK_1	292	298	PF00069	0.373
MOD_PK_1	478	484	PF00069	0.368
MOD_PKA_1	291	297	PF00069	0.364
MOD_PKA_1	339	345	PF00069	0.299
MOD_PKA_1	559	565	PF00069	0.567
MOD_PKA_2	21	27	PF00069	0.741
MOD_PKA_2	273	279	PF00069	0.465
MOD_PKA_2	291	297	PF00069	0.409
MOD_PKA_2	339	345	PF00069	0.305
MOD_PKA_2	559	565	PF00069	0.492
MOD_PKA_2	590	596	PF00069	0.543
MOD_PKB_1	557	565	PF00069	0.435
MOD_Plk_1	319	325	PF00069	0.361
MOD_Plk_1	372	378	PF00069	0.609
MOD_Plk_1	439	445	PF00069	0.393
MOD_Plk_1	482	488	PF00069	0.368
MOD_Plk_1	507	513	PF00069	0.269
MOD_Plk_1	532	538	PF00069	0.274
MOD_Plk_4	155	161	PF00069	0.576
MOD_Plk_4	222	228	PF00069	0.463
MOD_Plk_4	237	243	PF00069	0.440
MOD_Plk_4	373	379	PF00069	0.475
MOD_Plk_4	418	424	PF00069	0.421
MOD_Plk_4	439	445	PF00069	0.497
MOD_Plk_4	565	571	PF00069	0.478
MOD_ProDKin_1	181	187	PF00069	0.400
MOD_ProDKin_1	37	43	PF00069	0.679
MOD_ProDKin_1	422	428	PF00069	0.444
MOD_ProDKin_1	468	474	PF00069	0.354
MOD_SUMO_rev_2	117	122	PF00179	0.490
TRG_DiLeu_BaEn_1	605	610	PF01217	0.410
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.484
TRG_ENDOCYTIC_2	323	326	PF00928	0.374
TRG_ENDOCYTIC_2	416	419	PF00928	0.489
TRG_ENDOCYTIC_2	503	506	PF00928	0.356
TRG_ENDOCYTIC_2	90	93	PF00928	0.462
TRG_ER_diArg_1	291	293	PF00400	0.499
TRG_ER_diArg_1	338	340	PF00400	0.365
TRG_ER_diArg_1	557	560	PF00400	0.510
TRG_NES_CRM1_1	266	277	PF08389	0.456
TRG_NES_CRM1_1	490	502	PF08389	0.472
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N9	Leptomonas seymouri	23%	95%
A0A1X0NEN5	Trypanosomatidae	22%	100%
A0A1X0NG16	Trypanosomatidae	22%	100%
A0A3Q8ISJ9	Leishmania donovani	84%	100%
A4HJ96	Leishmania braziliensis	73%	100%
A4I6P1	Leishmania infantum	85%	100%
D0A0X4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	93%
Q4Q6E7	Leishmania major	84%	100%
Q4QFY4	Leishmania major	24%	98%