Putative monoglyceride lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

monoglyceride lipase, putative

Species:

Leishmania mexicana

UniProt:

E9B1R1_LEIMU

TriTrypDb:

LmxM.30.1140

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1R1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016298	lipase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0047372	acylglycerol lipase activity	5	7
GO:0052689	carboxylic ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.328
CLV_PCSK_SKI1_1	12	16	PF00082	0.470
CLV_PCSK_SKI1_1	266	270	PF00082	0.313
DOC_CDC14_PxL_1	61	69	PF14671	0.152
DOC_CKS1_1	13	18	PF01111	0.469
DOC_CKS1_1	170	175	PF01111	0.163
DOC_CKS1_1	204	209	PF01111	0.269
DOC_MAPK_MEF2A_6	187	194	PF00069	0.278
DOC_MAPK_MEF2A_6	73	81	PF00069	0.311
DOC_PP1_RVXF_1	56	63	PF00149	0.274
DOC_PP4_FxxP_1	62	65	PF00568	0.311
DOC_USP7_MATH_1	129	133	PF00917	0.274
DOC_USP7_UBL2_3	187	191	PF12436	0.278
DOC_USP7_UBL2_3	196	200	PF12436	0.278
DOC_WW_Pin1_4	12	17	PF00397	0.494
DOC_WW_Pin1_4	169	174	PF00397	0.163
DOC_WW_Pin1_4	203	208	PF00397	0.269
DOC_WW_Pin1_4	51	56	PF00397	0.476
LIG_14-3-3_CanoR_1	108	116	PF00244	0.328
LIG_14-3-3_CanoR_1	176	182	PF00244	0.258
LIG_AP2alpha_2	215	217	PF02296	0.367
LIG_APCC_ABBA_1	250	255	PF00400	0.311
LIG_BIR_III_4	154	158	PF00653	0.269
LIG_BRCT_BRCA1_1	185	189	PF00533	0.345
LIG_BRCT_BRCA1_1	264	268	PF00533	0.274
LIG_BRCT_BRCA1_2	185	191	PF00533	0.345
LIG_EH1_1	139	147	PF00400	0.250
LIG_FHA_1	108	114	PF00498	0.400
LIG_FHA_1	204	210	PF00498	0.387
LIG_FHA_1	52	58	PF00498	0.495
LIG_KLC1_Yacidic_2	102	107	PF13176	0.311
LIG_LIR_Apic_2	203	207	PF02991	0.311
LIG_LIR_Gen_1	107	116	PF02991	0.275
LIG_LIR_Gen_1	71	81	PF02991	0.306
LIG_LIR_Gen_1	84	91	PF02991	0.193
LIG_LIR_Nem_3	107	112	PF02991	0.251
LIG_LIR_Nem_3	125	130	PF02991	0.252
LIG_LIR_Nem_3	156	161	PF02991	0.230
LIG_LIR_Nem_3	186	192	PF02991	0.345
LIG_LIR_Nem_3	244	250	PF02991	0.281
LIG_LIR_Nem_3	71	77	PF02991	0.264
LIG_LIR_Nem_3	84	89	PF02991	0.222
LIG_LYPXL_yS_3	127	130	PF13949	0.152
LIG_MYND_1	23	27	PF01753	0.422
LIG_PCNA_PIPBox_1	178	187	PF02747	0.269
LIG_PCNA_yPIPBox_3	200	212	PF02747	0.287
LIG_Pex14_2	184	188	PF04695	0.311
LIG_Pex14_2	40	44	PF04695	0.498
LIG_SH2_CRK	13	17	PF00017	0.500
LIG_SH2_CRK	204	208	PF00017	0.460
LIG_SH2_CRK	74	78	PF00017	0.250
LIG_SH2_GRB2like	218	221	PF00017	0.311
LIG_SH2_NCK_1	13	17	PF00017	0.497
LIG_SH2_NCK_1	74	78	PF00017	0.367
LIG_SH2_STAP1	218	222	PF00017	0.152
LIG_SH2_STAP1	74	78	PF00017	0.309
LIG_SH2_STAT5	105	108	PF00017	0.250
LIG_SH2_STAT5	86	89	PF00017	0.306
LIG_SH3_1	187	193	PF00018	0.194
LIG_SH3_2	190	195	PF14604	0.269
LIG_SH3_2	53	58	PF14604	0.427
LIG_SH3_3	17	23	PF00018	0.442
LIG_SH3_3	187	193	PF00018	0.465
LIG_SH3_3	50	56	PF00018	0.460
MOD_CDK_SPxK_1	12	18	PF00069	0.471
MOD_CDK_SPxxK_3	169	176	PF00069	0.163
MOD_CDK_SPxxK_3	51	58	PF00069	0.281
MOD_CK1_1	132	138	PF00069	0.294
MOD_CK1_1	203	209	PF00069	0.402
MOD_CK1_1	51	57	PF00069	0.288
MOD_CK2_1	96	102	PF00069	0.352
MOD_GlcNHglycan	154	158	PF01048	0.290
MOD_GlcNHglycan	163	166	PF01048	0.219
MOD_GlcNHglycan	5	8	PF01048	0.485
MOD_GSK3_1	258	265	PF00069	0.383
MOD_NEK2_1	122	127	PF00069	0.389
MOD_NEK2_1	138	143	PF00069	0.205
MOD_NEK2_1	168	173	PF00069	0.400
MOD_NEK2_1	177	182	PF00069	0.407
MOD_NEK2_1	262	267	PF00069	0.342
MOD_PIKK_1	129	135	PF00454	0.349
MOD_PK_1	73	79	PF00069	0.367
MOD_PKA_2	107	113	PF00069	0.216
MOD_Plk_2-3	258	264	PF00069	0.194
MOD_Plk_4	132	138	PF00069	0.426
MOD_ProDKin_1	12	18	PF00069	0.490
MOD_ProDKin_1	169	175	PF00069	0.163
MOD_ProDKin_1	203	209	PF00069	0.269
MOD_ProDKin_1	51	57	PF00069	0.468
TRG_ENDOCYTIC_2	127	130	PF00928	0.287
TRG_ENDOCYTIC_2	74	77	PF00928	0.250
TRG_ENDOCYTIC_2	86	89	PF00928	0.250
TRG_ER_diArg_1	223	226	PF00400	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ITL6	Bodo saltans	47%	96%
A0A3R7L576	Trypanosoma rangeli	51%	100%
A0A3S7X4B8	Leishmania donovani	90%	100%
A0QNZ7	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	29%	100%
A4HJ94	Leishmania braziliensis	82%	100%
A4I6N9	Leishmania infantum	90%	100%
C9ZM73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZWV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
O07427	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
O34705	Bacillus subtilis (strain 168)	27%	100%
O35678	Mus musculus	34%	100%
O94305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	82%
P28321	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	99%
Q4Q6E9	Leishmania major	87%	100%
Q8R431	Rattus norvegicus	34%	100%
Q99685	Homo sapiens	34%	100%
Q9C942	Arabidopsis thaliana	24%	94%