Cilia- and flagella-associated protein 300

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4498), putative

Species:

Leishmania mexicana

UniProt:

E9B1Q7_LEIMU

TriTrypDb:

LmxM.30.1100

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005856	cytoskeleton	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9B1Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Q7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.661
CLV_C14_Caspase3-7	21	25	PF00656	0.467
CLV_PCSK_KEX2_1	182	184	PF00082	0.587
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.643
CLV_PCSK_SKI1_1	102	106	PF00082	0.369
CLV_PCSK_SKI1_1	134	138	PF00082	0.568
CLV_PCSK_SKI1_1	157	161	PF00082	0.671
CLV_PCSK_SKI1_1	199	203	PF00082	0.425
CLV_PCSK_SKI1_1	251	255	PF00082	0.304
CLV_PCSK_SKI1_1	29	33	PF00082	0.488
CLV_Separin_Metazoa	144	148	PF03568	0.534
DEG_APCC_DBOX_1	156	164	PF00400	0.571
DEG_Nend_Nbox_1	1	3	PF02207	0.525
DOC_CYCLIN_RxL_1	26	33	PF00134	0.284
DOC_CYCLIN_RxL_1	99	107	PF00134	0.382
DOC_PP1_RVXF_1	128	134	PF00149	0.453
DOC_PP4_FxxP_1	105	108	PF00568	0.498
DOC_USP7_MATH_1	14	18	PF00917	0.614
DOC_USP7_MATH_1	27	31	PF00917	0.465
DOC_USP7_MATH_1	7	11	PF00917	0.646
DOC_USP7_MATH_1	70	74	PF00917	0.641
DOC_USP7_MATH_1	83	87	PF00917	0.577
DOC_WW_Pin1_4	104	109	PF00397	0.399
DOC_WW_Pin1_4	68	73	PF00397	0.749
LIG_14-3-3_CanoR_1	134	143	PF00244	0.558
LIG_14-3-3_CanoR_1	51	59	PF00244	0.601
LIG_14-3-3_CanoR_1	76	85	PF00244	0.432
LIG_Actin_WH2_2	148	163	PF00022	0.524
LIG_APCC_ABBA_1	187	192	PF00400	0.617
LIG_BIR_III_2	24	28	PF00653	0.479
LIG_FHA_1	173	179	PF00498	0.474
LIG_FHA_1	350	356	PF00498	0.369
LIG_FHA_2	123	129	PF00498	0.550
LIG_FHA_2	139	145	PF00498	0.426
LIG_FHA_2	165	171	PF00498	0.655
LIG_FHA_2	227	233	PF00498	0.643
LIG_LIR_Apic_2	103	108	PF02991	0.491
LIG_LIR_Apic_2	175	179	PF02991	0.674
LIG_LIR_Gen_1	137	146	PF02991	0.439
LIG_LIR_Gen_1	261	272	PF02991	0.455
LIG_LIR_Nem_3	137	143	PF02991	0.437
LIG_LIR_Nem_3	26	31	PF02991	0.505
LIG_LIR_Nem_3	261	267	PF02991	0.478
LIG_LIR_Nem_3	293	298	PF02991	0.559
LIG_LIR_Nem_3	33	38	PF02991	0.521
LIG_LIR_Nem_3	47	53	PF02991	0.354
LIG_SH2_CRK	28	32	PF00017	0.512
LIG_SH2_CRK	295	299	PF00017	0.464
LIG_SH2_CRK	329	333	PF00017	0.535
LIG_SH2_CRK	362	366	PF00017	0.453
LIG_SH2_CRK	50	54	PF00017	0.473
LIG_SH2_NCK_1	338	342	PF00017	0.369
LIG_SH2_PTP2	364	367	PF00017	0.453
LIG_SH2_SRC	221	224	PF00017	0.479
LIG_SH2_SRC	287	290	PF00017	0.478
LIG_SH2_STAT5	176	179	PF00017	0.656
LIG_SH2_STAT5	287	290	PF00017	0.464
LIG_SH2_STAT5	362	365	PF00017	0.453
LIG_SH3_3	66	72	PF00018	0.634
LIG_TRAF2_1	258	261	PF00917	0.535
LIG_TRAF2_1	308	311	PF00917	0.569
LIG_TRAF2_1	318	321	PF00917	0.500
LIG_TYR_ITIM	327	332	PF00017	0.440
LIG_TYR_ITIM	360	365	PF00017	0.464
LIG_WRC_WIRS_1	56	61	PF05994	0.599
MOD_CDK_SPxxK_3	104	111	PF00069	0.400
MOD_CK1_1	30	36	PF00069	0.287
MOD_CK1_1	71	77	PF00069	0.654
MOD_CK2_1	138	144	PF00069	0.433
MOD_CK2_1	221	227	PF00069	0.677
MOD_CK2_1	255	261	PF00069	0.527
MOD_CK2_1	333	339	PF00069	0.495
MOD_CK2_1	55	61	PF00069	0.655
MOD_GlcNHglycan	10	13	PF01048	0.604
MOD_GlcNHglycan	16	19	PF01048	0.434
MOD_GlcNHglycan	209	212	PF01048	0.434
MOD_GlcNHglycan	240	243	PF01048	0.540
MOD_GlcNHglycan	273	276	PF01048	0.392
MOD_GlcNHglycan	323	326	PF01048	0.363
MOD_GlcNHglycan	341	344	PF01048	0.230
MOD_GlcNHglycan	64	67	PF01048	0.643
MOD_GlcNHglycan	79	82	PF01048	0.620
MOD_GlcNHglycan	85	88	PF01048	0.545
MOD_GSK3_1	100	107	PF00069	0.242
MOD_GSK3_1	134	141	PF00069	0.528
MOD_GSK3_1	14	21	PF00069	0.558
MOD_GSK3_1	51	58	PF00069	0.583
MOD_GSK3_1	70	77	PF00069	0.608
MOD_N-GLC_2	361	363	PF02516	0.253
MOD_NEK2_1	100	105	PF00069	0.326
MOD_NEK2_1	298	303	PF00069	0.530
MOD_NEK2_2	243	248	PF00069	0.356
MOD_NEK2_2	344	349	PF00069	0.550
MOD_PKA_2	138	144	PF00069	0.541
MOD_PKA_2	207	213	PF00069	0.433
MOD_PKB_1	49	57	PF00069	0.509
MOD_Plk_1	333	339	PF00069	0.544
MOD_Plk_2-3	164	170	PF00069	0.700
MOD_Plk_2-3	192	198	PF00069	0.521
MOD_Plk_2-3	228	234	PF00069	0.720
MOD_Plk_2-3	55	61	PF00069	0.596
MOD_Plk_4	172	178	PF00069	0.494
MOD_Plk_4	18	24	PF00069	0.406
MOD_Plk_4	27	33	PF00069	0.480
MOD_Plk_4	333	339	PF00069	0.494
MOD_Plk_4	344	350	PF00069	0.461
MOD_Plk_4	372	378	PF00069	0.535
MOD_ProDKin_1	104	110	PF00069	0.396
MOD_ProDKin_1	68	74	PF00069	0.752
MOD_SUMO_rev_2	124	131	PF00179	0.390
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.433
TRG_ENDOCYTIC_2	264	267	PF00928	0.453
TRG_ENDOCYTIC_2	28	31	PF00928	0.519
TRG_ENDOCYTIC_2	295	298	PF00928	0.467
TRG_ENDOCYTIC_2	329	332	PF00928	0.550
TRG_ENDOCYTIC_2	362	365	PF00928	0.464
TRG_ENDOCYTIC_2	50	53	PF00928	0.370
TRG_NES_CRM1_1	293	306	PF08389	0.582
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P369	Leptomonas seymouri	51%	100%
A0A0S4JGK6	Bodo saltans	29%	100%
A0A1X0NJZ3	Trypanosomatidae	30%	97%
A0A3S7X4F5	Leishmania donovani	87%	100%
A0A422NQV4	Trypanosoma rangeli	37%	100%
A4HJ90	Leishmania braziliensis	78%	100%
A4I6N4	Leishmania infantum	87%	100%
C9ZM71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q6F3	Leishmania major	86%	100%
V5DGC7	Trypanosoma cruzi	39%	96%