SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1Q3_LEIMU

TriTrypDb:

LmxM.30.1060

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B1Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Q3

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.538
CLV_C14_Caspase3-7	297	301	PF00656	0.518
CLV_C14_Caspase3-7	352	356	PF00656	0.585
CLV_C14_Caspase3-7	423	427	PF00656	0.493
CLV_NRD_NRD_1	138	140	PF00675	0.248
CLV_NRD_NRD_1	217	219	PF00675	0.259
CLV_NRD_NRD_1	492	494	PF00675	0.519
CLV_NRD_NRD_1	533	535	PF00675	0.609
CLV_PCSK_KEX2_1	138	140	PF00082	0.248
CLV_PCSK_KEX2_1	211	213	PF00082	0.299
CLV_PCSK_KEX2_1	492	494	PF00082	0.522
CLV_PCSK_KEX2_1	533	535	PF00082	0.660
CLV_PCSK_KEX2_1	80	82	PF00082	0.292
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.299
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.292
CLV_PCSK_SKI1_1	132	136	PF00082	0.282
CLV_PCSK_SKI1_1	27	31	PF00082	0.549
CLV_PCSK_SKI1_1	322	326	PF00082	0.253
CLV_PCSK_SKI1_1	338	342	PF00082	0.300
CLV_PCSK_SKI1_1	365	369	PF00082	0.284
CLV_PCSK_SKI1_1	66	70	PF00082	0.438
CLV_PCSK_SKI1_1	76	80	PF00082	0.318
DEG_Nend_Nbox_1	1	3	PF02207	0.567
DOC_CYCLIN_RxL_1	188	199	PF00134	0.475
DOC_CYCLIN_RxL_1	319	326	PF00134	0.519
DOC_MAPK_DCC_7	327	336	PF00069	0.499
DOC_MAPK_gen_1	327	336	PF00069	0.499
DOC_MAPK_gen_1	76	86	PF00069	0.529
DOC_MAPK_HePTP_8	324	336	PF00069	0.499
DOC_MAPK_MEF2A_6	327	336	PF00069	0.499
DOC_MAPK_MEF2A_6	80	88	PF00069	0.491
DOC_MAPK_RevD_3	63	77	PF00069	0.407
DOC_PP2B_LxvP_1	86	89	PF13499	0.489
DOC_USP7_MATH_1	227	231	PF00917	0.541
DOC_USP7_MATH_1	253	257	PF00917	0.499
DOC_USP7_MATH_1	288	292	PF00917	0.554
DOC_USP7_MATH_1	294	298	PF00917	0.444
DOC_USP7_MATH_1	409	413	PF00917	0.461
DOC_USP7_MATH_1	448	452	PF00917	0.499
DOC_USP7_MATH_1	512	516	PF00917	0.655
DOC_USP7_MATH_1	93	97	PF00917	0.572
DOC_USP7_UBL2_3	359	363	PF12436	0.518
DOC_USP7_UBL2_3	76	80	PF12436	0.502
DOC_WW_Pin1_4	167	172	PF00397	0.446
DOC_WW_Pin1_4	446	451	PF00397	0.427
DOC_WW_Pin1_4	5	10	PF00397	0.536
DOC_WW_Pin1_4	516	521	PF00397	0.738
DOC_WW_Pin1_4	91	96	PF00397	0.549
LIG_14-3-3_CanoR_1	138	143	PF00244	0.446
LIG_14-3-3_CanoR_1	15	22	PF00244	0.579
LIG_14-3-3_CanoR_1	327	332	PF00244	0.525
LIG_14-3-3_CanoR_1	66	74	PF00244	0.446
LIG_Actin_WH2_2	50	68	PF00022	0.469
LIG_BIR_III_4	25	29	PF00653	0.520
LIG_BIR_III_4	355	359	PF00653	0.499
LIG_eIF4E_1	173	179	PF01652	0.470
LIG_FHA_1	316	322	PF00498	0.374
LIG_FHA_1	426	432	PF00498	0.529
LIG_FHA_1	457	463	PF00498	0.499
LIG_FHA_1	57	63	PF00498	0.342
LIG_FHA_1	85	91	PF00498	0.515
LIG_FHA_2	200	206	PF00498	0.430
LIG_Integrin_RGD_1	81	83	PF01839	0.270
LIG_LIR_Gen_1	127	135	PF02991	0.446
LIG_LIR_Gen_1	18	29	PF02991	0.487
LIG_LIR_Gen_1	449	458	PF02991	0.538
LIG_LIR_Nem_3	127	131	PF02991	0.446
LIG_LIR_Nem_3	140	145	PF02991	0.446
LIG_LIR_Nem_3	170	176	PF02991	0.486
LIG_LIR_Nem_3	18	24	PF02991	0.501
LIG_LIR_Nem_3	449	455	PF02991	0.538
LIG_LIR_Nem_3	477	483	PF02991	0.344
LIG_LYPXL_S_1	172	176	PF13949	0.270
LIG_LYPXL_yS_3	173	176	PF13949	0.470
LIG_NRBOX	320	326	PF00104	0.432
LIG_Pex14_1	224	228	PF04695	0.446
LIG_PTB_Apo_2	407	414	PF02174	0.529
LIG_PTB_Phospho_1	407	413	PF10480	0.500
LIG_SH2_CRK	128	132	PF00017	0.529
LIG_SH2_CRK	452	456	PF00017	0.512
LIG_SH2_CRK	485	489	PF00017	0.495
LIG_SH2_NCK_1	115	119	PF00017	0.572
LIG_SH2_NCK_1	228	232	PF00017	0.529
LIG_SH2_SRC	206	209	PF00017	0.461
LIG_SH2_SRC	281	284	PF00017	0.461
LIG_SH2_SRC	369	372	PF00017	0.499
LIG_SH2_STAP1	115	119	PF00017	0.499
LIG_SH2_STAP1	206	210	PF00017	0.461
LIG_SH2_STAP1	476	480	PF00017	0.371
LIG_SH2_STAP1	74	78	PF00017	0.529
LIG_SH2_STAT5	175	178	PF00017	0.446
LIG_SH2_STAT5	413	416	PF00017	0.464
LIG_SH2_STAT5	472	475	PF00017	0.434
LIG_SH2_STAT5	480	483	PF00017	0.302
LIG_SH3_3	120	126	PF00018	0.550
LIG_SH3_3	168	174	PF00018	0.467
LIG_SH3_3	194	200	PF00018	0.446
LIG_SH3_3	31	37	PF00018	0.312
LIG_SH3_3	398	404	PF00018	0.567
MOD_CK1_1	106	112	PF00069	0.404
MOD_CK1_1	127	133	PF00069	0.464
MOD_CK1_1	20	26	PF00069	0.513
MOD_CK1_1	268	274	PF00069	0.467
MOD_CK1_1	4	10	PF00069	0.560
MOD_CK1_1	425	431	PF00069	0.518
MOD_CK1_1	442	448	PF00069	0.448
MOD_CK1_1	515	521	PF00069	0.651
MOD_CK1_1	524	530	PF00069	0.450
MOD_CK2_1	199	205	PF00069	0.430
MOD_CK2_1	424	430	PF00069	0.572
MOD_CK2_1	488	494	PF00069	0.606
MOD_GlcNHglycan	180	183	PF01048	0.332
MOD_GlcNHglycan	229	232	PF01048	0.329
MOD_GlcNHglycan	266	270	PF01048	0.328
MOD_GlcNHglycan	290	293	PF01048	0.309
MOD_GlcNHglycan	300	304	PF01048	0.282
MOD_GlcNHglycan	441	444	PF01048	0.290
MOD_GlcNHglycan	446	449	PF01048	0.273
MOD_GlcNHglycan	476	479	PF01048	0.273
MOD_GlcNHglycan	515	518	PF01048	0.772
MOD_GlcNHglycan	529	532	PF01048	0.408
MOD_GlcNHglycan	91	94	PF01048	0.337
MOD_GlcNHglycan	95	98	PF01048	0.314
MOD_GSK3_1	1	8	PF00069	0.541
MOD_GSK3_1	133	140	PF00069	0.600
MOD_GSK3_1	323	330	PF00069	0.461
MOD_GSK3_1	386	393	PF00069	0.529
MOD_GSK3_1	418	425	PF00069	0.499
MOD_GSK3_1	426	433	PF00069	0.442
MOD_GSK3_1	438	445	PF00069	0.386
MOD_GSK3_1	474	481	PF00069	0.384
MOD_GSK3_1	512	519	PF00069	0.643
MOD_GSK3_1	535	542	PF00069	0.526
MOD_GSK3_1	89	96	PF00069	0.498
MOD_N-GLC_1	294	299	PF02516	0.307
MOD_N-GLC_1	409	414	PF02516	0.289
MOD_NEK2_1	1	6	PF00069	0.538
MOD_NEK2_1	42	47	PF00069	0.411
MOD_NEK2_1	468	473	PF00069	0.529
MOD_NEK2_2	478	483	PF00069	0.239
MOD_PIKK_1	273	279	PF00454	0.523
MOD_PKA_1	138	144	PF00069	0.435
MOD_PKA_2	137	143	PF00069	0.446
MOD_PKA_2	14	20	PF00069	0.546
MOD_PKA_2	456	462	PF00069	0.491
MOD_Plk_1	17	23	PF00069	0.605
MOD_Plk_1	315	321	PF00069	0.414
MOD_Plk_1	409	415	PF00069	0.492
MOD_Plk_1	466	472	PF00069	0.446
MOD_Plk_4	17	23	PF00069	0.605
MOD_Plk_4	386	392	PF00069	0.448
MOD_Plk_4	42	48	PF00069	0.435
MOD_Plk_4	468	474	PF00069	0.478
MOD_Plk_4	478	484	PF00069	0.302
MOD_Plk_4	524	530	PF00069	0.522
MOD_Plk_4	535	541	PF00069	0.532
MOD_ProDKin_1	167	173	PF00069	0.446
MOD_ProDKin_1	446	452	PF00069	0.427
MOD_ProDKin_1	5	11	PF00069	0.532
MOD_ProDKin_1	516	522	PF00069	0.736
MOD_ProDKin_1	91	97	PF00069	0.549
TRG_DiLeu_BaEn_1	58	63	PF01217	0.420
TRG_DiLeu_BaEn_4	463	469	PF01217	0.464
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.489
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.529
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.461
TRG_ENDOCYTIC_2	128	131	PF00928	0.464
TRG_ENDOCYTIC_2	173	176	PF00928	0.464
TRG_ENDOCYTIC_2	281	284	PF00928	0.499
TRG_ENDOCYTIC_2	369	372	PF00928	0.461
TRG_ENDOCYTIC_2	452	455	PF00928	0.512
TRG_ENDOCYTIC_2	485	488	PF00928	0.488
TRG_ER_diArg_1	137	139	PF00400	0.576
TRG_ER_diArg_1	532	534	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM8	Leptomonas seymouri	52%	71%
A0A1X0NJ79	Trypanosomatidae	38%	95%
A0A3S7X4A8	Leishmania donovani	89%	100%
A4HJ86	Leishmania braziliensis	76%	100%
A4I6N0	Leishmania infantum	89%	100%
C9ZM67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	88%
Q4Q6F7	Leishmania major	89%	100%
V5BPH7	Trypanosoma cruzi	41%	86%