RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9B1Q1_LEIMU

TriTrypDb:

LmxM.30.1040

Length:

766

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Q1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.452
CLV_C14_Caspase3-7	384	388	PF00656	0.685
CLV_C14_Caspase3-7	607	611	PF00656	0.499
CLV_C14_Caspase3-7	716	720	PF00656	0.401
CLV_MEL_PAP_1	472	478	PF00089	0.424
CLV_NRD_NRD_1	246	248	PF00675	0.390
CLV_NRD_NRD_1	404	406	PF00675	0.392
CLV_NRD_NRD_1	474	476	PF00675	0.517
CLV_NRD_NRD_1	550	552	PF00675	0.666
CLV_NRD_NRD_1	643	645	PF00675	0.621
CLV_PCSK_KEX2_1	404	406	PF00082	0.392
CLV_PCSK_KEX2_1	473	475	PF00082	0.613
CLV_PCSK_KEX2_1	549	551	PF00082	0.675
CLV_PCSK_KEX2_1	643	645	PF00082	0.621
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.675
CLV_PCSK_SKI1_1	650	654	PF00082	0.553
CLV_PCSK_SKI1_1	722	726	PF00082	0.611
DEG_APCC_DBOX_1	649	657	PF00400	0.552
DEG_COP1_1	9	19	PF00400	0.693
DEG_SCF_TRCP1_1	719	725	PF00400	0.362
DEG_SPOP_SBC_1	199	203	PF00917	0.522
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.752
DOC_MAPK_DCC_7	492	500	PF00069	0.351
DOC_MAPK_DCC_7	549	558	PF00069	0.567
DOC_MAPK_gen_1	549	558	PF00069	0.662
DOC_MAPK_MEF2A_6	492	500	PF00069	0.351
DOC_MAPK_MEF2A_6	549	558	PF00069	0.662
DOC_MAPK_MEF2A_6	650	659	PF00069	0.551
DOC_MAPK_RevD_3	460	475	PF00069	0.276
DOC_PP1_RVXF_1	720	727	PF00149	0.623
DOC_PP2B_LxvP_1	349	352	PF13499	0.755
DOC_PP4_FxxP_1	686	689	PF00568	0.418
DOC_USP7_MATH_1	214	218	PF00917	0.626
DOC_USP7_MATH_1	41	45	PF00917	0.655
DOC_USP7_MATH_1	517	521	PF00917	0.571
DOC_USP7_MATH_1	543	547	PF00917	0.672
DOC_USP7_MATH_1	557	561	PF00917	0.525
DOC_USP7_MATH_1	61	65	PF00917	0.542
DOC_USP7_MATH_2	13	19	PF00917	0.592
DOC_WW_Pin1_4	155	160	PF00397	0.489
DOC_WW_Pin1_4	175	180	PF00397	0.453
DOC_WW_Pin1_4	273	278	PF00397	0.561
DOC_WW_Pin1_4	316	321	PF00397	0.543
DOC_WW_Pin1_4	36	41	PF00397	0.541
DOC_WW_Pin1_4	9	14	PF00397	0.770
LIG_14-3-3_CanoR_1	279	287	PF00244	0.539
LIG_14-3-3_CanoR_1	550	554	PF00244	0.485
LIG_14-3-3_CanoR_1	681	689	PF00244	0.449
LIG_Actin_WH2_2	361	378	PF00022	0.618
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_BIR_III_2	478	482	PF00653	0.601
LIG_BRCT_BRCA1_1	628	632	PF00533	0.654
LIG_eIF4E_1	651	657	PF01652	0.549
LIG_FHA_1	26	32	PF00498	0.619
LIG_FHA_1	338	344	PF00498	0.506
LIG_FHA_1	421	427	PF00498	0.467
LIG_FHA_1	446	452	PF00498	0.678
LIG_FHA_1	495	501	PF00498	0.540
LIG_FHA_1	51	57	PF00498	0.661
LIG_FHA_1	539	545	PF00498	0.506
LIG_FHA_1	636	642	PF00498	0.533
LIG_FHA_1	78	84	PF00498	0.506
LIG_FHA_2	189	195	PF00498	0.625
LIG_GBD_Chelix_1	464	472	PF00786	0.439
LIG_Integrin_isoDGR_2	679	681	PF01839	0.473
LIG_LIR_Apic_2	683	689	PF02991	0.403
LIG_LIR_Gen_1	104	110	PF02991	0.627
LIG_LIR_Gen_1	344	354	PF02991	0.495
LIG_LIR_Gen_1	489	498	PF02991	0.419
LIG_LIR_LC3C_4	194	199	PF02991	0.579
LIG_LIR_Nem_3	104	108	PF02991	0.627
LIG_LIR_Nem_3	344	349	PF02991	0.497
LIG_LIR_Nem_3	489	493	PF02991	0.406
LIG_LIR_Nem_3	645	651	PF02991	0.573
LIG_LIR_Nem_3	749	755	PF02991	0.628
LIG_NRBOX	421	427	PF00104	0.562
LIG_NRBOX	467	473	PF00104	0.270
LIG_PCNA_yPIPBox_3	91	99	PF02747	0.547
LIG_PDZ_Class_2	761	766	PF00595	0.519
LIG_Pex14_1	120	124	PF04695	0.627
LIG_Pex14_2	727	731	PF04695	0.583
LIG_SH2_STAT5	105	108	PF00017	0.627
LIG_SH2_STAT5	139	142	PF00017	0.516
LIG_SH2_STAT5	186	189	PF00017	0.367
LIG_SH2_STAT5	651	654	PF00017	0.549
LIG_SH3_1	271	277	PF00018	0.461
LIG_SH3_1	551	557	PF00018	0.656
LIG_SH3_2	145	150	PF14604	0.538
LIG_SH3_2	274	279	PF14604	0.474
LIG_SH3_3	142	148	PF00018	0.613
LIG_SH3_3	271	277	PF00018	0.491
LIG_SH3_3	34	40	PF00018	0.617
LIG_SH3_3	551	557	PF00018	0.656
LIG_SUMO_SIM_anti_2	361	366	PF11976	0.516
LIG_SUMO_SIM_par_1	194	203	PF11976	0.611
LIG_TRAF2_1	510	513	PF00917	0.541
LIG_TRAF2_1	628	631	PF00917	0.481
LIG_TRAF2_1	662	665	PF00917	0.574
LIG_WRC_WIRS_1	343	348	PF05994	0.497
LIG_WRC_WIRS_1	487	492	PF05994	0.503
LIG_WRC_WIRS_1	558	563	PF05994	0.677
MOD_CDC14_SPxK_1	158	161	PF00782	0.497
MOD_CDC14_SPxK_1	276	279	PF00782	0.480
MOD_CDK_SPxK_1	155	161	PF00069	0.496
MOD_CDK_SPxK_1	273	279	PF00069	0.473
MOD_CK1_1	18	24	PF00069	0.623
MOD_CK1_1	202	208	PF00069	0.551
MOD_CK1_1	289	295	PF00069	0.660
MOD_CK1_1	3	9	PF00069	0.713
MOD_CK1_1	332	338	PF00069	0.583
MOD_CK1_1	36	42	PF00069	0.539
MOD_CK1_1	378	384	PF00069	0.648
MOD_CK1_1	420	426	PF00069	0.465
MOD_CK1_1	44	50	PF00069	0.645
MOD_CK1_1	552	558	PF00069	0.482
MOD_CK1_1	57	63	PF00069	0.522
MOD_CK1_1	635	641	PF00069	0.491
MOD_CK1_1	64	70	PF00069	0.581
MOD_CK2_1	69	75	PF00069	0.566
MOD_CK2_1	9	15	PF00069	0.699
MOD_GlcNHglycan	17	20	PF01048	0.511
MOD_GlcNHglycan	2	5	PF01048	0.801
MOD_GlcNHglycan	202	205	PF01048	0.673
MOD_GlcNHglycan	216	219	PF01048	0.696
MOD_GlcNHglycan	258	261	PF01048	0.691
MOD_GlcNHglycan	290	294	PF01048	0.742
MOD_GlcNHglycan	296	299	PF01048	0.650
MOD_GlcNHglycan	331	334	PF01048	0.610
MOD_GlcNHglycan	377	380	PF01048	0.718
MOD_GlcNHglycan	443	446	PF01048	0.706
MOD_GlcNHglycan	59	62	PF01048	0.494
MOD_GlcNHglycan	617	621	PF01048	0.754
MOD_GlcNHglycan	634	637	PF01048	0.421
MOD_GlcNHglycan	672	675	PF01048	0.518
MOD_GlcNHglycan	719	722	PF01048	0.603
MOD_GSK3_1	131	138	PF00069	0.422
MOD_GSK3_1	198	205	PF00069	0.685
MOD_GSK3_1	285	292	PF00069	0.644
MOD_GSK3_1	316	323	PF00069	0.648
MOD_GSK3_1	337	344	PF00069	0.611
MOD_GSK3_1	441	448	PF00069	0.698
MOD_GSK3_1	50	57	PF00069	0.593
MOD_GSK3_1	539	546	PF00069	0.504
MOD_GSK3_1	60	67	PF00069	0.542
MOD_GSK3_1	616	623	PF00069	0.737
MOD_GSK3_1	626	633	PF00069	0.581
MOD_N-GLC_1	175	180	PF02516	0.580
MOD_N-GLC_1	50	55	PF02516	0.628
MOD_N-GLC_1	57	62	PF02516	0.616
MOD_N-GLC_1	717	722	PF02516	0.642
MOD_N-GLC_2	262	264	PF02516	0.599
MOD_N-GLC_2	265	267	PF02516	0.569
MOD_N-GLC_2	583	585	PF02516	0.515
MOD_NEK2_1	342	347	PF00069	0.581
MOD_NEK2_1	375	380	PF00069	0.749
MOD_NEK2_1	428	433	PF00069	0.478
MOD_NEK2_1	69	74	PF00069	0.645
MOD_NEK2_1	742	747	PF00069	0.452
MOD_NEK2_1	77	82	PF00069	0.483
MOD_PIKK_1	381	387	PF00454	0.618
MOD_PIKK_1	420	426	PF00454	0.510
MOD_PIKK_1	453	459	PF00454	0.576
MOD_PIKK_1	50	56	PF00454	0.662
MOD_PIKK_1	736	742	PF00454	0.510
MOD_PK_1	549	555	PF00069	0.486
MOD_PKA_1	549	555	PF00069	0.486
MOD_PKA_2	278	284	PF00069	0.509
MOD_PKA_2	293	299	PF00069	0.517
MOD_PKA_2	375	381	PF00069	0.644
MOD_PKA_2	549	555	PF00069	0.486
MOD_PKA_2	680	686	PF00069	0.437
MOD_PKA_2	69	75	PF00069	0.566
MOD_PKA_2	745	751	PF00069	0.552
MOD_Plk_1	188	194	PF00069	0.505
MOD_Plk_1	420	426	PF00069	0.465
MOD_Plk_1	50	56	PF00069	0.630
MOD_Plk_1	586	592	PF00069	0.568
MOD_Plk_1	644	650	PF00069	0.473
MOD_Plk_1	722	728	PF00069	0.598
MOD_Plk_2-3	575	581	PF00069	0.499
MOD_Plk_4	41	47	PF00069	0.657
MOD_Plk_4	494	500	PF00069	0.538
MOD_Plk_4	543	549	PF00069	0.682
MOD_Plk_4	557	563	PF00069	0.558
MOD_Plk_4	566	572	PF00069	0.602
MOD_Plk_4	64	70	PF00069	0.653
MOD_Plk_4	688	694	PF00069	0.333
MOD_Plk_4	722	728	PF00069	0.486
MOD_Plk_4	759	765	PF00069	0.494
MOD_ProDKin_1	155	161	PF00069	0.496
MOD_ProDKin_1	175	181	PF00069	0.451
MOD_ProDKin_1	273	279	PF00069	0.565
MOD_ProDKin_1	316	322	PF00069	0.548
MOD_ProDKin_1	36	42	PF00069	0.544
MOD_ProDKin_1	9	15	PF00069	0.772
TRG_DiLeu_BaEn_1	421	426	PF01217	0.462
TRG_DiLeu_BaEn_1	688	693	PF01217	0.509
TRG_DiLeu_BaLyEn_6	738	743	PF01217	0.512
TRG_ENDOCYTIC_2	105	108	PF00928	0.627
TRG_ENDOCYTIC_2	122	125	PF00928	0.434
TRG_ENDOCYTIC_2	139	142	PF00928	0.357
TRG_ER_diArg_1	106	109	PF00400	0.627
TRG_ER_diArg_1	403	405	PF00400	0.316
TRG_ER_diArg_1	472	475	PF00400	0.491
TRG_ER_diArg_1	500	503	PF00400	0.574
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IET1	Leishmania donovani	81%	99%
A4I6M8	Leishmania infantum	82%	99%
Q4Q6F9	Leishmania major	82%	100%