RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1Q0_LEIMU

TriTrypDb:

LmxM.30.1030

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1Q0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1Q0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.608
CLV_C14_Caspase3-7	142	146	PF00656	0.643
CLV_C14_Caspase3-7	27	31	PF00656	0.626
CLV_C14_Caspase3-7	308	312	PF00656	0.373
CLV_C14_Caspase3-7	552	556	PF00656	0.528
CLV_NRD_NRD_1	162	164	PF00675	0.524
CLV_NRD_NRD_1	255	257	PF00675	0.282
CLV_NRD_NRD_1	406	408	PF00675	0.632
CLV_NRD_NRD_1	485	487	PF00675	0.651
CLV_NRD_NRD_1	772	774	PF00675	0.399
CLV_PCSK_FUR_1	858	862	PF00082	0.489
CLV_PCSK_KEX2_1	255	257	PF00082	0.282
CLV_PCSK_KEX2_1	306	308	PF00082	0.421
CLV_PCSK_KEX2_1	406	408	PF00082	0.547
CLV_PCSK_KEX2_1	484	486	PF00082	0.662
CLV_PCSK_KEX2_1	642	644	PF00082	0.399
CLV_PCSK_KEX2_1	772	774	PF00082	0.399
CLV_PCSK_KEX2_1	860	862	PF00082	0.425
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.400
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.396
CLV_PCSK_PC1ET2_1	860	862	PF00082	0.425
CLV_PCSK_SKI1_1	564	568	PF00082	0.548
CLV_PCSK_SKI1_1	779	783	PF00082	0.348
CLV_PCSK_SKI1_1	812	816	PF00082	0.411
CLV_PCSK_SKI1_1	861	865	PF00082	0.388
CLV_PCSK_SKI1_1	868	872	PF00082	0.374
DEG_APCC_DBOX_1	778	786	PF00400	0.345
DEG_SPOP_SBC_1	436	440	PF00917	0.530
DEG_SPOP_SBC_1	760	764	PF00917	0.524
DEG_SPOP_SBC_1	842	846	PF00917	0.456
DOC_CKS1_1	331	336	PF01111	0.553
DOC_CYCLIN_RxL_1	196	206	PF00134	0.312
DOC_CYCLIN_yClb5_NLxxxL_5	640	649	PF00134	0.454
DOC_CYCLIN_yCln2_LP_2	520	523	PF00134	0.592
DOC_MAPK_gen_1	255	261	PF00069	0.475
DOC_MAPK_gen_1	858	865	PF00069	0.458
DOC_MAPK_MEF2A_6	779	788	PF00069	0.344
DOC_PP1_RVXF_1	859	866	PF00149	0.407
DOC_PP2B_LxvP_1	126	129	PF13499	0.607
DOC_PP2B_LxvP_1	520	523	PF13499	0.596
DOC_PP4_FxxP_1	519	522	PF00568	0.673
DOC_PP4_FxxP_1	721	724	PF00568	0.560
DOC_USP7_MATH_1	17	21	PF00917	0.564
DOC_USP7_MATH_1	188	192	PF00917	0.446
DOC_USP7_MATH_1	214	218	PF00917	0.502
DOC_USP7_MATH_1	24	28	PF00917	0.502
DOC_USP7_MATH_1	312	316	PF00917	0.455
DOC_USP7_MATH_1	386	390	PF00917	0.587
DOC_USP7_MATH_1	436	440	PF00917	0.618
DOC_USP7_MATH_1	530	534	PF00917	0.553
DOC_USP7_MATH_1	55	59	PF00917	0.550
DOC_USP7_MATH_1	610	614	PF00917	0.544
DOC_USP7_MATH_1	749	753	PF00917	0.700
DOC_USP7_MATH_1	760	764	PF00917	0.523
DOC_USP7_MATH_1	82	86	PF00917	0.664
DOC_USP7_MATH_1	842	846	PF00917	0.526
DOC_USP7_MATH_1	93	97	PF00917	0.532
DOC_USP7_MATH_2	13	19	PF00917	0.556
DOC_USP7_UBL2_3	173	177	PF12436	0.469
DOC_WW_Pin1_4	103	108	PF00397	0.575
DOC_WW_Pin1_4	120	125	PF00397	0.479
DOC_WW_Pin1_4	292	297	PF00397	0.402
DOC_WW_Pin1_4	330	335	PF00397	0.609
DOC_WW_Pin1_4	337	342	PF00397	0.597
DOC_WW_Pin1_4	352	357	PF00397	0.538
DOC_WW_Pin1_4	363	368	PF00397	0.600
DOC_WW_Pin1_4	392	397	PF00397	0.640
DOC_WW_Pin1_4	430	435	PF00397	0.651
DOC_WW_Pin1_4	439	444	PF00397	0.610
DOC_WW_Pin1_4	446	451	PF00397	0.596
DOC_WW_Pin1_4	493	498	PF00397	0.553
DOC_WW_Pin1_4	5	10	PF00397	0.564
LIG_14-3-3_CanoR_1	623	630	PF00244	0.366
LIG_14-3-3_CanoR_1	643	652	PF00244	0.386
LIG_14-3-3_CanoR_1	868	877	PF00244	0.369
LIG_BIR_III_2	288	292	PF00653	0.447
LIG_BIR_III_2	647	651	PF00653	0.385
LIG_BIR_III_4	586	590	PF00653	0.354
LIG_CtBP_PxDLS_1	396	400	PF00389	0.503
LIG_eIF4E_1	780	786	PF01652	0.341
LIG_EVH1_1	126	130	PF00568	0.607
LIG_FHA_1	188	194	PF00498	0.433
LIG_FHA_1	195	201	PF00498	0.374
LIG_FHA_1	24	30	PF00498	0.674
LIG_FHA_1	342	348	PF00498	0.596
LIG_FHA_1	417	423	PF00498	0.681
LIG_FHA_1	476	482	PF00498	0.587
LIG_FHA_1	615	621	PF00498	0.442
LIG_FHA_2	132	138	PF00498	0.544
LIG_FHA_2	306	312	PF00498	0.461
LIG_FHA_2	436	442	PF00498	0.525
LIG_FHA_2	494	500	PF00498	0.589
LIG_FHA_2	529	535	PF00498	0.612
LIG_FHA_2	552	558	PF00498	0.451
LIG_FHA_2	870	876	PF00498	0.440
LIG_IBAR_NPY_1	149	151	PF08397	0.556
LIG_LIR_Apic_2	152	156	PF02991	0.576
LIG_LIR_Apic_2	392	397	PF02991	0.639
LIG_LIR_Apic_2	518	522	PF02991	0.673
LIG_LIR_Gen_1	113	119	PF02991	0.604
LIG_LIR_Gen_1	221	227	PF02991	0.475
LIG_LIR_Gen_1	33	42	PF02991	0.639
LIG_LIR_Gen_1	451	462	PF02991	0.626
LIG_LIR_Gen_1	888	896	PF02991	0.375
LIG_LIR_Nem_3	113	117	PF02991	0.605
LIG_LIR_Nem_3	171	175	PF02991	0.469
LIG_LIR_Nem_3	221	225	PF02991	0.475
LIG_LIR_Nem_3	314	319	PF02991	0.436
LIG_LIR_Nem_3	33	37	PF02991	0.594
LIG_LIR_Nem_3	451	457	PF02991	0.637
LIG_LIR_Nem_3	696	702	PF02991	0.718
LIG_LIR_Nem_3	774	780	PF02991	0.366
LIG_LIR_Nem_3	78	83	PF02991	0.729
LIG_LIR_Nem_3	837	843	PF02991	0.452
LIG_LIR_Nem_3	864	869	PF02991	0.404
LIG_LIR_Nem_3	888	894	PF02991	0.381
LIG_MYND_1	124	128	PF01753	0.608
LIG_NRBOX	593	599	PF00104	0.360
LIG_PAM2_1	352	364	PF00658	0.616
LIG_PCNA_yPIPBox_3	273	286	PF02747	0.443
LIG_Pex14_1	237	241	PF04695	0.475
LIG_Pex14_2	866	870	PF04695	0.405
LIG_SH2_CRK	114	118	PF00017	0.675
LIG_SH2_CRK	153	157	PF00017	0.578
LIG_SH2_CRK	840	844	PF00017	0.434
LIG_SH2_GRB2like	316	319	PF00017	0.438
LIG_SH2_NCK_1	114	118	PF00017	0.492
LIG_SH2_NCK_1	709	713	PF00017	0.463
LIG_SH2_NCK_1	804	808	PF00017	0.378
LIG_SH2_SRC	373	376	PF00017	0.580
LIG_SH2_SRC	41	44	PF00017	0.593
LIG_SH2_STAP1	32	36	PF00017	0.601
LIG_SH2_STAP1	804	808	PF00017	0.378
LIG_SH2_STAT3	697	700	PF00017	0.489
LIG_SH2_STAT5	151	154	PF00017	0.586
LIG_SH2_STAT5	160	163	PF00017	0.542
LIG_SH2_STAT5	222	225	PF00017	0.475
LIG_SH2_STAT5	373	376	PF00017	0.628
LIG_SH2_STAT5	4	7	PF00017	0.605
LIG_SH2_STAT5	41	44	PF00017	0.641
LIG_SH2_STAT5	780	783	PF00017	0.341
LIG_SH3_3	121	127	PF00018	0.641
LIG_SH3_3	262	268	PF00018	0.584
LIG_SH3_3	328	334	PF00018	0.522
LIG_SH3_3	345	351	PF00018	0.603
LIG_SH3_3	469	475	PF00018	0.679
LIG_SH3_5	156	160	PF00018	0.558
LIG_SH3_5	450	454	PF00018	0.620
LIG_SUMO_SIM_anti_2	593	599	PF11976	0.360
LIG_SUMO_SIM_par_1	593	599	PF11976	0.373
LIG_TRAF2_1	176	179	PF00917	0.468
LIG_TRAF2_1	791	794	PF00917	0.361
LIG_TRFH_1	519	523	PF08558	0.672
LIG_UBA3_1	298	306	PF00899	0.409
LIG_UBA3_1	633	642	PF00899	0.335
LIG_WRC_WIRS_1	454	459	PF05994	0.628
LIG_WW_2	124	127	PF00397	0.611
MOD_CAAXbox	902	905	PF01239	0.355
MOD_CDK_SPxxK_3	352	359	PF00069	0.619
MOD_CDK_SPxxK_3	5	12	PF00069	0.564
MOD_CK1_1	106	112	PF00069	0.683
MOD_CK1_1	3	9	PF00069	0.584
MOD_CK1_1	414	420	PF00069	0.804
MOD_CK1_1	423	429	PF00069	0.789
MOD_CK1_1	439	445	PF00069	0.536
MOD_CK1_1	488	494	PF00069	0.504
MOD_CK1_1	506	512	PF00069	0.756
MOD_CK1_1	761	767	PF00069	0.487
MOD_CK2_1	254	260	PF00069	0.317
MOD_CK2_1	493	499	PF00069	0.592
MOD_CK2_1	590	596	PF00069	0.395
MOD_CK2_1	723	729	PF00069	0.680
MOD_CK2_1	731	737	PF00069	0.606
MOD_CK2_1	760	766	PF00069	0.506
MOD_CK2_1	788	794	PF00069	0.358
MOD_CK2_1	869	875	PF00069	0.382
MOD_GlcNHglycan	19	22	PF01048	0.604
MOD_GlcNHglycan	256	259	PF01048	0.344
MOD_GlcNHglycan	275	278	PF01048	0.418
MOD_GlcNHglycan	335	338	PF01048	0.660
MOD_GlcNHglycan	416	419	PF01048	0.665
MOD_GlcNHglycan	43	46	PF01048	0.695
MOD_GlcNHglycan	463	466	PF01048	0.682
MOD_GlcNHglycan	488	491	PF01048	0.721
MOD_GlcNHglycan	551	554	PF01048	0.672
MOD_GlcNHglycan	612	615	PF01048	0.514
MOD_GlcNHglycan	749	752	PF01048	0.716
MOD_GlcNHglycan	763	766	PF01048	0.397
MOD_GlcNHglycan	801	804	PF01048	0.401
MOD_GlcNHglycan	818	821	PF01048	0.530
MOD_GlcNHglycan	854	857	PF01048	0.728
MOD_GlcNHglycan	89	92	PF01048	0.563
MOD_GSK3_1	106	113	PF00069	0.540
MOD_GSK3_1	203	210	PF00069	0.312
MOD_GSK3_1	333	340	PF00069	0.736
MOD_GSK3_1	382	389	PF00069	0.615
MOD_GSK3_1	407	414	PF00069	0.790
MOD_GSK3_1	416	423	PF00069	0.687
MOD_GSK3_1	435	442	PF00069	0.666
MOD_GSK3_1	452	459	PF00069	0.598
MOD_GSK3_1	461	468	PF00069	0.509
MOD_GSK3_1	493	500	PF00069	0.569
MOD_GSK3_1	610	617	PF00069	0.522
MOD_GSK3_1	651	658	PF00069	0.291
MOD_GSK3_1	747	754	PF00069	0.606
MOD_GSK3_1	756	763	PF00069	0.545
MOD_GSK3_1	852	859	PF00069	0.701
MOD_N-GLC_1	120	125	PF02516	0.684
MOD_N-GLC_1	229	234	PF02516	0.326
MOD_N-GLC_1	643	648	PF02516	0.385
MOD_N-GLC_1	693	698	PF02516	0.557
MOD_N-GLC_1	747	752	PF02516	0.572
MOD_N-GLC_2	834	836	PF02516	0.436
MOD_NEK2_1	139	144	PF00069	0.676
MOD_NEK2_1	16	21	PF00069	0.531
MOD_NEK2_1	194	199	PF00069	0.376
MOD_NEK2_1	244	249	PF00069	0.352
MOD_NEK2_1	254	259	PF00069	0.352
MOD_NEK2_1	335	340	PF00069	0.635
MOD_NEK2_1	421	426	PF00069	0.531
MOD_NEK2_1	47	52	PF00069	0.620
MOD_NEK2_1	549	554	PF00069	0.627
MOD_NEK2_1	577	582	PF00069	0.392
MOD_NEK2_1	667	672	PF00069	0.451
MOD_NEK2_1	693	698	PF00069	0.661
MOD_NEK2_1	826	831	PF00069	0.529
MOD_NEK2_2	587	592	PF00069	0.347
MOD_PIKK_1	577	583	PF00454	0.421
MOD_PIKK_1	622	628	PF00454	0.363
MOD_PIKK_1	667	673	PF00454	0.457
MOD_PIKK_1	678	684	PF00454	0.533
MOD_PIKK_1	93	99	PF00454	0.666
MOD_PK_1	511	517	PF00069	0.528
MOD_PKA_1	485	491	PF00069	0.517
MOD_PKA_2	254	260	PF00069	0.336
MOD_PKA_2	485	491	PF00069	0.517
MOD_PKA_2	622	628	PF00069	0.392
MOD_PKB_1	484	492	PF00069	0.517
MOD_PKB_1	562	570	PF00069	0.459
MOD_Plk_1	452	458	PF00069	0.625
MOD_Plk_1	47	53	PF00069	0.603
MOD_Plk_1	564	570	PF00069	0.457
MOD_Plk_1	693	699	PF00069	0.503
MOD_Plk_1	861	867	PF00069	0.376
MOD_Plk_2-3	110	116	PF00069	0.661
MOD_Plk_2-3	30	36	PF00069	0.645
MOD_Plk_4	203	209	PF00069	0.312
MOD_Plk_4	312	318	PF00069	0.413
MOD_Plk_4	511	517	PF00069	0.567
MOD_Plk_4	651	657	PF00069	0.275
MOD_Plk_4	723	729	PF00069	0.492
MOD_ProDKin_1	103	109	PF00069	0.574
MOD_ProDKin_1	120	126	PF00069	0.479
MOD_ProDKin_1	292	298	PF00069	0.401
MOD_ProDKin_1	330	336	PF00069	0.613
MOD_ProDKin_1	337	343	PF00069	0.598
MOD_ProDKin_1	352	358	PF00069	0.538
MOD_ProDKin_1	363	369	PF00069	0.601
MOD_ProDKin_1	392	398	PF00069	0.639
MOD_ProDKin_1	430	436	PF00069	0.651
MOD_ProDKin_1	439	445	PF00069	0.612
MOD_ProDKin_1	446	452	PF00069	0.595
MOD_ProDKin_1	493	499	PF00069	0.555
MOD_ProDKin_1	5	11	PF00069	0.563
MOD_SUMO_for_1	176	179	PF00179	0.468
MOD_SUMO_rev_2	739	749	PF00179	0.640
TRG_DiLeu_BaEn_1	179	184	PF01217	0.462
TRG_DiLeu_BaEn_1	766	771	PF01217	0.457
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.615
TRG_DiLeu_BaLyEn_6	625	630	PF01217	0.345
TRG_ENDOCYTIC_2	114	117	PF00928	0.604
TRG_ENDOCYTIC_2	222	225	PF00928	0.312
TRG_ENDOCYTIC_2	239	242	PF00928	0.312
TRG_ENDOCYTIC_2	316	319	PF00928	0.438
TRG_ENDOCYTIC_2	454	457	PF00928	0.654
TRG_ENDOCYTIC_2	585	588	PF00928	0.400
TRG_ENDOCYTIC_2	718	721	PF00928	0.574
TRG_ENDOCYTIC_2	840	843	PF00928	0.534
TRG_ER_diArg_1	180	183	PF00400	0.461
TRG_ER_diArg_1	223	226	PF00400	0.343
TRG_ER_diArg_1	254	256	PF00400	0.319
TRG_ER_diArg_1	484	486	PF00400	0.534
TRG_ER_diArg_1	771	773	PF00400	0.408
TRG_NES_CRM1_1	586	599	PF08389	0.452
TRG_NES_CRM1_1	647	661	PF08389	0.381
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	592	596	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	643	647	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P425	Leptomonas seymouri	56%	99%
A0A3S7X4F6	Leishmania donovani	91%	100%
A4HJ83	Leishmania braziliensis	80%	99%
A4I6M7	Leishmania infantum	91%	100%
Q4Q6G0	Leishmania major	90%	100%