Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1P5_LEIMU

TriTrypDb:

LmxM.30.0980

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1P5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	639	643	PF00656	0.730
CLV_NRD_NRD_1	110	112	PF00675	0.485
CLV_NRD_NRD_1	164	166	PF00675	0.445
CLV_NRD_NRD_1	223	225	PF00675	0.529
CLV_NRD_NRD_1	305	307	PF00675	0.486
CLV_NRD_NRD_1	354	356	PF00675	0.563
CLV_NRD_NRD_1	400	402	PF00675	0.482
CLV_NRD_NRD_1	581	583	PF00675	0.720
CLV_NRD_NRD_1	588	590	PF00675	0.746
CLV_NRD_NRD_1	63	65	PF00675	0.423
CLV_NRD_NRD_1	716	718	PF00675	0.541
CLV_NRD_NRD_1	730	732	PF00675	0.428
CLV_NRD_NRD_1	768	770	PF00675	0.530
CLV_PCSK_KEX2_1	110	112	PF00082	0.387
CLV_PCSK_KEX2_1	164	166	PF00082	0.433
CLV_PCSK_KEX2_1	223	225	PF00082	0.529
CLV_PCSK_KEX2_1	400	402	PF00082	0.482
CLV_PCSK_KEX2_1	586	588	PF00082	0.735
CLV_PCSK_KEX2_1	63	65	PF00082	0.423
CLV_PCSK_PC1ET2_1	586	588	PF00082	0.735
CLV_PCSK_PC7_1	582	588	PF00082	0.604
CLV_PCSK_SKI1_1	342	346	PF00082	0.532
CLV_PCSK_SKI1_1	423	427	PF00082	0.531
CLV_PCSK_SKI1_1	428	432	PF00082	0.513
CLV_PCSK_SKI1_1	592	596	PF00082	0.687
CLV_PCSK_SKI1_1	87	91	PF00082	0.425
CLV_PCSK_SKI1_1	98	102	PF00082	0.415
DEG_APCC_DBOX_1	153	161	PF00400	0.498
DEG_APCC_DBOX_1	341	349	PF00400	0.513
DEG_APCC_DBOX_1	761	769	PF00400	0.535
DEG_APCC_DBOX_1	86	94	PF00400	0.396
DEG_SCF_FBW7_1	603	610	PF00400	0.499
DEG_SCF_FBW7_2	555	561	PF00400	0.673
DOC_CKS1_1	278	283	PF01111	0.602
DOC_CKS1_1	555	560	PF01111	0.709
DOC_CKS1_1	685	690	PF01111	0.584
DOC_CKS1_1	83	88	PF01111	0.453
DOC_CYCLIN_RxL_1	339	347	PF00134	0.592
DOC_CYCLIN_RxL_1	589	602	PF00134	0.496
DOC_MAPK_gen_1	152	160	PF00069	0.423
DOC_MAPK_gen_1	355	362	PF00069	0.440
DOC_MAPK_MEF2A_6	154	162	PF00069	0.421
DOC_MAPK_MEF2A_6	355	362	PF00069	0.445
DOC_MAPK_MEF2A_6	435	443	PF00069	0.389
DOC_PP2B_LxvP_1	204	207	PF13499	0.529
DOC_PP2B_LxvP_1	381	384	PF13499	0.631
DOC_PP2B_LxvP_1	472	475	PF13499	0.541
DOC_PP4_FxxP_1	380	383	PF00568	0.465
DOC_USP7_MATH_1	484	488	PF00917	0.697
DOC_USP7_MATH_1	527	531	PF00917	0.682
DOC_USP7_MATH_1	544	548	PF00917	0.566
DOC_USP7_MATH_1	607	611	PF00917	0.770
DOC_USP7_UBL2_3	172	176	PF12436	0.607
DOC_USP7_UBL2_3	586	590	PF12436	0.769
DOC_WW_Pin1_4	111	116	PF00397	0.602
DOC_WW_Pin1_4	246	251	PF00397	0.607
DOC_WW_Pin1_4	274	279	PF00397	0.530
DOC_WW_Pin1_4	49	54	PF00397	0.646
DOC_WW_Pin1_4	554	559	PF00397	0.683
DOC_WW_Pin1_4	565	570	PF00397	0.746
DOC_WW_Pin1_4	603	608	PF00397	0.586
DOC_WW_Pin1_4	684	689	PF00397	0.612
DOC_WW_Pin1_4	74	79	PF00397	0.493
DOC_WW_Pin1_4	742	747	PF00397	0.455
DOC_WW_Pin1_4	82	87	PF00397	0.414
LIG_14-3-3_CanoR_1	12	19	PF00244	0.414
LIG_14-3-3_CanoR_1	394	398	PF00244	0.473
LIG_14-3-3_CanoR_1	400	410	PF00244	0.464
LIG_14-3-3_CanoR_1	486	494	PF00244	0.767
LIG_14-3-3_CanoR_1	695	703	PF00244	0.670
LIG_14-3-3_CanoR_1	709	714	PF00244	0.489
LIG_14-3-3_CanoR_1	762	766	PF00244	0.468
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_BRCT_BRCA1_1	363	367	PF00533	0.526
LIG_CaM_NSCaTE_8	239	246	PF13499	0.502
LIG_Clathr_ClatBox_1	292	296	PF01394	0.501
LIG_deltaCOP1_diTrp_1	407	410	PF00928	0.542
LIG_FHA_1	186	192	PF00498	0.376
LIG_FHA_1	203	209	PF00498	0.510
LIG_FHA_1	266	272	PF00498	0.533
LIG_FHA_1	339	345	PF00498	0.525
LIG_FHA_1	394	400	PF00498	0.413
LIG_FHA_1	464	470	PF00498	0.425
LIG_FHA_1	49	55	PF00498	0.685
LIG_FHA_1	5	11	PF00498	0.600
LIG_FHA_1	555	561	PF00498	0.715
LIG_FHA_1	604	610	PF00498	0.597
LIG_FHA_1	734	740	PF00498	0.567
LIG_FHA_1	77	83	PF00498	0.601
LIG_FHA_2	175	181	PF00498	0.607
LIG_FHA_2	188	194	PF00498	0.420
LIG_FHA_2	3	9	PF00498	0.623
LIG_FHA_2	402	408	PF00498	0.562
LIG_FHA_2	409	415	PF00498	0.549
LIG_FHA_2	497	503	PF00498	0.784
LIG_FHA_2	600	606	PF00498	0.607
LIG_FHA_2	637	643	PF00498	0.609
LIG_Integrin_RGD_1	334	336	PF01839	0.382
LIG_LIR_Apic_2	377	383	PF02991	0.542
LIG_LIR_Apic_2	686	692	PF02991	0.585
LIG_LIR_Gen_1	147	155	PF02991	0.453
LIG_LIR_Gen_1	193	203	PF02991	0.398
LIG_LIR_Gen_1	238	247	PF02991	0.415
LIG_LIR_Gen_1	253	262	PF02991	0.428
LIG_LIR_Gen_1	55	65	PF02991	0.544
LIG_LIR_Nem_3	147	151	PF02991	0.416
LIG_LIR_Nem_3	193	198	PF02991	0.403
LIG_LIR_Nem_3	238	242	PF02991	0.412
LIG_LIR_Nem_3	253	257	PF02991	0.434
LIG_LIR_Nem_3	279	285	PF02991	0.518
LIG_LIR_Nem_3	336	340	PF02991	0.582
LIG_LIR_Nem_3	55	60	PF02991	0.530
LIG_NRBOX	307	313	PF00104	0.461
LIG_NRBOX	593	599	PF00104	0.495
LIG_Pex14_2	726	730	PF04695	0.439
LIG_SH2_CRK	102	106	PF00017	0.498
LIG_SH2_CRK	199	203	PF00017	0.390
LIG_SH2_CRK	254	258	PF00017	0.567
LIG_SH2_CRK	57	61	PF00017	0.537
LIG_SH2_NCK_1	254	258	PF00017	0.525
LIG_SH2_PTP2	148	151	PF00017	0.491
LIG_SH2_STAP1	144	148	PF00017	0.459
LIG_SH2_STAP1	24	28	PF00017	0.555
LIG_SH2_STAP1	340	344	PF00017	0.552
LIG_SH2_STAP1	57	61	PF00017	0.491
LIG_SH2_STAT3	232	235	PF00017	0.479
LIG_SH2_STAT5	148	151	PF00017	0.499
LIG_SH2_STAT5	232	235	PF00017	0.320
LIG_SH2_STAT5	254	257	PF00017	0.564
LIG_SH2_STAT5	340	343	PF00017	0.593
LIG_SH2_STAT5	738	741	PF00017	0.578
LIG_SH3_1	224	230	PF00018	0.576
LIG_SH3_1	275	281	PF00018	0.568
LIG_SH3_3	224	230	PF00018	0.590
LIG_SH3_3	275	281	PF00018	0.545
LIG_SH3_3	40	46	PF00018	0.776
LIG_SH3_3	546	552	PF00018	0.668
LIG_SH3_3	560	566	PF00018	0.534
LIG_SH3_3	606	612	PF00018	0.506
LIG_SH3_3	648	654	PF00018	0.734
LIG_SH3_3	655	661	PF00018	0.743
LIG_SH3_3	682	688	PF00018	0.594
LIG_SH3_5	53	57	PF00018	0.558
LIG_SUMO_SIM_anti_2	238	246	PF11976	0.395
LIG_SUMO_SIM_anti_2	470	475	PF11976	0.490
LIG_SUMO_SIM_par_1	238	246	PF11976	0.430
LIG_SUMO_SIM_par_1	291	296	PF11976	0.425
LIG_SUMO_SIM_par_1	465	470	PF11976	0.459
LIG_TRAF2_1	217	220	PF00917	0.343
LIG_TYR_ITIM	146	151	PF00017	0.441
LIG_UBA3_1	471	476	PF00899	0.583
LIG_UBA3_1	710	718	PF00899	0.589
MOD_CDK_SPK_2	82	87	PF00069	0.442
MOD_CDK_SPxxK_3	111	118	PF00069	0.579
MOD_CK1_1	11	17	PF00069	0.560
MOD_CK1_1	127	133	PF00069	0.552
MOD_CK1_1	147	153	PF00069	0.209
MOD_CK1_1	178	184	PF00069	0.498
MOD_CK1_1	2	8	PF00069	0.617
MOD_CK1_1	245	251	PF00069	0.523
MOD_CK1_1	373	379	PF00069	0.578
MOD_CK1_1	485	491	PF00069	0.725
MOD_CK1_1	500	506	PF00069	0.679
MOD_CK1_1	601	607	PF00069	0.697
MOD_CK1_1	641	647	PF00069	0.729
MOD_CK1_1	684	690	PF00069	0.567
MOD_CK1_1	712	718	PF00069	0.608
MOD_CK1_1	758	764	PF00069	0.578
MOD_CK1_1	77	83	PF00069	0.611
MOD_CK2_1	12	18	PF00069	0.512
MOD_CK2_1	174	180	PF00069	0.533
MOD_CK2_1	187	193	PF00069	0.421
MOD_CK2_1	2	8	PF00069	0.639
MOD_CK2_1	213	219	PF00069	0.596
MOD_CK2_1	347	353	PF00069	0.507
MOD_CK2_1	401	407	PF00069	0.588
MOD_CK2_1	408	414	PF00069	0.514
MOD_CK2_1	496	502	PF00069	0.502
MOD_CK2_1	599	605	PF00069	0.604
MOD_CK2_1	671	677	PF00069	0.456
MOD_CK2_1	745	751	PF00069	0.580
MOD_Cter_Amidation	353	356	PF01082	0.541
MOD_Cter_Amidation	583	586	PF01082	0.793
MOD_GlcNHglycan	177	180	PF01048	0.559
MOD_GlcNHglycan	215	219	PF01048	0.440
MOD_GlcNHglycan	313	316	PF01048	0.313
MOD_GlcNHglycan	33	36	PF01048	0.687
MOD_GlcNHglycan	349	352	PF01048	0.586
MOD_GlcNHglycan	390	393	PF01048	0.474
MOD_GlcNHglycan	476	479	PF01048	0.598
MOD_GlcNHglycan	504	507	PF01048	0.771
MOD_GlcNHglycan	515	518	PF01048	0.750
MOD_GlcNHglycan	546	549	PF01048	0.760
MOD_GSK3_1	123	130	PF00069	0.461
MOD_GSK3_1	174	181	PF00069	0.525
MOD_GSK3_1	242	249	PF00069	0.536
MOD_GSK3_1	4	11	PF00069	0.434
MOD_GSK3_1	480	487	PF00069	0.662
MOD_GSK3_1	496	503	PF00069	0.620
MOD_GSK3_1	561	568	PF00069	0.708
MOD_GSK3_1	599	606	PF00069	0.695
MOD_GSK3_1	709	716	PF00069	0.554
MOD_GSK3_1	73	80	PF00069	0.559
MOD_N-GLC_1	742	747	PF02516	0.501
MOD_NEK2_1	1	6	PF00069	0.615
MOD_NEK2_1	101	106	PF00069	0.492
MOD_NEK2_1	185	190	PF00069	0.438
MOD_NEK2_1	243	248	PF00069	0.490
MOD_NEK2_1	252	257	PF00069	0.547
MOD_NEK2_1	31	36	PF00069	0.596
MOD_NEK2_1	311	316	PF00069	0.583
MOD_NEK2_1	344	349	PF00069	0.585
MOD_NEK2_1	362	367	PF00069	0.319
MOD_NEK2_1	452	457	PF00069	0.523
MOD_NEK2_1	482	487	PF00069	0.566
MOD_NEK2_1	559	564	PF00069	0.705
MOD_NEK2_1	598	603	PF00069	0.743
MOD_NEK2_2	750	755	PF00069	0.582
MOD_PIKK_1	185	191	PF00454	0.430
MOD_PIKK_1	252	258	PF00454	0.534
MOD_PIKK_1	452	458	PF00454	0.480
MOD_PIKK_1	755	761	PF00454	0.585
MOD_PIKK_1	77	83	PF00454	0.585
MOD_PK_1	325	331	PF00069	0.591
MOD_PKA_1	172	178	PF00069	0.635
MOD_PKA_1	400	406	PF00069	0.542
MOD_PKA_2	11	17	PF00069	0.611
MOD_PKA_2	213	219	PF00069	0.550
MOD_PKA_2	393	399	PF00069	0.466
MOD_PKA_2	400	406	PF00069	0.469
MOD_PKA_2	480	486	PF00069	0.654
MOD_PKA_2	500	506	PF00069	0.527
MOD_PKA_2	511	517	PF00069	0.705
MOD_PKA_2	681	687	PF00069	0.470
MOD_PKA_2	694	700	PF00069	0.531
MOD_PKA_2	761	767	PF00069	0.488
MOD_Plk_1	243	249	PF00069	0.533
MOD_Plk_1	295	301	PF00069	0.463
MOD_Plk_1	55	61	PF00069	0.548
MOD_Plk_1	599	605	PF00069	0.783
MOD_Plk_1	750	756	PF00069	0.580
MOD_Plk_2-3	660	666	PF00069	0.612
MOD_Plk_2-3	681	687	PF00069	0.619
MOD_Plk_4	144	150	PF00069	0.430
MOD_Plk_4	187	193	PF00069	0.379
MOD_Plk_4	317	323	PF00069	0.539
MOD_Plk_4	393	399	PF00069	0.445
MOD_Plk_4	463	469	PF00069	0.420
MOD_Plk_4	55	61	PF00069	0.466
MOD_Plk_4	571	577	PF00069	0.506
MOD_Plk_4	64	70	PF00069	0.412
MOD_Plk_4	733	739	PF00069	0.555
MOD_ProDKin_1	111	117	PF00069	0.595
MOD_ProDKin_1	246	252	PF00069	0.617
MOD_ProDKin_1	274	280	PF00069	0.525
MOD_ProDKin_1	49	55	PF00069	0.633
MOD_ProDKin_1	554	560	PF00069	0.690
MOD_ProDKin_1	565	571	PF00069	0.747
MOD_ProDKin_1	603	609	PF00069	0.589
MOD_ProDKin_1	684	690	PF00069	0.615
MOD_ProDKin_1	74	80	PF00069	0.492
MOD_ProDKin_1	742	748	PF00069	0.461
MOD_ProDKin_1	82	88	PF00069	0.414
MOD_SUMO_for_1	367	370	PF00179	0.517
MOD_SUMO_rev_2	665	671	PF00179	0.324
TRG_DiLeu_BaEn_1	18	23	PF01217	0.536
TRG_DiLeu_BaEn_1	288	293	PF01217	0.521
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.541
TRG_DiLeu_BaLyEn_6	439	444	PF01217	0.521
TRG_ENDOCYTIC_2	102	105	PF00928	0.489
TRG_ENDOCYTIC_2	148	151	PF00928	0.448
TRG_ENDOCYTIC_2	199	202	PF00928	0.391
TRG_ENDOCYTIC_2	254	257	PF00928	0.564
TRG_ENDOCYTIC_2	57	60	PF00928	0.545
TRG_ER_diArg_1	109	111	PF00400	0.357
TRG_ER_diArg_1	164	166	PF00400	0.451
TRG_ER_diArg_1	223	225	PF00400	0.529
TRG_ER_diArg_1	399	401	PF00400	0.462
TRG_ER_diArg_1	63	65	PF00400	0.431
TRG_NLS_MonoExtC_3	581	586	PF00514	0.751
TRG_NLS_MonoExtN_4	714	721	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	372	377	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD12	Leptomonas seymouri	55%	94%
A0A3S5H7P7	Leishmania donovani	90%	100%
A4HJ78	Leishmania braziliensis	76%	98%
A4I6M2	Leishmania infantum	90%	100%
C9ZTI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A527	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q6G5	Leishmania major	90%	100%
V5BCP2	Trypanosoma cruzi	31%	100%