Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1P4_LEIMU

TriTrypDb:

LmxM.30.0970

Length:

887

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.581
CLV_C14_Caspase3-7	149	153	PF00656	0.697
CLV_C14_Caspase3-7	532	536	PF00656	0.657
CLV_C14_Caspase3-7	692	696	PF00656	0.486
CLV_NRD_NRD_1	14	16	PF00675	0.437
CLV_NRD_NRD_1	192	194	PF00675	0.521
CLV_NRD_NRD_1	341	343	PF00675	0.550
CLV_NRD_NRD_1	567	569	PF00675	0.555
CLV_NRD_NRD_1	604	606	PF00675	0.633
CLV_NRD_NRD_1	69	71	PF00675	0.483
CLV_NRD_NRD_1	748	750	PF00675	0.617
CLV_NRD_NRD_1	764	766	PF00675	0.530
CLV_NRD_NRD_1	779	781	PF00675	0.497
CLV_NRD_NRD_1	838	840	PF00675	0.511
CLV_NRD_NRD_1	860	862	PF00675	0.563
CLV_NRD_NRD_1	882	884	PF00675	0.580
CLV_PCSK_KEX2_1	14	16	PF00082	0.437
CLV_PCSK_KEX2_1	192	194	PF00082	0.521
CLV_PCSK_KEX2_1	341	343	PF00082	0.347
CLV_PCSK_KEX2_1	349	351	PF00082	0.437
CLV_PCSK_KEX2_1	567	569	PF00082	0.548
CLV_PCSK_KEX2_1	604	606	PF00082	0.591
CLV_PCSK_KEX2_1	669	671	PF00082	0.576
CLV_PCSK_KEX2_1	748	750	PF00082	0.617
CLV_PCSK_KEX2_1	764	766	PF00082	0.530
CLV_PCSK_KEX2_1	781	783	PF00082	0.479
CLV_PCSK_KEX2_1	882	884	PF00082	0.580
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.431
CLV_PCSK_PC1ET2_1	669	671	PF00082	0.576
CLV_PCSK_PC1ET2_1	781	783	PF00082	0.481
CLV_PCSK_PC7_1	337	343	PF00082	0.344
CLV_PCSK_PC7_1	665	671	PF00082	0.538
CLV_PCSK_SKI1_1	337	341	PF00082	0.413
CLV_PCSK_SKI1_1	363	367	PF00082	0.518
CLV_PCSK_SKI1_1	567	571	PF00082	0.510
CLV_PCSK_SKI1_1	609	613	PF00082	0.539
CLV_PCSK_SKI1_1	71	75	PF00082	0.564
CLV_PCSK_SKI1_1	749	753	PF00082	0.615
CLV_Separin_Metazoa	482	486	PF03568	0.423
DEG_APCC_DBOX_1	336	344	PF00400	0.410
DEG_APCC_DBOX_1	472	480	PF00400	0.426
DEG_SPOP_SBC_1	230	234	PF00917	0.512
DEG_SPOP_SBC_1	711	715	PF00917	0.539
DOC_CKS1_1	717	722	PF01111	0.673
DOC_MAPK_gen_1	341	348	PF00069	0.438
DOC_MAPK_gen_1	473	480	PF00069	0.429
DOC_MAPK_gen_1	67	77	PF00069	0.423
DOC_MAPK_gen_1	861	869	PF00069	0.547
DOC_MAPK_MEF2A_6	287	294	PF00069	0.538
DOC_MAPK_MEF2A_6	473	480	PF00069	0.429
DOC_MAPK_MEF2A_6	70	79	PF00069	0.428
DOC_MAPK_MEF2A_6	871	880	PF00069	0.515
DOC_MAPK_NFAT4_5	473	481	PF00069	0.429
DOC_USP7_MATH_1	126	130	PF00917	0.595
DOC_USP7_MATH_1	156	160	PF00917	0.561
DOC_USP7_MATH_1	16	20	PF00917	0.498
DOC_USP7_MATH_1	181	185	PF00917	0.570
DOC_USP7_MATH_1	526	530	PF00917	0.681
DOC_USP7_MATH_1	701	705	PF00917	0.544
DOC_USP7_MATH_2	517	523	PF00917	0.520
DOC_WW_Pin1_4	220	225	PF00397	0.683
DOC_WW_Pin1_4	286	291	PF00397	0.538
DOC_WW_Pin1_4	372	377	PF00397	0.501
DOC_WW_Pin1_4	398	403	PF00397	0.477
DOC_WW_Pin1_4	527	532	PF00397	0.519
DOC_WW_Pin1_4	560	565	PF00397	0.531
DOC_WW_Pin1_4	626	631	PF00397	0.586
DOC_WW_Pin1_4	716	721	PF00397	0.670
DOC_WW_Pin1_4	728	733	PF00397	0.595
LIG_14-3-3_CanoR_1	106	116	PF00244	0.547
LIG_14-3-3_CanoR_1	15	25	PF00244	0.584
LIG_14-3-3_CanoR_1	419	427	PF00244	0.518
LIG_14-3-3_CanoR_1	442	452	PF00244	0.518
LIG_14-3-3_CanoR_1	609	614	PF00244	0.545
LIG_14-3-3_CanoR_1	755	761	PF00244	0.596
LIG_14-3-3_CanoR_1	764	772	PF00244	0.558
LIG_14-3-3_CanoR_1	780	789	PF00244	0.479
LIG_14-3-3_CanoR_1	795	803	PF00244	0.451
LIG_14-3-3_CanoR_1	839	846	PF00244	0.488
LIG_14-3-3_CanoR_1	868	878	PF00244	0.549
LIG_14-3-3_CanoR_1	92	99	PF00244	0.597
LIG_Actin_RPEL_3	480	499	PF02755	0.390
LIG_BIR_III_2	137	141	PF00653	0.574
LIG_BIR_III_2	152	156	PF00653	0.582
LIG_BRCT_BRCA1_1	231	235	PF00533	0.568
LIG_BRCT_BRCA1_1	239	243	PF00533	0.471
LIG_BRCT_BRCA1_1	521	525	PF00533	0.621
LIG_CaM_IQ_9	59	74	PF13499	0.426
LIG_Clathr_ClatBox_1	291	295	PF01394	0.532
LIG_Clathr_ClatBox_1	364	368	PF01394	0.412
LIG_Clathr_ClatBox_1	388	392	PF01394	0.431
LIG_Clathr_ClatBox_1	493	497	PF01394	0.407
LIG_CtBP_PxDLS_1	688	692	PF00389	0.487
LIG_eIF4E_1	488	494	PF01652	0.438
LIG_FHA_1	755	761	PF00498	0.572
LIG_FHA_1	830	836	PF00498	0.503
LIG_FHA_2	109	115	PF00498	0.503
LIG_FHA_2	595	601	PF00498	0.621
LIG_FHA_2	610	616	PF00498	0.540
LIG_FHA_2	692	698	PF00498	0.674
LIG_FHA_2	764	770	PF00498	0.550
LIG_LIR_Gen_1	110	118	PF02991	0.555
LIG_LIR_Gen_1	196	204	PF02991	0.432
LIG_LIR_Gen_1	217	224	PF02991	0.722
LIG_LIR_Gen_1	390	398	PF02991	0.479
LIG_LIR_Gen_1	474	484	PF02991	0.400
LIG_LIR_Gen_1	615	624	PF02991	0.643
LIG_LIR_Gen_1	83	91	PF02991	0.486
LIG_LIR_Nem_3	110	116	PF02991	0.547
LIG_LIR_Nem_3	196	200	PF02991	0.497
LIG_LIR_Nem_3	217	221	PF02991	0.721
LIG_LIR_Nem_3	390	394	PF02991	0.465
LIG_LIR_Nem_3	421	427	PF02991	0.498
LIG_LIR_Nem_3	474	480	PF02991	0.400
LIG_LIR_Nem_3	615	620	PF02991	0.629
LIG_LIR_Nem_3	83	87	PF02991	0.475
LIG_LIR_Nem_3	848	852	PF02991	0.465
LIG_LYPXL_yS_3	849	852	PF13949	0.559
LIG_NRBOX	475	481	PF00104	0.425
LIG_Pex14_1	17	21	PF04695	0.486
LIG_PTAP_UEV_1	279	284	PF05743	0.450
LIG_SH2_CRK	266	270	PF00017	0.576
LIG_SH2_CRK	610	614	PF00017	0.544
LIG_SH2_CRK	84	88	PF00017	0.498
LIG_SH2_NCK_1	610	614	PF00017	0.544
LIG_SH2_STAP1	641	645	PF00017	0.555
LIG_SH2_STAP1	84	88	PF00017	0.486
LIG_SH2_STAT5	21	24	PF00017	0.506
LIG_SH2_STAT5	396	399	PF00017	0.573
LIG_SH2_STAT5	488	491	PF00017	0.471
LIG_SH2_STAT5	492	495	PF00017	0.412
LIG_SH2_STAT5	641	644	PF00017	0.560
LIG_SH2_STAT5	851	854	PF00017	0.572
LIG_SH3_2	377	382	PF14604	0.380
LIG_SH3_2	584	589	PF14604	0.617
LIG_SH3_3	10	16	PF00018	0.445
LIG_SH3_3	137	143	PF00018	0.580
LIG_SH3_3	175	181	PF00018	0.598
LIG_SH3_3	277	283	PF00018	0.448
LIG_SH3_3	368	374	PF00018	0.511
LIG_SH3_3	528	534	PF00018	0.575
LIG_SH3_3	581	587	PF00018	0.617
LIG_SH3_3	627	633	PF00018	0.507
LIG_SH3_3	726	732	PF00018	0.580
LIG_SUMO_SIM_anti_2	361	369	PF11976	0.421
LIG_SUMO_SIM_par_1	361	369	PF11976	0.448
LIG_SUMO_SIM_par_1	465	472	PF11976	0.472
LIG_SUMO_SIM_par_1	687	692	PF11976	0.491
LIG_TRAF2_1	155	158	PF00917	0.508
LIG_TRAF2_1	61	64	PF00917	0.575
LIG_TRAF2_1	612	615	PF00917	0.539
LIG_WRC_WIRS_1	388	393	PF05994	0.442
MOD_CDK_SPxK_1	716	722	PF00069	0.612
MOD_CDK_SPxxK_3	286	293	PF00069	0.538
MOD_CDK_SPxxK_3	560	567	PF00069	0.533
MOD_CK1_1	131	137	PF00069	0.564
MOD_CK1_1	159	165	PF00069	0.663
MOD_CK1_1	184	190	PF00069	0.506
MOD_CK1_1	223	229	PF00069	0.562
MOD_CK1_1	234	240	PF00069	0.606
MOD_CK1_1	375	381	PF00069	0.468
MOD_CK1_1	401	407	PF00069	0.541
MOD_CK1_1	417	423	PF00069	0.565
MOD_CK1_1	443	449	PF00069	0.621
MOD_CK1_1	618	624	PF00069	0.607
MOD_CK1_1	640	646	PF00069	0.627
MOD_CK1_1	756	762	PF00069	0.573
MOD_CK1_1	763	769	PF00069	0.537
MOD_CK1_1	838	844	PF00069	0.536
MOD_CK2_1	117	123	PF00069	0.568
MOD_CK2_1	223	229	PF00069	0.477
MOD_CK2_1	387	393	PF00069	0.368
MOD_CK2_1	526	532	PF00069	0.577
MOD_CK2_1	609	615	PF00069	0.550
MOD_CK2_1	644	650	PF00069	0.581
MOD_CK2_1	691	697	PF00069	0.494
MOD_GlcNHglycan	128	131	PF01048	0.621
MOD_GlcNHglycan	144	147	PF01048	0.652
MOD_GlcNHglycan	149	152	PF01048	0.650
MOD_GlcNHglycan	161	164	PF01048	0.650
MOD_GlcNHglycan	167	170	PF01048	0.588
MOD_GlcNHglycan	236	239	PF01048	0.468
MOD_GlcNHglycan	253	256	PF01048	0.457
MOD_GlcNHglycan	33	36	PF01048	0.578
MOD_GlcNHglycan	41	44	PF01048	0.560
MOD_GlcNHglycan	458	462	PF01048	0.540
MOD_GlcNHglycan	464	467	PF01048	0.541
MOD_GlcNHglycan	521	524	PF01048	0.701
MOD_GlcNHglycan	579	583	PF01048	0.606
MOD_GlcNHglycan	617	620	PF01048	0.687
MOD_GlcNHglycan	643	646	PF01048	0.568
MOD_GlcNHglycan	684	687	PF01048	0.744
MOD_GlcNHglycan	732	735	PF01048	0.640
MOD_GlcNHglycan	840	843	PF01048	0.521
MOD_GlcNHglycan	857	861	PF01048	0.479
MOD_GlcNHglycan	871	874	PF01048	0.496
MOD_GlcNHglycan	9	12	PF01048	0.451
MOD_GSK3_1	108	115	PF00069	0.503
MOD_GSK3_1	126	133	PF00069	0.555
MOD_GSK3_1	157	164	PF00069	0.638
MOD_GSK3_1	16	23	PF00069	0.428
MOD_GSK3_1	220	227	PF00069	0.729
MOD_GSK3_1	230	237	PF00069	0.562
MOD_GSK3_1	244	251	PF00069	0.645
MOD_GSK3_1	401	408	PF00069	0.691
MOD_GSK3_1	414	421	PF00069	0.642
MOD_GSK3_1	590	597	PF00069	0.694
MOD_GSK3_1	625	632	PF00069	0.576
MOD_GSK3_1	633	640	PF00069	0.568
MOD_GSK3_1	678	685	PF00069	0.597
MOD_GSK3_1	687	694	PF00069	0.613
MOD_GSK3_1	712	719	PF00069	0.670
MOD_GSK3_1	749	756	PF00069	0.618
MOD_GSK3_1	805	812	PF00069	0.550
MOD_N-GLC_1	118	123	PF02516	0.504
MOD_N-GLC_1	443	448	PF02516	0.534
MOD_N-GLC_1	527	532	PF02516	0.562
MOD_N-GLC_1	796	801	PF02516	0.517
MOD_N-GLC_1	855	860	PF02516	0.529
MOD_NEK2_1	214	219	PF00069	0.627
MOD_NEK2_1	244	249	PF00069	0.653
MOD_NEK2_1	418	423	PF00069	0.522
MOD_NEK2_1	426	431	PF00069	0.569
MOD_NEK2_1	450	455	PF00069	0.616
MOD_NEK2_1	624	629	PF00069	0.570
MOD_NEK2_1	689	694	PF00069	0.475
MOD_NEK2_1	721	726	PF00069	0.638
MOD_NEK2_1	869	874	PF00069	0.537
MOD_NEK2_2	701	706	PF00069	0.486
MOD_NEK2_2	9	14	PF00069	0.538
MOD_OFUCOSY	819	824	PF10250	0.569
MOD_PIKK_1	181	187	PF00454	0.522
MOD_PIKK_1	822	828	PF00454	0.485
MOD_PKA_1	781	787	PF00069	0.482
MOD_PKA_2	126	132	PF00069	0.601
MOD_PKA_2	418	424	PF00069	0.512
MOD_PKA_2	450	456	PF00069	0.595
MOD_PKA_2	588	594	PF00069	0.623
MOD_PKA_2	721	727	PF00069	0.764
MOD_PKA_2	754	760	PF00069	0.597
MOD_PKA_2	763	769	PF00069	0.572
MOD_PKA_2	781	787	PF00069	0.510
MOD_PKA_2	805	811	PF00069	0.508
MOD_PKA_2	838	844	PF00069	0.493
MOD_PKB_1	793	801	PF00069	0.469
MOD_PKB_1	90	98	PF00069	0.513
MOD_Plk_1	117	123	PF00069	0.502
MOD_Plk_1	295	301	PF00069	0.645
MOD_Plk_2-3	112	118	PF00069	0.556
MOD_Plk_2-3	387	393	PF00069	0.442
MOD_Plk_4	231	237	PF00069	0.581
MOD_Plk_4	248	254	PF00069	0.439
MOD_ProDKin_1	220	226	PF00069	0.681
MOD_ProDKin_1	286	292	PF00069	0.538
MOD_ProDKin_1	372	378	PF00069	0.498
MOD_ProDKin_1	398	404	PF00069	0.476
MOD_ProDKin_1	527	533	PF00069	0.519
MOD_ProDKin_1	560	566	PF00069	0.530
MOD_ProDKin_1	626	632	PF00069	0.588
MOD_ProDKin_1	716	722	PF00069	0.671
MOD_ProDKin_1	728	734	PF00069	0.594
MOD_SUMO_rev_2	823	832	PF00179	0.490
TRG_DiLeu_BaEn_2	392	398	PF01217	0.507
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.540
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.416
TRG_ENDOCYTIC_2	113	116	PF00928	0.552
TRG_ENDOCYTIC_2	197	200	PF00928	0.636
TRG_ENDOCYTIC_2	610	613	PF00928	0.540
TRG_ENDOCYTIC_2	84	87	PF00928	0.499
TRG_ENDOCYTIC_2	849	852	PF00928	0.559
TRG_ER_diArg_1	13	15	PF00400	0.443
TRG_ER_diArg_1	192	194	PF00400	0.521
TRG_ER_diArg_1	324	327	PF00400	0.453
TRG_ER_diArg_1	340	342	PF00400	0.419
TRG_ER_diArg_1	484	487	PF00400	0.418
TRG_ER_diArg_1	567	569	PF00400	0.549
TRG_ER_diArg_1	792	795	PF00400	0.578
TRG_ER_diArg_1	803	806	PF00400	0.500
TRG_ER_diArg_1	882	884	PF00400	0.580
TRG_NLS_MonoExtN_4	666	673	PF00514	0.538
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	622	626	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	749	754	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ59	Leptomonas seymouri	31%	100%
A0A3Q8IG32	Leishmania donovani	78%	99%
A4I6M1	Leishmania infantum	79%	99%
Q4Q6G6	Leishmania major	80%	100%