Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania mexicana

UniProt:

E9B1N7_LEIMU

TriTrypDb:

LmxM.30.0860

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1N7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.616
CLV_C14_Caspase3-7	393	397	PF00656	0.686
CLV_C14_Caspase3-7	535	539	PF00656	0.631
CLV_C14_Caspase3-7	78	82	PF00656	0.705
CLV_NRD_NRD_1	198	200	PF00675	0.337
CLV_NRD_NRD_1	243	245	PF00675	0.466
CLV_NRD_NRD_1	357	359	PF00675	0.587
CLV_NRD_NRD_1	466	468	PF00675	0.556
CLV_NRD_NRD_1	484	486	PF00675	0.663
CLV_PCSK_KEX2_1	200	202	PF00082	0.339
CLV_PCSK_KEX2_1	357	359	PF00082	0.600
CLV_PCSK_KEX2_1	484	486	PF00082	0.537
CLV_PCSK_KEX2_1	54	56	PF00082	0.397
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.317
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.397
CLV_PCSK_PC7_1	196	202	PF00082	0.339
CLV_PCSK_SKI1_1	271	275	PF00082	0.318
CLV_PCSK_SKI1_1	476	480	PF00082	0.638
CLV_PCSK_SKI1_1	54	58	PF00082	0.395
DEG_APCC_DBOX_1	270	278	PF00400	0.317
DEG_SCF_FBW7_2	295	302	PF00400	0.556
DOC_CDC14_PxL_1	325	333	PF14671	0.513
DOC_CKS1_1	336	341	PF01111	0.531
DOC_CKS1_1	427	432	PF01111	0.786
DOC_CYCLIN_RxL_1	49	58	PF00134	0.458
DOC_MAPK_MEF2A_6	509	518	PF00069	0.669
DOC_PP2B_LxvP_1	102	105	PF13499	0.466
DOC_PP2B_LxvP_1	292	295	PF13499	0.447
DOC_PP2B_LxvP_1	353	356	PF13499	0.685
DOC_PP2B_LxvP_1	57	60	PF13499	0.503
DOC_PP4_FxxP_1	326	329	PF00568	0.762
DOC_USP7_MATH_1	109	113	PF00917	0.348
DOC_USP7_MATH_1	186	190	PF00917	0.426
DOC_USP7_MATH_1	194	198	PF00917	0.392
DOC_USP7_MATH_1	260	264	PF00917	0.310
DOC_USP7_MATH_1	315	319	PF00917	0.590
DOC_USP7_MATH_1	364	368	PF00917	0.730
DOC_USP7_MATH_1	532	536	PF00917	0.638
DOC_USP7_MATH_1	64	68	PF00917	0.524
DOC_USP7_UBL2_3	461	465	PF12436	0.648
DOC_USP7_UBL2_3	594	598	PF12436	0.573
DOC_USP7_UBL2_3	600	604	PF12436	0.592
DOC_WW_Pin1_4	295	300	PF00397	0.624
DOC_WW_Pin1_4	335	340	PF00397	0.636
DOC_WW_Pin1_4	344	349	PF00397	0.644
DOC_WW_Pin1_4	387	392	PF00397	0.634
DOC_WW_Pin1_4	415	420	PF00397	0.773
DOC_WW_Pin1_4	426	431	PF00397	0.633
DOC_WW_Pin1_4	62	67	PF00397	0.553
DOC_WW_Pin1_4	89	94	PF00397	0.466
LIG_14-3-3_CanoR_1	135	140	PF00244	0.339
LIG_14-3-3_CanoR_1	158	163	PF00244	0.216
LIG_14-3-3_CanoR_1	283	287	PF00244	0.609
LIG_14-3-3_CanoR_1	357	363	PF00244	0.584
LIG_14-3-3_CanoR_1	369	376	PF00244	0.581
LIG_Actin_WH2_2	181	198	PF00022	0.317
LIG_Actin_WH2_2	267	285	PF00022	0.466
LIG_APCC_ABBA_1	251	256	PF00400	0.339
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_FHA_1	118	124	PF00498	0.339
LIG_FHA_1	320	326	PF00498	0.557
LIG_FHA_1	348	354	PF00498	0.695
LIG_FHA_1	433	439	PF00498	0.598
LIG_FHA_1	48	54	PF00498	0.386
LIG_FHA_1	90	96	PF00498	0.466
LIG_FHA_2	15	21	PF00498	0.553
LIG_FHA_2	454	460	PF00498	0.626
LIG_Integrin_RGD_1	431	433	PF01839	0.647
LIG_LIR_Gen_1	249	259	PF02991	0.349
LIG_LIR_Gen_1	572	581	PF02991	0.509
LIG_LIR_Gen_1	97	108	PF02991	0.295
LIG_LIR_Nem_3	249	254	PF02991	0.349
LIG_LIR_Nem_3	256	262	PF02991	0.352
LIG_LIR_Nem_3	34	40	PF02991	0.395
LIG_LIR_Nem_3	386	392	PF02991	0.524
LIG_LIR_Nem_3	572	577	PF02991	0.511
LIG_LIR_Nem_3	97	103	PF02991	0.347
LIG_MYND_1	329	333	PF01753	0.695
LIG_PCNA_PIPBox_1	247	256	PF02747	0.270
LIG_PCNA_yPIPBox_3	244	254	PF02747	0.270
LIG_PCNA_yPIPBox_3	465	479	PF02747	0.572
LIG_PTB_Apo_2	133	140	PF02174	0.339
LIG_SH2_CRK	100	104	PF00017	0.283
LIG_SH2_CRK	279	283	PF00017	0.487
LIG_SH2_NCK_1	259	263	PF00017	0.339
LIG_SH2_SRC	259	262	PF00017	0.310
LIG_SH2_STAP1	100	104	PF00017	0.339
LIG_SH2_STAP1	126	130	PF00017	0.339
LIG_SH2_STAT5	16	19	PF00017	0.541
LIG_SH2_STAT5	35	38	PF00017	0.450
LIG_SH3_3	143	149	PF00018	0.414
LIG_SH3_3	24	30	PF00018	0.647
LIG_SH3_3	385	391	PF00018	0.627
LIG_SH3_CIN85_PxpxPR_1	340	345	PF14604	0.717
LIG_SUMO_SIM_anti_2	174	179	PF11976	0.340
LIG_SUMO_SIM_par_1	209	216	PF11976	0.399
LIG_SUMO_SIM_par_1	38	44	PF11976	0.373
LIG_TRFH_1	376	380	PF08558	0.689
LIG_TYR_ITIM	257	262	PF00017	0.339
LIG_TYR_ITIM	277	282	PF00017	0.465
LIG_WW_3	354	358	PF00397	0.669
MOD_CAAXbox	607	610	PF01239	0.565
MOD_CDC14_SPxK_1	65	68	PF00782	0.580
MOD_CDK_SPK_2	426	431	PF00069	0.722
MOD_CDK_SPxK_1	62	68	PF00069	0.556
MOD_CK1_1	151	157	PF00069	0.350
MOD_CK1_1	218	224	PF00069	0.425
MOD_CK1_1	263	269	PF00069	0.335
MOD_CK1_1	347	353	PF00069	0.792
MOD_CK1_1	367	373	PF00069	0.767
MOD_CK1_1	415	421	PF00069	0.562
MOD_CK1_1	525	531	PF00069	0.518
MOD_CK1_1	62	68	PF00069	0.706
MOD_CK2_1	14	20	PF00069	0.563
MOD_CK2_1	64	70	PF00069	0.480
MOD_Cter_Amidation	482	485	PF01082	0.606
MOD_GlcNHglycan	190	193	PF01048	0.391
MOD_GlcNHglycan	196	199	PF01048	0.456
MOD_GlcNHglycan	223	227	PF01048	0.402
MOD_GlcNHglycan	230	233	PF01048	0.329
MOD_GlcNHglycan	261	265	PF01048	0.339
MOD_GlcNHglycan	326	329	PF01048	0.606
MOD_GlcNHglycan	360	363	PF01048	0.581
MOD_GlcNHglycan	405	409	PF01048	0.711
MOD_GlcNHglycan	414	417	PF01048	0.586
MOD_GlcNHglycan	498	501	PF01048	0.684
MOD_GlcNHglycan	525	528	PF01048	0.733
MOD_GSK3_1	126	133	PF00069	0.414
MOD_GSK3_1	144	151	PF00069	0.239
MOD_GSK3_1	186	193	PF00069	0.269
MOD_GSK3_1	218	225	PF00069	0.354
MOD_GSK3_1	315	322	PF00069	0.615
MOD_GSK3_1	364	371	PF00069	0.636
MOD_GSK3_1	378	385	PF00069	0.647
MOD_GSK3_1	422	429	PF00069	0.804
MOD_GSK3_1	43	50	PF00069	0.395
MOD_GSK3_1	444	451	PF00069	0.730
MOD_GSK3_1	532	539	PF00069	0.639
MOD_GSK3_1	55	62	PF00069	0.460
MOD_GSK3_1	75	82	PF00069	0.440
MOD_GSK3_1	94	101	PF00069	0.196
MOD_N-GLC_1	135	140	PF02516	0.339
MOD_N-GLC_1	221	226	PF02516	0.316
MOD_N-GLC_1	315	320	PF02516	0.606
MOD_N-GLC_1	583	588	PF02516	0.410
MOD_N-GLC_2	606	608	PF02516	0.614
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	144	149	PF00069	0.326
MOD_NEK2_1	282	287	PF00069	0.557
MOD_NEK2_1	304	309	PF00069	0.588
MOD_NEK2_1	445	450	PF00069	0.740
MOD_NEK2_1	75	80	PF00069	0.719
MOD_NEK2_2	109	114	PF00069	0.339
MOD_NEK2_2	130	135	PF00069	0.317
MOD_PIKK_1	378	384	PF00454	0.592
MOD_PK_1	55	61	PF00069	0.571
MOD_PKA_1	357	363	PF00069	0.543
MOD_PKA_1	596	602	PF00069	0.620
MOD_PKA_2	282	288	PF00069	0.610
MOD_PKA_2	356	362	PF00069	0.622
MOD_PKA_2	368	374	PF00069	0.564
MOD_PKA_2	554	560	PF00069	0.754
MOD_PKA_2	590	596	PF00069	0.422
MOD_Plk_1	130	136	PF00069	0.334
MOD_Plk_1	14	20	PF00069	0.563
MOD_Plk_1	43	49	PF00069	0.396
MOD_Plk_1	75	81	PF00069	0.662
MOD_Plk_2-3	14	20	PF00069	0.563
MOD_Plk_2-3	233	239	PF00069	0.216
MOD_Plk_2-3	372	378	PF00069	0.696
MOD_Plk_2-3	70	76	PF00069	0.685
MOD_Plk_4	135	141	PF00069	0.333
MOD_Plk_4	151	157	PF00069	0.317
MOD_Plk_4	158	164	PF00069	0.383
MOD_Plk_4	304	310	PF00069	0.595
MOD_Plk_4	48	54	PF00069	0.386
MOD_Plk_4	532	538	PF00069	0.642
MOD_Plk_4	98	104	PF00069	0.283
MOD_ProDKin_1	295	301	PF00069	0.621
MOD_ProDKin_1	335	341	PF00069	0.640
MOD_ProDKin_1	344	350	PF00069	0.648
MOD_ProDKin_1	387	393	PF00069	0.636
MOD_ProDKin_1	415	421	PF00069	0.776
MOD_ProDKin_1	426	432	PF00069	0.633
MOD_ProDKin_1	62	68	PF00069	0.561
MOD_ProDKin_1	89	95	PF00069	0.466
MOD_SUMO_rev_2	459	466	PF00179	0.709
MOD_SUMO_rev_2	469	478	PF00179	0.553
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.455
TRG_ENDOCYTIC_2	100	103	PF00928	0.283
TRG_ENDOCYTIC_2	259	262	PF00928	0.344
TRG_ENDOCYTIC_2	279	282	PF00928	0.487
TRG_ER_diArg_1	201	204	PF00400	0.462
TRG_ER_diArg_1	356	358	PF00400	0.583
TRG_ER_diArg_1	552	555	PF00400	0.577
TRG_NLS_MonoExtC_3	198	203	PF00514	0.399
TRG_NLS_MonoExtC_3	595	600	PF00514	0.536
TRG_NLS_MonoExtN_4	196	203	PF00514	0.317
TRG_NLS_MonoExtN_4	594	601	PF00514	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTB6	Leptomonas seymouri	45%	97%
A0A3Q8IER9	Leishmania donovani	86%	100%
A4HJ62	Leishmania braziliensis	63%	99%
A4I6I0	Leishmania infantum	87%	100%
Q4Q6H7	Leishmania major	83%	100%