IMD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9B1N6_LEIMU

TriTrypDb:

LmxM.30.0851

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1N6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.419
CLV_C14_Caspase3-7	348	352	PF00656	0.517
CLV_NRD_NRD_1	166	168	PF00675	0.424
CLV_NRD_NRD_1	191	193	PF00675	0.389
CLV_NRD_NRD_1	268	270	PF00675	0.548
CLV_NRD_NRD_1	320	322	PF00675	0.517
CLV_PCSK_KEX2_1	191	193	PF00082	0.405
CLV_PCSK_SKI1_1	104	108	PF00082	0.476
CLV_PCSK_SKI1_1	111	115	PF00082	0.481
CLV_PCSK_SKI1_1	117	121	PF00082	0.403
CLV_PCSK_SKI1_1	122	126	PF00082	0.332
CLV_PCSK_SKI1_1	237	241	PF00082	0.386
CLV_PCSK_SKI1_1	321	325	PF00082	0.607
DOC_CYCLIN_RxL_1	188	199	PF00134	0.437
DOC_MAPK_gen_1	188	196	PF00069	0.330
DOC_USP7_MATH_1	138	142	PF00917	0.451
DOC_USP7_MATH_1	146	150	PF00917	0.451
DOC_USP7_MATH_1	160	164	PF00917	0.462
DOC_USP7_MATH_1	22	26	PF00917	0.405
DOC_USP7_MATH_1	409	413	PF00917	0.457
DOC_USP7_MATH_1	53	57	PF00917	0.417
DOC_USP7_UBL2_3	103	107	PF12436	0.503
DOC_WW_Pin1_4	282	287	PF00397	0.574
DOC_WW_Pin1_4	383	388	PF00397	0.481
LIG_14-3-3_CanoR_1	293	302	PF00244	0.548
LIG_14-3-3_CanoR_1	376	382	PF00244	0.548
LIG_Actin_WH2_2	88	105	PF00022	0.436
LIG_AP2alpha_1	171	175	PF02296	0.429
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_BRCT_BRCA1_1	47	51	PF00533	0.407
LIG_BRCT_BRCA1_1	55	59	PF00533	0.425
LIG_FHA_1	177	183	PF00498	0.326
LIG_FHA_1	200	206	PF00498	0.415
LIG_FHA_1	245	251	PF00498	0.473
LIG_FHA_1	333	339	PF00498	0.655
LIG_FHA_2	207	213	PF00498	0.422
LIG_FHA_2	40	46	PF00498	0.414
LIG_FHA_2	403	409	PF00498	0.477
LIG_FHA_2	58	64	PF00498	0.397
LIG_LIR_Gen_1	172	182	PF02991	0.530
LIG_LIR_Gen_1	48	59	PF02991	0.447
LIG_LIR_Nem_3	172	178	PF02991	0.428
LIG_LIR_Nem_3	25	29	PF02991	0.467
LIG_LIR_Nem_3	353	358	PF02991	0.594
LIG_LIR_Nem_3	48	54	PF02991	0.442
LIG_PCNA_yPIPBox_3	20	34	PF02747	0.291
LIG_Pex14_2	171	175	PF04695	0.443
LIG_SH2_GRB2like	272	275	PF00017	0.490
LIG_SH2_SRC	272	275	PF00017	0.487
LIG_SH2_SRC	67	70	PF00017	0.382
LIG_SH2_STAP1	150	154	PF00017	0.352
LIG_SH2_STAT5	193	196	PF00017	0.439
LIG_SH2_STAT5	222	225	PF00017	0.370
LIG_SH2_STAT5	272	275	PF00017	0.490
LIG_SH2_STAT5	372	375	PF00017	0.781
LIG_SH2_STAT5	391	394	PF00017	0.489
LIG_SH2_STAT5	67	70	PF00017	0.393
LIG_SH3_3	303	309	PF00018	0.579
LIG_SH3_3	337	343	PF00018	0.529
LIG_SH3_3	414	420	PF00018	0.578
LIG_SH3_3	92	98	PF00018	0.405
LIG_TRAF2_1	214	217	PF00917	0.426
LIG_TRAF2_1	288	291	PF00917	0.524
LIG_TRFH_1	254	258	PF08558	0.589
LIG_UBA3_1	33	38	PF00899	0.418
LIG_WRC_WIRS_1	23	28	PF05994	0.401
LIG_WRC_WIRS_1	273	278	PF05994	0.491
LIG_WRC_WIRS_1	371	376	PF05994	0.579
LIG_WW_1	369	372	PF00397	0.572
LIG_WW_1	388	391	PF00397	0.553
MOD_CK1_1	149	155	PF00069	0.521
MOD_CK1_1	163	169	PF00069	0.365
MOD_CK1_1	174	180	PF00069	0.381
MOD_CK1_1	380	386	PF00069	0.561
MOD_CK1_1	412	418	PF00069	0.512
MOD_CK1_1	58	64	PF00069	0.377
MOD_CK2_1	102	108	PF00069	0.597
MOD_CK2_1	272	278	PF00069	0.491
MOD_CK2_1	341	347	PF00069	0.605
MOD_CK2_1	39	45	PF00069	0.418
MOD_CK2_1	402	408	PF00069	0.474
MOD_CK2_1	57	63	PF00069	0.547
MOD_CK2_1	74	80	PF00069	0.456
MOD_Cter_Amidation	267	270	PF01082	0.483
MOD_GlcNHglycan	298	301	PF01048	0.519
MOD_GlcNHglycan	315	318	PF01048	0.559
MOD_GlcNHglycan	343	346	PF01048	0.577
MOD_GlcNHglycan	383	386	PF01048	0.577
MOD_GlcNHglycan	411	414	PF01048	0.492
MOD_GSK3_1	144	151	PF00069	0.464
MOD_GSK3_1	196	203	PF00069	0.328
MOD_GSK3_1	240	247	PF00069	0.467
MOD_GSK3_1	278	285	PF00069	0.658
MOD_GSK3_1	356	363	PF00069	0.544
MOD_GSK3_1	377	384	PF00069	0.565
MOD_GSK3_1	398	405	PF00069	0.487
MOD_GSK3_1	408	415	PF00069	0.525
MOD_GSK3_1	53	60	PF00069	0.422
MOD_N-GLC_1	196	201	PF02516	0.321
MOD_NEK2_1	102	107	PF00069	0.416
MOD_NEK2_1	144	149	PF00069	0.481
MOD_NEK2_1	171	176	PF00069	0.406
MOD_NEK2_1	196	201	PF00069	0.314
MOD_NEK2_1	296	301	PF00069	0.582
MOD_NEK2_1	7	12	PF00069	0.363
MOD_PIKK_1	356	362	PF00454	0.590
MOD_Plk_1	171	177	PF00069	0.466
MOD_Plk_1	196	202	PF00069	0.320
MOD_Plk_2-3	74	80	PF00069	0.398
MOD_Plk_4	171	177	PF00069	0.419
MOD_Plk_4	196	202	PF00069	0.408
MOD_Plk_4	272	278	PF00069	0.503
MOD_Plk_4	377	383	PF00069	0.564
MOD_ProDKin_1	282	288	PF00069	0.575
MOD_ProDKin_1	383	389	PF00069	0.486
MOD_SUMO_for_1	113	116	PF00179	0.408
MOD_SUMO_rev_2	402	412	PF00179	0.451
TRG_ENDOCYTIC_2	193	196	PF00928	0.439
TRG_ENDOCYTIC_2	87	90	PF00928	0.391
TRG_ER_diArg_1	190	192	PF00400	0.404
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S1	Leptomonas seymouri	47%	92%
A0A3Q8IG21	Leishmania donovani	77%	100%
A0A3Q8IIE7	Leishmania donovani	73%	100%
A4H6C6	Leishmania braziliensis	24%	100%
A4HJ56	Leishmania braziliensis	59%	100%
A4I6H9	Leishmania infantum	76%	100%
E9AHL0	Leishmania infantum	73%	100%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q6H8	Leishmania major	75%	100%
Q4Q6I6	Leishmania major	72%	100%
Q4QI82	Leishmania major	25%	100%