Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1N3_LEIMU

TriTrypDb:

LmxM.30.0810

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

Expansion

Sequence features

E9B1N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1N3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.457
CLV_NRD_NRD_1	281	283	PF00675	0.502
CLV_NRD_NRD_1	296	298	PF00675	0.316
CLV_NRD_NRD_1	30	32	PF00675	0.607
CLV_NRD_NRD_1	335	337	PF00675	0.323
CLV_NRD_NRD_1	393	395	PF00675	0.416
CLV_NRD_NRD_1	539	541	PF00675	0.611
CLV_PCSK_FUR_1	28	32	PF00082	0.437
CLV_PCSK_KEX2_1	220	222	PF00082	0.457
CLV_PCSK_KEX2_1	281	283	PF00082	0.499
CLV_PCSK_KEX2_1	30	32	PF00082	0.607
CLV_PCSK_KEX2_1	335	337	PF00082	0.328
CLV_PCSK_KEX2_1	395	397	PF00082	0.417
CLV_PCSK_KEX2_1	539	541	PF00082	0.488
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.446
CLV_PCSK_PC7_1	26	32	PF00082	0.432
CLV_PCSK_PC7_1	331	337	PF00082	0.314
CLV_PCSK_SKI1_1	151	155	PF00082	0.470
CLV_PCSK_SKI1_1	427	431	PF00082	0.256
CLV_PCSK_SKI1_1	464	468	PF00082	0.555
CLV_PCSK_SKI1_1	504	508	PF00082	0.280
CLV_PCSK_SKI1_1	617	621	PF00082	0.370
CLV_PCSK_SKI1_1	72	76	PF00082	0.404
CLV_PCSK_SKI1_1	97	101	PF00082	0.352
CLV_Separin_Metazoa	177	181	PF03568	0.616
DEG_Nend_Nbox_1	1	3	PF02207	0.605
DOC_MAPK_DCC_7	592	600	PF00069	0.295
DOC_MAPK_gen_1	217	225	PF00069	0.641
DOC_MAPK_gen_1	297	305	PF00069	0.563
DOC_MAPK_HePTP_8	614	626	PF00069	0.313
DOC_MAPK_MEF2A_6	180	189	PF00069	0.608
DOC_MAPK_MEF2A_6	489	496	PF00069	0.547
DOC_MAPK_MEF2A_6	500	509	PF00069	0.547
DOC_MAPK_MEF2A_6	563	570	PF00069	0.279
DOC_MAPK_MEF2A_6	592	600	PF00069	0.287
DOC_MAPK_MEF2A_6	617	626	PF00069	0.477
DOC_MAPK_NFAT4_5	489	497	PF00069	0.532
DOC_PIKK_1	77	84	PF02985	0.593
DOC_PP1_RVXF_1	95	102	PF00149	0.524
DOC_PP2B_LxvP_1	187	190	PF13499	0.609
DOC_PP4_FxxP_1	317	320	PF00568	0.593
DOC_USP7_MATH_1	159	163	PF00917	0.605
DOC_USP7_MATH_1	227	231	PF00917	0.692
DOC_USP7_MATH_1	258	262	PF00917	0.742
DOC_USP7_MATH_1	425	429	PF00917	0.585
DOC_USP7_MATH_1	487	491	PF00917	0.469
DOC_USP7_MATH_1	558	562	PF00917	0.455
DOC_USP7_MATH_1	577	581	PF00917	0.308
DOC_USP7_MATH_1	62	66	PF00917	0.709
DOC_USP7_MATH_1	86	90	PF00917	0.464
DOC_WW_Pin1_4	135	140	PF00397	0.507
DOC_WW_Pin1_4	262	267	PF00397	0.685
DOC_WW_Pin1_4	54	59	PF00397	0.765
LIG_14-3-3_CanoR_1	12	20	PF00244	0.754
LIG_14-3-3_CanoR_1	504	510	PF00244	0.469
LIG_14-3-3_CanoR_1	97	102	PF00244	0.535
LIG_Actin_WH2_2	77	95	PF00022	0.645
LIG_APCC_ABBA_1	618	623	PF00400	0.507
LIG_APCC_ABBAyCdc20_2	617	623	PF00400	0.506
LIG_BH_BH3_1	442	458	PF00452	0.337
LIG_BIR_III_4	557	561	PF00653	0.273
LIG_BRCT_BRCA1_1	309	313	PF00533	0.514
LIG_BRCT_BRCA1_1	438	442	PF00533	0.466
LIG_BRCT_BRCA1_1	584	588	PF00533	0.289
LIG_eIF4E_1	115	121	PF01652	0.624
LIG_eIF4E_1	613	619	PF01652	0.528
LIG_FHA_1	126	132	PF00498	0.557
LIG_FHA_1	377	383	PF00498	0.569
LIG_FHA_1	414	420	PF00498	0.547
LIG_FHA_1	469	475	PF00498	0.381
LIG_FHA_1	476	482	PF00498	0.389
LIG_FHA_1	516	522	PF00498	0.305
LIG_FHA_1	599	605	PF00498	0.431
LIG_FHA_1	98	104	PF00498	0.564
LIG_FHA_2	136	142	PF00498	0.561
LIG_FHA_2	237	243	PF00498	0.736
LIG_GBD_Chelix_1	512	520	PF00786	0.301
LIG_LIR_Apic_2	315	320	PF02991	0.584
LIG_LIR_Gen_1	257	266	PF02991	0.612
LIG_LIR_Gen_1	435	446	PF02991	0.349
LIG_LIR_Gen_1	580	590	PF02991	0.333
LIG_LIR_LC3C_4	518	522	PF02991	0.286
LIG_LIR_Nem_3	113	118	PF02991	0.627
LIG_LIR_Nem_3	141	145	PF02991	0.577
LIG_LIR_Nem_3	257	262	PF02991	0.611
LIG_LIR_Nem_3	310	316	PF02991	0.520
LIG_LIR_Nem_3	428	433	PF02991	0.332
LIG_LIR_Nem_3	435	441	PF02991	0.326
LIG_LIR_Nem_3	580	586	PF02991	0.321
LIG_LIR_Nem_3	608	613	PF02991	0.356
LIG_LYPXL_SIV_4	612	620	PF13949	0.274
LIG_MAD2	72	80	PF02301	0.542
LIG_PCNA_PIPBox_1	349	358	PF02747	0.571
LIG_PCNA_yPIPBox_3	349	359	PF02747	0.580
LIG_Pex14_2	313	317	PF04695	0.566
LIG_Pex14_2	438	442	PF04695	0.422
LIG_Pex14_2	461	465	PF04695	0.363
LIG_PTB_Apo_2	299	306	PF02174	0.542
LIG_SH2_CRK	353	357	PF00017	0.614
LIG_SH2_CRK	406	410	PF00017	0.629
LIG_SH2_NCK_1	137	141	PF00017	0.624
LIG_SH2_NCK_1	197	201	PF00017	0.647
LIG_SH2_PTP2	117	120	PF00017	0.477
LIG_SH2_SRC	613	616	PF00017	0.198
LIG_SH2_STAP1	532	536	PF00017	0.339
LIG_SH2_STAP1	583	587	PF00017	0.369
LIG_SH2_STAP1	610	614	PF00017	0.428
LIG_SH2_STAT5	117	120	PF00017	0.560
LIG_SH2_STAT5	137	140	PF00017	0.555
LIG_SH2_STAT5	337	340	PF00017	0.526
LIG_SH2_STAT5	445	448	PF00017	0.397
LIG_SH2_STAT5	613	616	PF00017	0.469
LIG_SH3_3	153	159	PF00018	0.573
LIG_SH3_3	182	188	PF00018	0.626
LIG_SH3_3	263	269	PF00018	0.649
LIG_SH3_3	471	477	PF00018	0.495
LIG_SH3_3	570	576	PF00018	0.338
LIG_SUMO_SIM_anti_2	518	524	PF11976	0.456
LIG_SUMO_SIM_anti_2	533	538	PF11976	0.239
LIG_SUMO_SIM_anti_2	601	608	PF11976	0.372
LIG_SUMO_SIM_par_1	492	497	PF11976	0.633
LIG_SxIP_EBH_1	417	427	PF03271	0.507
LIG_TRAF2_1	261	264	PF00917	0.828
LIG_TRAF2_1	35	38	PF00917	0.703
LIG_TYR_ITSM	111	118	PF00017	0.369
LIG_UBA3_1	222	226	PF00899	0.448
LIG_UBA3_1	418	423	PF00899	0.471
LIG_UBA3_1	516	525	PF00899	0.445
LIG_WRC_WIRS_1	292	297	PF05994	0.439
LIG_WRC_WIRS_1	458	463	PF05994	0.523
LIG_WRC_WIRS_1	466	471	PF05994	0.452
LIG_WW_2	185	188	PF00397	0.483
MOD_CK1_1	122	128	PF00069	0.474
MOD_CK1_1	162	168	PF00069	0.686
MOD_CK1_1	212	218	PF00069	0.598
MOD_CK1_1	468	474	PF00069	0.286
MOD_CK2_1	21	27	PF00069	0.603
MOD_CK2_1	236	242	PF00069	0.688
MOD_CK2_1	258	264	PF00069	0.707
MOD_CK2_1	32	38	PF00069	0.616
MOD_GlcNHglycan	161	164	PF01048	0.750
MOD_GlcNHglycan	283	286	PF01048	0.519
MOD_GlcNHglycan	308	312	PF01048	0.351
MOD_GSK3_1	120	127	PF00069	0.511
MOD_GSK3_1	189	196	PF00069	0.612
MOD_GSK3_1	209	216	PF00069	0.624
MOD_GSK3_1	238	245	PF00069	0.606
MOD_GSK3_1	258	265	PF00069	0.616
MOD_GSK3_1	432	439	PF00069	0.400
MOD_GSK3_1	465	472	PF00069	0.364
MOD_GSK3_1	52	59	PF00069	0.703
MOD_GSK3_1	578	585	PF00069	0.343
MOD_GSK3_1	97	104	PF00069	0.374
MOD_LATS_1	279	285	PF00433	0.435
MOD_N-GLC_1	578	583	PF02516	0.414
MOD_N-GLC_2	567	569	PF02516	0.521
MOD_NEK2_1	101	106	PF00069	0.339
MOD_NEK2_1	120	125	PF00069	0.436
MOD_NEK2_1	213	218	PF00069	0.607
MOD_NEK2_1	283	288	PF00069	0.515
MOD_NEK2_1	412	417	PF00069	0.434
MOD_NEK2_1	419	424	PF00069	0.403
MOD_NEK2_1	436	441	PF00069	0.329
MOD_NEK2_1	457	462	PF00069	0.464
MOD_NEK2_1	465	470	PF00069	0.289
MOD_NEK2_1	485	490	PF00069	0.333
MOD_NEK2_1	568	573	PF00069	0.461
MOD_NEK2_1	598	603	PF00069	0.372
MOD_NEK2_1	605	610	PF00069	0.389
MOD_NEK2_2	425	430	PF00069	0.494
MOD_PIKK_1	101	107	PF00454	0.373
MOD_PIKK_1	195	201	PF00454	0.501
MOD_PIKK_1	21	27	PF00454	0.658
MOD_PIKK_1	33	39	PF00454	0.809
MOD_PIKK_1	86	92	PF00454	0.371
MOD_PKA_1	281	287	PF00069	0.492
MOD_PKA_2	281	287	PF00069	0.497
MOD_PKA_2	296	302	PF00069	0.502
MOD_PKA_2	52	58	PF00069	0.596
MOD_Plk_1	376	382	PF00069	0.471
MOD_Plk_1	578	584	PF00069	0.484
MOD_Plk_4	111	117	PF00069	0.469
MOD_Plk_4	127	133	PF00069	0.370
MOD_Plk_4	189	195	PF00069	0.724
MOD_Plk_4	291	297	PF00069	0.536
MOD_Plk_4	312	318	PF00069	0.476
MOD_Plk_4	457	463	PF00069	0.440
MOD_Plk_4	469	475	PF00069	0.349
MOD_Plk_4	515	521	PF00069	0.331
MOD_Plk_4	582	588	PF00069	0.417
MOD_Plk_4	605	611	PF00069	0.364
MOD_Plk_4	97	103	PF00069	0.386
MOD_ProDKin_1	135	141	PF00069	0.367
MOD_ProDKin_1	262	268	PF00069	0.615
MOD_ProDKin_1	54	60	PF00069	0.720
MOD_SUMO_rev_2	391	397	PF00179	0.575
MOD_SUMO_rev_2	89	95	PF00179	0.493
TRG_DiLeu_BaEn_1	377	382	PF01217	0.385
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.453
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.396
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.341
TRG_ENDOCYTIC_2	115	118	PF00928	0.428
TRG_ENDOCYTIC_2	259	262	PF00928	0.598
TRG_ENDOCYTIC_2	292	295	PF00928	0.471
TRG_ENDOCYTIC_2	314	317	PF00928	0.432
TRG_ENDOCYTIC_2	353	356	PF00928	0.453
TRG_ENDOCYTIC_2	445	448	PF00928	0.358
TRG_ENDOCYTIC_2	532	535	PF00928	0.419
TRG_ENDOCYTIC_2	583	586	PF00928	0.488
TRG_ENDOCYTIC_2	613	616	PF00928	0.402
TRG_ER_diArg_1	220	222	PF00400	0.462
TRG_ER_diArg_1	28	31	PF00400	0.761
TRG_ER_diArg_1	280	282	PF00400	0.629
TRG_ER_diArg_1	334	336	PF00400	0.374
TRG_ER_diArg_1	394	397	PF00400	0.495
TRG_ER_diArg_1	538	540	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	39%	100%
A0A0N1HRT9	Leptomonas seymouri	34%	100%
A0A0N1P9A0	Leptomonas seymouri	34%	100%
A0A0N1PBU6	Leptomonas seymouri	34%	100%
A0A0S4J1E5	Bodo saltans	23%	100%
A0A1X0P9W4	Trypanosomatidae	33%	100%
A0A3Q8IFF3	Leishmania donovani	63%	97%
A0A3Q8ISH4	Leishmania donovani	83%	100%
A0A3R7KFP4	Trypanosoma rangeli	29%	100%
A0A3S7X483	Leishmania donovani	48%	97%
A0A3S7X888	Leishmania donovani	32%	99%
A4HB26	Leishmania braziliensis	32%	100%
A4HJ59	Leishmania braziliensis	41%	100%
A4HJ60	Leishmania braziliensis	55%	100%
A4I6H4	Leishmania infantum	48%	97%
A4I6H5	Leishmania infantum	83%	100%
A4IA83	Leishmania infantum	32%	99%
C9ZM24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q6I2	Leishmania major	83%	100%
Q4Q6I3	Leishmania major	49%	100%
V5B5A9	Trypanosoma cruzi	28%	100%