Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1N2_LEIMU

TriTrypDb:

LmxM.30.0800

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

E9B1N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1N2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.641
CLV_C14_Caspase3-7	470	474	PF00656	0.473
CLV_C14_Caspase3-7	75	79	PF00656	0.460
CLV_NRD_NRD_1	299	301	PF00675	0.483
CLV_NRD_NRD_1	314	316	PF00675	0.370
CLV_NRD_NRD_1	353	355	PF00675	0.317
CLV_NRD_NRD_1	411	413	PF00675	0.414
CLV_NRD_NRD_1	606	608	PF00675	0.334
CLV_NRD_NRD_1	63	65	PF00675	0.671
CLV_PCSK_KEX2_1	299	301	PF00082	0.489
CLV_PCSK_KEX2_1	353	355	PF00082	0.326
CLV_PCSK_KEX2_1	413	415	PF00082	0.421
CLV_PCSK_KEX2_1	606	608	PF00082	0.258
CLV_PCSK_KEX2_1	63	65	PF00082	0.601
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.418
CLV_PCSK_PC7_1	349	355	PF00082	0.315
CLV_PCSK_SKI1_1	140	144	PF00082	0.417
CLV_PCSK_SKI1_1	276	280	PF00082	0.552
CLV_PCSK_SKI1_1	485	489	PF00082	0.456
DEG_APCC_DBOX_1	484	492	PF00400	0.242
DEG_SPOP_SBC_1	193	197	PF00917	0.614
DOC_MAPK_gen_1	299	307	PF00069	0.623
DOC_MAPK_gen_1	315	323	PF00069	0.595
DOC_MAPK_gen_1	482	491	PF00069	0.398
DOC_MAPK_gen_1	606	613	PF00069	0.459
DOC_MAPK_MEF2A_6	485	493	PF00069	0.188
DOC_MAPK_MEF2A_6	606	613	PF00069	0.572
DOC_PP1_RVXF_1	96	103	PF00149	0.321
DOC_PP4_FxxP_1	335	338	PF00568	0.614
DOC_PP4_FxxP_1	49	52	PF00568	0.544
DOC_PP4_FxxP_1	88	91	PF00568	0.252
DOC_USP7_MATH_1	198	202	PF00917	0.742
DOC_USP7_MATH_1	241	245	PF00917	0.620
DOC_USP7_MATH_1	52	56	PF00917	0.589
LIG_14-3-3_CanoR_1	15	23	PF00244	0.497
LIG_14-3-3_CanoR_1	179	185	PF00244	0.765
LIG_14-3-3_CanoR_1	98	103	PF00244	0.336
LIG_Actin_WH2_2	301	317	PF00022	0.454
LIG_Actin_WH2_2	78	96	PF00022	0.414
LIG_BH_BH3_1	460	476	PF00452	0.336
LIG_BIR_III_4	240	244	PF00653	0.659
LIG_EH1_1	486	494	PF00400	0.188
LIG_eIF4E_1	116	122	PF01652	0.355
LIG_eIF4E_1	629	635	PF01652	0.457
LIG_FHA_1	117	123	PF00498	0.270
LIG_FHA_1	188	194	PF00498	0.664
LIG_FHA_1	395	401	PF00498	0.478
LIG_FHA_1	432	438	PF00498	0.335
LIG_FHA_1	498	504	PF00498	0.438
LIG_FHA_1	514	520	PF00498	0.468
LIG_FHA_1	618	624	PF00498	0.382
LIG_FHA_2	468	474	PF00498	0.343
LIG_FHA_2	73	79	PF00498	0.284
LIG_LIR_Apic_2	333	338	PF02991	0.599
LIG_LIR_Apic_2	46	52	PF02991	0.402
LIG_LIR_Gen_1	457	468	PF02991	0.395
LIG_LIR_Gen_1	501	512	PF02991	0.360
LIG_LIR_Gen_1	620	630	PF02991	0.312
LIG_LIR_Gen_1	8	16	PF02991	0.389
LIG_LIR_LC3C_4	516	520	PF02991	0.184
LIG_LIR_Nem_3	115	121	PF02991	0.340
LIG_LIR_Nem_3	141	146	PF02991	0.565
LIG_LIR_Nem_3	203	208	PF02991	0.770
LIG_LIR_Nem_3	457	463	PF02991	0.333
LIG_LIR_Nem_3	501	507	PF02991	0.304
LIG_LIR_Nem_3	620	625	PF02991	0.339
LIG_LIR_Nem_3	626	632	PF02991	0.345
LIG_LIR_Nem_3	8	13	PF02991	0.390
LIG_NRBOX	633	639	PF00104	0.397
LIG_PCNA_PIPBox_1	367	376	PF02747	0.565
LIG_PCNA_yPIPBox_3	367	377	PF02747	0.572
LIG_Pex14_2	331	335	PF04695	0.555
LIG_Pex14_2	456	460	PF04695	0.386
LIG_Pex14_2	524	528	PF04695	0.239
LIG_PTB_Apo_2	317	324	PF02174	0.573
LIG_SH2_CRK	118	122	PF00017	0.315
LIG_SH2_CRK	371	375	PF00017	0.597
LIG_SH2_CRK	424	428	PF00017	0.521
LIG_SH2_CRK	504	508	PF00017	0.360
LIG_SH2_GRB2like	134	137	PF00017	0.545
LIG_SH2_SRC	152	155	PF00017	0.504
LIG_SH2_STAP1	138	142	PF00017	0.445
LIG_SH2_STAP1	504	508	PF00017	0.242
LIG_SH2_STAT5	118	121	PF00017	0.327
LIG_SH2_STAT5	134	137	PF00017	0.536
LIG_SH2_STAT5	138	141	PF00017	0.570
LIG_SH2_STAT5	152	155	PF00017	0.637
LIG_SH2_STAT5	234	237	PF00017	0.541
LIG_SH2_STAT5	355	358	PF00017	0.531
LIG_SH2_STAT5	602	605	PF00017	0.647
LIG_SH2_STAT5	629	632	PF00017	0.455
LIG_SH3_2	247	252	PF14604	0.593
LIG_SH3_3	101	107	PF00018	0.318
LIG_SH3_3	244	250	PF00018	0.627
LIG_SH3_3	505	511	PF00018	0.335
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.301
LIG_SUMO_SIM_anti_2	516	522	PF11976	0.210
LIG_SUMO_SIM_anti_2	624	629	PF11976	0.430
LIG_SUMO_SIM_par_1	451	457	PF11976	0.404
LIG_SUMO_SIM_par_1	592	597	PF11976	0.477
LIG_TRAF2_1	259	262	PF00917	0.584
LIG_TRAF2_1	3	6	PF00917	0.397
LIG_TYR_ITIM	502	507	PF00017	0.242
LIG_UBA3_1	307	316	PF00899	0.448
LIG_UBA3_1	436	441	PF00899	0.383
LIG_UBA3_1	540	546	PF00899	0.373
LIG_UBA3_1	633	642	PF00899	0.403
LIG_WRC_WIRS_1	310	315	PF05994	0.557
LIG_WRC_WIRS_1	476	481	PF05994	0.594
LIG_WRC_WIRS_1	484	489	PF05994	0.430
MOD_CK1_1	225	231	PF00069	0.658
MOD_CK1_1	469	475	PF00069	0.409
MOD_CK1_1	513	519	PF00069	0.323
MOD_Cter_Amidation	61	64	PF01082	0.575
MOD_GlcNHglycan	168	171	PF01048	0.609
MOD_GlcNHglycan	222	227	PF01048	0.498
MOD_GlcNHglycan	26	30	PF01048	0.715
MOD_GlcNHglycan	271	274	PF01048	0.499
MOD_GlcNHglycan	283	286	PF01048	0.472
MOD_GlcNHglycan	301	304	PF01048	0.404
MOD_GlcNHglycan	528	531	PF01048	0.410
MOD_GSK3_1	112	119	PF00069	0.416
MOD_GSK3_1	162	169	PF00069	0.674
MOD_GSK3_1	17	24	PF00069	0.476
MOD_GSK3_1	183	190	PF00069	0.731
MOD_GSK3_1	194	201	PF00069	0.797
MOD_GSK3_1	462	469	PF00069	0.442
MOD_GSK3_1	483	490	PF00069	0.460
MOD_GSK3_1	494	501	PF00069	0.340
MOD_GSK3_1	617	624	PF00069	0.359
MOD_GSK3_1	72	79	PF00069	0.345
MOD_N-GLC_1	568	573	PF02516	0.343
MOD_N-GLC_2	589	591	PF02516	0.398
MOD_NEK2_1	166	171	PF00069	0.803
MOD_NEK2_1	301	306	PF00069	0.637
MOD_NEK2_1	430	435	PF00069	0.336
MOD_NEK2_1	437	442	PF00069	0.333
MOD_NEK2_1	454	459	PF00069	0.335
MOD_NEK2_1	462	467	PF00069	0.332
MOD_NEK2_1	475	480	PF00069	0.558
MOD_NEK2_1	483	488	PF00069	0.333
MOD_NEK2_1	544	549	PF00069	0.443
MOD_NEK2_1	573	578	PF00069	0.465
MOD_NEK2_1	587	592	PF00069	0.570
MOD_NEK2_1	617	622	PF00069	0.378
MOD_NEK2_1	72	77	PF00069	0.399
MOD_NEK2_2	177	182	PF00069	0.570
MOD_NEK2_2	200	205	PF00069	0.614
MOD_OFUCOSY	570	577	PF10250	0.254
MOD_PIKK_1	198	204	PF00454	0.631
MOD_PK_1	63	69	PF00069	0.339
MOD_PKA_1	299	305	PF00069	0.578
MOD_PKA_1	63	69	PF00069	0.339
MOD_PKA_2	136	142	PF00069	0.537
MOD_PKA_2	14	20	PF00069	0.447
MOD_PKA_2	269	275	PF00069	0.642
MOD_PKA_2	299	305	PF00069	0.582
MOD_PKA_2	314	320	PF00069	0.568
MOD_PKA_2	63	69	PF00069	0.346
MOD_PKA_2	72	78	PF00069	0.274
MOD_Plk_1	109	115	PF00069	0.367
MOD_Plk_1	162	168	PF00069	0.678
MOD_Plk_1	222	228	PF00069	0.609
MOD_Plk_1	394	400	PF00069	0.477
MOD_Plk_1	513	519	PF00069	0.291
MOD_Plk_2-3	555	561	PF00069	0.497
MOD_Plk_4	112	118	PF00069	0.370
MOD_Plk_4	162	168	PF00069	0.646
MOD_Plk_4	200	206	PF00069	0.742
MOD_Plk_4	309	315	PF00069	0.609
MOD_Plk_4	330	336	PF00069	0.577
MOD_Plk_4	443	449	PF00069	0.276
MOD_Plk_4	475	481	PF00069	0.534
MOD_Plk_4	498	504	PF00069	0.408
MOD_Plk_4	513	519	PF00069	0.402
MOD_Plk_4	544	550	PF00069	0.549
MOD_SUMO_rev_2	409	415	PF00179	0.632
TRG_DiLeu_BaEn_1	274	279	PF01217	0.718
TRG_DiLeu_BaEn_1	395	400	PF01217	0.528
TRG_DiLeu_BaEn_1	514	519	PF01217	0.286
TRG_DiLeu_BaEn_3	5	11	PF01217	0.380
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.601
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.587
TRG_DiLeu_BaLyEn_6	633	638	PF01217	0.286
TRG_ENDOCYTIC_2	118	121	PF00928	0.335
TRG_ENDOCYTIC_2	146	149	PF00928	0.573
TRG_ENDOCYTIC_2	310	313	PF00928	0.587
TRG_ENDOCYTIC_2	332	335	PF00928	0.558
TRG_ENDOCYTIC_2	371	374	PF00928	0.540
TRG_ENDOCYTIC_2	504	507	PF00928	0.378
TRG_ENDOCYTIC_2	550	553	PF00928	0.555
TRG_ENDOCYTIC_2	629	632	PF00928	0.414
TRG_ER_diArg_1	293	296	PF00400	0.726
TRG_ER_diArg_1	298	300	PF00400	0.664
TRG_ER_diArg_1	352	354	PF00400	0.514
TRG_ER_diArg_1	412	415	PF00400	0.568
TRG_ER_diArg_1	606	608	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	276	281	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	39%	100%
A0A0N1HRT9	Leptomonas seymouri	37%	100%
A0A0N1P9A0	Leptomonas seymouri	32%	100%
A0A0N1PBU6	Leptomonas seymouri	30%	100%
A0A3Q8IFF3	Leishmania donovani	65%	100%
A0A3Q8ISH4	Leishmania donovani	47%	100%
A0A3S7X483	Leishmania donovani	77%	100%
A0A3S7X888	Leishmania donovani	29%	100%
A4HB26	Leishmania braziliensis	31%	100%
A4HJ59	Leishmania braziliensis	46%	99%
A4HJ60	Leishmania braziliensis	42%	100%
A4I6H4	Leishmania infantum	77%	100%
A4I6H5	Leishmania infantum	47%	100%
A4IA83	Leishmania infantum	28%	100%
C9ZM24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q6I2	Leishmania major	46%	97%
Q4Q6I3	Leishmania major	75%	100%