Putative c2 domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

c2 domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1N1_LEIMU

TriTrypDb:

LmxM.30.0790

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1N1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	264	266	PF00675	0.573
CLV_PCSK_KEX2_1	264	266	PF00082	0.573
DOC_ANK_TNKS_1	127	134	PF00023	0.402
DOC_CKS1_1	257	262	PF01111	0.493
DOC_MAPK_gen_1	19	29	PF00069	0.288
DOC_MAPK_MEF2A_6	22	31	PF00069	0.288
DOC_PIKK_1	76	84	PF02985	0.320
DOC_PP2B_LxvP_1	176	179	PF13499	0.601
DOC_PP4_MxPP_1	145	148	PF00568	0.414
DOC_USP7_UBL2_3	36	40	PF12436	0.387
DOC_WW_Pin1_4	110	115	PF00397	0.355
DOC_WW_Pin1_4	256	261	PF00397	0.521
LIG_14-3-3_CanoR_1	135	141	PF00244	0.507
LIG_FHA_1	101	107	PF00498	0.349
LIG_FHA_1	135	141	PF00498	0.538
LIG_FHA_1	161	167	PF00498	0.472
LIG_FHA_1	66	72	PF00498	0.232
LIG_FHA_1	94	100	PF00498	0.353
LIG_LIR_Apic_2	152	156	PF02991	0.441
LIG_LIR_Gen_1	102	108	PF02991	0.331
LIG_LIR_Gen_1	24	31	PF02991	0.359
LIG_LIR_Nem_3	102	107	PF02991	0.356
LIG_LIR_Nem_3	24	29	PF02991	0.359
LIG_Pex14_1	54	58	PF04695	0.338
LIG_PTB_Apo_2	52	59	PF02174	0.288
LIG_SH2_CRK	153	157	PF00017	0.430
LIG_SH2_CRK	196	200	PF00017	0.569
LIG_SH2_CRK	209	213	PF00017	0.548
LIG_SH2_CRK	226	230	PF00017	0.577
LIG_SH2_CRK	236	240	PF00017	0.652
LIG_SH2_CRK	257	261	PF00017	0.607
LIG_SH2_CRK	271	275	PF00017	0.554
LIG_SH2_PTP2	198	201	PF00017	0.545
LIG_SH2_PTP2	26	29	PF00017	0.320
LIG_SH2_SRC	207	210	PF00017	0.582
LIG_SH2_STAP1	184	188	PF00017	0.566
LIG_SH2_STAP1	88	92	PF00017	0.440
LIG_SH2_STAT3	159	162	PF00017	0.409
LIG_SH2_STAT5	159	162	PF00017	0.473
LIG_SH2_STAT5	198	201	PF00017	0.593
LIG_SH2_STAT5	26	29	PF00017	0.320
LIG_SH3_1	209	215	PF00018	0.558
LIG_SH3_1	226	232	PF00018	0.683
LIG_SH3_3	169	175	PF00018	0.541
LIG_SH3_3	17	23	PF00018	0.354
LIG_SH3_3	196	202	PF00018	0.716
LIG_SH3_3	209	215	PF00018	0.652
LIG_SH3_3	226	232	PF00018	0.608
LIG_SH3_3	248	254	PF00018	0.576
LIG_SUMO_SIM_par_1	120	125	PF11976	0.415
LIG_SUMO_SIM_par_1	136	141	PF11976	0.484
MOD_CK2_1	110	116	PF00069	0.454
MOD_GlcNHglycan	184	187	PF01048	0.573
MOD_GSK3_1	84	91	PF00069	0.270
MOD_N-GLC_1	34	39	PF02516	0.206
MOD_NEK2_1	107	112	PF00069	0.629
MOD_NEK2_1	84	89	PF00069	0.270
MOD_PIKK_1	160	166	PF00454	0.484
MOD_PIKK_1	65	71	PF00454	0.288
MOD_PKA_2	134	140	PF00069	0.442
MOD_Plk_1	65	71	PF00069	0.239
MOD_Plk_4	100	106	PF00069	0.326
MOD_Plk_4	141	147	PF00069	0.533
MOD_ProDKin_1	110	116	PF00069	0.350
MOD_ProDKin_1	256	262	PF00069	0.516
TRG_ENDOCYTIC_2	196	199	PF00928	0.574
TRG_ENDOCYTIC_2	26	29	PF00928	0.320
TRG_ER_diArg_1	264	266	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M8	Leptomonas seymouri	64%	100%
A0A3S7X485	Leishmania donovani	86%	96%
A0A3S7X4C0	Leishmania donovani	45%	100%
A4HJ57	Leishmania braziliensis	45%	100%
A4HJ58	Leishmania braziliensis	72%	98%
A4I6H2	Leishmania infantum	49%	100%
A4I6H3	Leishmania infantum	87%	96%
E9B1L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	99%
Q9BHE8	Leishmania major	85%	100%
Q9BHF8	Leishmania major	37%	100%