Putative c2 domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

c2 domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1N0_LEIMU

TriTrypDb:

LmxM.30.0780

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1N0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.313
CLV_NRD_NRD_1	33	35	PF00675	0.214
CLV_NRD_NRD_1	38	40	PF00675	0.264
CLV_PCSK_KEX2_1	18	20	PF00082	0.227
CLV_PCSK_KEX2_1	38	40	PF00082	0.244
CLV_PCSK_PC7_1	34	40	PF00082	0.204
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.432
DOC_PIKK_1	76	84	PF02985	0.298
DOC_PP2B_LxvP_1	184	187	PF13499	0.477
DOC_PP2B_LxvP_1	224	227	PF13499	0.506
DOC_PP4_FxxP_1	175	178	PF00568	0.454
DOC_USP7_MATH_1	130	134	PF00917	0.405
DOC_USP7_MATH_1	253	257	PF00917	0.506
DOC_USP7_UBL2_3	36	40	PF12436	0.307
DOC_WW_Pin1_4	269	274	PF00397	0.512
LIG_14-3-3_CanoR_1	38	46	PF00244	0.253
LIG_14-3-3_CanoR_1	97	107	PF00244	0.273
LIG_Actin_WH2_2	92	110	PF00022	0.254
LIG_FHA_1	147	153	PF00498	0.533
LIG_FHA_1	40	46	PF00498	0.304
LIG_FHA_1	94	100	PF00498	0.434
LIG_FHA_2	160	166	PF00498	0.491
LIG_LIR_Apic_2	174	178	PF02991	0.493
LIG_LIR_Apic_2	256	261	PF02991	0.559
LIG_LIR_Gen_1	101	112	PF02991	0.309
LIG_LIR_Gen_1	165	175	PF02991	0.520
LIG_LIR_Nem_3	101	107	PF02991	0.334
LIG_LIR_Nem_3	165	170	PF02991	0.517
LIG_MAD2	44	52	PF02301	0.227
LIG_MYND_1	227	231	PF01753	0.420
LIG_PDZ_Class_1	269	274	PF00595	0.483
LIG_PTB_Apo_2	169	176	PF02174	0.467
LIG_SH2_CRK	258	262	PF00017	0.637
LIG_SH2_SRC	235	238	PF00017	0.515
LIG_SH2_STAP1	41	45	PF00017	0.204
LIG_SH2_STAP1	88	92	PF00017	0.325
LIG_SH2_STAT3	200	203	PF00017	0.527
LIG_SH2_STAT3	206	209	PF00017	0.552
LIG_SH2_STAT3	213	216	PF00017	0.582
LIG_SH2_STAT3	247	250	PF00017	0.617
LIG_SH2_STAT5	206	209	PF00017	0.559
LIG_SH2_STAT5	223	226	PF00017	0.620
LIG_SH2_STAT5	26	29	PF00017	0.310
LIG_SH2_STAT5	41	44	PF00017	0.310
LIG_SH3_1	211	217	PF00018	0.452
LIG_SH3_1	258	264	PF00018	0.534
LIG_SH3_3	167	173	PF00018	0.613
LIG_SH3_3	184	190	PF00018	0.539
LIG_SH3_3	191	197	PF00018	0.551
LIG_SH3_3	211	217	PF00018	0.524
LIG_SH3_3	224	230	PF00018	0.609
LIG_SH3_3	239	245	PF00018	0.630
LIG_SH3_3	258	264	PF00018	0.675
LIG_SH3_3	55	61	PF00018	0.204
LIG_SUMO_SIM_par_1	120	125	PF11976	0.404
LIG_TRAF2_1	139	142	PF00917	0.387
LIG_TRFH_1	213	217	PF08558	0.453
MOD_CK1_1	91	97	PF00069	0.204
MOD_CK2_1	110	116	PF00069	0.470
MOD_CK2_1	136	142	PF00069	0.393
MOD_GlcNHglycan	113	116	PF01048	0.342
MOD_GlcNHglycan	175	178	PF01048	0.509
MOD_GSK3_1	103	110	PF00069	0.481
MOD_NEK2_1	103	108	PF00069	0.505
MOD_PKA_1	34	40	PF00069	0.260
MOD_Plk_4	131	137	PF00069	0.447
MOD_Plk_4	195	201	PF00069	0.453
MOD_Plk_4	243	249	PF00069	0.567
MOD_Plk_4	253	259	PF00069	0.595
MOD_SUMO_rev_2	139	146	PF00179	0.345
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.478
TRG_ENDOCYTIC_2	265	268	PF00928	0.540
TRG_NLS_Bipartite_1	18	39	PF00514	0.204
TRG_NLS_MonoExtC_3	34	39	PF00514	0.204
TRG_NLS_MonoExtN_4	34	39	PF00514	0.204
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D0	Leptomonas seymouri	62%	95%
A0A3Q8IFD2	Leishmania donovani	33%	98%
A0A3S7X485	Leishmania donovani	44%	100%
A0A3S7X4C0	Leishmania donovani	68%	100%
A4HJ46	Leishmania braziliensis	38%	96%
A4HJ57	Leishmania braziliensis	60%	87%
A4HJ58	Leishmania braziliensis	53%	100%
A4I6G2	Leishmania infantum	33%	98%
A4I6H2	Leishmania infantum	68%	100%
A4I6H3	Leishmania infantum	45%	100%
E9B1L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	98%
Q9BHE7	Leishmania major	78%	100%
Q9BHE8	Leishmania major	45%	99%
Q9BHF8	Leishmania major	35%	100%