IMD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9B1M9_LEIMU

TriTrypDb:

LmxM.30.0771

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1M9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1M9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.580
CLV_NRD_NRD_1	153	155	PF00675	0.552
CLV_PCSK_KEX2_1	140	142	PF00082	0.411
CLV_PCSK_KEX2_1	15	17	PF00082	0.580
CLV_PCSK_KEX2_1	176	178	PF00082	0.522
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.471
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.579
CLV_PCSK_SKI1_1	145	149	PF00082	0.617
CLV_PCSK_SKI1_1	173	177	PF00082	0.543
DOC_MAPK_gen_1	15	25	PF00069	0.566
DOC_MAPK_gen_1	85	93	PF00069	0.387
DOC_MAPK_MEF2A_6	86	95	PF00069	0.354
DOC_USP7_MATH_1	175	179	PF00917	0.524
DOC_USP7_MATH_1	189	193	PF00917	0.384
DOC_USP7_MATH_1	67	71	PF00917	0.576
DOC_USP7_UBL2_3	151	155	PF12436	0.470
DOC_USP7_UBL2_3	165	169	PF12436	0.627
DOC_USP7_UBL2_3	205	209	PF12436	0.582
LIG_14-3-3_CanoR_1	141	149	PF00244	0.526
LIG_14-3-3_CanoR_1	154	163	PF00244	0.526
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_BIR_III_3	1	5	PF00653	0.533
LIG_BRCT_BRCA1_1	200	204	PF00533	0.557
LIG_FHA_1	113	119	PF00498	0.532
LIG_FHA_1	191	197	PF00498	0.538
LIG_FHA_2	46	52	PF00498	0.570
LIG_LIR_Gen_1	70	78	PF02991	0.653
LIG_LIR_Nem_3	201	206	PF02991	0.588
LIG_LIR_Nem_3	59	63	PF02991	0.573
LIG_LIR_Nem_3	70	74	PF02991	0.500
LIG_MLH1_MIPbox_1	200	204	PF16413	0.557
LIG_PDZ_Class_2	210	215	PF00595	0.384
LIG_REV1ctd_RIR_1	201	209	PF16727	0.555
LIG_SH2_STAT5	46	49	PF00017	0.432
LIG_SH2_STAT5	52	55	PF00017	0.418
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.350
LIG_SUMO_SIM_par_1	195	201	PF11976	0.519
MOD_CK1_1	122	128	PF00069	0.562
MOD_CK1_1	143	149	PF00069	0.452
MOD_CK1_1	192	198	PF00069	0.561
MOD_CK2_1	45	51	PF00069	0.571
MOD_CK2_1	73	79	PF00069	0.681
MOD_GlcNHglycan	144	148	PF01048	0.539
MOD_GlcNHglycan	34	37	PF01048	0.557
MOD_GlcNHglycan	64	67	PF01048	0.480
MOD_GSK3_1	119	126	PF00069	0.577
MOD_N-GLC_2	210	212	PF02516	0.338
MOD_NEK2_1	32	37	PF00069	0.479
MOD_PIKK_1	112	118	PF00454	0.558
MOD_PIKK_1	198	204	PF00454	0.487
MOD_PKA_1	140	146	PF00069	0.428
MOD_PKA_1	154	160	PF00069	0.587
MOD_PKA_2	140	146	PF00069	0.390
MOD_PKA_2	8	14	PF00069	0.429
MOD_Plk_1	143	149	PF00069	0.569
MOD_Plk_4	192	198	PF00069	0.459
MOD_Plk_4	67	73	PF00069	0.640
MOD_SUMO_rev_2	166	175	PF00179	0.457
MOD_SUMO_rev_2	77	87	PF00179	0.593
TRG_DiLeu_BaEn_1	134	139	PF01217	0.437
TRG_DiLeu_BaEn_1	144	149	PF01217	0.532
TRG_ENDOCYTIC_2	60	63	PF00928	0.567
TRG_NES_CRM1_1	102	116	PF08389	0.448
TRG_NLS_Bipartite_1	140	155	PF00514	0.374
TRG_NLS_MonoExtC_3	150	155	PF00514	0.393
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D2	Leptomonas seymouri	26%	73%
A0A0N1HUM2	Leptomonas seymouri	26%	78%
A0A3Q8IF80	Leishmania donovani	85%	72%
A4I6H0	Leishmania infantum	84%	72%
E9B1M7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q6I7	Leishmania major	87%	100%