F-BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1M8_LEIMU

TriTrypDb:

LmxM.30.0770

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1M8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.443
CLV_NRD_NRD_1	191	193	PF00675	0.355
CLV_NRD_NRD_1	279	281	PF00675	0.508
CLV_PCSK_KEX2_1	191	193	PF00082	0.398
CLV_PCSK_KEX2_1	272	274	PF00082	0.489
CLV_PCSK_KEX2_1	279	281	PF00082	0.482
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.489
CLV_PCSK_SKI1_1	104	108	PF00082	0.433
CLV_PCSK_SKI1_1	111	115	PF00082	0.452
CLV_PCSK_SKI1_1	117	121	PF00082	0.456
CLV_PCSK_SKI1_1	122	126	PF00082	0.402
CLV_PCSK_SKI1_1	174	178	PF00082	0.367
CLV_PCSK_SKI1_1	237	241	PF00082	0.461
DOC_CYCLIN_RxL_1	188	199	PF00134	0.452
DOC_MAPK_gen_1	188	196	PF00069	0.299
DOC_PP1_RVXF_1	253	259	PF00149	0.489
DOC_PP1_RVXF_1	78	85	PF00149	0.273
DOC_USP7_MATH_1	160	164	PF00917	0.398
DOC_USP7_MATH_1	22	26	PF00917	0.430
DOC_USP7_MATH_1	53	57	PF00917	0.546
DOC_USP7_UBL2_3	103	107	PF12436	0.578
LIG_Actin_WH2_2	88	105	PF00022	0.513
LIG_AP2alpha_1	171	175	PF02296	0.412
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_BRCT_BRCA1_1	47	51	PF00533	0.406
LIG_BRCT_BRCA1_1	55	59	PF00533	0.419
LIG_CaM_IQ_9	161	176	PF13499	0.302
LIG_FHA_1	209	215	PF00498	0.604
LIG_FHA_1	245	251	PF00498	0.651
LIG_FHA_1	286	292	PF00498	0.507
LIG_FHA_2	207	213	PF00498	0.551
LIG_FHA_2	40	46	PF00498	0.582
LIG_FHA_2	58	64	PF00498	0.551
LIG_LIR_Gen_1	172	182	PF02991	0.373
LIG_LIR_Gen_1	48	59	PF02991	0.457
LIG_LIR_Nem_3	172	178	PF02991	0.416
LIG_LIR_Nem_3	25	29	PF02991	0.563
LIG_LIR_Nem_3	48	54	PF02991	0.447
LIG_PDZ_Class_2	288	293	PF00595	0.468
LIG_Pex14_2	171	175	PF04695	0.385
LIG_SH2_CRK	271	275	PF00017	0.464
LIG_SH2_GRB2like	257	260	PF00017	0.458
LIG_SH2_SRC	67	70	PF00017	0.385
LIG_SH2_STAP1	150	154	PF00017	0.328
LIG_SH2_STAT5	193	196	PF00017	0.405
LIG_SH2_STAT5	222	225	PF00017	0.333
LIG_SH2_STAT5	257	260	PF00017	0.458
LIG_SH2_STAT5	264	267	PF00017	0.450
LIG_SH2_STAT5	67	70	PF00017	0.404
LIG_SH3_3	92	98	PF00018	0.401
LIG_TYR_ITIM	269	274	PF00017	0.464
LIG_WRC_WIRS_1	23	28	PF05994	0.430
MOD_CK1_1	149	155	PF00069	0.463
MOD_CK1_1	163	169	PF00069	0.332
MOD_CK1_1	58	64	PF00069	0.425
MOD_CK2_1	102	108	PF00069	0.521
MOD_CK2_1	39	45	PF00069	0.496
MOD_CK2_1	57	63	PF00069	0.590
MOD_GlcNHglycan	231	234	PF01048	0.487
MOD_GSK3_1	144	151	PF00069	0.387
MOD_GSK3_1	196	203	PF00069	0.426
MOD_GSK3_1	240	247	PF00069	0.494
MOD_GSK3_1	53	60	PF00069	0.455
MOD_N-GLC_1	183	188	PF02516	0.518
MOD_N-GLC_1	196	201	PF02516	0.293
MOD_NEK2_1	102	107	PF00069	0.481
MOD_NEK2_1	144	149	PF00069	0.460
MOD_NEK2_1	196	201	PF00069	0.489
MOD_NEK2_1	7	12	PF00069	0.480
MOD_Plk_1	196	202	PF00069	0.342
MOD_Plk_4	196	202	PF00069	0.363
MOD_SUMO_for_1	113	116	PF00179	0.434
TRG_ENDOCYTIC_2	193	196	PF00928	0.405
TRG_ENDOCYTIC_2	271	274	PF00928	0.467
TRG_ENDOCYTIC_2	87	90	PF00928	0.402
TRG_ER_diArg_1	190	192	PF00400	0.367
TRG_ER_diArg_1	278	280	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P348	Leptomonas seymouri	21%	67%
A0A1X0NK28	Trypanosomatidae	34%	72%
A0A3Q8IG21	Leishmania donovani	73%	70%
A0A3Q8IIE7	Leishmania donovani	72%	94%
A0A3S7WQB3	Leishmania donovani	21%	70%
A0A422NQZ1	Trypanosoma rangeli	32%	71%
A4H6C6	Leishmania braziliensis	22%	100%
A4HJ56	Leishmania braziliensis	61%	67%
A4HTM7	Leishmania infantum	21%	70%
A4I6H9	Leishmania infantum	72%	70%
E9AHL0	Leishmania infantum	72%	94%
E9AMG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	70%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9B1N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	70%
Q4Q6H8	Leishmania major	68%	67%
Q4Q6I6	Leishmania major	68%	100%
Q4QI82	Leishmania major	22%	100%