IMD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1M7_LEIMU

TriTrypDb:

LmxM.30.0760

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1M7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1M7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	214	220	PF00089	0.527
CLV_NRD_NRD_1	15	17	PF00675	0.513
CLV_NRD_NRD_1	153	155	PF00675	0.629
CLV_NRD_NRD_1	243	245	PF00675	0.653
CLV_PCSK_KEX2_1	140	142	PF00082	0.393
CLV_PCSK_KEX2_1	15	17	PF00082	0.513
CLV_PCSK_KEX2_1	176	178	PF00082	0.511
CLV_PCSK_KEX2_1	243	245	PF00082	0.653
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.438
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.516
CLV_PCSK_SKI1_1	145	149	PF00082	0.569
CLV_PCSK_SKI1_1	173	177	PF00082	0.529
DOC_MAPK_gen_1	15	25	PF00069	0.495
DOC_MAPK_gen_1	85	93	PF00069	0.378
DOC_MAPK_MEF2A_6	86	95	PF00069	0.347
DOC_USP7_MATH_1	175	179	PF00917	0.508
DOC_USP7_MATH_1	189	193	PF00917	0.583
DOC_USP7_MATH_1	281	285	PF00917	0.701
DOC_USP7_MATH_1	296	300	PF00917	0.535
DOC_USP7_MATH_1	67	71	PF00917	0.537
DOC_USP7_UBL2_3	151	155	PF12436	0.464
DOC_USP7_UBL2_3	165	169	PF12436	0.650
DOC_USP7_UBL2_3	205	209	PF12436	0.598
DOC_WW_Pin1_4	216	221	PF00397	0.569
LIG_14-3-3_CanoR_1	141	149	PF00244	0.533
LIG_14-3-3_CanoR_1	154	163	PF00244	0.502
LIG_14-3-3_CanoR_1	243	249	PF00244	0.605
LIG_14-3-3_CanoR_1	289	295	PF00244	0.487
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BIR_III_3	1	5	PF00653	0.511
LIG_BRCT_BRCA1_1	200	204	PF00533	0.502
LIG_FHA_1	113	119	PF00498	0.515
LIG_FHA_1	191	197	PF00498	0.527
LIG_FHA_1	237	243	PF00498	0.611
LIG_FHA_2	230	236	PF00498	0.669
LIG_FHA_2	46	52	PF00498	0.513
LIG_LIR_Gen_1	70	78	PF02991	0.574
LIG_LIR_Nem_3	201	206	PF02991	0.621
LIG_LIR_Nem_3	59	63	PF02991	0.492
LIG_LIR_Nem_3	70	74	PF02991	0.468
LIG_MLH1_MIPbox_1	200	204	PF16413	0.502
LIG_REV1ctd_RIR_1	201	209	PF16727	0.506
LIG_SH2_STAP1	290	294	PF00017	0.596
LIG_SH2_STAT5	46	49	PF00017	0.447
LIG_SH2_STAT5	52	55	PF00017	0.450
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.352
LIG_SUMO_SIM_par_1	195	201	PF11976	0.517
LIG_SxIP_EBH_1	282	292	PF03271	0.472
LIG_WRC_WIRS_1	265	270	PF05994	0.598
MOD_CDC14_SPxK_1	219	222	PF00782	0.616
MOD_CDK_SPxK_1	216	222	PF00069	0.604
MOD_CK1_1	122	128	PF00069	0.548
MOD_CK1_1	143	149	PF00069	0.462
MOD_CK1_1	192	198	PF00069	0.604
MOD_CK1_1	247	253	PF00069	0.616
MOD_CK2_1	45	51	PF00069	0.476
MOD_CK2_1	73	79	PF00069	0.664
MOD_GlcNHglycan	144	148	PF01048	0.524
MOD_GlcNHglycan	257	260	PF01048	0.644
MOD_GlcNHglycan	283	286	PF01048	0.661
MOD_GlcNHglycan	34	37	PF01048	0.485
MOD_GlcNHglycan	64	67	PF01048	0.451
MOD_GSK3_1	119	126	PF00069	0.524
MOD_GSK3_1	247	254	PF00069	0.614
MOD_GSK3_1	264	271	PF00069	0.688
MOD_NEK2_1	32	37	PF00069	0.448
MOD_PIKK_1	112	118	PF00454	0.568
MOD_PIKK_1	198	204	PF00454	0.486
MOD_PK_1	244	250	PF00069	0.600
MOD_PKA_1	140	146	PF00069	0.438
MOD_PKA_1	154	160	PF00069	0.568
MOD_PKA_2	140	146	PF00069	0.415
MOD_PKA_2	275	281	PF00069	0.609
MOD_PKA_2	8	14	PF00069	0.433
MOD_Plk_1	143	149	PF00069	0.492
MOD_Plk_1	250	256	PF00069	0.635
MOD_Plk_2-3	229	235	PF00069	0.570
MOD_Plk_4	192	198	PF00069	0.427
MOD_Plk_4	67	73	PF00069	0.553
MOD_ProDKin_1	216	222	PF00069	0.573
MOD_SUMO_rev_2	166	175	PF00179	0.421
MOD_SUMO_rev_2	77	87	PF00179	0.518
TRG_DiLeu_BaEn_1	134	139	PF01217	0.397
TRG_DiLeu_BaEn_1	144	149	PF01217	0.466
TRG_ENDOCYTIC_2	265	268	PF00928	0.598
TRG_ENDOCYTIC_2	60	63	PF00928	0.489
TRG_ER_diArg_1	242	244	PF00400	0.607
TRG_NES_CRM1_1	102	116	PF08389	0.416
TRG_NLS_Bipartite_1	140	155	PF00514	0.364
TRG_NLS_MonoExtC_3	150	155	PF00514	0.392
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D2	Leptomonas seymouri	23%	100%
A0A0N1HUM2	Leptomonas seymouri	26%	100%
A0A3Q8IF80	Leishmania donovani	88%	100%
A4I6H0	Leishmania infantum	87%	100%
E9B1M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q6I7	Leishmania major	89%	100%