Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family, putative

Species:

Leishmania mexicana

UniProt:

E9B1M5_LEIMU

TriTrypDb:

LmxM.30.0740

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1M5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0008104	protein localization	4	10
GO:0009306	protein secretion	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0030254	protein secretion by the type III secretion system	4	10
GO:0032940	secretion by cell	3	10
GO:0033036	macromolecule localization	2	10
GO:0035592	establishment of protein localization to extracellular region	4	10
GO:0045184	establishment of protein localization	3	10
GO:0046903	secretion	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0055085	transmembrane transport	2	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071692	protein localization to extracellular region	5	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0071806	protein transmembrane transport	3	10
GO:0140352	export from cell	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.536
CLV_C14_Caspase3-7	192	196	PF00656	0.532
CLV_NRD_NRD_1	14	16	PF00675	0.461
CLV_NRD_NRD_1	34	36	PF00675	0.255
CLV_PCSK_KEX2_1	34	36	PF00082	0.404
CLV_PCSK_SKI1_1	15	19	PF00082	0.395
CLV_PCSK_SKI1_1	219	223	PF00082	0.342
CLV_PCSK_SKI1_1	35	39	PF00082	0.261
CLV_PCSK_SKI1_1	45	49	PF00082	0.362
DEG_APCC_DBOX_1	21	29	PF00400	0.391
DEG_APCC_DBOX_1	260	268	PF00400	0.461
DEG_Nend_UBRbox_2	1	3	PF02207	0.489
DEG_SPOP_SBC_1	293	297	PF00917	0.542
DOC_MAPK_gen_1	15	21	PF00069	0.432
DOC_MAPK_gen_1	261	269	PF00069	0.461
DOC_MAPK_MEF2A_6	210	217	PF00069	0.542
DOC_USP7_MATH_1	169	173	PF00917	0.675
DOC_USP7_MATH_1	200	204	PF00917	0.481
DOC_USP7_MATH_1	87	91	PF00917	0.665
DOC_USP7_UBL2_3	201	205	PF12436	0.428
DOC_WW_Pin1_4	100	105	PF00397	0.500
LIG_14-3-3_CanoR_1	187	194	PF00244	0.670
LIG_14-3-3_CanoR_1	321	326	PF00244	0.534
LIG_14-3-3_CanoR_1	35	41	PF00244	0.420
LIG_APCC_ABBA_1	312	317	PF00400	0.479
LIG_BRCT_BRCA1_1	213	217	PF00533	0.479
LIG_BRCT_BRCA1_2	213	219	PF00533	0.540
LIG_eIF4E_1	245	251	PF01652	0.461
LIG_FHA_1	220	226	PF00498	0.461
LIG_FHA_1	239	245	PF00498	0.461
LIG_FHA_1	293	299	PF00498	0.473
LIG_FHA_2	127	133	PF00498	0.694
LIG_FHA_2	225	231	PF00498	0.542
LIG_GBD_Chelix_1	207	215	PF00786	0.328
LIG_Integrin_RGD_1	22	24	PF01839	0.430
LIG_Integrin_RGD_TGFB_3	22	28	PF01839	0.395
LIG_LIR_Gen_1	228	239	PF02991	0.521
LIG_LIR_Nem_3	228	234	PF02991	0.521
LIG_SH2_CRK	247	251	PF00017	0.461
LIG_SH2_NCK_1	237	241	PF00017	0.542
LIG_SH2_SRC	237	240	PF00017	0.483
LIG_SH2_SRC	245	248	PF00017	0.438
LIG_SH2_STAP1	247	251	PF00017	0.461
LIG_SH2_STAP1	265	269	PF00017	0.461
LIG_SH2_STAT3	120	123	PF00017	0.706
LIG_SH2_STAT5	245	248	PF00017	0.461
LIG_SH2_STAT5	36	39	PF00017	0.431
LIG_SH3_3	252	258	PF00018	0.528
LIG_SUMO_SIM_par_1	290	297	PF11976	0.462
LIG_WW_3	176	180	PF00397	0.631
MOD_CK1_1	102	108	PF00069	0.548
MOD_CK1_1	189	195	PF00069	0.622
MOD_CK1_1	249	255	PF00069	0.540
MOD_CK2_1	126	132	PF00069	0.781
MOD_Cter_Amidation	13	16	PF01082	0.461
MOD_GlcNHglycan	123	126	PF01048	0.753
MOD_GlcNHglycan	172	175	PF01048	0.710
MOD_GlcNHglycan	183	186	PF01048	0.605
MOD_GSK3_1	229	236	PF00069	0.461
MOD_GSK3_1	245	252	PF00069	0.461
MOD_GSK3_1	36	43	PF00069	0.294
MOD_GSK3_1	98	105	PF00069	0.512
MOD_N-GLC_1	219	224	PF02516	0.261
MOD_NEK2_1	211	216	PF00069	0.482
MOD_NEK2_1	269	274	PF00069	0.461
MOD_NEK2_1	294	299	PF00069	0.458
MOD_NEK2_1	315	320	PF00069	0.474
MOD_NEK2_1	55	60	PF00069	0.414
MOD_NEK2_2	200	205	PF00069	0.423
MOD_PIKK_1	126	132	PF00454	0.574
MOD_PIKK_1	284	290	PF00454	0.496
MOD_PKA_2	126	132	PF00069	0.651
MOD_PKA_2	186	192	PF00069	0.676
MOD_Plk_1	219	225	PF00069	0.461
MOD_Plk_1	229	235	PF00069	0.461
MOD_Plk_1	55	61	PF00069	0.482
MOD_Plk_4	246	252	PF00069	0.523
MOD_Plk_4	269	275	PF00069	0.461
MOD_Plk_4	3	9	PF00069	0.285
MOD_Plk_4	315	321	PF00069	0.552
MOD_Plk_4	55	61	PF00069	0.446
MOD_ProDKin_1	100	106	PF00069	0.499
TRG_DiLeu_BaEn_1	44	49	PF01217	0.505
TRG_ENDOCYTIC_2	247	250	PF00928	0.461
TRG_ENDOCYTIC_2	265	268	PF00928	0.461
TRG_ER_diArg_1	33	35	PF00400	0.381
TRG_NES_CRM1_1	202	216	PF08389	0.377
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT22	Leptomonas seymouri	57%	99%
A0A1X0P075	Trypanosomatidae	45%	92%
A0A3S7X487	Leishmania donovani	88%	100%
A4HJ54	Leishmania braziliensis	69%	94%
A4I6G8	Leishmania infantum	88%	100%
D0A443	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	91%
Q9BHG3	Leishmania major	87%	96%
V5BJ53	Trypanosoma cruzi	45%	94%