LeishMANIAdb
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MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
major facilitator superfamily, putative
Species:
Leishmania mexicana
UniProt:
E9B1M3_LEIMU
TriTrypDb:
LmxM.30.0720
Length:
971

Annotations

LeishMANIAdb annotations

Part of a gigantic, highly expanded family of Kinetoplastid transporters. Most similar to plant nodulins and animal monocarboxylate transporters.. Likely one of the main nutrient transporters in Kinetoplastida.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

E9B1M3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1M3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 7
GO:0022857 transmembrane transporter activity 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.726
CLV_C14_Caspase3-7 138 142 PF00656 0.535
CLV_C14_Caspase3-7 420 424 PF00656 0.661
CLV_C14_Caspase3-7 501 505 PF00656 0.782
CLV_MEL_PAP_1 27 33 PF00089 0.564
CLV_NRD_NRD_1 120 122 PF00675 0.548
CLV_NRD_NRD_1 144 146 PF00675 0.395
CLV_NRD_NRD_1 363 365 PF00675 0.312
CLV_NRD_NRD_1 40 42 PF00675 0.593
CLV_NRD_NRD_1 886 888 PF00675 0.624
CLV_NRD_NRD_1 912 914 PF00675 0.463
CLV_NRD_NRD_1 925 927 PF00675 0.410
CLV_PCSK_KEX2_1 13 15 PF00082 0.594
CLV_PCSK_KEX2_1 144 146 PF00082 0.395
CLV_PCSK_KEX2_1 362 364 PF00082 0.340
CLV_PCSK_KEX2_1 42 44 PF00082 0.603
CLV_PCSK_KEX2_1 886 888 PF00082 0.627
CLV_PCSK_KEX2_1 912 914 PF00082 0.427
CLV_PCSK_KEX2_1 925 927 PF00082 0.396
CLV_PCSK_PC1ET2_1 13 15 PF00082 0.594
CLV_PCSK_PC1ET2_1 362 364 PF00082 0.340
CLV_PCSK_PC1ET2_1 42 44 PF00082 0.575
CLV_PCSK_SKI1_1 130 134 PF00082 0.582
CLV_PCSK_SKI1_1 147 151 PF00082 0.273
CLV_PCSK_SKI1_1 182 186 PF00082 0.564
CLV_PCSK_SKI1_1 296 300 PF00082 0.512
CLV_PCSK_SKI1_1 338 342 PF00082 0.364
CLV_PCSK_SKI1_1 763 767 PF00082 0.421
CLV_PCSK_SKI1_1 933 937 PF00082 0.473
DEG_SCF_SKP2-CKS1_1 390 397 PF00560 0.364
DOC_ANK_TNKS_1 398 405 PF00023 0.354
DOC_CKS1_1 18 23 PF01111 0.750
DOC_CKS1_1 554 559 PF01111 0.675
DOC_MAPK_gen_1 144 150 PF00069 0.563
DOC_MAPK_gen_1 362 370 PF00069 0.554
DOC_MAPK_gen_1 437 445 PF00069 0.661
DOC_MAPK_gen_1 777 785 PF00069 0.639
DOC_MAPK_MEF2A_6 363 372 PF00069 0.554
DOC_MAPK_MEF2A_6 516 524 PF00069 0.801
DOC_MAPK_MEF2A_6 536 544 PF00069 0.653
DOC_MAPK_MEF2A_6 580 587 PF00069 0.769
DOC_MAPK_MEF2A_6 891 899 PF00069 0.362
DOC_PP1_RVXF_1 145 151 PF00149 0.554
DOC_PP1_RVXF_1 28 34 PF00149 0.744
DOC_PP2B_LxvP_1 415 418 PF13499 0.407
DOC_PP2B_LxvP_1 568 571 PF13499 0.787
DOC_PP2B_LxvP_1 72 75 PF13499 0.777
DOC_PP2B_LxvP_1 79 82 PF13499 0.720
DOC_PP2B_PxIxI_1 580 586 PF00149 0.765
DOC_PP4_FxxP_1 197 200 PF00568 0.348
DOC_SPAK_OSR1_1 145 149 PF12202 0.564
DOC_USP7_MATH_1 215 219 PF00917 0.421
DOC_USP7_MATH_1 418 422 PF00917 0.541
DOC_USP7_MATH_1 518 522 PF00917 0.679
DOC_USP7_MATH_1 530 534 PF00917 0.664
DOC_USP7_MATH_1 634 638 PF00917 0.676
DOC_USP7_MATH_1 655 659 PF00917 0.664
DOC_USP7_MATH_1 755 759 PF00917 0.352
DOC_USP7_MATH_1 791 795 PF00917 0.348
DOC_USP7_MATH_1 900 904 PF00917 0.348
DOC_USP7_UBL2_3 112 116 PF12436 0.768
DOC_WW_Pin1_4 17 22 PF00397 0.856
DOC_WW_Pin1_4 338 343 PF00397 0.564
DOC_WW_Pin1_4 391 396 PF00397 0.364
DOC_WW_Pin1_4 535 540 PF00397 0.834
DOC_WW_Pin1_4 550 555 PF00397 0.767
DOC_WW_Pin1_4 653 658 PF00397 0.790
DOC_WW_Pin1_4 74 79 PF00397 0.777
DOC_WW_Pin1_4 872 877 PF00397 0.451
LIG_14-3-3_CanoR_1 121 126 PF00244 0.656
LIG_14-3-3_CanoR_1 30 34 PF00244 0.799
LIG_14-3-3_CanoR_1 354 361 PF00244 0.540
LIG_14-3-3_CanoR_1 48 56 PF00244 0.626
LIG_14-3-3_CanoR_1 580 586 PF00244 0.879
LIG_Actin_WH2_2 386 401 PF00022 0.421
LIG_APCC_ABBA_1 585 590 PF00400 0.778
LIG_BIR_II_1 1 5 PF00653 0.894
LIG_BRCT_BRCA1_1 828 832 PF00533 0.404
LIG_deltaCOP1_diTrp_1 708 713 PF00928 0.348
LIG_eIF4E_1 706 712 PF01652 0.512
LIG_FHA_1 101 107 PF00498 0.798
LIG_FHA_1 159 165 PF00498 0.348
LIG_FHA_1 24 30 PF00498 0.772
LIG_FHA_1 275 281 PF00498 0.564
LIG_FHA_1 381 387 PF00498 0.421
LIG_FHA_1 637 643 PF00498 0.777
LIG_FHA_1 681 687 PF00498 0.696
LIG_FHA_1 696 702 PF00498 0.566
LIG_FHA_1 714 720 PF00498 0.348
LIG_FHA_1 780 786 PF00498 0.593
LIG_FHA_1 829 835 PF00498 0.348
LIG_FHA_2 10 16 PF00498 0.800
LIG_FHA_2 122 128 PF00498 0.746
LIG_FHA_2 136 142 PF00498 0.547
LIG_FHA_2 339 345 PF00498 0.525
LIG_FHA_2 574 580 PF00498 0.815
LIG_FHA_2 657 663 PF00498 0.661
LIG_FHA_2 703 709 PF00498 0.543
LIG_FHA_2 835 841 PF00498 0.474
LIG_Integrin_RGD_1 643 645 PF01839 0.448
LIG_IRF3_LxIS_1 153 158 PF10401 0.421
LIG_LIR_Apic_2 206 210 PF02991 0.512
LIG_LIR_Apic_2 674 679 PF02991 0.636
LIG_LIR_Apic_2 689 694 PF02991 0.612
LIG_LIR_Gen_1 166 176 PF02991 0.246
LIG_LIR_Gen_1 288 299 PF02991 0.360
LIG_LIR_Gen_1 304 313 PF02991 0.353
LIG_LIR_Gen_1 645 654 PF02991 0.734
LIG_LIR_Gen_1 708 717 PF02991 0.351
LIG_LIR_Gen_1 801 812 PF02991 0.334
LIG_LIR_Nem_3 166 171 PF02991 0.407
LIG_LIR_Nem_3 282 286 PF02991 0.348
LIG_LIR_Nem_3 288 294 PF02991 0.348
LIG_LIR_Nem_3 304 309 PF02991 0.360
LIG_LIR_Nem_3 645 649 PF02991 0.712
LIG_LIR_Nem_3 703 709 PF02991 0.551
LIG_LIR_Nem_3 801 807 PF02991 0.248
LIG_LIR_Nem_3 829 835 PF02991 0.404
LIG_LYPXL_yS_3 706 709 PF13949 0.472
LIG_NRBOX 222 228 PF00104 0.348
LIG_Pex14_1 710 714 PF04695 0.348
LIG_Pex14_1 863 867 PF04695 0.410
LIG_Pex14_2 146 150 PF04695 0.512
LIG_Pex14_2 197 201 PF04695 0.348
LIG_Pex14_2 228 232 PF04695 0.348
LIG_Pex14_2 291 295 PF04695 0.357
LIG_Pex14_2 299 303 PF04695 0.303
LIG_REV1ctd_RIR_1 296 304 PF16727 0.354
LIG_SH2_CRK 247 251 PF00017 0.246
LIG_SH2_CRK 646 650 PF00017 0.778
LIG_SH2_CRK 676 680 PF00017 0.677
LIG_SH2_CRK 714 718 PF00017 0.421
LIG_SH2_CRK 914 918 PF00017 0.602
LIG_SH2_GRB2like 676 679 PF00017 0.689
LIG_SH2_PTP2 691 694 PF00017 0.689
LIG_SH2_STAP1 255 259 PF00017 0.348
LIG_SH2_STAP1 365 369 PF00017 0.383
LIG_SH2_STAP1 54 58 PF00017 0.746
LIG_SH2_STAP1 769 773 PF00017 0.600
LIG_SH2_STAP1 870 874 PF00017 0.417
LIG_SH2_STAP1 914 918 PF00017 0.611
LIG_SH2_STAT3 355 358 PF00017 0.554
LIG_SH2_STAT5 188 191 PF00017 0.421
LIG_SH2_STAT5 324 327 PF00017 0.480
LIG_SH2_STAT5 330 333 PF00017 0.529
LIG_SH2_STAT5 349 352 PF00017 0.434
LIG_SH2_STAT5 378 381 PF00017 0.338
LIG_SH2_STAT5 388 391 PF00017 0.348
LIG_SH2_STAT5 691 694 PF00017 0.670
LIG_SH2_STAT5 714 717 PF00017 0.355
LIG_SH2_STAT5 748 751 PF00017 0.407
LIG_SH2_STAT5 833 836 PF00017 0.299
LIG_SH2_STAT5 851 854 PF00017 0.348
LIG_SH2_STAT5 867 870 PF00017 0.313
LIG_SH2_STAT5 881 884 PF00017 0.457
LIG_SH2_STAT5 896 899 PF00017 0.265
LIG_SH2_STAT5 908 911 PF00017 0.399
LIG_SH3_3 101 107 PF00018 0.673
LIG_SH3_3 18 24 PF00018 0.774
LIG_SH3_3 32 38 PF00018 0.680
LIG_SH3_3 539 545 PF00018 0.843
LIG_SH3_3 551 557 PF00018 0.731
LIG_SH3_3 575 581 PF00018 0.757
LIG_SH3_3 72 78 PF00018 0.775
LIG_SH3_3 780 786 PF00018 0.515
LIG_SH3_3 924 930 PF00018 0.695
LIG_Sin3_3 169 176 PF02671 0.246
LIG_SUMO_SIM_anti_2 440 449 PF11976 0.562
LIG_SUMO_SIM_anti_2 810 816 PF11976 0.325
LIG_SUMO_SIM_par_1 153 161 PF11976 0.407
LIG_SUMO_SIM_par_1 212 218 PF11976 0.407
LIG_SUMO_SIM_par_1 781 787 PF11976 0.561
LIG_TRAF2_1 438 441 PF00917 0.689
LIG_TRAF2_1 489 492 PF00917 0.772
LIG_TYR_ITIM 245 250 PF00017 0.246
LIG_TYR_ITIM 704 709 PF00017 0.554
LIG_TYR_ITIM 712 717 PF00017 0.348
LIG_WRC_WIRS_1 280 285 PF05994 0.348
MOD_CDK_SPK_2 338 343 PF00069 0.537
MOD_CDK_SPK_2 872 877 PF00069 0.326
MOD_CDK_SPxK_1 391 397 PF00069 0.364
MOD_CDK_SPxxK_3 553 560 PF00069 0.680
MOD_CDK_SPxxK_3 653 660 PF00069 0.764
MOD_CK1_1 156 162 PF00069 0.421
MOD_CK1_1 190 196 PF00069 0.421
MOD_CK1_1 46 52 PF00069 0.685
MOD_CK1_1 550 556 PF00069 0.720
MOD_CK1_1 614 620 PF00069 0.695
MOD_CK1_1 656 662 PF00069 0.867
MOD_CK1_1 674 680 PF00069 0.569
MOD_CK1_1 875 881 PF00069 0.468
MOD_CK1_1 903 909 PF00069 0.348
MOD_CK1_1 953 959 PF00069 0.721
MOD_CK2_1 177 183 PF00069 0.337
MOD_CK2_1 33 39 PF00069 0.768
MOD_CK2_1 338 344 PF00069 0.585
MOD_CK2_1 529 535 PF00069 0.761
MOD_CK2_1 573 579 PF00069 0.757
MOD_CK2_1 92 98 PF00069 0.779
MOD_CMANNOS 863 866 PF00535 0.421
MOD_Cter_Amidation 963 966 PF01082 0.442
MOD_GlcNHglycan 113 116 PF01048 0.498
MOD_GlcNHglycan 189 192 PF01048 0.421
MOD_GlcNHglycan 283 286 PF01048 0.389
MOD_GlcNHglycan 504 507 PF01048 0.482
MOD_GlcNHglycan 549 552 PF01048 0.611
MOD_GlcNHglycan 632 635 PF01048 0.616
MOD_GlcNHglycan 651 654 PF01048 0.522
MOD_GlcNHglycan 828 831 PF01048 0.404
MOD_GlcNHglycan 93 97 PF01048 0.642
MOD_GlcNHglycan 952 955 PF01048 0.524
MOD_GSK3_1 153 160 PF00069 0.421
MOD_GSK3_1 281 288 PF00069 0.247
MOD_GSK3_1 29 36 PF00069 0.753
MOD_GSK3_1 530 537 PF00069 0.820
MOD_GSK3_1 54 61 PF00069 0.808
MOD_GSK3_1 611 618 PF00069 0.758
MOD_GSK3_1 626 633 PF00069 0.667
MOD_GSK3_1 645 652 PF00069 0.694
MOD_GSK3_1 668 675 PF00069 0.678
MOD_GSK3_1 696 703 PF00069 0.561
MOD_GSK3_1 824 831 PF00069 0.348
MOD_GSK3_1 899 906 PF00069 0.348
MOD_GSK3_1 950 957 PF00069 0.628
MOD_N-GLC_1 46 51 PF02516 0.549
MOD_N-GLC_1 465 470 PF02516 0.445
MOD_N-GLC_1 614 619 PF02516 0.586
MOD_NEK2_1 155 160 PF00069 0.352
MOD_NEK2_1 228 233 PF00069 0.348
MOD_NEK2_1 279 284 PF00069 0.348
MOD_NEK2_1 286 291 PF00069 0.348
MOD_NEK2_1 29 34 PF00069 0.862
MOD_NEK2_1 311 316 PF00069 0.438
MOD_NEK2_1 377 382 PF00069 0.500
MOD_NEK2_1 564 569 PF00069 0.789
MOD_NEK2_1 611 616 PF00069 0.682
MOD_NEK2_1 649 654 PF00069 0.809
MOD_NEK2_1 700 705 PF00069 0.560
MOD_NEK2_1 713 718 PF00069 0.348
MOD_NEK2_1 724 729 PF00069 0.393
MOD_NEK2_1 750 755 PF00069 0.299
MOD_NEK2_1 798 803 PF00069 0.271
MOD_NEK2_1 826 831 PF00069 0.332
MOD_NEK2_1 899 904 PF00069 0.407
MOD_NEK2_2 163 168 PF00069 0.407
MOD_NEK2_2 177 182 PF00069 0.354
MOD_NEK2_2 581 586 PF00069 0.792
MOD_PIKK_1 158 164 PF00454 0.348
MOD_PIKK_1 354 360 PF00454 0.512
MOD_PIKK_1 48 54 PF00454 0.757
MOD_PKA_1 121 127 PF00069 0.719
MOD_PKA_1 912 918 PF00069 0.616
MOD_PKA_2 120 126 PF00069 0.661
MOD_PKA_2 29 35 PF00069 0.752
MOD_PKA_2 502 508 PF00069 0.731
MOD_PKA_2 668 674 PF00069 0.732
MOD_PKA_2 89 95 PF00069 0.789
MOD_PKA_2 912 918 PF00069 0.616
MOD_PKB_1 352 360 PF00069 0.512
MOD_PKB_1 41 49 PF00069 0.663
MOD_PKB_1 777 785 PF00069 0.645
MOD_Plk_1 182 188 PF00069 0.337
MOD_Plk_1 530 536 PF00069 0.775
MOD_Plk_1 54 60 PF00069 0.752
MOD_Plk_1 634 640 PF00069 0.723
MOD_Plk_2-3 423 429 PF00069 0.672
MOD_Plk_4 163 169 PF00069 0.530
MOD_Plk_4 182 188 PF00069 0.236
MOD_Plk_4 215 221 PF00069 0.407
MOD_Plk_4 236 242 PF00069 0.364
MOD_Plk_4 286 292 PF00069 0.348
MOD_Plk_4 54 60 PF00069 0.801
MOD_Plk_4 696 702 PF00069 0.556
MOD_Plk_4 779 785 PF00069 0.606
MOD_Plk_4 798 804 PF00069 0.240
MOD_Plk_4 828 834 PF00069 0.519
MOD_Plk_4 904 910 PF00069 0.388
MOD_ProDKin_1 17 23 PF00069 0.853
MOD_ProDKin_1 338 344 PF00069 0.564
MOD_ProDKin_1 391 397 PF00069 0.364
MOD_ProDKin_1 535 541 PF00069 0.836
MOD_ProDKin_1 550 556 PF00069 0.767
MOD_ProDKin_1 653 659 PF00069 0.790
MOD_ProDKin_1 74 80 PF00069 0.776
MOD_ProDKin_1 872 878 PF00069 0.454
MOD_SUMO_for_1 438 441 PF00179 0.689
MOD_SUMO_rev_2 36 44 PF00179 0.765
MOD_SUMO_rev_2 946 951 PF00179 0.607
TRG_DiLeu_BaEn_1 440 445 PF01217 0.589
TRG_DiLeu_BaLyEn_6 578 583 PF01217 0.759
TRG_ENDOCYTIC_2 205 208 PF00928 0.512
TRG_ENDOCYTIC_2 247 250 PF00928 0.412
TRG_ENDOCYTIC_2 365 368 PF00928 0.438
TRG_ENDOCYTIC_2 378 381 PF00928 0.279
TRG_ENDOCYTIC_2 624 627 PF00928 0.668
TRG_ENDOCYTIC_2 646 649 PF00928 0.777
TRG_ENDOCYTIC_2 706 709 PF00928 0.545
TRG_ENDOCYTIC_2 714 717 PF00928 0.348
TRG_ENDOCYTIC_2 740 743 PF00928 0.452
TRG_ENDOCYTIC_2 748 751 PF00928 0.363
TRG_ENDOCYTIC_2 769 772 PF00928 0.590
TRG_ENDOCYTIC_2 896 899 PF00928 0.348
TRG_ENDOCYTIC_2 914 917 PF00928 0.561
TRG_ER_diArg_1 143 145 PF00400 0.603
TRG_ER_diArg_1 335 338 PF00400 0.605
TRG_ER_diArg_1 351 354 PF00400 0.450
TRG_ER_diArg_1 363 365 PF00400 0.512
TRG_ER_diArg_1 451 454 PF00400 0.700
TRG_ER_diArg_1 912 914 PF00400 0.657
TRG_ER_diArg_1 925 927 PF00400 0.610
TRG_NES_CRM1_1 55 67 PF08389 0.688
TRG_NLS_MonoExtN_4 361 366 PF00514 0.512

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NZT1 Trypanosomatidae 38% 100%
A0A3Q8IG09 Leishmania donovani 86% 99%
A0A422NL17 Trypanosoma rangeli 39% 100%
A4HJ52 Leishmania braziliensis 72% 100%
A4I6G6 Leishmania infantum 86% 99%
Q4Q6J1 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS