LeishMANIAdb
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Putative ATP-dependent zinc metallopeptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATP-dependent zinc metallopeptidase
Gene product:
metallo-peptidase, Clan MA(E), Family M41
Species:
Leishmania mexicana
UniProt:
E9B1M1_LEIMU
TriTrypDb:
LmxM.30.0700
Length:
885

Annotations

LeishMANIAdb annotations

Homologous to bacterial FtsH and Eukaryotic AFG3 proteins. Probably involved in mitochondrial protein processing.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 20
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0016020 membrane 2 17
GO:0110165 cellular anatomical entity 1 18
GO:0005739 mitochondrion 5 1
GO:0005745 m-AAA complex 4 2
GO:0032991 protein-containing complex 1 2
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098796 membrane protein complex 2 2
GO:0098798 mitochondrial protein-containing complex 2 2
GO:0098800 inner mitochondrial membrane protein complex 3 2
GO:1902494 catalytic complex 2 2
GO:1905368 peptidase complex 3 2

Expansion

Sequence features

E9B1M1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1M1

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 20
GO:0006807 nitrogen compound metabolic process 2 20
GO:0008152 metabolic process 1 20
GO:0019538 protein metabolic process 3 20
GO:0043170 macromolecule metabolic process 3 20
GO:0044238 primary metabolic process 2 20
GO:0071704 organic substance metabolic process 2 20
GO:1901564 organonitrogen compound metabolic process 3 20
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 2
GO:0016485 protein processing 5 2
GO:0022607 cellular component assembly 4 2
GO:0034982 mitochondrial protein processing 6 2
GO:0043933 protein-containing complex organization 4 2
GO:0051604 protein maturation 4 2
GO:0065003 protein-containing complex assembly 5 2
GO:0071840 cellular component organization or biogenesis 2 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 21
GO:0003824 catalytic activity 1 21
GO:0004175 endopeptidase activity 4 20
GO:0004176 ATP-dependent peptidase activity 2 20
GO:0004222 metalloendopeptidase activity 5 20
GO:0005488 binding 1 21
GO:0005524 ATP binding 5 21
GO:0008233 peptidase activity 3 20
GO:0008237 metallopeptidase activity 4 20
GO:0016462 pyrophosphatase activity 5 21
GO:0016787 hydrolase activity 2 21
GO:0016817 hydrolase activity, acting on acid anhydrides 3 21
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 21
GO:0016887 ATP hydrolysis activity 7 21
GO:0017076 purine nucleotide binding 4 21
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 21
GO:0030554 adenyl nucleotide binding 5 21
GO:0032553 ribonucleotide binding 3 21
GO:0032555 purine ribonucleotide binding 4 21
GO:0032559 adenyl ribonucleotide binding 5 21
GO:0035639 purine ribonucleoside triphosphate binding 4 21
GO:0036094 small molecule binding 2 21
GO:0043167 ion binding 2 21
GO:0043168 anion binding 3 21
GO:0097159 organic cyclic compound binding 2 21
GO:0097367 carbohydrate derivative binding 2 21
GO:0140096 catalytic activity, acting on a protein 2 20
GO:0140657 ATP-dependent activity 1 20
GO:1901265 nucleoside phosphate binding 3 21
GO:1901363 heterocyclic compound binding 2 21

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 213 217 PF00656 0.473
CLV_C14_Caspase3-7 431 435 PF00656 0.450
CLV_C14_Caspase3-7 460 464 PF00656 0.450
CLV_C14_Caspase3-7 541 545 PF00656 0.710
CLV_C14_Caspase3-7 751 755 PF00656 0.463
CLV_NRD_NRD_1 112 114 PF00675 0.455
CLV_NRD_NRD_1 421 423 PF00675 0.329
CLV_NRD_NRD_1 469 471 PF00675 0.342
CLV_NRD_NRD_1 48 50 PF00675 0.452
CLV_NRD_NRD_1 585 587 PF00675 0.564
CLV_NRD_NRD_1 629 631 PF00675 0.290
CLV_NRD_NRD_1 781 783 PF00675 0.281
CLV_NRD_NRD_1 825 827 PF00675 0.342
CLV_NRD_NRD_1 880 882 PF00675 0.442
CLV_PCSK_FUR_1 627 631 PF00082 0.246
CLV_PCSK_KEX2_1 112 114 PF00082 0.389
CLV_PCSK_KEX2_1 173 175 PF00082 0.585
CLV_PCSK_KEX2_1 439 441 PF00082 0.239
CLV_PCSK_KEX2_1 469 471 PF00082 0.263
CLV_PCSK_KEX2_1 48 50 PF00082 0.428
CLV_PCSK_KEX2_1 585 587 PF00082 0.545
CLV_PCSK_KEX2_1 629 631 PF00082 0.290
CLV_PCSK_KEX2_1 825 827 PF00082 0.342
CLV_PCSK_PC1ET2_1 173 175 PF00082 0.585
CLV_PCSK_PC1ET2_1 439 441 PF00082 0.239
CLV_PCSK_PC1ET2_1 585 587 PF00082 0.412
CLV_PCSK_SKI1_1 102 106 PF00082 0.433
CLV_PCSK_SKI1_1 343 347 PF00082 0.316
CLV_PCSK_SKI1_1 379 383 PF00082 0.250
CLV_PCSK_SKI1_1 415 419 PF00082 0.259
CLV_PCSK_SKI1_1 618 622 PF00082 0.388
CLV_PCSK_SKI1_1 747 751 PF00082 0.284
CLV_PCSK_SKI1_1 783 787 PF00082 0.334
CLV_PCSK_SKI1_1 810 814 PF00082 0.252
CLV_PCSK_SKI1_1 825 829 PF00082 0.263
DEG_APCC_DBOX_1 139 147 PF00400 0.450
DEG_Nend_UBRbox_3 1 3 PF02207 0.606
DEG_SCF_FBW7_1 502 508 PF00400 0.612
DOC_ANK_TNKS_1 86 93 PF00023 0.617
DOC_CKS1_1 34 39 PF01111 0.723
DOC_CKS1_1 502 507 PF01111 0.611
DOC_CYCLIN_RxL_1 412 420 PF00134 0.471
DOC_CYCLIN_yCln2_LP_2 811 817 PF00134 0.542
DOC_MAPK_gen_1 314 322 PF00069 0.595
DOC_MAPK_gen_1 422 430 PF00069 0.471
DOC_MAPK_gen_1 469 476 PF00069 0.463
DOC_MAPK_gen_1 492 502 PF00069 0.450
DOC_MAPK_gen_1 750 760 PF00069 0.524
DOC_MAPK_JIP1_4 256 262 PF00069 0.433
DOC_MAPK_MEF2A_6 140 149 PF00069 0.272
DOC_MAPK_MEF2A_6 256 264 PF00069 0.347
DOC_MAPK_MEF2A_6 717 726 PF00069 0.462
DOC_MAPK_MEF2A_6 753 760 PF00069 0.463
DOC_PP2B_LxvP_1 372 375 PF13499 0.439
DOC_USP7_MATH_1 15 19 PF00917 0.722
DOC_USP7_MATH_1 159 163 PF00917 0.435
DOC_USP7_MATH_1 387 391 PF00917 0.450
DOC_USP7_MATH_1 397 401 PF00917 0.450
DOC_USP7_MATH_1 592 596 PF00917 0.777
DOC_USP7_MATH_1 90 94 PF00917 0.641
DOC_USP7_UBL2_3 312 316 PF12436 0.622
DOC_USP7_UBL2_3 339 343 PF12436 0.537
DOC_USP7_UBL2_3 360 364 PF12436 0.615
DOC_USP7_UBL2_3 419 423 PF12436 0.524
DOC_USP7_UBL2_3 846 850 PF12436 0.521
DOC_WW_Pin1_4 234 239 PF00397 0.430
DOC_WW_Pin1_4 30 35 PF00397 0.755
DOC_WW_Pin1_4 5 10 PF00397 0.744
DOC_WW_Pin1_4 501 506 PF00397 0.577
DOC_WW_Pin1_4 557 562 PF00397 0.652
DOC_WW_Pin1_4 602 607 PF00397 0.660
LIG_14-3-3_CanoR_1 267 275 PF00244 0.263
LIG_14-3-3_CanoR_1 35 41 PF00244 0.756
LIG_14-3-3_CanoR_1 48 53 PF00244 0.634
LIG_14-3-3_CanoR_1 691 700 PF00244 0.462
LIG_14-3-3_CanoR_1 877 885 PF00244 0.710
LIG_Actin_WH2_2 509 524 PF00022 0.517
LIG_Actin_WH2_2 766 784 PF00022 0.463
LIG_APCC_ABBA_1 188 193 PF00400 0.397
LIG_APCC_ABBAyCdc20_2 425 431 PF00400 0.439
LIG_BIR_III_4 434 438 PF00653 0.450
LIG_FHA_1 150 156 PF00498 0.398
LIG_FHA_1 270 276 PF00498 0.306
LIG_FHA_1 344 350 PF00498 0.504
LIG_FHA_1 365 371 PF00498 0.513
LIG_FHA_1 502 508 PF00498 0.594
LIG_FHA_1 564 570 PF00498 0.724
LIG_FHA_1 807 813 PF00498 0.450
LIG_FHA_1 836 842 PF00498 0.430
LIG_FHA_2 235 241 PF00498 0.578
LIG_FHA_2 250 256 PF00498 0.516
LIG_FHA_2 452 458 PF00498 0.455
LIG_FHA_2 526 532 PF00498 0.696
LIG_FHA_2 578 584 PF00498 0.763
LIG_FHA_2 746 752 PF00498 0.450
LIG_FHA_2 861 867 PF00498 0.450
LIG_Integrin_RGD_1 470 472 PF01839 0.250
LIG_LIR_Apic_2 134 139 PF02991 0.688
LIG_LIR_Apic_2 799 804 PF02991 0.506
LIG_LIR_Gen_1 141 151 PF02991 0.291
LIG_LIR_Gen_1 166 175 PF02991 0.340
LIG_LIR_Gen_1 18 25 PF02991 0.765
LIG_LIR_Gen_1 185 195 PF02991 0.343
LIG_LIR_Gen_1 356 366 PF02991 0.584
LIG_LIR_Gen_1 400 409 PF02991 0.449
LIG_LIR_Gen_1 80 91 PF02991 0.602
LIG_LIR_Gen_1 863 871 PF02991 0.450
LIG_LIR_Nem_3 141 147 PF02991 0.266
LIG_LIR_Nem_3 166 171 PF02991 0.437
LIG_LIR_Nem_3 18 23 PF02991 0.783
LIG_LIR_Nem_3 185 190 PF02991 0.402
LIG_LIR_Nem_3 330 335 PF02991 0.542
LIG_LIR_Nem_3 356 361 PF02991 0.580
LIG_LIR_Nem_3 400 405 PF02991 0.449
LIG_LIR_Nem_3 614 620 PF02991 0.526
LIG_LIR_Nem_3 80 86 PF02991 0.707
LIG_LIR_Nem_3 863 867 PF02991 0.450
LIG_NRBOX 454 460 PF00104 0.439
LIG_PCNA_PIPBox_1 849 858 PF02747 0.450
LIG_Pex14_1 282 286 PF04695 0.274
LIG_Pex14_2 288 292 PF04695 0.274
LIG_PTAP_UEV_1 552 557 PF05743 0.638
LIG_PTB_Apo_2 739 746 PF02174 0.433
LIG_SH2_CRK 20 24 PF00017 0.768
LIG_SH2_CRK 358 362 PF00017 0.528
LIG_SH2_CRK 789 793 PF00017 0.463
LIG_SH2_GRB2like 184 187 PF00017 0.323
LIG_SH2_NCK_1 20 24 PF00017 0.749
LIG_SH2_SRC 789 792 PF00017 0.506
LIG_SH2_SRC 864 867 PF00017 0.506
LIG_SH2_STAP1 184 188 PF00017 0.333
LIG_SH2_STAP1 306 310 PF00017 0.694
LIG_SH2_STAP1 52 56 PF00017 0.585
LIG_SH2_STAP1 613 617 PF00017 0.549
LIG_SH2_STAP1 635 639 PF00017 0.518
LIG_SH2_STAP1 736 740 PF00017 0.463
LIG_SH2_STAP1 835 839 PF00017 0.463
LIG_SH2_STAP1 864 868 PF00017 0.481
LIG_SH2_STAT5 11 14 PF00017 0.720
LIG_SH2_STAT5 187 190 PF00017 0.304
LIG_SH2_STAT5 198 201 PF00017 0.305
LIG_SH2_STAT5 20 23 PF00017 0.710
LIG_SH2_STAT5 299 302 PF00017 0.632
LIG_SH2_STAT5 358 361 PF00017 0.550
LIG_SH2_STAT5 406 409 PF00017 0.439
LIG_SH2_STAT5 429 432 PF00017 0.439
LIG_SH2_STAT5 739 742 PF00017 0.462
LIG_SH2_STAT5 791 794 PF00017 0.481
LIG_SH2_STAT5 870 873 PF00017 0.541
LIG_SH3_3 31 37 PF00018 0.740
LIG_SH3_3 499 505 PF00018 0.462
LIG_SH3_3 547 553 PF00018 0.718
LIG_SH3_3 797 803 PF00018 0.488
LIG_SUMO_SIM_anti_2 472 479 PF11976 0.462
LIG_SUMO_SIM_anti_2 837 843 PF11976 0.542
LIG_SUMO_SIM_par_1 147 152 PF11976 0.341
LIG_SUMO_SIM_par_1 837 843 PF11976 0.542
LIG_TRAF2_1 580 583 PF00917 0.786
LIG_TYR_ITIM 862 867 PF00017 0.481
LIG_WRC_WIRS_1 792 797 PF05994 0.463
MOD_CDK_SPK_2 30 35 PF00069 0.598
MOD_CK1_1 10 16 PF00069 0.719
MOD_CK1_1 18 24 PF00069 0.689
MOD_CK1_1 233 239 PF00069 0.568
MOD_CK1_1 525 531 PF00069 0.634
MOD_CK1_1 533 539 PF00069 0.682
MOD_CK1_1 560 566 PF00069 0.755
MOD_CK1_1 602 608 PF00069 0.773
MOD_CK1_1 806 812 PF00069 0.490
MOD_CK2_1 451 457 PF00069 0.452
MOD_CK2_1 577 583 PF00069 0.730
MOD_CK2_1 608 614 PF00069 0.676
MOD_CK2_1 622 628 PF00069 0.548
MOD_CK2_1 670 676 PF00069 0.454
MOD_CK2_1 691 697 PF00069 0.450
MOD_CK2_1 745 751 PF00069 0.450
MOD_Cter_Amidation 110 113 PF01082 0.422
MOD_Cter_Amidation 467 470 PF01082 0.281
MOD_GlcNHglycan 161 164 PF01048 0.592
MOD_GlcNHglycan 389 392 PF01048 0.254
MOD_GlcNHglycan 531 535 PF01048 0.554
MOD_GlcNHglycan 610 613 PF01048 0.444
MOD_GlcNHglycan 67 72 PF01048 0.538
MOD_GlcNHglycan 731 734 PF01048 0.250
MOD_GlcNHglycan 92 95 PF01048 0.461
MOD_GSK3_1 159 166 PF00069 0.386
MOD_GSK3_1 230 237 PF00069 0.501
MOD_GSK3_1 245 252 PF00069 0.499
MOD_GSK3_1 308 315 PF00069 0.661
MOD_GSK3_1 323 330 PF00069 0.625
MOD_GSK3_1 501 508 PF00069 0.631
MOD_GSK3_1 521 528 PF00069 0.464
MOD_GSK3_1 530 537 PF00069 0.661
MOD_GSK3_1 557 564 PF00069 0.677
MOD_GSK3_1 568 575 PF00069 0.684
MOD_GSK3_1 600 607 PF00069 0.682
MOD_GSK3_1 687 694 PF00069 0.563
MOD_GSK3_1 69 76 PF00069 0.674
MOD_GSK3_1 7 14 PF00069 0.688
MOD_GSK3_1 752 759 PF00069 0.452
MOD_GSK3_1 771 778 PF00069 0.370
MOD_GSK3_1 872 879 PF00069 0.629
MOD_GSK3_1 90 97 PF00069 0.697
MOD_N-GLC_1 608 613 PF02516 0.542
MOD_N-GLC_1 670 675 PF02516 0.204
MOD_N-GLC_1 743 748 PF02516 0.346
MOD_N-GLC_1 806 811 PF02516 0.301
MOD_N-GLC_2 527 529 PF02516 0.354
MOD_N-GLC_2 641 643 PF02516 0.290
MOD_N-GLC_2 653 655 PF02516 0.208
MOD_NEK2_1 260 265 PF00069 0.483
MOD_NEK2_1 269 274 PF00069 0.281
MOD_NEK2_1 294 299 PF00069 0.395
MOD_NEK2_1 476 481 PF00069 0.447
MOD_NEK2_1 568 573 PF00069 0.691
MOD_NEK2_1 722 727 PF00069 0.461
MOD_NEK2_1 745 750 PF00069 0.534
MOD_NEK2_1 82 87 PF00069 0.644
MOD_PIKK_1 204 210 PF00454 0.377
MOD_PIKK_1 25 31 PF00454 0.655
MOD_PIKK_1 294 300 PF00454 0.553
MOD_PIKK_1 457 463 PF00454 0.450
MOD_PIKK_1 568 574 PF00454 0.770
MOD_PIKK_1 73 79 PF00454 0.601
MOD_PKA_1 48 54 PF00069 0.688
MOD_PKA_2 159 165 PF00069 0.455
MOD_PKA_2 18 24 PF00069 0.764
MOD_PKA_2 356 362 PF00069 0.519
MOD_PKA_2 48 54 PF00069 0.670
MOD_PKA_2 637 643 PF00069 0.523
MOD_PKA_2 752 758 PF00069 0.463
MOD_PKA_2 873 879 PF00069 0.571
MOD_PKB_1 689 697 PF00069 0.506
MOD_Plk_1 260 266 PF00069 0.436
MOD_Plk_1 451 457 PF00069 0.450
MOD_Plk_1 564 570 PF00069 0.781
MOD_Plk_1 587 593 PF00069 0.759
MOD_Plk_1 608 614 PF00069 0.595
MOD_Plk_1 670 676 PF00069 0.433
MOD_Plk_1 806 812 PF00069 0.532
MOD_Plk_2-3 577 583 PF00069 0.721
MOD_Plk_2-3 860 866 PF00069 0.450
MOD_Plk_4 377 383 PF00069 0.450
MOD_Plk_4 564 570 PF00069 0.728
MOD_Plk_4 7 13 PF00069 0.777
MOD_Plk_4 722 728 PF00069 0.492
MOD_Plk_4 796 802 PF00069 0.506
MOD_ProDKin_1 234 240 PF00069 0.433
MOD_ProDKin_1 30 36 PF00069 0.753
MOD_ProDKin_1 5 11 PF00069 0.745
MOD_ProDKin_1 501 507 PF00069 0.577
MOD_ProDKin_1 557 563 PF00069 0.651
MOD_ProDKin_1 602 608 PF00069 0.657
MOD_SUMO_for_1 341 344 PF00179 0.539
MOD_SUMO_for_1 573 576 PF00179 0.773
MOD_SUMO_for_1 857 860 PF00179 0.506
MOD_SUMO_rev_2 124 133 PF00179 0.706
MOD_SUMO_rev_2 193 197 PF00179 0.345
MOD_SUMO_rev_2 595 601 PF00179 0.792
MOD_SUMO_rev_2 847 852 PF00179 0.542
TRG_DiLeu_BaEn_2 346 352 PF01217 0.496
TRG_DiLeu_BaLyEn_6 627 632 PF01217 0.503
TRG_ENDOCYTIC_2 187 190 PF00928 0.282
TRG_ENDOCYTIC_2 198 201 PF00928 0.314
TRG_ENDOCYTIC_2 20 23 PF00928 0.767
TRG_ENDOCYTIC_2 358 361 PF00928 0.550
TRG_ENDOCYTIC_2 406 409 PF00928 0.439
TRG_ENDOCYTIC_2 789 792 PF00928 0.449
TRG_ENDOCYTIC_2 864 867 PF00928 0.481
TRG_ER_diArg_1 412 415 PF00400 0.431
TRG_ER_diArg_1 47 49 PF00400 0.654
TRG_ER_diArg_1 629 631 PF00400 0.514
TRG_ER_diArg_1 689 692 PF00400 0.538
TRG_ER_diArg_1 86 89 PF00400 0.710
TRG_ER_diLys_1 882 885 PF00400 0.672
TRG_NES_CRM1_1 404 416 PF08389 0.439
TRG_NLS_MonoExtN_4 419 426 PF00514 0.524
TRG_Pf-PMV_PEXEL_1 415 420 PF00026 0.250
TRG_Pf-PMV_PEXEL_1 618 623 PF00026 0.425
TRG_Pf-PMV_PEXEL_1 629 633 PF00026 0.337
TRG_Pf-PMV_PEXEL_1 691 695 PF00026 0.342

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PGD9 Leptomonas seymouri 70% 89%
A0A0S4JGG9 Bodo saltans 30% 100%
A0A0S4JTL4 Bodo saltans 55% 100%
A0A1X0NJP5 Trypanosomatidae 59% 100%
A0A1X0NW32 Trypanosomatidae 32% 100%
A0A3Q8ICE7 Leishmania donovani 93% 100%
A0A3Q8IFG3 Leishmania donovani 33% 100%
A0A3R7L0P7 Trypanosoma rangeli 33% 100%
A0A422NQX8 Trypanosoma rangeli 62% 98%
A4HJ48 Leishmania braziliensis 82% 100%
A4HKD8 Leishmania braziliensis 32% 100%
A4I6G4 Leishmania infantum 93% 100%
A4I809 Leishmania infantum 33% 100%
C9ZN81 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 100%
E9B2S6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
Q4Q5D1 Leishmania major 33% 100%
Q4Q6J3 Leishmania major 92% 100%
V5B3P7 Trypanosoma cruzi 55% 100%
V5BP04 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS